-
1
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303-1310.
-
(2001)
Crit Care Med
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
2
-
-
29744447480
-
The effect of age on the development and outcome of adult sepsis
-
Martin GS, Mannino DM, Moss M. The effect of age on the development and outcome of adult sepsis. Crit Care Med 2006;34:15-21.
-
(2006)
Crit Care Med
, vol.34
, pp. 15-21
-
-
Martin, G.S.1
Mannino, D.M.2
Moss, M.3
-
3
-
-
0141819138
-
The protein C pathway
-
Esmon CT. The protein C pathway. Chest 2003;124:26S-32S.
-
(2003)
Chest
, vol.124
-
-
Esmon, C.T.1
-
4
-
-
0037352279
-
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
-
Cheng T, Liu D, Griffin JH, Fernandez JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med 2003;9:338-342.
-
(2003)
Nat Med
, vol.9
, pp. 338-342
-
-
Cheng, T.1
Liu, D.2
Griffin, J.H.3
Fernandez, J.A.4
Castellino, F.5
Rosen, E.D.6
Fukudome, K.7
Zlokovic, B.V.8
-
5
-
-
0033815368
-
Pathophysiology of disseminated intravascular coagulation in sepsis
-
ten Cate H. Pathophysiology of disseminated intravascular coagulation in sepsis. Crit Care Med 2000;28:S9-11.
-
(2000)
Crit Care Med
, vol.28
-
-
ten Cate, H.1
-
6
-
-
10244250329
-
Patients with severe sepsis vary markedly in their ability to generate activate protein C
-
Liaw PC, Esmon CT, Kahnamoui K, Schmidt S, Kahnamoui S, Ferrell G, Beaudin S, Julian JA, Weitz JI, Crowther M, et al. Patients with severe sepsis vary markedly in their ability to generate activate protein C. Blood 2004;104:3958-3964.
-
(2004)
Blood
, vol.104
, pp. 3958-3964
-
-
Liaw, P.C.1
Esmon, C.T.2
Kahnamoui, K.3
Schmidt, S.4
Kahnamoui, S.5
Ferrell, G.6
Beaudin, S.7
Julian, J.A.8
Weitz, J.I.9
Crowther, M.10
-
7
-
-
0038128677
-
Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study
-
de Kleijn ED, de Groot R, Hack CE, Mulder PG, Engl W, Moritz B, Joosten KF, Hazelzet JA. Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study. Crit Care Med 2003;31:1839-1847.
-
(2003)
Crit Care Med
, vol.31
, pp. 1839-1847
-
-
de Kleijn, E.D.1
de Groot, R.2
Hack, C.E.3
Mulder, P.G.4
Engl, W.5
Moritz, B.6
Joosten, K.F.7
Hazelzet, J.A.8
-
8
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699-709.
-
(2001)
N Engl J Med
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.L.2
Laterre, P.F.3
LaRosa, S.P.4
Dhainaut, J.F.5
Lopez-Rodriguez, A.6
Steingrub, J.S.7
Garber, G.E.8
Helterbrand, J.D.9
Ely, E.W.10
-
9
-
-
25444492831
-
Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
-
Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, Francois B, Guy JS, Bruckmann M, Rea-Neto A, et al. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 2005;353:1332-1341.
-
(2005)
N Engl J Med
, vol.353
, pp. 1332-1341
-
-
Abraham, E.1
Laterre, P.F.2
Garg, R.3
Levy, H.4
Talwar, D.5
Trzaskoma, B.L.6
Francois, B.7
Guy, J.S.8
Bruckmann, M.9
Rea-Neto, A.10
-
10
-
-
19944430219
-
Inflammatory, hemostatic, and clinical changes in a baboon experimental model for heatstroke
-
Bouchama A, Roberts G, Al Mohanna F, El-Sayed R, Lach B, Chollet-Martin S, Ollivier V, Al Baradei R, Loualich A, Nakeeb S, et al. Inflammatory, hemostatic, and clinical changes in a baboon experimental model for heatstroke. J Appl Physiol 2005;98:697-705.
-
(2005)
J Appl Physiol
, vol.98
, pp. 697-705
-
-
Bouchama, A.1
Roberts, G.2
Al Mohanna, F.3
El-Sayed, R.4
Lach, B.5
Chollet-Martin, S.6
Ollivier, V.7
Al Baradei, R.8
Loualich, A.9
Nakeeb, S.10
-
11
-
-
0036209320
-
Elevated plasma procoagulant and fibrinolytic markers in patients with chronic obstructive pulmonary disease
-
Ashitani J, Mukae H, Arimura Y, Matsukura S. Elevated plasma procoagulant and fibrinolytic markers in patients with chronic obstructive pulmonary disease. Intern Med 2002;41:181-185.
-
(2002)
Intern Med
, vol.41
, pp. 181-185
-
-
Ashitani, J.1
Mukae, H.2
Arimura, Y.3
Matsukura, S.4
-
12
-
-
21344433664
-
Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: Implication of the protein C anticoagulant pathway
-
Adrie C, Monchi M, Laurent I, Um S, Yan SB, Thuong M, Cariou A, Charpentier J, Dhainaut JF. Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathway. J Am Coll Cardiol 2005;46:21-28.
-
(2005)
J Am Coll Cardiol
, vol.46
, pp. 21-28
-
-
Adrie, C.1
Monchi, M.2
Laurent, I.3
Um, S.4
Yan, S.B.5
Thuong, M.6
Cariou, A.7
Charpentier, J.8
Dhainaut, J.F.9
-
13
-
-
0034007647
-
Changes of the hemostatic network in critically ill patients: Is there a difference between sepsis, trauma, and neurosurgery patients?
-
Boldt J, Papsdorf M, Rothe A, Kumle B, Piper S. Changes of the hemostatic network in critically ill patients: is there a difference between sepsis, trauma, and neurosurgery patients? Crit Care Med 2000;28:445-450.
-
(2000)
Crit Care Med
, vol.28
, pp. 445-450
-
-
Boldt, J.1
Papsdorf, M.2
Rothe, A.3
Kumle, B.4
Piper, S.5
-
14
-
-
36048972770
-
Biological study of the thrombomodulin-protein C complex in severe sepsis patients [abstract]
-
Diehl JL, Borgel D, Bornstain C, Lerolle N, Aiach M, Fagon JY. Biological study of the thrombomodulin-protein C complex in severe sepsis patients [abstract]. Proc Am Thorac Soc 2006;3:A648.
-
(2006)
Proc Am Thorac Soc
, vol.3
-
-
Diehl, J.L.1
Borgel, D.2
Bornstain, C.3
Lerolle, N.4
Aiach, M.5
Fagon, J.Y.6
-
15
-
-
29744446460
-
Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis
-
Borgel D, Clauser S, Bornstain C, Bieche I, Bissery A, Remones V, Fagon JY, Aiach M, Diehl JL. Elevated growth-arrest-specific protein 6 plasma levels in patients with severe sepsis. Crit Care Med 2006;34:219-222.
-
(2006)
Crit Care Med
, vol.34
, pp. 219-222
-
-
Borgel, D.1
Clauser, S.2
Bornstain, C.3
Bieche, I.4
Bissery, A.5
Remones, V.6
Fagon, J.Y.7
Aiach, M.8
Diehl, J.L.9
-
17
-
-
0035625064
-
Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain
-
Borgel D, Gaussem P, Garbay C, Bachelot-Loza C, Kaabache T, Liu WQ, Brohard-Bohn B, Le Bonniec B, Aiach M, Gandrille S. Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain. Biochem J 2001;360:499-506.
-
(2001)
Biochem J
, vol.360
, pp. 499-506
-
-
Borgel, D.1
Gaussem, P.2
Garbay, C.3
Bachelot-Loza, C.4
Kaabache, T.5
Liu, W.Q.6
Brohard-Bohn, B.7
Le Bonniec, B.8
Aiach, M.9
Gandrille, S.10
-
18
-
-
0037369218
-
An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN
-
Dupont A, Fontana P, Bachelot-Loza C, Reny JL, Bieche I, Desvard F, Aiach M, Gaussem P. An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN. Blood 2003;101:1833-1840.
-
(2003)
Blood
, vol.101
, pp. 1833-1840
-
-
Dupont, A.1
Fontana, P.2
Bachelot-Loza, C.3
Reny, J.L.4
Bieche, I.5
Desvard, F.6
Aiach, M.7
Gaussem, P.8
-
19
-
-
0842328843
-
Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia
-
Pawlinski R, Pedersen B, Schabbauer G, Tencati M, Holscher T, Boisvert W, Andrade-Gordon P, Frank RD, Mackman N. Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia. Blood 2004;103:1342-1347.
-
(2004)
Blood
, vol.103
, pp. 1342-1347
-
-
Pawlinski, R.1
Pedersen, B.2
Schabbauer, G.3
Tencati, M.4
Holscher, T.5
Boisvert, W.6
Andrade-Gordon, P.7
Frank, R.D.8
Mackman, N.9
-
20
-
-
21544447526
-
Regulation of blood coagulation by the protein C anticoagulant pathway: Novel insights into structure-function relationships and molecular recognition
-
Dahlback B, Villoutreix BO. Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition. Arterioscler Thromb Vasc Biol 2005;25:1311-1320.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 1311-1320
-
-
Dahlback, B.1
Villoutreix, B.O.2
-
21
-
-
33644801469
-
The interactions between inflammation and coagulation
-
Esmon CT. The interactions between inflammation and coagulation. Br J Haematol 2005;131:417-430.
-
(2005)
Br J Haematol
, vol.131
, pp. 417-430
-
-
Esmon, C.T.1
-
22
-
-
0038690407
-
Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: A randomized controlled trial
-
Abraham E, Reinhart K, Opal S, Demeyer I, Doig C, Rodriguez AL, Beale R, Svoboda P, Laterre PF, Simon S, et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA 2003;290:238-247.
-
(2003)
JAMA
, vol.290
, pp. 238-247
-
-
Abraham, E.1
Reinhart, K.2
Opal, S.3
Demeyer, I.4
Doig, C.5
Rodriguez, A.L.6
Beale, R.7
Svoboda, P.8
Laterre, P.F.9
Simon, S.10
-
23
-
-
1842600276
-
-
Kinasewitz GT, Yan SB, Basson B, Comp P, Russell JA, Cariou A, Um SL, Utterback B, Laterre PF, Dhainaut JF. Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism. Crit Care 2004;8:R82-R90.
-
Kinasewitz GT, Yan SB, Basson B, Comp P, Russell JA, Cariou A, Um SL, Utterback B, Laterre PF, Dhainaut JF. Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism. Crit Care 2004;8:R82-R90.
-
-
-
-
24
-
-
0037588986
-
The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
-
Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003;101:3765-3777.
-
(2003)
Blood
, vol.101
, pp. 3765-3777
-
-
Aird, W.C.1
-
25
-
-
0027944985
-
The coagulopathy of heat stroke: Alterations in coagulation and fibrinolysis in heat stroke patients during the pilgrimage (Haj) to Makkah
-
al-Mashhadani SA, Gader AG, al Harthi SS, Kangav D, Shaheen FA, Bogus F. The coagulopathy of heat stroke: alterations in coagulation and fibrinolysis in heat stroke patients during the pilgrimage (Haj) to Makkah. Blood Coagul Fibrinolysis 1994;5:731-736.
-
(1994)
Blood Coagul Fibrinolysis
, vol.5
, pp. 731-736
-
-
al-Mashhadani, S.A.1
Gader, A.G.2
al Harthi, S.S.3
Kangav, D.4
Shaheen, F.A.5
Bogus, F.6
-
26
-
-
26444440564
-
Two-way interactions between inflammation and coagulation
-
Levi M, van der Poll T. Two-way interactions between inflammation and coagulation. Trends Cardiovasc Med 2005;15:254-259.
-
(2005)
Trends Cardiovasc Med
, vol.15
, pp. 254-259
-
-
Levi, M.1
van der Poll, T.2
-
27
-
-
0031973176
-
Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes
-
Kurosawa S, Stearns-Kurosawa DJ, Carson CW, D'Angelo A, Della Valle P, Esmon CT. Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood 1998;91:725-727.
-
(1998)
Blood
, vol.91
, pp. 725-727
-
-
Kurosawa, S.1
Stearns-Kurosawa, D.J.2
Carson, C.W.3
D'Angelo, A.4
Della Valle, P.5
Esmon, C.T.6
-
28
-
-
0035833529
-
Dysfunction of endothelial protein C activation in severe meningococcal sepsis
-
Faust SN, Levin M, Harrison OB, Goldin RD, Lockhart MS, Kondaveeti S, Laszik Z, Esmon CT, Heyderman RS. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med 2001;345:408-416.
-
(2001)
N Engl J Med
, vol.345
, pp. 408-416
-
-
Faust, S.N.1
Levin, M.2
Harrison, O.B.3
Goldin, R.D.4
Lockhart, M.S.5
Kondaveeti, S.6
Laszik, Z.7
Esmon, C.T.8
Heyderman, R.S.9
-
29
-
-
0842307339
-
A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis
-
Saposnik B, Reny JL, Gaussem P, Emmerich J, Aiach M, Gandrille S. A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis. Blood 2004;103:1311-1318.
-
(2004)
Blood
, vol.103
, pp. 1311-1318
-
-
Saposnik, B.1
Reny, J.L.2
Gaussem, P.3
Emmerich, J.4
Aiach, M.5
Gandrille, S.6
-
30
-
-
0034161458
-
Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo
-
Gu JM, Katsuura Y, Ferrell GL, Grammas P, Esmon CT. Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood 2000;95:1687-1693.
-
(2000)
Blood
, vol.95
, pp. 1687-1693
-
-
Gu, J.M.1
Katsuura, Y.2
Ferrell, G.L.3
Grammas, P.4
Esmon, C.T.5
-
31
-
-
0029873131
-
A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes
-
Grey ST, Hancock WW. A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes. J Immunol 1996;156:2256-2263.
-
(1996)
J Immunol
, vol.156
, pp. 2256-2263
-
-
Grey, S.T.1
Hancock, W.W.2
-
32
-
-
0023089665
-
Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro
-
Moore KL, Andreoli SP, Esmon NL, Esmon CT, Bang NU. Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest 1987;79:124-130.
-
(1987)
J Clin Invest
, vol.79
, pp. 124-130
-
-
Moore, K.L.1
Andreoli, S.P.2
Esmon, N.L.3
Esmon, C.T.4
Bang, N.U.5
-
33
-
-
0035122535
-
Effect of intradermal tumor necrosis factor-alpha-induced inflammation on coagulation factors in dermal vessel endothelium: An in vivo study of human skin biopsies
-
Speiser W, Kapiotis S, Kopp CW, Simonitsch I, Jilma B, Jansen B, Exner M, Chott A. Effect of intradermal tumor necrosis factor-alpha-induced inflammation on coagulation factors in dermal vessel endothelium: an in vivo study of human skin biopsies. Thromb Haemost 2001;85:362-367.
-
(2001)
Thromb Haemost
, vol.85
, pp. 362-367
-
-
Speiser, W.1
Kapiotis, S.2
Kopp, C.W.3
Simonitsch, I.4
Jilma, B.5
Jansen, B.6
Exner, M.7
Chott, A.8
-
34
-
-
0026662994
-
Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation
-
Conway EM, Nowakowski B, Steiner-Mosonyi M. Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation. Blood 1992;80:1254-1263.
-
(1992)
Blood
, vol.80
, pp. 1254-1263
-
-
Conway, E.M.1
Nowakowski, B.2
Steiner-Mosonyi, M.3
-
35
-
-
0033860427
-
Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications
-
Mesters RM, Helterbrand J, Utterback BG, Yan B, Chao YB, Fernandez JA, Griffin JH, Hartman DL. Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications. Crit Care Med 2000;28:2209-2216.
-
(2000)
Crit Care Med
, vol.28
, pp. 2209-2216
-
-
Mesters, R.M.1
Helterbrand, J.2
Utterback, B.G.3
Yan, B.4
Chao, Y.B.5
Fernandez, J.A.6
Griffin, J.H.7
Hartman, D.L.8
-
36
-
-
12444249948
-
Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis
-
Dhainaut JF, Yan SB, Margolis BD, Lorente JA, Russell JA, Freebairn RC, Spapen HD, Riess H, Basson B, Johnson G III, et al. Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis. Thromb Haemost 2003;90:642-653.
-
(2003)
Thromb Haemost
, vol.90
, pp. 642-653
-
-
Dhainaut, J.F.1
Yan, S.B.2
Margolis, B.D.3
Lorente, J.A.4
Russell, J.A.5
Freebairn, R.C.6
Spapen, H.D.7
Riess, H.8
Basson, B.9
Johnson III, G.10
-
37
-
-
0024507407
-
Diurnal variation of tissue-type plasminogen activator and its rapid inhibitor (PAI-1)
-
Angleton P, Chandler WL, Schmer G. Diurnal variation of tissue-type plasminogen activator and its rapid inhibitor (PAI-1). Circulation 1989;79:101-106.
-
(1989)
Circulation
, vol.79
, pp. 101-106
-
-
Angleton, P.1
Chandler, W.L.2
Schmer, G.3
|