Early lung cancer diagnosis by biosensors

International Journal of Molecular Sciences

Volumn 14, Issue 8, 2013, Pages 15479-15509

  Zhang, Yuqian ^a   Yang, Dongliang ^a   Weng, Lixing ^a   Wang, Lianhui ^a  

^a NANJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Biomarker; Biosensor; Early diagnosis; Lung cancer; MicroRNA; Tumor associated antigen

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; CA 19-9 ANTIGEN; COMPLEMENTARY DNA; CYCLOOXYGENASE 2; CYTOKERATIN 18; EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; MICRORNA; MICRORNA 133B; MICRORNA 142 3P; MICRORNA 206; MICRORNA 29; MICRORNA 29A; MICRORNA 29B; MICRORNA 29C; MICRORNA 449C; MUCIN 1; MYC PROTEIN; NY ESO 1 ANTIGEN; PROTEIN P53; QUANTUM DOT; TUMOR ANTIGEN; TUMOR MARKER; UNCLASSIFIED DRUG; VASCULOTROPIN; VILLIN;

ANALYTIC METHOD; BIOSENSOR; CANCER DIAGNOSIS; CHROMATOPHORE; DNA LIBRARY; EARLY DIAGNOSIS; ENZYME ACTIVITY; ENZYME REGULATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE PRODUCT; HUMAN; LUNG CANCER; MICROARRAY ANALYSIS; MICROFLUIDICS; MOLECULAR IMAGING; MULTIPLE AFFINITY PROTEIN PROFILING; PHAGE DISPLAY; PROTEIN EXPRESSION; PROTEIN MICROARRAY; QUORUM SENSING; REVERSE CAPTURE MICROARRAY; REVIEW; RNA ANALYSIS; SENSITIVITY AND SPECIFICITY; SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT; TRANSDUCER;

ANTIGENS, NEOPLASM; AUTOANTIBODIES; BIOSENSING TECHNIQUES; CARCINOMA, NON-SMALL-CELL LUNG; EARLY DETECTION OF CANCER; HUMANS; LUNG NEOPLASMS; MICRORNAS; TUMOR MARKERS, BIOLOGICAL;

EID: 84880788852     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms140815479     Document Type: Review

References (176)

1. Jemal, A.; Bray, F.; Center, M.M.; Ferlay, J.; Ward, E.; Forman, D. Global cancer statistics. CA: Cancer J. Clin. 2011, 61, 69-90.
2. Ferlay, J.; Shin, H.-R.; Bray, F.; Forman, D.; Mathers, C.; Parkin, D.M. Estimates of worldwide burden of cancer in 2008: Globocan 2008. Int. J. Cancer 2010, 127, 2893-;2917.
3. Chiang, C.J.; Chen, Y.C.; Chen, C.J.; You, S.L.; Lai, M.S. Cancer trends in Taiwan. Jpn. J. Clin. Oncol. 2010, 40, 897-904.
4. Bray, F.; Jemal, A.; Grey, N.; Ferlay, J.; Forman, D. Global cancer transitions according to the human development index (2008-2030): A population-based study. Lancet Oncol. 2012, 13, 790-801.
5. Reddy, C.; Chilla, D.; Boltax, J. Lung cancer screening: A review of available data and current guidelines. Hosp. Pract. 2011, 39, 107-112.
6. Shirvani, S.M.; Jiang, J.; Chang, J.Y.; Welsh, J.W.; Gomez, D.R.; Swisher, S.; Buchholz, T.A.; Smith, B.D. Comparative effectiveness of 5 treatment strategies for early-stage non-small cell lung cancer in the elderly. Int. J. of Radiat. Oncol. Biol. Phys. 2012, 84, 1060-1070.
7. Farlow, E.C.; Patel, K.; Basu, S.; Lee, B.S.; Kim, A.W.; Coon, J.S.; Faber, L.P.; Bonomi, P.; Liptay, M.J.; Borgia, J.A. Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of non-small cell lung cancer. Clin. Cancer Res. 2010, 16, 3452-3462.
8. Conrad, D.H.; Goyette, J.; Thomas, P.S. Proteomics as a Method for early detection of cancer: A review of proteomics, exhaled breath condensate, and lung cancer screening. J. Gen. Intern. Med. 2008, 23, 78-84.
9. Aberle, D.R.; Adams, A.M.; Berg, C.D.; Black, W.C.; Clapp, J.D.; Fagerstrom, R.M.; Gareen, I.F.; Gatsonis, C.; Marcus, P.M.; Sicks, J.D.; et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N. Engl. J. Med. 2011, 365, 395-409.
10. Oken, M.M.; Hocking, W.G.; Kvale, P.A.; Andriole, G.L.; Buys, S.S.; Church, T.R.; Crawford, E.D.; Fouad, M.N.; Lsaacs, C.; Reding, D.J.; et al. Screening by chest radiograph and lung cancer mortality the prostate, lung, colorectal, and ovarian (plco) randomized trial. J. Am. Med. Assoc. 2011, 306, 1865-1873.
11. Smith, R.A.; Brooks, D.; Cokkinides, V.; Saslow, D.; Brawley, O.W. Cancer screening in the united states, 2013: A review of current american cancer society guidelines, current issues in cancer screening, and new guidance on cervical cancer screening and lung cancer screening. CA: Cancer J. Clin. 2013, 63, 87-105.
12. Chicklore, S.; Goh, V.; Siddique, M.; Roy, A.; Marsden, P.K.; Cook, G.J.R. Quantifying Tumour Heterogeneity in F-18-Fdg Pet/Ct Imaging by Texture Analysis. Eur. J. Nucl. Med. Mol. Imaging 2013, 40, 133-140.
13. Asselin, M.C.; O'Connor, J.P.B.; Boellaard, R.; Thacker, N.A.; Jackson, A. Quantifying heterogeneity in human tumours using Mri and Pet. Eur. J. Cancer 2012, 48, 447-455.
14. De Geus-Oei, L.-F.; van der Heijden, H.F.M.; Visser, E.P.; Hermsen, R.; van Hoom, B.A.; Timmer-Bonte, J.N.H.; Willemsen, A.T.; Pruim, J.; Corstens, F.H.M.; Krabbe, P.F.M.; et al. Chemotherapy response evaluation with f-18-fdg pet in patients with non-small cell lung cancer. J. Nucl. Med. 2007, 48, 1592-1598.
15. Ippolito, D.; Capraro, C.; Guerra, L.; De Ponti, E.; Messa, C.; Sironi, S. Feasibility of perfusion ct technique integrated into conventional (18)fdg/pet-ct studies in lung cancer patients: Clinical staging and functional information in a single study. Eur. J. Nucl. Med. Mol. Imaging 2013, 40, 156-165.
16. Peng, G.; Hakim, M.; Broza, Y.Y.; Billan, S.; Abdah-Bortnyak, R.; Kuten, A.; Tisch, U.; Haick, H. Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors. Br. J. Cancer 2010, 103, 542-551.
17. Balgkouranidou, I.; Liloglou, T.; Lianidou, E.S. Lung cancer epigenetics: emerging biomarkers. Biomark. Med. 2013, 7, 49-58.
18. Hassanein, M.; Callison, J.C.; Callaway-Lane, C.; Aldrich, M.C.; Grogan, E.L.; Massion, P.P. The state of molecular biomarkers for the early detection of lung cancer. Cancer Prev. Res. 2012, 5, 992-1006.
19. Zhong, L.; Coe, S.P.; Stromberg, A.J.; Khattar, N.H.; Jett, J.R.; Hirschowitz, E.A. Profiling tumor-associated antibodies for early detection of non-small cell lung cancer. J. Thorac. Oncol. 2006, 1, 513-519.
20. Tothill, I.E. Biosensors for cancer markers diagnosis. Semin. Cell Dev. Biol. 2009, 20, 55-62.
21. Tomizaki, K.-Y.; Usui, K.; Mihara, H. Protein-detecting microarrays: current accomplishments and requirements. ChemBioChem 2005, 6, 782-799.
22. Nowsheen, S.; Aziz, K.; Panayiotidis, M.I.; Georgakilas, A.G. Molecular markers for cancer prognosis and treatment: Have we struck gold? Cancer Lett. 2012, 327, 142-152.
23. Calin, G.A.; Croce, C.M. Microrna signatures in human cancers. Nat. Reviews Cancer 2006, 6, 857-866.
24. Esquela-Kerscher, A.; Slack, F.J. Oncomirs-micrornas with a role in Cancer. Nat. Rev. Cancer 2006, 6, 259-269.
25. Chen, X.; Ba, Y.; Ma, L.; Cai, X.; Yin, Y.; Wang, K.; Guo, J.; Zhang, Y.; Chen, J.; Guo, X.; et al. Characterization of micrornas in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008, 18, 997-1006.
26. Lodes, M.J.; Caraballo, M.; Suciu, D.; Munro, S.; Kumar, A.; Anderson, B. Detection of cancer with serum mirnas on an oligonucleotide microarray. PLoS One 2009, 4, e6229.
27. Hu, Z.; Yang, Z.; Tian, T.; Liang, J.; Jin, G.; Shen, H. Association between microrna polymorphisms, expressions, lung cancer development and prognosis. Biomed. Pharmacother. 2009, 63, 322.
28. Yanaihara, N.; Caplen, N.; Bowman, E.; Seike, M.; Kumamoto, K.; Yi, M.; Stephens, R.M.; Okamoto, A.; Yokota, J.; Tanaka, T.; et al. Unique microrna molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006, 9, 189-198.
29. Zandberga, E.; Kozirovskis, V.; Abols, A.; Andrejeva, D.; Purkalne, G.; Line, A. Cell-free micrornas as diagnostic, prognostic, and predictive biomarkers for lung cancer. Genes Chromosomes Cancer 2013, 52, 356-369.
30. Schmitt, M.J.; Margue, C.; Behrmann, I.; Kreis, S. Mirna-29: A microrna family with tumor-suppressing and immune-modulating properties. Curr. Mol. Med. 2013, 13, 572-585.
31. Wu, J.J.; Yang, T.; Li, X.; Yang, Q.Y.; Liu, R.; Huang, J.K.; Li, Y.Q.; Yang, C.F.; Jiang, Y.G. Alteration of serum mir-206 and mir-133b is associated with lung carcinogenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Toxicol. Appl. Pharmacol. 2013, 267, 238-246.
32. Miao, L.J.; Huang, S.F.; Sun, Z.T.; Gao, Z.Y.; Zhang, R.X.; Liu, Y.; Wang, J. Mir-449c targets C-myc and inhibits nsclc cell progression. FEBS Lett. 2013, 587, 1359-1365.
33. Kaduthanam, S.; Gade, S.; Meister, M.; Brase, J.C.; Johannes, M.; Dienemann, H.; Warth, A.; Schnabel, P.A.; Herth, F.J.F.; Sultmann, H.; et al. Serum mir-142-3p is associated with early relapse in operable lung adenocarcinoma patients. Lung Cancer (Amsterdam, The Netherlands) 2013, 80, 223-227.
34. Huang, B.; Luo, W.; Sun, L.; Zhang, Q.; Jiang, L.; Chang, J.; Qiu, X.; Wang, E. Mirna-125a-3p is a negative regulator of the rhoa-actomyosin pathway in a549 cells. Int. J. Oncol. 2013, 42, 1734-1742.
35. Lubin, R.; Zalcman, G.; Bouchet, L.; Tredaniel, J.; Legros, Y.; Cazals, D.; Hirsch, A.; Soussi, T. Serum P53 antibodies as early markers of lung-cancer. Nat. Med. 1995, 1, 701-702.
36. Trivers, G.E.; DeBenedetti, V.M.G.; Gawley, H.L.; Caron, G.; Harrington, A.M.; Bennett, W.P.; Jett, J.R.; Colby, T.V.; Tazelaar, H.; Pairolero, P.; et al. Anti-p53 antibodies in sera from patients with chronic obstructive pulmonary disease can predate a diagnosis of cancer. Clin. Cancer Res. 1996, 2, 1767-1775.
37. Bermejo-Perez, M.J.; Marquez-Calderon, S.; Lianos-Mendez, A. Cancer Surveillance based on imaging techniques in carriers of brca1/2 gene mutations: A Systematic review. Br. J. Radiol. 2008, 81, 172-179.
38. Chapman, C.; Murray, A.; Chakrabarti, J.; Thorpe, A.; Woolston, C.; Sahin, U.; Barnes, A.; Robertson, J. Autoantibodies in breast cancer: Their use as an aid to early diagnosis. Ann. Oncol. 2007, 18, 868-873.
39. Luna Coronell, J.A.; Syed, P.; Sergelen, K.; Gyurjan, I.; Weinhausel, A. The current status of cancer biomarker research using tumour-associated antigens for minimal invasive and early cancer diagnostics. J. Proteomics 2012, 76, 102-115.
40. Casiano, C.A.; Mediavilla-Varela, M.; Tan, E.M. Tumor-associated antigen arrays for the serological diagnosis of cancer. Mol. C.ll. Proteomics 2006, 5, 1745-1759.
41. Wagner, P.D.; Verma, M.; Srivastava, S. Challenges for biomarkers in cancer detection. In Circulating Nucleic Acids in Plasma/Serum III and Serum Proteomics, Hoon, D.S.B., Taback, B., Eds. 2004; Volume 1022, pp. 9-16.
42. Ladd, J.; Lu, H.; Taylor, A.D.; Goodell, V.; Disis, M.L.; Jiang, S. Direct detection of carcinoembryonic antigen autoantibodies in clinical human serum samples using a surface plasmon resonance sensor. Coll. Surf. B 2009, 70, 1-6.
43. Tan, H.T.; Low, J.; Lim, S.G.; Chung, M.C.M. Serum autoantibodies as biomarkers for early cancer detection. FEBS J. 2009, 276, 6880-6904.
44. Gunawardana, C.G.; Diamandis, E.P. High throughput proteomic strategies for identifying tumour-associated antigens. Cancer Lett. 2007, 249, 110-119.
45. Brichory, F.; Beer, D.; Le Naour, F.; Giordano, T.; Hanash, S. Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer. Cancer Res. 2001, 61, 7908-7912.
46. Brichory, F.M.; Misek, D.E.; Yim, A.M.; Krause, M.C.; Giordano, T.J.; Beer, D.G.; Hanash, S.M. An immune response manifested by the common occurrence of annexins i and ii autoantibodies and high circulating levels of il-6 in lung cancer. Proc. Natl. Acad. Sci. USA 2001, 98, 9824-9829.
47. Pereira-Faca, S.R.; Kuick, R.; Puravs, E.; Zhang, Q.; Krasnoselsky, A.L.; Phanstiel, D.; Qiu, J.; Misek, D.E.; Hinderer, R.; Tammemagi, M.; et al. Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer. Cancer Res. 2007, 67, 12000-12006.
48. Canelle, L.; Bousquet, J.; Pionneau, C.; Deneux, L.; Imam-Sghiouar, N.; Caron, M.; Joubert-Caron, R. An efficient proteomics-based approach for the screening of autoantibodies. J. Immunol. Methods 2005, 299, 77-89.
49. Li, C.; Li, X.Y.; Tang, C.E.; Yi, H.; Duan, C.J. Screen biomarkers of human lung squamous carcinoma by serological proteome analysis of htb-182. Transact. Nonferr. Met. Soc. China 2006, 16, 839-844.
50. Wang, X.J.; Yu, J.J.; Sreekumar, A.; Varambally, S.; Shen, R.L.; Giacherio, D.; Mehra, R.; Montie, J.E.; Pienta, K.J.; Sanda, M.G.; et al. Autoantibody signatures in prostate cancer. N. Engl. J. Med. 2005, 353, 1224-1235.
51. Wu, L.; Chang, W.; Zhao, J.; Yu, Y.; Tan, X.; Su, T.; Zhao, L.; Huang, S.; Liu, S.; Cao, G. Development of autoantibody signatures as novel diagnostic biomarkers of non-small cell lung cancer. Clin. Cancer Res. 2010, 16, 3760-3768.
52. Sahin, U.; Tureci, O.; Schmitt, H.; Cochlovius, B.; Johannes, T.; Schmits, R.; Stenner, F.; Luo, G.R.; Schobert, I.; Pfreundschuh, M. Human neoplasms elicit multiple specific immune-responses in the autologous host. Proc. Natl. Acad. Sci. USA 1995, 92, 11810-11813.
53. Song, M.H.; Ha, J.M.; Shin, D.H.; Lee, C.H.; Old, L.; Lee, S.Y. Kp-Cot-23 (Ccdc83) is a novel immunogenic cancer/testis antigen in colon cancer. Int. J. Oncol. 2012, 41, 1820-1826.
54. Cancer Immunome Datebase (CID) Home Page. Available online: http://ludwig-sun5.unil.ch/CancerImmunomeDB/Intro.php (accessed on 20 March 2013).
55. Liu, H.Y.; Peng, L.P.; Ran, Y.L.; Zhang, L.Z.; Zhang, D.C.; Zhu, Y.K.; Yang, Z.H. Screening and identification of human lung cancer-related antigens. Acta Biochim. Et Biophys. Sinica 2002, 34, 171-175.
56. Gure, A.O.; Stockert, E.; Scanlan, M.J.; Keresztes, R.S.; Jager, D.; Altorki, N.K.; Old, L.J.; Chen, Y.T. Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer. Proc. Natl. Acad. Sci. USA 2000, 97, 4198-4203.
57. Kijanka, G.; Murphy, D. Protein arrays as tools for serum autoantibody marker discovery in cancer. J. Proteomics 2009, 72, 936-944.
58. Nam, M.J.; Madoz-Gurpide, J.; Wang, H.; Lescure, P.; Schmalbach, C.E.; Zhao, R.; Misek, D.E.; Kuick, R.; Brenner, D.E.; Hanash, S.M. Molecular profiling of the immune response in colon cancer using protein microarrays: Occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3. Proteomics 2003, 3, 2108-2115.
59. Qiu, J.; Madoz-Gurpide, J.; Misek, D.E.; Kuick, R.; Brenner, D.E.; Michailidis, G.; Haab, B.B.; Omenn, G.S.; Hanash, S. Development of natural protein microarrays for diagnosing cancer based on an antibody response to tumor antigens. J. Proteome Res. 2004, 3, 261-267.
60. Madoz-Gurpide, J.; Wang, H.; Misek, D.E.; Brichory, F.; Hanash, S.M. Protein based microarrays: A tool for probing the proteome of cancer cells and tissues. Proteomics 2001, 1, 1279-1287.
61. Qin, S.Z.; Qiu, W.L.; Ehrlich, J.R.; Ferdinand, A.S.; Richie, J.P.; O'Leary, M.P.; Lee, M.L.T.; Liu, B.C.S. Development of a Reverse Capture" autoantibody microarray for studies of antigen-autoantibody profiling. Proteomics 2006, 6, 3199-3209.
62. Ehrlich, J.R.; Tang, L.; Caiazzo, R.J., Jr.; Cramer, D.W.; Ng, S.K.; Ng, S.W.; Liu, B.C.S. The "Reverse Capture" autoantibody microarray: An innovative approach to profiling the autoantibody response to tissue-derived native antigens. Methods Mol. Biol. 2008, 441, 175-192.
63. Ehrlich, J.R.; Qin, S.; Liu, B.C.S. The "Reverse Capture" autoantibody microarray: A native antigen-based platform for autoantibody profiling. Nat. Protoc. 2006, 1, 452-460.
64. Miller, J.C.; Zhou, H.P.; Kwekel, J.; Cavallo, R.; Burke, J.; Butler, E.B.; Teh, B.S.; Haab, B.B. Antibody Microarray profiling of human prostate cancer sera Antibody screening and identification of potential biomarkers: Proteomics 2003, 3, 56-63.
65. Hardouin, J.; Lasserre, J.-P.; Sylvius, L.; Joubert-Caron, R.; Caron, M. Cancer immunomics- From Serological proteome analysis to multiple affinity protein profiling. Ann. N. Y. Acad. Sci. 2007, 1107, 223-230.
66. Caron, M.; Joubert-Caron, R.; Canelle, L.; Hardouin, J. Serological proteome analysis (serpa) and multiple affinity protein profiling (mapping) to discover cancer biomarkers. Mol. Cell. Proteomics 2005, 4, 142-142.
67. Qiu, J.; Choi, G.; Li, L.; Wang, H.; Pitteri, S.J.; Pereira-Faca, S.R.; Krasnoselsky, A.L.; Randolph, T.W.; Omenn, G.S.; Edelstein, C.; et al. Occurrence of autoantibodies to annexin i, 14-3-3 theta and lamr1 in prediagnostic lung cancer sera. J. Clin. Oncol. 2008, 26, 5060-5066.
68. Nakanishi, T.; Takeuchi, T.; Ueda, K.; Murao, H.; Shimizu, A. Detection of eight antibodies in cancer patients' sera against proteins derived from the adenocarcinoma a549 cell line using proteomics-based analysis. J. Chromatogr. B 2006, 838, 15-20.
69. He, P.; Naka, T.; Serada, S.; Fujimoto, M.; Tanaka, T.; Hashimoto, S.; Shima, Y.; Yamadori, T.; Suzuki, H.; Hirashima, T.; et al. Proteomics-Based identification of alpha-enolase as a tumor antigen in non-small lung cancer. Cancer Sci. 2007, 98, 1234-1240.
70. Yang, F.; Xiao, Z.Q.; Zhang, X.Z.; Li, C.; Zhang, P.F.; Li, M.Y.; Chen, Y.; Zhu, G.Q.; Sun, Y.; Liu, Y.F.; et al. Identification of tumor antigens in human lung squamous carcinoma by serological proteome analysis. J. Proteome Res. 2007, 6, 751-758.
71. Soussi, T. P53 antibodies in the sera of patients with various types of cancer: A review. Cancer Res. 2000, 60, 1777-1788.
72. Nagashio, R.; Sato, Y.; Jiang, S.X.; Ryuge, S.; Kodera, Y.; Maeda, T.; Nakajima, T. Detection of tumor-specific autoantibodies in sera of patients with lung cancer. Lung Cancer 2008, 62, 364-373.
73. Tureci, O.; Mack, U.; Luxemburger, U.; Heinen, H.; Krummenauer, F.; Sester, M.; Sester, U.; Sybrecht, G.W.; Sahin, U. Humoral immune responses of lung cancer patients against tumor antigen ny-eso-1. Cancer Lett. 2006, 236, 64-71.
74. Sezginturk, M.K. A new impedimetric biosensor utilizing vegf receptor-1 (flt-1): Early diagnosis of vascular endothelial growth factor in breast cancer. Biosens. Bioelectron. 2011, 26, 4032-4039.
75. Chapman, C.J.; Murray, A.; McElveen, J.E.; Sahin, U.; Luxemburger, U.; Tuereci, O.; Wiewrodt, R.; Barnes, A.C.; Robertson, J.F. Autoantibodies in lung cancer: Possibilities for early detection and subsequent cure. Thorax 2008, 63, 228-233.
76. Looi, K.; Megliorino, R.; Shi, F.D.; Peng, X.X.; Chen, Y.; Zhang, J.Y. Humoral immune response to p16, a cyclin-dependent kinase inhibitor in human malignancies. Oncol. Rep. 2006, 16, 1105-1110.
77. Diesinger, I.; Bauer, C.; Brass, N.; Schaefers, H.J.; Comtesse, N.; Sybrecht, G.; Meese, E. Toward a more complete recognition of immunoreactive antigens in squamous cell lung carcinoma. Int. J. Cancer 2002, 102, 372-378.
78. Titulaer, M.J.; Klooster, R.; Potman, M.; Sabater, L.; Graus, G.; Hegeman, I.M.; Thijssen, P.E.; Wirtz, P.W.; Twijnstra, A.; Smitt, P.A.E.S.; et al. Sox antibodies in small-cell lung cancer and lambert-eaton myasthenic syndrome: frequency and relation with survival. J. Clin. Oncol. 2009, 27, 4260-4267.
79. Sabater, L.; Titulaer, M.; Saiz, A.; Verschuuren, J.; Guere, A.O.; Graus, F. Sox1 antibodies are markers of paraneoplastic lambert-eaton myasthenic syndrome. Neurology 2008, 70, 924-928.
80. Nonaka, Y.; Abe, K.; Ikebukuro, K. Electrochemical detection of vascular endothelial growth factor with aptamer sandwich. Electrochemistry 2012, 80, 363-366.
81. Cho, H.; Yeh, E.C.; Sinha, R.; Laurence T.A.; Bearinger, J.P.; Lee, L.P. Single-step nanoplasmonic vegf(165) aptasensor for early cancer diagnosis. ACS Nano 2012, 6, 7607-7614.
82. Remy-Martin, F.; El Osta, M.; Lucchi, G.; Zeggari, R.; Leblois, T.; Bellon, S.; Ducoroy, P.; Boireau, W. Surface plasmon resonance imaging in arrays coupled with mass spectrometry (supra-ms): Proof of concept of on-chip characterization of a potential breast cancer marker in human plasma. Anal. Bioanal. Chem. 2012, 404, 423-432.
83. Altintas, Z.; Uludag, Y.; Gurbuz, Y.; Tothill, I.E. Surface plasmon resonance based immunosensor for the detection of the cancer biomarker carcinoembryonic antigen. Talanta 2011, 86, 377-383.
84. Noah, N.M.; Mwilu, S.K.; Sadik, O.A.; Fatah, A.A.; Arcilesi, R.D. Immunosensors for quantifying cyclooxygenase 2 pain biomarkers. Clin. Chim. Acta 2011, 412, 1391-1398.
85. Zhou, Y.; Wang, Z.; Yue, W.; Tang, K.; Ruan, W.; Zhang, Q.; Liu, L.; Label-Free detection of p53 antibody using a microcantilever biosensor with piezoresistive readout. IEEE Sens. 2009, doi:10.1109/ICSENS.2009.5398558
86. Wang, X.; Zhang, X.; He, P.; Fang, Y. Sensitive detection of p53 tumor suppressor gene using an enzyme-based solid-state electrochemiluminescence sensing platform. Biosens. Bioelectron. 2011, 26, 3608-3613.
87. Wang, Y.; Zhu, X.; Wu, M.; Xia, N.; Wang, J.; Zhou, F. Simultaneous and label-free determination of wild-type and mutant p53 at a single surface plasmon resonance chip preimmobilized with consensus dna and monoclonal antibody. Anal. Chem. 2009, 81, 8441-8446.
88. Ilyas, A.; Asghar, W.; Allen, P.B.; Duhon, H.; Ellington, A.D.; Iqbal, S.M. Electrical detection of cancer biomarker using aptamers with nanogap break-junctions. Nanotechnology 2012, 23, doi:10.1088/0957-4484/23/27/275502
89. Chung, J.W.; Bernhardt, R.; Pyun, J.C. Additive assay of cancer marker ca 19-9 by spr biosensor. Sens. Actuators B 2006, 118, 28-32.
90. Ladd, J.; Taylor, A.D.; Piliarik, M.; Homola, J.; Jiang, S. Label-free detection of cancer biomarker candidates using surface plasmon resonance imaging. Anal. Bioanal. Chem. 2009, 393, 1157-1163.
91. Piliarik, M.; Bockova, M.; Homola, J. Surface plasmon resonance biosensor for parallelized detection of protein biomarkers in diluted blood plasma. Biosens. Bioelectron. 2010, 26, 1656-1661.
92. Carrascosa, L.G.; Calle, A.; Lechuga, L.M. Label-free detection of dna mutations by spr: Application to the early detection of inherited breast cancer. Anal. Bioanal. Chem. 2009, 393, 1173-1182.
93. Sato, Y.; Fujimoto, K.; Kawaguchi, H. Detection of a k-ras point mutation employing peptide nucleic acid at the surface of a spr biosensor. Coll. Surf. B 2003, 27, 23-31.
94. McCauley, T.G.; Hamaguchi, N.; Stanton, M. Aptamer-based biosensor arrays for detection and quantification of biological macromolecules. Anal. Biochem. 2003, 319, 244-250.
95. Pan, C.; Guo, M.; Nie, Z.; Xiao, X.; Yao, S. Aptamer-based electrochemical sensor for label-free recognition and detection of cancer cells. Electroanalysis 2009, 21, 1321-1326.
96. Glokler, J.; Angenendt, P. Protein and antibody microarray technology. J. Chromatogr. B 2003, 797, 229-240.
97. Lin, J.H.; Ju, H.X. Electrochemical and chemiluminescent immunosensors for tumor markers. Biosens. Bioelectron. 2005, 20, 1461-1470.
98. Wang, J. Electrochemical biosensors: Towards point-of-care cancer diagnostics. Biosens. Bioelectron. 2006, 21, 1887-1892.
99. Pohlmann, C.; Sprinzl, M. Electrochemical detection of micrornas via gap hybridization assay. Anal. Chem. 2010, 82, 4434-4440.
100. Altintas, Z.; Kallempudi, S.S.; Sezerman, U.; Gurbuz, Y. Anovel magnetic particle-modified electrochemical sensor for immunosensor applications. Sens. Actuators B 2012, 174, 187-194.
101. 4 @Au magnetic nanoparticles attracted on fe (iii) phthlocyanine/ chitosan-membrane modified screen-printed carbon electrode by a magnet. In Mechanical and Aerospace Engineering, Proceedings of the 2nd International Conference on Mechnaical and Aerospace Engineering (ICMAE 2011), Bangkok, Thailand, 29-31 July, 2011; Fan, W., Ed.; Trans Tech Publications LTD: Stafa-Zurich, Switzerland, 2012; Volume 110-116, pp. 519-526.
102. Altintas, Z.; Tothill, I.E. DNA-based biosensor platforms for the detection of tp53 mutation. Sens. Actuators B 2012, 169, 188-194.
103. Chen, Y.; Huang, X.; Shi, H.; Mu, B. A novel and cost-effective method for early lung cancer detection in immunized serum. Asian Pac. J. Cancer Prev. 2011, 12, 3009-3012.
104. Chen, Y.; Huang, X.H.; Shi, H.S.; Mu, B.; Lv, Q. Rapid detection of ovarian cancer from immunized serum using a quartz crystal microbalance immunosensor. Asian Pac. J. Cancer Prev. 2012, 13, 3423-3426.
105. Sadhasivam, S.; Chen, J.C.; Savitha, S.; Lin, F.H.; Yang, Y.Y.; Lee, C.H. A real time detection of the ovarian tumor associated antigen 1 (ovta 1) in human serum by quartz crystal microbalance immobilized with anti-ovta 1 polyclonal chicken igy antibodies. Mater. Sci. Eng. C 2012, 32, 2073-2078.
106. Piliarik, M.; Vaisocherova, H.; Homola, J. Surface plasmon resonance biosensing. Methods Mol. Biol. 2009, 503, 65-88.
107. Donzella, V.; Crea, F. Optical biosensors to analyze novel biomarkers in oncology. J. Biophotonics 2011, 4, 442-452.
108. Choi, S.; Chae, J. A microfluidic biosensor based on competitive protein adsorption for thyroglobulin detection. Biosens. Bioelectron. 2009, 25, 118-123.
109. Vaisocherova, H.; Faca, V.M.; Taylor, A.D.; Hanash, S.; Jiang, S. Comparative study of spr and elisa methods based on analysis of cd166/alcam levels in cancer and control human sera. Biosens. Bioelectron. 2009, 24, 2143-2148.
110. Uludag, Y.; Tothill, I.E. Cancer biomarker detection in serum samples using surface plasmon resonance and quartz crystal microbalance sensors with nanoparticle signal amplification. Anal. Chem.2012, 84, 5898-5904.
111. Ayela, C.; Roquet, F.; Valera, L.; Granier, C.; Nicu, L.; Pugniere, M. Antibody-antigenic peptide interactions monitored by spr and qcm-d-a model for spr detection of ia-2 autoantibodies in human serum. Biosens. Bioelectron. 2007, 22, 3113-3119.
112. Situ, C.; Wylie, A.R.G.; Douglas, A.; Elliott, C.T. Reduction of severe bovine serum associated matrix effects on carboxymethylated dextran coated biosensor surfaces. Talanta 2008, 76, 832-836.
113. Trevino, J.; Calle, A.; Rodriguez-Frade, J.M.; Mellado, M.; Lechuga, L.M. Determination of human growth hormone in human serum samples by surface plasmon resonance immunoassay. Talanta 2009, 78, 1011-1016.
114. Choi, S.H.; Lee, J.W.; Sim, S.J. Enhanced performance of a surface plasmon resonance immunosensor for detecting ab-gad antibody based on the modified self-assembled monolayers. Biosens. Bioelectron. 2005, 21, 378-383.
115. Sato, Y.; Hosokawa, K.; Maeda, M. Detection of non-cross-linking interaction between DNA-modified gold nanoparticles and a dna-modified flat gold surface using surface plasmon resonance imaging on a microchip. Coll. Surf. B 2008, 62, 71-76.
116. Jung, J.; Na, K.; Lee, J.; Kim, K.W.; Hyun, J. Enhanced surface plasmon resonance by au nanoparticles immobilized on a dielectric sio2 layer on a gold surface. Anal. Chim. Acta 2009, 651, 91-97.
117. Suwansa-ard, S.; Kanatharana, P.; Asawatreratanakul, P.; Wongkittisuksa, B.; Limsakul, C.; Thavarungkul, P. Comparison of surface plasmon resonance and capacitive immunosensors for cancer antigen 125 detection in human serum samples. Biosens. Bioelectron. 2009, 24, 3436-3441.
118. Scarano, S.; Mascini, M.; Turner, A.P.F.; Minunni, M. Surface plasmon resonance imaging for affinity-based biosensors. Biosens. Bioelectron. 2010, 25, 957-966.
119. Hu, W.; Liu, Y.; Lu, Z.; Li, C.M. Poly oligo(ethylene glycol) methacrylate-co-glycidyl methacrylate brush substrate for sensitive surface plasmon resonance imaging protein arrays. Adv. Funct. Mater. 2010, 20, 3497-3503.
120. Resch-Genger, U.; Grabolle, M.; Cavaliere-Jaricot, S.; Nitschke, R.; Nann, T. Quantum dots versus organic dyes as fluorescent labels. Nat. Methods 2008, 5, 763-775.
121. Mihindukulasuriya, S.H.; Morcone, T.K.; McGown, L.B. Characterization of acridone dyes for use in four-decay detection in dna sequencing. Electrophoresis 2003, 24, 20-25.
122. Carion, O.; Mahler, B.; Pons, T.; Dubertret, B. Synthesis, encapsulation, purification and coupling of single quantum dots in phospholipid micelles for their use in cellular and in vivo imaging. Nat. Protoc. 2007, 2, 2383-2390.
123. So, M.K.; Xu, C.J.; Loening, A.M.; Gambhir, S.S.; Rao, J.H. Self-illuminating quantum dot conjugates for in vivo imaging. Nat. Biotechnol. 2006, 24, 339-343.
124. Wu, X.Y.; Liu, H.J.; Liu, J.Q.; Haley, K.N.; Treadway, J.A.; Larson, J.P.; Ge, N.F.; Peale, F.; Bruchez, M.P. Immunofluorescent labeling of cancer marker her2 and other cellular targets with semiconductor quantum dots. Nat. Biotechnol. 2003, 21, 452-452.
125. Gao, X.H.; Cui, Y.Y.; Levenson, R.M.; Chung, L.W.K.; Nie, S.M. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat. Biotechnol. 2004, 22, 969-976.
126. Jaiswal, J.K.; Mattoussi, H.; Mauro, J.M.; Simon, S.M. Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nat. Biotechnol. 2003, 21, 47-51.
127. Bruchez, M.; Moronne, M.; Gin, P.; Weiss, S.; Alivisatos, A.P. Semiconductor nanocrystals as fluorescent biological labels. Science 1998, 281, 2013-2016.
128. Liu, W.; Howarth, M.; Greytak, A.B.; Zheng, Y.; Nocera, D.G.; Ting, A.Y.; Bawendi, M.G. Compact biocompatible quantum dots functionalized for cellular imaging. J. Am. Chem. Soc. 2008, 130, 1274-1284.
129. Hinds, S.; Myrskog, S.; Levina, L.; Koleilat, G.; Yang, J.; Kelley, S.O.; Sargent, E.H. Nir-emitting colloidal quantum dots having 26% luminescence quantum yield in buffer solution. J. Am. Chem. Soc. 2007, 129, 7218-7219.
130. Fernee, M.J.; Jensen, P.; Rubinsztein-Dunlop, H. Origin of the large homogeneous line widths obtained from strongly quantum confined pbs nanocrystals at room temperature. J. Phys. Chem.C 2007, 111, 4984-4989.
131. Shavel, A.; Gaponik, N.; Eychmueller, A. Factors governing the quality of aqueous cdte nanocrystals: calculations and experiment. J. Phys. Chem.B 2006, 110, 19280-19284.
132. Jiang, W.; Singhal, A.; Zheng, J.; Wang, C.; Chan, W.C.W. Optimizing the synthesis of red- to near-ir-emitting cds-capped cdtexse1-x alloyed quantum dots for biomedical imaging. Chem. Mater. 2006, 18, 4845-4854.
133. Wang, X.Y.; Qu, L.H.; Zhang, J.Y.; Peng, X.G.; Xiao, M. Surface-related emission in highly luminescent cdse quantum dots. Nano Lett. 2003, 3, 1103-1106.
134. Talapin, D.V.; Mekis, I.; Gotzinger, S.; Kornowski, A.; Benson, O.; Weller, H. Cdse/Cds/Zns and Cdse/Znse/Zns core-shell-shell nanocrystals. J. Phys. Chem.B 2004, 108, 18826-18831.
135. Chan, W.C.W.; Nie, S.M. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 1998, 281, 2016-2018.
136. Gopalakrishnan, G.; Danelon, C.; Izewska, P.; Prummer, M.; Bolinger, P.Y.; Geissbuehler, I.; Demurtas, D.; Dubochet, J.; Vogel, H. Multifunctional lipid/quantum dot hybrid nanocontainers for controlled targeting of live cells. Angew. Chem.-Int. Edition 2006, 45, 5478-5483.
137. Kairdolf, B.A.; Mancini, M.C.; Smith, A.M.; Nie, S. Minimizing nonspecific cellular binding of quantum dots with hydroxyl-derivatizied surface coatings. Anal. Chem.2008, 80, 3029-3034.
138. Lau, P.C.; Norwood, R.A.; Mansuripur, M.; Peyghambarian, N. An effective and simple oxygen nanosensor made from mpa-capped water soluble cdte nanocrystals. Nanotechnology 2013, doi:10.1088/0957-4484/24/1/015501
139. Zhang, H.; Cui, Z.C.; Wang, Y.; Zhang, K.; Ji, X.L.; Lu, C.L.; Yang, B.; Gao, M.Y. From water-soluble cdte nanocrystals to fluorescent nanocrystal-polymer transparent composites using polymerizable surfactants. Adv. Mater. 2003, 15, 777-780.
140. Li, L.; Qian, H.F.; Ren, J.C. Rapid synthesis of highly luminescent Cdte nanocrystals in the aqueous phase by microwave irradiation with controllable temperature. Chemi. Commun. 2005, 528-530.
141. He, Y.; Lu, H.T.; Sai, L.M.; Lai, W.Y.; Fan, Q.L.; Wang, L.H.; Huang, W. Synthesis of Cdte nanocrystals through program process of microwave irradiation. J. Phys. Chem.B 2006, 110, 13352-13356.
142. He, Y.; Sai, L.M.; Lu, H.T.; Hu, M.; Lai, W.Y.; Fan, Q.L.; Wang, L.H.; Huang, W. Microwave-assisted synthesis of water-dispersed cdte nanocrystals with high luminescent efficiency and narrow size distribution. Chem. Mater. 2007, 19, 359-365.
143. He, Y.; Lu, H.T.; Sai, L.M.; Su, Y.Y.; Hu, M.; Fan, C.H.; Huang, W,; Wang, L.H. Microwave synthesis of water-dispersed Cdte/Cds/Zns core-shell-shell quantum dots with excellent photostability and biocompatibility. Adv. Mater. 2008, 20, 3416-3421.
144. Yuwen, L.; Bao, B.; Liu, G.; Tian, J.; Lu, H.; Luo, Z.; Zhu, X.; Boey, F.; Zhang, H.; Wang, L. One-pot encapsulation of luminescent quantum dots synthesized in aqueous solution by amphiphilic polymers. Small 2011, 7, 1456-1463.
145. Yuwen, L.; Lu, H.; He, Y.; Chen, L.; Hu, M.; Bao, B.; Boey, F.; Zhang, H.; Wang, L. A facile low temperature growth of cdte nanocrystals using novel dithiocarbamate ligands in aqueous solution. J. Mater. Chem.2010, 20, 2788-2793.
146. Xing, Y.; Chaudry, Q.; Shen, C.; Kong, K.Y.; Zhau, H.E.; Wchung, L.; Petros, J.A.; O'Regan, R.M.; Yezhelyev, M.V.; Simons, J.W.; et al. Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry. Nat. Protoc. 2007, 2, 1152-1165.
147. Hu, M.; He, Y.; Song, S.; Yan, J.; Lu, H.T.; Weng, L.X.; Wang, L.H.; Fan, C. DNA-bridged bioconjugation of fluorescent quantum dots for highly sensitive microfluidic protein chips. Chem. Commun. 2010, 46, 6126-6128.
148. Hu, M.; Yan, J.; He. Y.; Lu, H.; Weng, L.; Song, S; Fan, C.; Wang, L. Ultrasensitive, multiplexed detection of cancer biomarkers directly in serum by using a quantum dot-based microfluidic protein chip. ACS Nano 2010, 4, 488-494.
149. Kim, J.; Seo, K.; Wang, J. Multiplexed electrochemical protein coding based on quantum dot (qd)-bioconjugates for a clinical barcode system. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2004, 1, 137-140.
150. Ma, H.L.; Wang, L.P.; Li, W.; Xu, S.K. Fret study of Qd protein bioconjugates. J. Pept. Sci. 2004, 10, 283-283.
151. Vinayaka, A.C.; Thakur, M.S. Photoabsorption and resonance energy transfer phenomenon in cdte-protein bioconjugates: An insight into qd-biomolecular interactions. Bioconj. Chem.2011, 22, 968-975.
152. Bakalova, R.; Zhelev, Z.; Ohba, H.; Baba, Y. Quantum Dot-based Western Blot technology for ultrasensitive detection of tracer proteins. J. Am. Chem. Soc. 2005, 127, 9328-9329.
153. Shingyoji, M.; Gerion, D.; Pinkel, D.; Gray, J.W.; Chen, F,Q. Quantum Dots-based reverse phase protein microarray. Talanta 2005, 67, 472-478.
154. Ligler, F.S.; Sapsford, K.E.; Golden, J.P.; Shriver-Lake, L,C.; Taitt, C.R.; Dyer, M.A.; Barone, S.; Myatt, C.J. The array biosensor: Portable, automated systems. Anal. Sci. 2007, 23, 5-10.
155. Yan, J.; Hu, M.; Li, D.; He, Y.; Zhao, R.; Jiang, X.; Song, S.; Wang, L.; Fan, C. A nano- and micro- integrated protein chip based on quantum dot probes and a microfluidic network. Nano Res. 2008, 1, 490-496.
156. Sapsford, K.E.; Berti, L.; Medintz, I.L. Materials for fluorescence resonance energy transfer analysis: beyond traditional donor-acceptor combinations. Angew. Chem.-Int. Edition 2006, 45, 4562-4588.
157. Jares-Erijman, E.A.; Jovin, T.M. Fret imaging. Nat. Biotechnol. 2003, 21, 1387-1395.
158. Miyawaki, A.; Sawano, A.; Kogure, T. Lighting up cells: Labelling proteins with fluorophores. Nat. Cell Biol. 2003, S1-S7.
159. Akinfieva, O.; Nabiev, I.; Sukhanova, A. New directions in quantum dot-based cytometry detection of cancer serum markers and tumor cells. Crit. Rev. Oncol. Hematol. 2013, 86, 1-14.
160. Bao, B.; Yuwen, L.; Zheng, X.; Weng, L.; Zhu, X.; Zhan, X.; Wang, L. A fluorescent conjugated polymer for trace detection of diamines and biogenic polyamines. J. Mater. Chem.2010, 20, 9628-9634.
161. Li, M.; Zhou, X.; Guo, S.; Wu, N. Detection of lead (ii) with a "turn-on" fluorescent biosensor based on energy transfer from Cdse/Zns quantum dots to graphene oxide. Biosens. Bioelectron. 2013, 43, 69-74.
162. He, Y.; Xiong, L.H.; Xing, X.J.; Tang, H.W.; Pang, D.W. An ultra-high sensitive platform for fluorescence detection of micrococcal nuclease based on graphene oxide. Biosens. Bioelectron. 2013, 42, 467-473.
163. Dong, H.; Gao, W.; Yan, F.; Ji, H.; Ju, H. Fluorescence resonance energy transfer between quantum dots and graphene oxide for sensing biomolecules. Anal. Chem. 2010, 82, 5511-5517.
164. Loh, K.P.; Bao, Q.; Eda, G.; Chhowalla, M. Graphene oxide as a chemically tunable platform for optical applications. Nat. Chem. 2010, 2, 1015-1024.
165. Hu, K.; Liu, J.; Chen, J.; Huang, Y.; Zhao, S.; Tian, J.; Zhang, G. An amplified graphene oxide-based fluorescence aptasensor based on target-triggered aptamer hairpin switch and strand-displacement polymerization recycling for bioassays. Biosens. Bioelectron. 2013, 42, 598-602.
166. Liang, J.; Wei, R.; He, S.; Liu, Y.; Guo, L.; Li, L. A highly sensitive and selective aptasensor based on graphene oxide fluorescence resonance energy transfer for the rapid determination of oncoprotein Pdgf-Bb. Analyst 2013, 138, 1726-1732.
167. Lin, M.-Y.; Lu, Y.-P.; Grumezescu, A.M.; Ho, F.H.; Kao, Y.H.; Yang, Y.S.; Yang, C.H. Tumor marker detection by aptamer-functionalized graphene oxide. Curr. Org. Chem.2013, 17, 132-136. (172)
168. Liu, Q.; Xu, X.; Zhang, L.; Luo, X.; Liang, Y. Assembly of single-stranded polydeoxyadenylic acid and beta-glucan probed by the sensing platform of graphene oxide based on the fluorescence resonance energy transfer and fluorescence anisotropy. Analyst 2013, 138, 2661-2668.
169. Yu, Y.; Cao, Q.; Zhou, M.; Cui, H. A novel homogeneous label-free aptasensor for 2,4, 6-trinitrotoluene detection based on an assembly strategy of electrochemiluminescent graphene oxide with gold nanoparticles and aptamer. Biosens. Bioelectron. 2013, 43, 137-142.
170. Zhu, C.; Zeng, Z.; Li, H.; Li, F.; Fan, C.; Zhang, H. Single-layer mos2-based nanoprobes for homogeneous detection of biomolecules. J. Am. Chem. Soc. 2013, 135, 5998-6001.
171. Tu, Y.; Li, W.; Wu, P.; Zhang, H.; Cai, C. Fluorescence quenching of graphene oxide integrating with the site-specific cleavage of the endonuclease for sensitive and selective microrna detection. Anal. Chem. 2013, 85, 2536-2542.
172. Pei, H.; Li, J.; Lv, M.; Wang, J.; Gao, J.; Lu, J.; Li, Y.; Huang, Q.; Hu, J.; Fan, C. A graphene-based sensor array for high-precision and adaptive target identification with ensemble aptamers. J. Am. Chem. Soc. 2012, 134, 13843-13849.
173. Geissler, D.; Stufler, S.; Loehmannscroeben, H.G.; Hildebrandt, N. Six-color time-resolved forster resonance energy transfer for ultrasensitive multiplexed biosensing. J. Am. Chem. Soc. 2013, 135, 1102-1109.
174. Watanabe, M.; Kajikawa, K. An optical fiber biosensor based on anomalous reflection of gold. Sens. Actuators B 2003, 89, 126-130.
175. Chang, Y.F.; Hung, S.H.; Lee, Y.J.; Chen, R.C.; Su, L.C.; Lai, C.S.; Chou, C. Discrimination of breast cancer by measuring prostate-specific antigen levels in women's serum. Anal. Chem. 2011, 83, 5324-5328.
176. Healy, D.A.; Hayes, C.J.; Leonard, P.; McKenna, L.; O'Kennedy, R. Biosensor developments: Application to prostate-specific antigen detection. Trends Biotechnol. 2007, 25, 125-131.