메뉴 건너뛰기




Volumn 46, Issue 5, 2011, Pages 365-375

The compartmentalization and translocation of the sphingosine kinases: Mechanisms and functions in cell signaling and sphingolipid metabolism

Author keywords

Ceramide; Lipid signaling; Membrane translocation; Sphingolipid; Sphingosine 1 phosphate

Indexed keywords

CELL PROTEIN; CERAMIDE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; LIPID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE D; PROTEIN KINASE C; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; UBIQUITIN PROTEIN LIGASE;

EID: 80053521000     PISSN: 10409238     EISSN: 15497798     Source Type: Journal    
DOI: 10.3109/10409238.2011.580097     Document Type: Review
Times cited : (50)

References (73)
  • 4
    • 33747072117 scopus 로고    scopus 로고
    • De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells
    • DOI 10.1016/j.cellsig.2006.01.018, PII S0898656806000337
    • Berdyshev EV, Gorshkova IA, Usatyuk P, Zhao Y, Saatian B, Hubbard W, Natarajan V. 2006. De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. Cell Signal 18:1779-1792. (Pubitemid 44216131)
    • (2006) Cellular Signalling , vol.18 , Issue.10 , pp. 1779-1792
    • Berdyshev, E.V.1    Gorshkova, I.A.2    Usatyuk, P.3    Zhao, Y.4    Saatian, B.5    Hubbard, W.6    Natarajan, V.7
  • 6
    • 50349102144 scopus 로고    scopus 로고
    • Opposite efects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-β/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway
    • Bu S, Kapanadze B, Hsu T, Trojanowska M. 2008. Opposite efects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on transforming growth factor-β/Smad signaling are mediated through the PTEN/PPM1A-dependent pathway. J Biol Chem 283:19593-19602.
    • (2008) J Biol Chem , vol.283 , pp. 19593-19602
    • Bu, S.1    Kapanadze, B.2    Hsu, T.3    Trojanowska, M.4
  • 7
    • 30744469407 scopus 로고    scopus 로고
    • Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts
    • DOI 10.1096/fj.05-4646fje
    • Bu S, Yamanaka M, Pei H, Bielawska A, Bielawski J, Hannun YA, Obeid L, Trojanowska M. 2006. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fbroblasts. FASEB J 20:184-186. (Pubitemid 43100508)
    • (2006) FASEB Journal , vol.20 , Issue.1 , pp. 184-186
    • Bu, S.1    Yamanaka, M.2    Pei, H.3    Bielawska, A.4    Bielawski, J.5    Hannun, Y.A.6    Obeid, L.7    Trojanowska, M.8
  • 8
    • 0026656429 scopus 로고
    • Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways
    • Buehrer BM, Bell RM. 1992. Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways. J Biol Chem 267:3154-3159.
    • (1992) J Biol Chem , vol.267 , pp. 3154-3159
    • Buehrer, B.M.1    Bell, R.M.2
  • 13
    • 59649120559 scopus 로고    scopus 로고
    • A lipid binding domain in sphingosine kinase 2
    • Don AS, Rosen H. 2009. A lipid binding domain in sphingosine kinase 2. Biochem Biophys Res Commun 380: 87-92.
    • (2009) Biochem Biophys Res Commun , vol.380 , pp. 87-92
    • Don, A.S.1    Rosen, H.2
  • 14
    • 11244300911 scopus 로고    scopus 로고
    • Interaction of cholesterol with sphingosine: Physicochemical characterization and impact on intestinal absorption
    • DOI 10.1194/jlr.M400199-JLR200
    • Garmy N, Taïeb N, Yahi N, Fantini J. 2005a. Interaction of cholesterol with sphingosine: Physicochemical characterization and impact on intestinal absorption. J Lipid Res 46:36-45. (Pubitemid 40066669)
    • (2005) Journal of Lipid Research , vol.46 , Issue.1 , pp. 36-45
    • Garmy, N.1    Taieb, N.2    Yahi, N.3    Fantini, J.4
  • 15
    • 22744441951 scopus 로고    scopus 로고
    • Apical uptake and transepithelial transport of sphingosine monomers through intact human intestinal epithelial cells: Physicochemical and molecular modeling studies
    • DOI 10.1016/j.abb.2005.06.001, PII S000398610500233X
    • Garmy N, Taïeb N, Yahi N, Fantini J. 2005b. Apical uptake and transepithelial transport of sphingosine monomers through intact human intestinal epithelial cells: Physicochemical and molecular modeling studies. Arch Biochem Biophys 440:91-100. (Pubitemid 41033348)
    • (2005) Archives of Biochemistry and Biophysics , vol.440 , Issue.1 , pp. 91-100
    • Garmy, N.1    Taieb, N.2    Yahi, N.3    Fantini, J.4
  • 16
    • 0025351642 scopus 로고
    • Intracellular calcium release mediated by sphingosine derivatives generated in cells
    • Ghosh TK, Bian J, Gill DL. 1990. Intracellular calcium release mediated by sphingosine derivatives generated in cells. Science 248:1653-1656.
    • (1990) Science , vol.248 , pp. 1653-1656
    • Ghosh, T.K.1    Bian, J.2    Gill, D.L.3
  • 17
    • 0028128763 scopus 로고
    • Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium
    • Ghosh TK, Bian J, Gill DL. 1994. Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J Biol Chem 269:22628-22635. (Pubitemid 24273370)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.36 , pp. 22628-22635
    • Ghosh, T.K.1    Bian, J.2    Gill, D.L.3
  • 19
    • 60549113475 scopus 로고    scopus 로고
    • The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: Possible role in regulating cell division
    • Gillies L, Lee SC, Long JS, Ktistakis N, Pyne NJ, Pyne S. 2009. The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: Possible role in regulating cell division. Cell Signal 21:675-684.
    • (2009) Cell Signal , vol.21 , pp. 675-684
    • Gillies, L.1    Lee, S.C.2    Long, J.S.3    Ktistakis, N.4    Pyne, N.J.5    Pyne, S.6
  • 23
    • 70450225052 scopus 로고    scopus 로고
    • Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition
    • Hengst JA, Guilford JM, Fox TE, Wang X, Conroy EJ, Yun JK. 2009. Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition. Arch Biochem Biophys 492:62-73.
    • (2009) Arch Biochem Biophys , vol.492 , pp. 62-73
    • Hengst, J.A.1    Guilford, J.M.2    Fox, T.E.3    Wang, X.4    Conroy, E.J.5    Yun, J.K.6
  • 24
    • 78751525273 scopus 로고    scopus 로고
    • The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720
    • Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T. 2011. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. J Biol Chem 286:1758-1766.
    • (2011) J Biol Chem , vol.286 , pp. 1758-1766
    • Hisano, Y.1    Kobayashi, N.2    Kawahara, A.3    Yamaguchi, A.4    Nishi, T.5
  • 26
    • 7444239039 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5′-phosphate binding domain exposed to the cytosol
    • DOI 10.1016/j.bbrc.2004.10.036, PII S0006291X04023113
    • Ikeda M, Kihara A, Igarashi Y. 2004. Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5′-phosphate binding domain exposed to the cytosol. Biochem Biophys Res Commun 325:338-343. (Pubitemid 39441198)
    • (2004) Biochemical and Biophysical Research Communications , vol.325 , Issue.1 , pp. 338-343
    • Ikeda, M.1    Kihara, A.2    Igarashi, Y.3
  • 27
    • 73649108890 scopus 로고    scopus 로고
    • Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium-and integrin-binding protein 1
    • Jarman KE, Moretti PA, Zebol JR, Pitson SM. 2010. Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium-and integrin-binding protein 1. J Biol Chem 285:483-492.
    • (2010) J Biol Chem , vol.285 , pp. 483-492
    • Jarman, K.E.1    Moretti, P.A.2    Zebol, J.R.3    Pitson, S.M.4
  • 28
    • 0037144434 scopus 로고    scopus 로고
    • PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)
    • Johnson KR, Becker KP, Facchinetti MM, Hannun YA, Obeid LM. 2002. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem 277:35257-35262.
    • (2002) J Biol Chem , vol.277 , pp. 35257-35262
    • Johnson, K.R.1    Becker, K.P.2    Facchinetti, M.M.3    Hannun, Y.A.4    Obeid, L.M.5
  • 29
    • 58849083220 scopus 로고    scopus 로고
    • The sphingolipid transporter spns2 functions in migration of zebrafsh myocardial precursors
    • Kawahara A, Nishi T, Hisano Y, Fukui H, Yamaguchi A, Mochizuki N. 2009. The sphingolipid transporter spns2 functions in migration of zebrafsh myocardial precursors. Science 323:524-527.
    • (2009) Science , vol.323 , pp. 524-527
    • Kawahara, A.1    Nishi, T.2    Hisano, Y.3    Fukui, H.4    Yamaguchi, A.5    Mochizuki, N.6
  • 30
    • 33645220593 scopus 로고    scopus 로고
    • Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization
    • DOI 10.1074/jbc.M510308200
    • Kihara A, Anada Y, Igarashi Y. 2006. Mouse sphingosine kinase isoforms SPHK1a and SPHK1b difer in enzymatic traits including stability, localization, modifcation, and oligomerization. J Biol Chem 281:4532-4539. (Pubitemid 43847885)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.7 , pp. 4532-4539
    • Kihara, A.1    Anada, Y.2    Igarashi, Y.3
  • 33
    • 34548189251 scopus 로고    scopus 로고
    • The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages
    • DOI 10.1074/jbc.M700193200
    • Kusner DJ, Tompson CR, Melrose NA, Pitson SM, Obeid LM, Iyer SS. 2007. The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages. J Biol Chem 282:23147-23162. (Pubitemid 47311959)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.32 , pp. 23147-23162
    • Kusner, D.J.1    Thompson, C.R.2    Melrose, N.A.3    Pitson, S.M.4    Obeid, L.M.5    Iyer, S.S.6
  • 37
    • 51349102583 scopus 로고    scopus 로고
    • Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration
    • Maceyka M, Alvarez SE, Milstien S, Spiegel S. 2008. Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration. Mol Cell Biol 28:5687-5697.
    • (2008) Mol Cell Biol , vol.28 , pp. 5687-5697
    • MacEyka, M.1    Alvarez, S.E.2    Milstien, S.3    Spiegel, S.4
  • 39
    • 0026712872 scopus 로고
    • Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver
    • Mandon EC, Ehses I, Rother J, van Echten G, Sandhof K. 1992. Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J Biol Chem 267:11144-11148.
    • (1992) J Biol Chem , vol.267 , pp. 11144-11148
    • Mandon, E.C.1    Ehses, I.2    Rother, J.3    Van Echten, G.4    Sandhof, K.5
  • 40
    • 50049090026 scopus 로고    scopus 로고
    • Ceramidases: Regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate
    • Mao C, Obeid LM. 2008. Ceramidases: Regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim Biophys Acta 1781:424-434.
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 424-434
    • Mao, C.1    Obeid, L.M.2
  • 41
    • 0034643903 scopus 로고    scopus 로고
    • Human sphingosine kinase: Molecular cloning, functional characterization and tissue distribution
    • DOI 10.1016/S0378-1119(00)00205-5, PII S0378111900002055
    • Melendez AJ, Carlos-Dias E, Gosink M, Allen JM, Takacs L. 2000. Human sphingosine kinase: Molecular cloning, functional characterization and tissue distribution. Gene 251:19-26. (Pubitemid 30339413)
    • (2000) Gene , vol.251 , Issue.1 , pp. 19-26
    • Melendez, A.J.1    Carlos-Dias, E.2    Gosink, M.3    Allen, J.M.4    Takacs, L.5
  • 43
    • 0037428384 scopus 로고    scopus 로고
    • Identification and characterization of a novel human sphingosine-1- phosphate phosphohydrolase, hSPP2
    • DOI 10.1074/jbc.M209514200
    • Ogawa C, Kihara A, Gokoh M, Igarashi Y. 2003. Identifcation and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2. J Biol Chem 278:1268-1272. (Pubitemid 36790810)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.2 , pp. 1268-1272
    • Ogawa, C.1    Kihara, A.2    Gokoh, M.3    Igarashi, Y.4
  • 45
    • 0032524291 scopus 로고    scopus 로고
    • Purification and characterization of rat kidney sphingosine kinase
    • DOI 10.1074/jbc.273.20.12576
    • Olivera A, Kohama T, Tu Z, Milstien S, Spiegel S. 1998. Purifcation and characterization of rat kidney sphingosine kinase. J Biol Chem 273:12576-12583. (Pubitemid 28240634)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.20 , pp. 12576-12583
    • Olivera, A.1    Kohama, T.2    Tu, Z.3    Milstien, S.4    Spiegel, S.5
  • 46
    • 77953680582 scopus 로고    scopus 로고
    • Inhibitors of the sphingosine kinase pathway as potential therapeutics
    • Pitman MR, Pitson SM. 2010. Inhibitors of the sphingosine kinase pathway as potential therapeutics. Curr Cancer Drug Targets 10 (4):354-367
    • (2010) Curr Cancer Drug Targets , vol.10 , Issue.4 , pp. 354-367
    • Pitman, M.R.1    Pitson, S.M.2
  • 47
    • 79551614173 scopus 로고    scopus 로고
    • Regulation of sphingosine kinase and sphingolipid signaling
    • Pitson SM. 2011. Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem Sci 36:97-107.
    • (2011) Trends Biochem Sci , vol.36 , pp. 97-107
    • Pitson, S.M.1
  • 50
  • 51
    • 0037162033 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors
    • DOI 10.1016/S1388-1981(02)00146-4, PII S1388198102001464
    • Pyne S, Pyne NJ. 2002. Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. Biochim Biophys Acta 1582:121-131. (Pubitemid 34634120)
    • (2002) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids , vol.1582 , Issue.1-3 , pp. 121-131
    • Pyne, S.1    Pyne, N.J.2
  • 54
    • 77953525991 scopus 로고    scopus 로고
    • An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines
    • Rigogliuso S, Donati C, Cassarà D, Taverna S, Salamone M, Bruni P, Vittorelli ML. 2010. An active form of sphingosine kinase-1 is released in the extracellular medium as component of membrane vesicles shed by two human tumor cell lines. J Oncol 2010:509329.
    • (2010) J Oncol , vol.2010 , pp. 509329
    • Rigogliuso, S.1    Donati, C.2    Cassarà, D.3    Taverna, S.4    Salamone, M.5    Bruni, P.6    Vittorelli, M.L.7
  • 56
    • 35948936347 scopus 로고    scopus 로고
    • Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin
    • DOI 10.1158/0008-5472.CAN-07-2090
    • Sankala HM, Hait NC, Paugh SW, Shida D, Lépine S, Elmore LW, Dent P, Milstien S, Spiegel S. 2007. Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res 67:10466-10474. (Pubitemid 350070822)
    • (2007) Cancer Research , vol.67 , Issue.21 , pp. 10466-10474
    • Sankala, H.M.1    Hait, N.C.2    Paugh, S.W.3    Shida, D.4    Lepine, S.5    Elmore, L.W.6    Dent, P.7    Milstien, S.8    Spiegel, S.9
  • 58
    • 77956862615 scopus 로고    scopus 로고
    • Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not afect the degradative fate of sphingosine-1- phosphate
    • Siow DL, Anderson CD, Berdyshev EV, Skobeleva A, Pitson SM, Wattenberg BW. 2010. Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not afect the degradative fate of sphingosine-1- phosphate. J Lipid Res 51:2546-2559.
    • (2010) J Lipid Res , vol.51 , pp. 2546-2559
    • Siow, D.L.1    Anderson, C.D.2    Berdyshev, E.V.3    Skobeleva, A.4    Pitson, S.M.5    Wattenberg, B.W.6
  • 60
    • 78049498376 scopus 로고    scopus 로고
    • Ceramide synthases: Roles in cell physiology and signaling
    • Stiban J, Tidhar R, Futerman AH. 2010. Ceramide synthases: Roles in cell physiology and signaling. Adv Exp Med Biol 688:60-71.
    • (2010) Adv Exp Med Biol , vol.688 , pp. 60-71
    • Stiban, J.1    Tidhar, R.2    Futerman, A.H.3
  • 63
    • 77952350477 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosis
    • Suhaiman L, De Blas GA, Obeid LM, Darszon A, Mayorga LS, Belmonte SA. 2010. Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosis. Journal of Biological Chemistry 285 (21):16302-16314
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.21 , pp. 16302-16314
    • Suhaiman, L.1    De Blas, G.A.2    Obeid, L.M.3    Darszon, A.4    Mayorga, L.S.5    Belmonte, S.A.6
  • 64
    • 33744951972 scopus 로고    scopus 로고
    • The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane
    • DOI 10.1074/jbc.M601042200
    • Sutherland CM, Moretti PA, Hewitt NM, Bagley CJ, Vadas MA, Pitson SM. 2006. The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane. J Biol Chem 281:11693-11701. (Pubitemid 43855427)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.17 , pp. 11693-11701
    • Sutherland, C.M.1    Moretti, P.A.B.2    Hewitt, N.M.3    Bagley, C.J.4    Vadas, M.A.5    Pitson, S.M.6
  • 65
    • 33645801577 scopus 로고    scopus 로고
    • Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: Modulation of sphingolipid levels and the induction of apoptosis
    • DOI 10.1096/fj.05-4412fje
    • Taha TA, Kitatani K, El-Alwani M, Bielawski J, Hannun YA, Obeid LM. 2006. Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: Modulation of sphingolipid levels and the induction of apoptosis. FASEB J 20:482-484. (Pubitemid 46671223)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 482-484
    • Taha, T.A.1    Kitatani, K.2    El-Alwani, M.3    Bielawski, J.4    Hannun, Y.A.5    Obeid, L.M.6
  • 67
    • 14844349788 scopus 로고    scopus 로고
    • Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: Inhibition of SK1 translocation by Mycobacterium tuberculosis
    • Tompson CR, Iyer SS, Melrose N, VanOosten R, Johnson K, Pitson SM, Obeid LM, Kusner DJ. 2005. Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: Inhibition of SK1 translocation by Mycobacterium tuberculosis. J Immunol 174:3551-3561. (Pubitemid 40354064)
    • (2005) Journal of Immunology , vol.174 , Issue.6 , pp. 3551-3561
    • Thompson, C.R.1    Iyer, S.S.2    Melrose, N.3    VanOosten, R.4    Johnson, K.5    Pitson, S.M.6    Obeid, L.M.7    Kusner, D.J.8
  • 68
    • 77954535502 scopus 로고    scopus 로고
    • FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
    • Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ. 2010. FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells. Cell Signal 22 (10):1536-1542
    • (2010) Cell Signal , vol.22 , Issue.10 , pp. 1536-1542
    • Tonelli, F.1    Lim, K.G.2    Loveridge, C.3    Long, J.4    Pitson, S.M.5    Tigyi, G.6    Bittman, R.7    Pyne, S.8    Pyne, N.J.9
  • 70
    • 33744807983 scopus 로고    scopus 로고
    • The sphingosine and diacylglycerol kinase superfamily of signaling kinases: Localization as a key to signaling function
    • DOI 10.1194/jlr.R600003-JLR200
    • Wattenberg BW, Pitson SM, Raben DM. 2006. The sphingosine and diacylglycerol kinase superfamily of signaling kinases: Localization as a key to signaling function. J Lipid Res 47:1128-1139. (Pubitemid 43830704)
    • (2006) Journal of Lipid Research , vol.47 , Issue.6 , pp. 1128-1139
    • Wattenberg, B.W.1    Pitson, S.M.2    Raben, D.M.3
  • 73
    • 9644277224 scopus 로고    scopus 로고
    • Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition
    • DOI 10.1016/j.febslet.2004.10.081, PII S0014579304013444
    • Yokota S, Taniguchi Y, Kihara A, Mitsutake S, Igarashi Y. 2004. Asp177 in C4 domain of mouse sphingosine kinase 1a is important for the sphingosine recognition. FEBS Lett 578:106-110. (Pubitemid 39576109)
    • (2004) FEBS Letters , vol.578 , Issue.1-2 , pp. 106-110
    • Yokota, S.1    Taniguchi, Y.2    Kihara, A.3    Mitsutake, S.4    Igarashi, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.