Profilin 1 is a potential biomarker for bladder cancer aggressiveness

Molecular and Cellular Proteomics

Volumn 11, Issue 4, 2012, Pages

  Zoidakis, Jerome ^a   Makridakis, Manousos ^a   Zerefos, Panagiotis G ^a   Bitsika, Vasiliki ^a   Esteban, Sergio ^b   Frantzi, Maria ^a   Stravodimos, Konstantinos ^c   Anagnou, Nikolaos P ^c   Roubelakis, Maria G ^a   Sanchez Carbayo, Marta ^b   Vlahou, Antonia ^a  

^a BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

^c UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CLUSTERIN; FIBRINOGEN; GELATINASE B; MICROSOMAL AMINOPEPTIDASE; MYELOBLASTIN; PROFILIN; PROFILIN I; UNCLASSIFIED DRUG; PFN1 PROTEIN, HUMAN; TUMOR MARKER; TUMOR PROTEIN;

ACTIN POLYMERIZATION; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CANCER INVASION; CANCER MORTALITY; CELL MOTILITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMOBILIZED METAL AFFINITY CHROMATOGRAPHY; IN VITRO STUDY; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN URINE LEVEL; URINALYSIS; WESTERN BLOTTING; ADULT; AFFINITY CHROMATOGRAPHY; AGED; BLADDER; BLADDER TUMOR; EPITHELIUM CELL; LIQUID CHROMATOGRAPHY; METABOLISM; MIDDLE AGED; PATHOLOGY; STROMA CELL; TANDEM MASS SPECTROMETRY; TUMOR INVASION; URINE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD13; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, LIQUID; EPITHELIAL CELLS; HUMANS; MIDDLE AGED; MYELOBLASTIN; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PROFILINS; STROMAL CELLS; TANDEM MASS SPECTROMETRY; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER; URINARY BLADDER NEOPLASMS;

EID: 84859808396     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M111.009449     Document Type: Article

References (63)

1. Dinney, C. P., McConkey, D. J., Millikan, R. E., Wu, X., Bar-Eli, M., Adam, L., Kamat, A. M., Siefker-Radtke, A. O., Tuziak, T., Sabichi, A. L., Grossman, H. B., Benedict, W. F., and Czerniak, B. (2004) Focus on bladder cancer. Cancer Cell 6, 111-116 (Pubitemid 39485683)
2. Parkin, D. M. (2008) The global burden of urinary bladder cancer. Scand. J. Urol. Nephrol. Suppl. 12-20
3. Konety, B. R. (2006) Molecular markers in bladder cancer: a critical appraisal. Urol. Oncol. 24, 326-337
4. Vrooman, O. P., and Witjes, J. A. (2008) Urinary markers in bladder cancer. Eur. Urol. 53, 909-916
5. Bischoff, C. J., and Clark, P. E. (2009) Bladder cancer. Curr. Opin. Oncol. 21, 272-277
6. Yi, J., Kim, C., and Gelfand, C. A. (2007) Inhibition of intrinsic proteolytic activities moderates preanalytical variability and instability of human plasma. J. Proteome Res. 6, 1768-1781 (Pubitemid 46814501)
7. Havanapan, P. O., and Thongboonkerd, V. (2009) Are protease inhibitors required for gel-based proteomics of kidney and urine? J. Proteome Res. 8, 3109-3117
8. Lotan, Y., Shariat, S. F., Schmitz-Drager, B. J., Sanchez-Carbayo, M., Jankevicius, F., Racioppi, M., Minner, S. J., Stöhr, B., Bassi, P. F., and Grossman, H. B. (2010) Considerations on implementing diagnostic markers into clinical decision making in bladder cancer. Urol. Oncol. 28, 441-448
9. Porath, J., Carlsson, J., Olsson, I., and Belfrage, G. (1975) Metal chelate affinity chromatography, a new approach to protein fractionation. Nature 258, 598-599
10. Block, H., Maertens, B., Spriestersbach, A., Brinker, N., Kubicek, J., Fabis, R., Labahn, J., and Schäfer, F. (2009) Immobilized-metal affinity chromatography (IMAC): a review. Methods Enzymol. 463, 439-473
11. Chevallet, M., Luche, S., and Rabilloud, T. (2006) Silver staining of proteins in polyacrylamide gels. Nat. Protoc. 1, 1852-1858 (Pubitemid 46773305)
12. Candiano, G., Bruschi, M., Musante, L., Santucci, L., Ghiggeri, G. M., Carnemolla, B., Orecchia, P., Zardi, L., and Righetti, P. G. (2004) Blue silver: a very sensitive colloidal Coomassie G-250 staining for proteome analysis. Electrophoresis 25, 1327-1333 (Pubitemid 38801651)
13. Orenes-Piñero, E., Corton, M., Gonzalez-Peramato, P., Algaba, F., Casal, I., Serrano, A., and Sánchez-Carbayo, M. (2007) Searching urinary tumor markers for bladder cancer using a two-dimensional differential gel electrophoresis (2D-DIGE) approach. J. Proteome Res. 6, 4440-4448
14. Makridakis, M., Gagos, S., Petrolekas, A., Roubelakis, M. G., Bitsika, V., Stravodimos, K., Pavlakis, K., Anagnou, N. P., Coleman, J., and Vlahou, A. (2009) Chromosomal and proteome analysis of a new T24-based cell line model for aggressive bladder cancer. Proteomics 9, 287-298
15. Chevallet, M., Diemer, H., Van Dorssealer, A., Villiers, C., and Rabilloud, T. (2007) Toward a better analysis of secreted proteins: the example of the myeloid cells secretome. Proteomics 7, 1757-1770 (Pubitemid 46910996)
16. Makridakis, M., Roubelakis, M. G., Bitsika, V., Dimuccio, V., Samiotaki, M., Kossida, S., Panayotou, G., Coleman, J., Candiano, G., Anagnou, N. P., and Vlahou, A. (2010) Analysis of secreted proteins for the study of bladder cancer cell aggressiveness. J. Proteome Res. 9, 3243-3259
17. Roubelakis, M. G., Pappa, K. I., Bitsika, V., Zagoura, D., Vlahou, A., Papadaki, H. A., Antsaklis, A., and Anagnou, N. P. (2007) Molecular and proteomic characterization of human mesenchymal stem cells derived from amniotic fluid: comparison to bone marrow mesenchymal stem cells. Stem Cells Dev. 16, 931-952
18. Mischak, H., Kolch, W., Aivaliotis, M., Bouyssié, D., Court, M., Dihazi, H., Dihazi, G. H., Franke, J., Garin, J., Gonzalez de Peredo, A., Iphofer, A., Jansch, L., Lacroix, C., Makridakis, M., Masselon, C., Metzger, J., Monsarrat, B., Mrug, M., Norling, M., Novak, J., Pich, A., Pitt, A., Bongcam- Rudloff, E., Siwy, J., Suzuki, H., Thongboonkerd, V., Wang, L. S., Zoidakis, J., Zurbig, P., Schanstra, J. P., and Vlahou, A. (2010) Comprehensive human urine standards for comparability and standardization in clinical proteome analysis. Proteomics Clin. Appl. 4, 464-478
19. Nutt, J. E., Durkan, G. C., Mellon, J. K., and Lunec, J. (2003) Matrix metalloproteinases (MMPs) in bladder cancer: the induction of MMP9 by epidermal growth factor and its detection in urine. BJU Int. 91, 99-104
20. Roy, R., Louis, G., Loughlin, K. R., Wiederschain, D., Kilroy, S. M., Lamb, C. C., Zurakowski, D., and Moses, M. A. (2008) Tumor-specific urinary matrix metalloproteinase fingerprinting: identification of high molecular weight urinary matrix metalloproteinase species. Clin. Cancer Res. 14, 6610-6617
21. Sier, C. F., Casetta, G., Verheijen, J. H., Tizzani, A., Agape, V., Kos, J., Blasi, F., and Hanemaaijer, R. (2000) Enhanced urinary gelatinase activities (matrix metalloproteinases 2 and 9) are associated with early-stage bladder carcinoma: a comparison with clinically used tumor markers. Clin. Cancer Res. 6, 2333-2340 (Pubitemid 30399200)
22. Topsakal, M., Karadeniz, T., Anac, M., Dönmezer, S., and Besisik, A. (2001) Assessment of fibrin-fibrinogen degradation products (Accu-Dx) test in bladder cancer patients. Eur. Urol. 39, 287-291 (Pubitemid 32245368)
23. Inagaki, Y., Tang, W., Zhang, L., Du, G., Xu, W., and Kokudo, N. (2010) Novel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis. Biosci. Trends 4, 56-60
24. Mina-Osorio, P. (2008) The moonlighting enzyme CD13: old and new functions to target. Trends Mol. Med. 14, 361-371
25. Mou, J., Fang, H., Liu, Y., Shang, L., Wang, Q., Zhang, L., and Xu, W. (2010) Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors. Bioorg. Med. Chem. 18, 887-895
26. Shamamian, P., Schwartz, J. D., Pocock, B. J., Monea, S., Whiting, D., Marcus, S. G., and Mignatti, P. (2001) Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis. J. Cell. Physiol. 189, 197-206 (Pubitemid 32946031)
27. Meyer-Hoffert, U., and Wiedow, O. (2010) Neutrophil serine proteases: mediators of innate immune responses. Curr. Opin. Hematol.
28. Bae, Y. H., Ding, Z., Zou, L., Wells, A., Gertler, F., and Roy, P. (2009) Loss of profilin-1 expression enhances breast cancer cell motility by Ena/ VASP proteins. J. Cell. Physiol. 219, 354-364
29. Grønborg, M., Kristiansen, T. Z., Iwahori, A., Chang, R., Reddy, R., Sato, N., Molina, H., Jensen, O. N., Hruban, R. H., Goggins, M. G., Maitra, A., and Pandey, A. (2006) Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol. Cell. Proteomics 5, 157-171 (Pubitemid 43169348)
30. Huang, C. M., Ananthaswamy, H. N., Barnes, S., Ma, Y., Kawai, M., and Elmets, C. A. (2006) Mass spectrometric proteomics profiles of in vivo tumor secretomes: capillary ultrafiltration sampling of regressive tumor masses. Proteomics 6, 6107-6116 (Pubitemid 44851395)
31. Janke, J., Schlüter, K., Jandrig, B., Theile, M., Kolble, K., Arnold, W., Grinstein, E., Schwartz, A., Estevéz-Schwarz, L., Schlag, P. M., Jockusch, B. M., and Scherneck, S. (2000) Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1. J. Exp. Med. 191, 1675-1686
32. Ji, H., Greening, D. W., Kapp, E. A., Moritz, R. L., and Simpson, R. J. (2009) Secretome-based proteomics reveals sulindac-modulated proteins released from colon cancer cells. Proteomics Clin. Appl. 3, 433-451
33. Jockusch, B. M., Murk, K., and Rothkegel, M. (2007) The profile of profilins. Rev. Physiol. Biochem. Pharmacol. 159, 131-149
34. Roy, P., and Jacobson, K. (2004) Overexpression of profilin reduces the migration of invasive breast cancer cells. Cell Motil. Cytoskeleton. 57, 84-95 (Pubitemid 38134049)
35. Witke, W. (2004) The role of profilin complexes in cell motility and other cellular processes. Trends Cell Biol. 14, 461-469
36. Wittenmayer, N., Jandrig, B., Rothkegel, M., Schlüter, K., Arnold, W., Haensch, W., Scherneck, S., and Jockusch, B. M. (2004) Tumor suppressor activity of profilin requires a functional actin binding site. Mol. Biol. Cell 15, 1600-1608 (Pubitemid 38401811)
37. Wu, N., Zhang, W., Yang, Y., Liang, Y. L., Wang, L. Y., Jin, J. W., Cai, X. M., and Zha, X. L. (2006) Profilin 1 obtained by proteomic analysis in all-trans retinoic acid-treated hepatocarcinoma cell lines is involved in inhibition of cell proliferation and migration. Proteomics 6, 6095-6106 (Pubitemid 44851394)
38. Zou, L., Ding, Z., and Roy, P. (2010) Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation. J. Cell. Physiol. 223, 623-629
39. Zou, L., Hazan, R., and Roy, P. (2009) Profilin-1 overexpression restores adherens junctions in MDA-MB-231 breast cancer cells in R-cadherin-dependent manner. Cell Motil. Cytoskeleton 66, 1048-1056
40. Gaberc-Porekar, V., and Menart, V. (2001) Perspectives of immobilized-metal affinity chromatography. J. Biochem. Biophys. Methods 49, 335-360 (Pubitemid 33022558)
41. Ueda, E. K., Gout, P. W., and Morganti, L. (2003) Current and prospective applications of metal ion-protein binding. J. Chromatogr. A 988, 1-23 (Pubitemid 36165010)
42. Papale, M., Pedicillo, M. C., Thatcher, B. J., Di Paolo, S., Lo Muzio, L., Bufo, P., Rocchetti, M. T., Centra, M., Ranieri, E., and Gesualdo, L. (2007) Urine profiling by SELDI-TOF/MS: monitoring of the critical steps in sample collection, handling and analysis. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 856, 205-213 (Pubitemid 47307442)
43. Cirulli, C., Chiappetta, G., Marino, G., Mauri, P., and Amoresano, A. (2008) Identification of free phosphopeptides in different biological fluids by a mass spectrometry approach. Anal. Bioanal. Chem. 392, 147-159
44. Talvas, J., Obled, A., Sayd, T., Chambon, C., Mordier, S., and Fafournoux, P. (2008) Phospho-proteomic approach to identify new targets of leucine deprivation in muscle cells. Anal. Biochem. 381, 148-150
45. Levin, Y., Jaros, J. A., Schwarz, E., and Bahn, S. (2010) Multidimensional protein fractionation of blood proteins coupled to data-independent nanoLC-MS/MS analysis. J. Proteomics 73, 689-695
46. De Bock, M., de Seny, D., Meuwis, M. A., Servais, A. C., Minh, T. Q., Closset, J., Chapelle, J. P., Louis, E., Malaise, M., Merville, M. P., and Fillet, M. (2010) Comparison of three methods for fractionation and enrichment of low molecular weight proteins for SELDI-TOF-MS differential analysis. Talanta 82, 245-254
47. de Seny, D., Fillet, M., Ribbens, C., Maree, R., Meuwis, M. A., Lutteri, L., Chapelle, J. P., Wehenkel, L., Louis, E., Merville, M. P., and Malaise, M. (2008) Monomeric calgranulins measured by SELDI-TOF mass spectrometry and calprotectin measured by ELISA as biomarkers in arthritis. Clin. Chem. 54, 1066-1075 (Pubitemid 351793415)
48. Banks, R. E., Stanley, A. J., Cairns, D. A., Barrett, J. H., Clarke, P., Thompson, D., and Selby, P. J. (2005) Influences of blood sample processing on low-molecular-weight proteome identified by surface-enhanced laser desorption/ionization mass spectrometry. Clin. Chem. 51, 1637-1649 (Pubitemid 41233099)
49. Andersen, J. D., Boylan, K. L., Xue, F. S., Anderson, L. B., Witthuhn, B. A., Markowski, T. W., Higgins, L., and Skubitz, A. P. (2010) Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in-gel electrophoresis. Electrophoresis 31, 599-610
50. Samland, A. K., and Sprenger, G. A. (2009) Transaldolase: from biochemistry to human disease. Int. J. Biochem. Cell Biol. 41, 1482-1494
51. Ma, Y., Peng, J., Huang, L., Liu, W., Zhang, P., and Qin, H. (2009) Searching for serum tumor markers for colorectal cancer using a 2-D DIGE approach. Electrophoresis 30, 2591-2599
52. Li, Y., Huang, J., Zhao, Y. L., He, J., Wang, W., Davies, K. E., Nosé, V., and Xiao, S. (2007) UTRN on chromosome 6q24 is mutated in multiple tumors. Oncogene 26, 6220-6228 (Pubitemid 47414369)
53. Barrett, J., and Rezvani, K. (2006) Neutrophil granule proteins as targets of leukemia-specific immune responses. Curr. Opin. Hematol. 13, 15-20
54. Durant, S., Pederzoli, M., Lepelletier, Y., Canteloup, S., Nusbaum, P., Lesavre, P., and Witko-Sarsat, V. (2004) Apoptosis-induced proteinase 3 membrane expression is independent from degranulation. J. Leukoc. Biol. 75, 87-98 (Pubitemid 38166783)
55. Tan, A., Etit, D., Bayol, U., Altinel, D., and Tan, S. (2011) Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. Ann. Diagn. Pathol. 15, 108-116
56. Murata, S., Iseki, M., Kinjo, M., Matsuzaki, O., Moriuchi, A., Ohtani, H., Sakurai, T., Satake, T., and Tsuzuki, T. (2010) Molecular and immunohistologic analyses cannot reliably solve diagnostic variation of flat intraepithelial lesions of the urinary bladder. Am. J. Clin. Pathol. 134, 862-872
57. Orenes-Piñero, E., Barderas, R., Rico, D., Casal, J. I., Gonzalez-Pisano, D., Navajo, J., Algaba, F., Piulats, J. M., and Sanchez-Carbayo, M. (2010) Serum and tissue profiling in bladder cancer combining protein and tissue arrays. J. Proteome Res. 9, 164-173
58. Matsushita, K., Cha, E. K., Matsumoto, K., Baba, S., Chromecki, T. F., Fajkovic, H., Sun, M., Karakiewicz, P. I., Scherr, D. S., and Shariat, S. F. (2011) Immunohistochemical biomarkers for bladder cancer prognosis. Int. J. Urol. 18, 616-629
59. Ru, Y., Dancik, G. M., and Theodorescu, D. (2011) Biomarkers for prognosis and treatment selection in advanced bladder cancer patients. Curr. Opin. Urol. 21, 420-427
60. Makridakis, M., and Vlahou, A. (2010) Secretome proteomics for discovery of cancer biomarkers. J. Proteomics 73, 2291-2305
61. Pavlou, M. P., and Diamandis, E. P. (2010) The cancer cell secretome: a good source for discovering biomarkers? J. Proteomics 73, 1896-1906
62. Staubach, S., Razawi, H., and Hanisch, F. G. (2009) Proteomics of MUC1- containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7. Proteomics 9, 2820-2835
63. Witke, W., Podtelejnikov, A. V., Di Nardo, A., Sutherland, J. D., Gurniak, C. B., Dotti, C., and Mann, M. (1998) In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. EMBO J. 17, 967-976 (Pubitemid 28077651)