Distribution of endothelial cell protein C/activated protein C receptor (EPCR) during mouse embryo development

Thrombosis and Haemostasis

Volumn 88, Issue 2, 2002, Pages 259-266

  Crawley, James T B ^a   Gu, Jian Ming ^a   Ferrell, Gary ^a   Esmon, Charles T ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Coagulation; Development; EPCR; Protein C; Thrombomodulin

Indexed keywords

ACTIVATED PROTEIN C; ENDOTHELIAL CELL PROTEIN C RECEPTOR; PROTEIN C; THROMBIN; THROMBOMODULIN; UNCLASSIFIED DRUG;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD CLOTTING; CELL SPECIFICITY; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; GENE DELETION; HEMOSTASIS; IMMUNOHISTOLOGY; LETHALITY; MATERNAL BLOOD; MOTHER FETUS RELATIONSHIP; MOUSE; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SOMATIC EMBRYOGENESIS; TROPHOBLAST;

EID: 0036336456     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1613196     Document Type: Article

References (22)

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4. Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor
5. The Gla26 residue of protein C is required for the binding of protein C to thrombomodulin and endothelial cell protein C receptor, but not to protein S and factor Va
6. The interaction between the endothelial cell protein C receptor and protein C is dictated by the gamma-carboxyglutamic acid domain of protein C
7. Human protein C receptor is present primarily on endothelium of large blood vessels: Implications for the control of the protein C pathway
8. Identification of functional endothelial protein C receptor in human plasma
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12. Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C
13. Reconstitution of rabbit thrombomodulin into phospholipid vesicles
14. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis
15. Targeted disruption of the endothelial cell protein C receptor (EPCR) causes early embryonic lethality in mice
16. Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system
17. Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo
18. Ultrastructure of trophoblast giant cell transformation during the invasive stage of implantation of the mouse embryo
19. Tissue-restricted expression of thrombomodulin in the placenta rescues thrombomodulin-deficient mice from early lethality and reveals a secondary developmental block
20. Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis
21. Tissue factor expression during human and mouse development
22. Characterization and regulation of the 5′-flanking region of the murine endothelial protein C receptor gene