Profilin1 facilitates staurosporine-triggered apoptosis by stabilizing the integrin β1-actin complex in breast cancer cells

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 4, 2012, Pages 824-835

  Yao, Wantong ^a,b   Yu, Xianjun ^a,b   Fang, Zhengyu ^a   Yin, Peng ^a   Zhao, Chao ^a   Li, Na ^a   Wang, Liying ^a   Li, Zengxia ^a   Zha, Xiliang ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

Actin; Apoptosis; Fibronectin; Integrin; Profilin1

Indexed keywords

ACTIN; BETA1 INTEGRIN; ENZYME INHIBITOR; PFN1 PROTEIN, HUMAN; PROFILIN; STAUROSPORINE;

APOPTOSIS; ARTICLE; BREAST TUMOR; CONFOCAL MICROSCOPY; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ACTINS; ANTIGENS, CD29; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; ENZYME INHIBITORS; FEMALE; FLOW CYTOMETRY; HUMANS; MICROSCOPY, CONFOCAL; PROFILINS; REAL-TIME POLYMERASE CHAIN REACTION; STAUROSPORINE;

EID: 84867882897     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01369.x     Document Type: Article

References (44)

1. Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell. 2003; 112: 453-65.
2. Kasina S, Rizwani W, Radhika KV, et al. Nitration of profilin effects its interaction with poly (L-proline) and actin. J Biochem. 2005; 138: 687-95.
3. Janke J, Schluter K, Jandrig B, et al. Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1. J Exp Med. 2000; 191: 1675-86.
4. Wittenmayer N, Jandrig B, Rothkegel M, et al. Tumour suppressor activity of profilin requires a functional actin binding site. Mol Biol Cell. 2004; 15: 1600-8.
5. Wu N, Zhang W, Yang Y, et al. Profilin 1 obtained by proteomic analysis in all-trans retinoic acid-treated hepatocarcinorna cell lines is involved in inhibition of cell proliferation and migration. Proteomics. 2006; 6: 6095-106.
6. Roy P, Jacobson K. Overexpression of profilin reduces the migration of invasive breast cancer cells. Cell Motil Cytoskeleton. 2004; 57: 84-95.
7. Janke J, Schluter K, Jandrig B, et al. Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1. J Exp Med. 2000; 191: 1675-85.
8. Coleman ML, Olson MF. Rho GTPase signalling pathways in the morphological changes associated with apoptosis. Cell Death Differ. 2002; 9: 493-504.
9. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002; 110: 673-87.
10. Luo BH, Carman CV, Springer TA. Structural basis of integrin regulation and signaling. Annu Rev Immunol. 2007; 25: 619-47.
11. Damsky CH, Ilic D. Integrin signaling: it's where the action is. Curr Opin Cell Biol. 2002; 14: 594-602.
12. Giancotti FG. Complexity and specificity of integrin signalling. Nat Cell Biol. 2000; 2: E13-4.
13. Newham P, Humphries MJ. Integrin adhesion receptors: structure, function and implications for biomedicine. Mol Med Today. 1996; 2: 304-13.
14. Pignatelli M, Hanby AM, Stamp GW. Low expression of beta 1, alpha 2 and alpha 3 subunits of VLA integrins in malignant mammary tumours. J Pathol. 1991; 165: 25-32.
15. Kim H, Sengupta A, Glogauer M, et al. Filamin A regulates cell spreading and survival via beta1 integrins. Exp Cell Res. 2008; 314: 834-46.
16. Liang YL, Fu Y, Chen SG, et al. Integrin beta1 subunit overexpressed in the SMMC-7721 cells regulates the promoter activity of p21(CIP1) and enhances its transcription. FEBS Lett. 2004; 558: 107-13.
17. Wang L, Liang Y, Li Z, et al. Increase in beta1-6 GlcNAc branching caused by Nacetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721. J Cell Biochem. 2007; 100: 230-41.
18. Zhang H, Ozaki I, Mizuta T, et al. Mechanism of beta 1-integrin-mediated hepatoma cell growth involves p27 and S-phase kinase-associated protein 2. Hepatology. 2003; 38: 305-13.
19. Fu Y, Fang Z, Liang Y, et al. Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway. J Cell Biochem. 2007; 102: 704-18.
20. Argraves WS, Suzuki S, Arai H, et al. Amino acid sequence of the human fibronectin receptor. J Cell Biol. 1987; 105: 1183-90.
21. Akiyama SK, Yamada KM. Biosynthesis and acquisition of biological activity of the fibronectin receptor. J Biol Chem. 1987; 262: 17536-42.
22. Triplett JW, Pavalko FM. Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis. Am J Physiol Cell Physiol. 2006; 291: C909-21.
23. Kuwada SK, Kuang J, Li X. Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells. J Biol Chem. 2005; 280: 19027-35.
24. Nakano H, Omura S. Chemical biology of natural indolocarbazole products: 30 years since the discovery of staurosporine. J Antibiot (Tokyo). 2009; 62: 17-26.
25. Yoshida Y, Chiba T, Tokunaga F, et al. E3 ubiquitin ligase that recognizes sugar chains. Nature. 2002; 418: 438-42.
26. Pollard TD, Blanchoin L, Mullins RD. Actin dynamics. J Cell Sci. 2001; 114: 3-4.
27. Neidt EM, Scott BJ, Kovar DR. Formin differentially utilizes profilin isoforms to rapidly assemble actin filaments. J Biol Chem. 2009; 284: 673-84.
28. Zaidel-Bar R, Itzkovitz S, Ma'ayan A, et al. Functional atlas of the integrin adhesome. Nat Cell Biol. 2007; 9: 858-67.
29. Rothkegel M, Mayboroda O, Rohde M, et al. Plant and animal profilins are functionally equivalent and stabilize microfilaments in living animal cells. J Cell Sci. 1996; 109: 83-90.
30. Finkel T, Theriot JA, Dise KR, et al. Dynamic actin structures stabilized by profilin. Proc Natl Acad Sci U S A. 1994; 91: 1510-4.
31. Varner JA, Cheresh DA. Integrins and cancer. Curr Opin Cell Biol. 1996; 8: 724-30.
32. O'Brien V, Frisch SM, Juliano RL. Expression of the integrin alpha 5 subunit in HT29 colon carcinoma cells suppresses apoptosis triggered by serum deprivation. Exp Cell Res. 1996; 224: 208-13.
33. Vitale M, Illario M, Di Matola T, et al. Integrin binding to immobilized collagen and fibronectin stimulates the proliferation of human thyroid cells in culture. Endocrinology. 1997; 138: 1642-8.
34. Chhabra ES, Higgs HN. The many faces of actin: matching assembly factors with cellular structures. Nat Cell Biol. 2007; 9: 1110-21.
35. Spector I, Shochet NR, Kashman Y, et al. Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells. Science. 1983; 219: 493-5.
36. Coue M, Brenner SL, Spector I, et al. Inhibition of actin polymerization by latrunculin A. FEBS Lett. 1987; 213: 316-8.
37. Yarmola EG, Somasundaram T, Boring TA, et al. Actin-latrunculin A structure and function. Differential modulation of actinbinding protein function by latrunculin A. J Biol Chem. 2000; 275: 28120-7.
38. Aoudjit F, Vuori K. Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene. 2001; 20: 4995-5004.
39. Tsagaraki I, Tsilibary EC, Tzinia AK. TIMP-1 interaction with alphavbeta3 integrin confers resistance to human osteosarcoma cell line MG-63 against TNFalpha-induced apoptosis. Cell Tissue Res. 2010; 342: 87-96.
40. Zou L, Ding Z, Roy P. Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation. J Cell Physiol. 223: 623-9.
41. Calderwood DA, Ginsberg MH. Talin forges the links between integrins and actin. Nat Cell Biol. 2003; 5: 694-7.
42. Kim DY, Ingano LA, Kovacs DM. Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretaselike cleavage. J Biol Chem. 2002; 277: 49976-81.
43. Ruoslahti E. Fibronectin and its alpha 5 beta 1 integrin receptor in malignancy. Invas Metast. 1994; 14: 87-97.
44. Qian F, Zhang ZC, Wu XF, et al. Interaction between integrin alpha(5) and fibronectin is required for metastasis of B16F10 melanoma cells. Biochem Biophys Res Commun. 2005; 333: 1269-75.