Label-free detection of p53 antibody using a microcantilever biosensor with piezoresistive readout

Proceedings of IEEE Sensors

Volumn , Issue , 2009, Pages 819-822

  Zhou, Youzheng ^a   Wang, Zheyao ^a   Yue, Wentao ^b   Tang, Kai ^b   Ruan, Wenzhou ^a   Zhang, Qi ^a   Liu, Litian ^a  

^a TSINGHUA UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOAFFINITY; CANCER DIAGNOSIS; CLINICAL APPLICATION; HUMAN CANCER; HUMAN SERUM; LABEL FREE; LABEL-FREE DETECTION; LOW COSTS; MICRO CANTILEVER SENSORS; MICRO-CANTILEVERS; MICROCANTILEVER BIOSENSORS; PIEZO-RESISTORS; PIEZORESISTIVE READ-OUT; QUANTITATIVE DETECTION; SURFACE STRESS;

ANTIBODIES; ANTIGENS; ATOMIC FORCE MICROSCOPY; BIOSENSORS; COMPOSITE MICROMECHANICS; LABELS;

CHEMICAL DETECTION;

EID: 77951136891     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ICSENS.2009.5398558     Document Type: Conference Paper

References (10)

1. M. Hollstein, D. Sidransky, B. Vogelstein, and C.C. Harris, "p53 mutations in human cancers," Science, vol. 253, pp. 49-53, 1991.
2. O. J. Finn, "Immune response as a biomarker for cancer detection and a lot more," New Engl. J. Med., vol. 353, pp. 1288-1290, 2005.
3. J. Fritz, M.K. Baller, H.P. Lang, H. Rothuizen, P. Vettiger, E. Meyer, et al., "Translating biomolecular recognition into nanomechanics," Science, vol. 288, pp. 316-318, 2000.
4. G. Wu, R.H. Datar, K.M. Hansen, T. Thundat, R.J. Cote and A. Majumdar, "Bioassay of prostate-specific antigen (PSA) using microcantilevers," Nat. Biotechnol., vol.19, pp. 856-860, 2001 (Pubitemid 32816756) .
5. K.W. Wee, G.Y. Kang, J. Park, J.Y. Kang, D.S. Yoon, J.H. Park and T.S. Kim, "Novel electrical detection of label-free disease marker proteins using piezoresistive self-sensing micro-cantilevers," Biosens. Bioelect., vol. 20, pp.1932-1938, 2005.
6. Z. Wang, Y. Zhou, C. Wang, Q. Zhang, W. Ruan and L. Liu, "A theoretical model for surface-stress piezoresistive microcantilever biosensors with discontinuous layers," Sens. Actuat., B: Chemical, vol. 138, pp. 598-606, 2009.
7. Y. Zhou, Z. Wang, C. Wang, W. Ruan and L. Liu, "Design, fabrication, and characterization of a two-step released silicon dioxide piezoresistive microcantilever immunosensor," J. Micromech. Microeng., vol. 19, 065026, 2009.
8. Y. Zhou, Q. Zhang, Z. Wang and L. Liu, "A silicon microcantilever biosensor fabricated on SOI wafers using a two-step releasing approach," IEEE Sensors 2008, pp. 227-230.
9. N. Patel, M.C. Davies, M. Hartshorne, R.J. Heaton, C.J. Roberts, et al., "Immobilization of protein molecules onto homogeneous and mixed carboxylate-terminated self-assembled monolayers," Langmuir, vol.13, pp. 6485-6490, 1997.
10. R. Berger, E. Delamarche, H.P. Lang, C. Gerber, J.K. Gimzewski, E. Meyer and H.-J. Güntherodt, "Surface stress in the self-assembly of alkanethiols on gold probed by a force microscopy technique,"Appl. Phys. A, vol.66, pp. S55-S59, 1998