High-throughput screening assay for sphingosine kinase inhibitors in whole blood using RapidFire® mass spectrometry

Journal of Biomolecular Screening

Volumn 16, Issue 2, 2011, Pages 272-277

  Highkin, Maureen K ^a   Yates, Matthew P ^a   Nemirovskiy, Olga V ^a   Lamarr, William A ^b   Munie, Grace E ^a   Rains, John W ^a   Masferrer, Jaime L ^a   Nagiec, Marek M ^a  

^a PFIZER INC   (United States)

^b BIOCIUS Life Sciences Inc   (United States)

Author keywords

384 well mixing; blood; DMS; LCMS; pin tool; S1P; SKI 2; sphingosine kinase

Indexed keywords

2 (4 HYDROXYANILINO) 4 (4 CHLOROPHENYL)THIAZOLE; DEXTRO ERYTHRO SPHINGOSINE 1 PHOSPHATE; PHOSPHOTRANSFERASE INHIBITOR; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; BLOOD ANALYSIS; CONTROLLED STUDY; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; MASS SPECTROMETER; MASS SPECTROMETRY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION;

AMINOPHENOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KINETICS; LYSOPHOSPHOLIPIDS; MASS SPECTROMETRY; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); SIGNAL TRANSDUCTION; SPHINGOSINE; THIAZOLES;

EID: 79951961104     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110391656     Document Type: Article

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