Parthenolide is neuroprotective in rat experimental stroke model: Downregulating NF- B, phospho-p38MAPK, and caspase-1 and ameliorating BBB permeability

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Dong, Lipeng ^a   Qiao, Huimin ^a   Zhang, Xiangjian ^a,b,c   Zhang, Xiaolin ^a   Wang, Chaohui ^a   Wang, Lina ^a   Cui, Lili ^a   Zhao, Jingru ^a   Xing, Yinxue ^a   Li, Yanhua ^a   Liu, Zongjie ^a   Zhu, Chunhua ^a,b,c  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Hebei Institute of Cardio Cerebral Vascular Diseases   (China)

^c Hebei Key Laboratory for Neurology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOGEN ACTIVATED PROTEIN KINASE P38; PARTHENOLIDE; CLAUDIN 5; CLDN5 PROTEIN, RAT; NONSTEROID ANTIINFLAMMATORY AGENT; SESQUITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN WATER; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; HYPOXIC ISCHEMIC ENCEPHALOPATHY; IMMUNOHISTOCHEMISTRY; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BRAIN EDEMA; BRAIN ISCHEMIA; CEREBRAL ARTERY DISEASE; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; MALE; METABOLISM; PATHOLOGY; PERMEABILITY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; DRUG EFFECTS; STROKE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD-BRAIN BARRIER; BRAIN EDEMA; BRAIN ISCHEMIA; CASPASE 1; CLAUDIN-5; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PERMEABILITY; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; STROKE;

EID: 84880780154     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/370804     Document Type: Article

References (46)

1. Donnan G. A., Fisher M., Macleod M., Davis S. M., Stroke. The Lancet 2008 371 9624 1612 1623 2-s2.0-43049135853 10.1016/S0140-6736(08)60694-7 (Pubitemid 351626845)
2. Dirnagl U., Iadecola C., Moskowitz M. A., Pathobiology of ischaemic stroke: an integrated view. Trends in Neurosciences 1999 22 9 391 397 2-s2.0-0033199996 10.1016/S0166-2236(99)01401-0 (Pubitemid 29453643)
3. Małek R., Borowicz K. K., Jargiełło M., Czuczwar S. J., Role of nuclear factor kappaB in the central nervous system. Pharmacological Reports 2007 59 1 25 33 (Pubitemid 46522699)
4. Thompson W. L., Van Eldik L. J., Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NF B and MAPK dependent pathways in rat astrocytes. Brain Research 2009 1287 47 57 2-s2.0-68049083543 10.1016/j.brainres.2009.06.081
5. Cui L., Zhang X., Yang R., Liu L., Wang L., Li M., Du W., Baicalein is neuroprotective in rat MCAO model: role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2. Pharmacology Biochemistry and Behavior 2010 96 4 469 475 2-s2.0-77956059859 10.1016/j.pbb.2010.07.007
6. Wang L., Zhang X., Liu L., Cui L., Yang R., Li M., Du W., Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF- B expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Brain Research 2010 1321 143 151 2-s2.0-77449130589 10.1016/j.brainres.2009.12.046
7. Liu Y., Zhang X.-J., Yang C.-H., Fan H.-G., Oxymatrine protects rat brains against permanent focal ischemia and downregulates NF- B expression. Brain Research 2009 1268 174 180 2-s2.0-64149117795 10.1016/j.brainres.2009.02. 069
8. Lamkanfi M., Kalai M., Saelens X., Declercq W., Vandenabeele P., Caspase-1 activates nuclear factor of the -enhancer in B cells independently of its enzymatic activity. Journal of Biological Chemistry 2004 279 23 24785 24793 2-s2.0-2642517305 10.1074/jbc.M400985200 (Pubitemid 38725346)
9. Martinon F., Tschopp J., Inflammatory caspases: Linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004 117 5 561 574 2-s2.0-2542457495 10.1016/j.cell.2004.05.004 (Pubitemid 38692523)
10. Rothwell N., Interleukin-1 and neuronal injury: Mechanisms, modification, and therapeutic potential. Brain, Behavior, and Immunity 2003 17 3 152 157 2-s2.0-0037410074 10.1016/S0889-1591(02)00098-3 (Pubitemid 36434364)
11. Ogura Y., Sutterwala F. S., Flavell R. A., The inflammasome: first line of the immune response to cell stress. Cell 2006 126 4 659 662 2-s2.0-33747191203 10.1016/j.cell.2006.08.002 (Pubitemid 44233635)
12. Schielke G. P., Yang G.-Y., Shivers B. D., Betz A. L., Reduced ischemic brain injury in interleukin-1 β converting enzyme-deficient mice. Journal of Cerebral Blood Flow and Metabolism 1998 18 2 180 185 2-s2.0-0031894316 (Pubitemid 28082515)
13. Rabuffetti M., Sciorati C., Tarozzo G., Clementi E., Manfredi A. A., Beltramo M., Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp- chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines. Journal of Neuroscience 2000 20 12 4398 4404 2-s2.0-0034660250 (Pubitemid 30396604)
14. Li H., Deng C.-Q., Chen B.-Y., Zhang S.-P., Liang Y., Luo X.-G., Total saponins of Panax Notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion. Journal of Ethnopharmacology 2009 121 3 412 418 2-s2.0-58149269089 10.1016/j.jep.2008.10. 042
15. Pandey D. K., Rajkumar R., Mahesh R., Radha R., Depressant-like effects of parthenolide in a rodent behavioural antidepressant test battery. Journal of Pharmacy and Pharmacology 2008 60 12 1643 1650 2-s2.0-56849088443 10.1211/jpp/60.12.0010
16. Heinrich M., Robles M., West J. E., Ortiz De Montellano B. R., Rodriguez E., Ethnopharmacology of Mexican asteraceae (compositae). Annual Review of Pharmacology and Toxicology 1998 38 539 565 2-s2.0-0031800969 (Pubitemid 28231505)
17. Schinella G. R., Giner R.-M., Del Carmen Recio M., De Buschiazzo P. M., Ríos J.-L., Máñez S., Anti-inflammatory effects of South American Tanacetum vulgare. Journal of Pharmacy and Pharmacology 1998 50 9 1069 1074 2-s2.0-0031716738 (Pubitemid 28464095)
18. Zingarelli B., Hake P. W., Denenberg A., Wong H. R., Sesquiterpene lactone parthenolide, an inhibitor of I B kinase complex and nuclear factor- B, exerts beneficial effects in myocardial reperfusion injury. Shock 2002 17 2 127 134 2-s2.0-0036484004
19. Longa E. Z., Weinstein P. R., Carlson S., Cummins R., Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989 20 1 84 91 2-s2.0-0024494427 (Pubitemid 19040218)
20. Yang C., Zhang X., Fan H., Liu Y., Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Research 2009 1282 133 141 2-s2.0-67649670106 10.1016/j.brainres.2009.05. 009
21. Hatashita S., Hoff J. T., Salamat S. M., Ischemic brain edema and the osmotic gradient between blood and brain. Journal of Cerebral Blood Flow and Metabolism 1988 8 4 552 559 2-s2.0-0023719493
22. Bederson J. B., Pitts L. H., Germano S. M., Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 1986 17 6 1304 1308 2-s2.0-0022870943 (Pubitemid 17008976)
23. Tatlisumak T., Carano R. A. D., Takano K., Opgenorth T. J., Sotak C. H., Fisher M., A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study. Stroke 1998 29 4 850 858 2-s2.0-0031945018 (Pubitemid 28173413)
24. Liu L., Zhang X., Wang L., Yang R., Cui L., Li M., Du W., Wang S., The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke. Brain Research Bulletin 2010 82 3-4 228 233 2-s2.0-77953540227 10.1016/j.brainresbull.2010.04.005
25. Qiao H. M., Dong L. P., Zhang X. J., Protective effect of luteolin in experimental ischemic stroke: upregulated SOD1, CAT, Bcl-2 and claudin-5, down-regulated MDA and Bax expression. Neurochemical Research 2012 37 9 2014 2024
26. Hu M., Zhang X., Liu W., Cui H., Di N., Longitudinal changes of defensive and offensive factors in focal cerebral ischemia-reperfusion in rats. Brain Research Bulletin 2009 79 6 371 375 2-s2.0-67449161544 10.1016/j.brainresbull. 2009.05.001
27. Chamorro Á., Hallenbeck J., The harms and benefits of inflammatory and immune responses in vascular disease. Stroke 2006 37 2 291 293 2-s2.0-33644863548 10.1161/01.STR.0000200561.69611.f8 (Pubitemid 43731945)
28. Simonyi A., Wang Q., Miller R. L., Yusof M., Shelat P. B., Sun A. Y., Sun G. Y., Polyphenols in cerebral ischemia: novel targets for neuroprotection. Molecular Neurobiology 2005 31 1-3 135 147 2-s2.0-20344382855 10.1385/MN:31:1-3:135 (Pubitemid 41271199)
29. Mocco J., Mack W. J., Ducruet A. F., Sosunov S. A., Sughrue M. E., Hassid B. G., Nair M. N., Laufer I., Komotar R. J., Holland M. C. H., Pinsky D. J., Connolly E. S. Jr., Complement component C3 mediates inflammatory injury following focal cerebral ischemia. Circulation Research 2006 99 2 209 217 2-s2.0-33747598070 10.1161/01.RES.0000232544.90675.42 (Pubitemid 44297045)
30. Fan H., Li L., Zhang X., Liu Y., Yang C., Yang Y., Yin J., Oxymatrine Downregulates TLR4, TLR2, MyD88, and NF-kappaB and protects rat brains against focal ischemia. Mediators of Inflammation 2009 2009 10 2-s2.0-77949293053 10.1155/2009/704706 704706
31. Qiao H., Zhang X., Zhu C., Dong L., Wang L., Zhang X., Xing Y., Wang C., Ji Y., Cao X., Luteolin downregulates TLR4, TLR5, NF- B and p-p38MAPK expression, upregulates the p-ERK expression, and protects rat brains against focal ischemia. Brain Research 2012 1448 71 81 2-s2.0-84858701903 10.1016/j.brainres.2012.02.003
32. Hwang D., Fischer N. H., Jang B. C., Tak H., Kim J. K., Lee W., Inhibition of the expression of inducible cyclooxygenase and proinflammatouy cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases. Biochemical and Biophysical Research Communications 1996 226 3 810 818 2-s2.0-0030600363 10.1006/bbrc.1996.1433 (Pubitemid 26348552)
33. López-Franco O., Hernández-Vargas P., Ortiz-Muñoz G., Parthenolide modulates the NF-kappaB-mediated inflammatory responses in experimental atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology 2006 26 8 1864 1870 (Pubitemid 44305342)
34. Sheehan M., Wong H. R., Hake P. W., Malhotra V., O'Connor M., Zingarelli A., Parthenolide, an inhibitor of the nuclear factor- B pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Molecular Pharmacology 2002 61 5 953 963 2-s2.0-0036237368 10.1124/mol.61.5.953 (Pubitemid 34441759)
35. Juliana C., Fernandes-Alnemri T., Wu J., Datta P., Solorzano L., Yu J.-W., Meng R., Quong A. A., Latz E., Scott C. P., Alnemri E. S., Anti-inflammatory compounds parthenolide and bay 11-7082 are direct inhibitors of the inflammasome. Journal of Biological Chemistry 2010 285 13 9792 9802 2-s2.0-77951240589 10.1074/jbc.M109.082305
36. Rummel C., Gerstberger R., Roth J., Hübschle T., Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats. Cytokine 2011 56 3 739 748 2-s2.0-81455131483 10.1016/j.cyto.2011.09.022
37. Kozak W., Wrotek S., Kozak A., Pyrogenicity of CpG-DNA in mice: role of interleukin-6, cyclooxygenases, and nuclear factor- B. American Journal of Physiology 2006 290 4 R871 R880 2-s2.0-33646487906 10.1152/ajpregu.00408.2005
38. Collino M., Aragno M., Mastrocola R., Gallicchio M., Rosa A. C., Dianzani C., Danni O., Thiemermann C., Fantozzi R., Modulation of the oxidative stress and inflammatory response by PPAR- γ agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. European Journal of Pharmacology 2006 530 1-3 70 80 2-s2.0-29844458758 10.1016/j.ejphar.2005.11.049 (Pubitemid 43037126)
39. Nito C., Kamada H., Endo H., Niizuma K., Myer D. J., Chan P. H., Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion. Journal of Cerebral Blood Flow and Metabolism 2008 28 10 1686 1696 2-s2.0-52549132911 10.1038/jcbfm.2008.60
40. Martinon F., Burns K., Tschopp J., The Inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL- β Molecular Cell 2002 10 2 417 426 2-s2.0-0036671894 10.1016/S1097-2765(02)00599-3 (Pubitemid 35007355)
41. Trendelenburg G., Acute neurodegeneration and the inflammasome: central processor for danger signals and the inflammatory response? Journal of Cerebral Blood Flow and Metabolism 2008 28 5 867 881 2-s2.0-42549161426 10.1038/sj.jcbfm.9600609 (Pubitemid 351589645)
42. Abulafia D. P., De Rivero Vaccari J. P., Lozano J. D., Lotocki G., Keane R. W., Dietrich W. D., Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice. Journal of Cerebral Blood Flow and Metabolism 2009 29 3 534 544 2-s2.0-61349152312 10.1038/jcbfm.2008.143
43. Krupinski J., Lopez E., Marti E., Ferrer I., Expression caspases and their substrates in the rat model of focal cerebral ischemia. Neurobiology of Disease 2000 7 4 332 342 2-s2.0-0033834275 10.1006/nbdi.2000.0310
44. Chiba H., Osanai M., Murata M., Kojima T., Sawada N., Transmembrane proteins of tight junctions. Biochimica et Biophysica Acta 2008 1778 3 588 600 2-s2.0-39849108966 10.1016/j.bbamem.2007.08.017 (Pubitemid 351317799)
45. Fukumoto K.-I., Takagi N., Yamamoto R., Moriyama Y., Takeo S., Tanonaka K., Prostanoid EP1 receptor antagonist reduces blood-brain barrier leakage after cerebral ischemia. European Journal of Pharmacology 2010 640 1-3 82 86 2-s2.0-77953807028 10.1016/j.ejphar.2010.05.001
46. Ji H., Zhang X., Du Y., Liu H., Li S., Li L., Polydatin modulates inflammation by decreasing NF- B activation and oxidative stress by increasing Gli1, Ptch1, SOD1 expression and ameliorates blood-brain barrier permeability for its neuroprotective effect in pMCAO rat brain. Brain Research Bulletin 2012 87 1 50 59 2-s2.0-84155166813 10.1016/j.brainresbull.2011.09.021