Induction of cell proliferation in old rat liver can reset certain gene expression levels characteristic of old liver to those associated with young liver

Age

Volumn 35, Issue 3, 2013, Pages 719-732

  Chishti, Muhammad A ^a,b   Kaya, Namik ^a   Binbakheet, Al Bandary ^a   Al Mohanna, Falah ^a   Goyns, Malcolm H ^a,c   Colak, Dilek ^a  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c Immorgene Concepts Ltd   (United Kingdom)

Author keywords

Aging; Global gene expression; Hepatectomy; Liver; Longevity; Microarray; Regeneration

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR E2F5; TRANSCRIPTOME;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CARCINOMA CELL; CASKIN1 GENE; CDH13 GENE; CELL PROLIFERATION; CEP350 GENE; CLTB GENE; CONTROLLED STUDY; DCN GENE; DOWN REGULATION; E2F5 GENE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC SELECTION; LIVER CELL CARCINOMA; LIVER REGENERATION; LONGEVITY; LUM GENE; MICROARRAY ANALYSIS; NID2 GENE; NONHUMAN; NRP1 GENE; PARTIAL HEPATECTOMY; PBSN GENE; RAT; SIGNAL TRANSDUCTION; SLC22A5 GENE; UBE216 GENE; UPREGULATION; WIT3 GENE;

AGING; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEOPLASM; HEPATECTOMY; HEPATOCYTES; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; LIVER REGENERATION; LONGEVITY; MALE; PILOT PROJECTS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM;

EID: 84880570540     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-012-9404-z     Document Type: Article

References (51)

1. Anderson J, Ramsay A, Gould S, Pritchard-Jones K (2001) PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma. Am J Pathol 159(3):1089-1096. doi: 10.1016/S0002-9440(10) 61784-1
2. Boyault S, Rickman DS, de Reynies A, Balabaud C, Rebouissou S, Jeannot E, Herault A, Saric J, Belghiti J, Franco D, Bioulac-Sage P, Laurent-Puig P, Zucman-Rossi J (2007) Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. Hepatol (Baltimore, Md) 45(1):42-52. doi: 10.1002/hep.21467
3. Cao SX, Dhahbi JM, Mote PL, Spindler SR (2001) Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc Natl Acad Sci USA 98(19):10630-10635. doi: 10.1073/pnas.191313598191313598
4. Chang KC, Shen Q, Oh IG, Jelinsky SA, Jenkins SF, Wang W, Wang Y, LaCava M, Yudt MR, Thompson CC, Freedman LP, Chung JH, Nagpal S (2008) Liver X receptor is a therapeutic target for photoaging and chronological skin aging. Mol Endocrinol 22(11):2407-2419. doi: 10.1210/me.2008-0232
5. Charlton MA, Merry BJ, Goyns MH (1999) Differential display analysis can reveal patterns of gene expression in immortalised hepatoma cells which are similar to those observed in young adult but not old adult liver cells. Cancer Lett 143(1):45-50
6. Colak D, Chishti MA, Al-Bakheet AB, Al-Qahtani A, Shoukri MM, Goyns MH, Ozand PT, Quackenbush J, Park BH, Kaya N (2010) Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old. Mol Cancer 9:146. doi: 10.1186/1476-4598-9-146
7. Conboy IM, Yousef H, Conboy MJ (2011) Embryonic anti-aging niche. Aging (Albany NY) 3(5):555-563
8. Gems D, Sutton AJ, Sundermeyer ML, Albert PS, King KV, Edgley ML, Larsen PL, Riddle DL (1998) Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150(1):129-155
9. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5(10):R80. doi: 10.1186/gb-2004-5-10-r80
10. Gerisch B, Weitzel C, Kober-Eisermann C, Rottiers V, Antebi A (2001) A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev Cell 1(6):841-851
11. Goyns MH (2002) Genes, telomeres and mammalian ageing. Mech Ageing Dev 123(7):791-799
12. Goyns MH, Charlton MA, Dunford JE, Lavery WL, Merry BJ, Salehi M, Simoes DC (1998) Differential display analysis of gene expression indicates that age-related changes are restricted to a small cohort of genes. Mech Ageing Dev 101(1-2):73-90
13. Hong SE, Heo HS, Kim DH, Kim MS, Kim CH, Lee J, Yoo MA, Yu BP, Leeuwenburgh C, Chung HY (2010) Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome. Age (Dordr) 32(1):15-30. doi: 10.1007/s11357-009-9106-3
14. Ito N, Hirose M, Shibata M, Tanaka H, Shirai T (1989) Modifying effects of simultaneous treatment with butylated hydroxyanisole (BHA) on rat tumor induction by 3,2′-dimethyl-4-aminobiphenyl, 2,2′-dihydroxy-di-n- propylnitrosamine and N-methylnitrosourea. Carcinogenesis 10(12):2255-2259
15. Karpac J, Hull-Thompson J, Falleur M, Jasper H (2009) JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell 8(3):288-295. doi: 10.1111/j.1474-9726.2009.00476.x
16. Kayo T, Allison DB, Weindruch R, Prolla TA (2001) Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc Natl Acad Sci USA 98(9):5093-5098. doi: 10.1073/pnas.081061898081061898
17. Kume S, Uzu T, Horiike K, Chin-Kanasaki M, Isshiki K, Araki S, Sugimoto T, Haneda M, Kashiwagi A, Koya D (2010) Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J Clin Invest 120(4):1043-1055. doi: 10.1172/JCI41376
18. Lee CK, Klopp RG, Weindruch R, Prolla TA (1999) Gene expression profile of aging and its retardation by caloric restriction. Science 285(5432):1390-1393
19. Lee CK, Weindruch R, Prolla TA (2000) Gene-expression profile of the ageing brain in mice. Nat Genet 25(3):294-297. doi: 10.1038/77046
20. Lee CK, Allison DB, Brand J, Weindruch R, Prolla TA (2002) Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc Natl Acad Sci USA 99(23):14988-14993. doi: 10.1073/pnas.232308999232308999
21. Li Y, Yan Q, Wolf NS (1997) Long-term caloric restriction delays age-related decline in proliferation capacity of murine lens epithelial cells in vitro and in vivo. Invest Ophthalmol Vis Sci 38(1):100-107
22. Liu YF, Zha BS, Zhang HL, Zhu XJ, Li YH, Zhu J, Guan XH, Feng ZQ, Zhang JP (2009) Characteristic gene expression profiles in the progression from liver cirrhosis to carcinoma induced by diethylnitrosamine in a rat model. J Exp Clin Cancer Res 28:107. doi: 10.1186/1756-9966-28-107
23. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25(4):402-408
24. Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA (2004) Gene regulation and DNA damage in the ageing human brain. Nature 429(6994):883-891. doi: 10.1038/nature02661nature02661
25. Ly DH, Lockhart DJ, Lerner RA, Schultz PG (2000) Mitotic misregulation and human aging. Science 287(5462):2486-2492
26. Mas VR, Maluf DG, Archer KJ, Yanek K, Kong X, Kulik L, Freise CE, Olthoff KM, Ghobrial RM, McIver P, Fisher R (2009) Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma. Mol Med 15(3-4):85-94
27. Masoro EJ (1992) Retardation of aging processes by food restriction: an experimental tool. Am J Clin Nutr 55(6 Suppl):1250S-1252S
28. Matsumura I, Tanaka H, Kanakura Y (2003) E2F1 and c-Myc in cell growth and death. Cell Cycle 2(4):333-338
29. Mori K, Blackshear PE, Lobenhofer EK, Parker JS, Orzech DP, Roycroft JH, Walker KL, Johnson KA, Marsh TA, Irwin RD, Boorman GA (2007) Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with age. Toxicol Pathol 35(2):242-251. doi: 10.1080/01926230601156286
30. Nasarre C, Roth M, Jacob L, Roth L, Koncina E, Thien A, Labourdette G, Poulet P, Hubert P, Cremel G, Roussel G, Aunis D, Bagnard D (2010) Peptide-based interference of the transmembrane domain of neuropilin-1 inhibits glioma growth in vivo. Oncogene 29(16):2381-2392. doi: 10.1038/onc.2010.9
31. Perez-Carreon JI, Lopez-Garcia C, Fattel-Fazenda S, Arce-Popoca E, Aleman-Lazarini L, Hernandez-Garcia S, Le Berre V, Sokol S, Francois JM, Villa-Trevino S (2006) Gene expression profile related to the progression of preneoplastic nodules toward hepatocellular carcinoma in rats. Neoplasia 8(5):373-383
32. Rodwell GE, Sonu R, Zahn JM, Lund J, Wilhelmy J, Wang L, Xiao W, Mindrinos M, Crane E, Segal E, Myers BD, Brooks JD, Davis RW, Higgins J, Owen AB, Kim SK (2004) A transcriptional profile of aging in the human kidney. PLoS Biol 2(12):e427. doi: 10.1371/journal.pbio.0020427
33. Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N, Braisted J, Klapa M, Currier T, Thiagarajan M, Sturn A, Snuffin M, Rezantsev A, Popov D, Ryltsov A, Kostukovich E, Borisovsky I, Liu Z, Vinsavich A, Trush V, Quackenbush J (2003) TM4: a free, open-source system for microarray data management and analysis. Biotechniques 34(2):374-378
34. Salehi M, Hodgkins MA, Merry BJ, Goyns MH (1996) Age-related changes in gene expression in the rat brain revealed by differential display. Experientia 52(9):888-891
35. Schumacher B, van der Pluijm I, Moorhouse MJ, Kosteas T, Robinson AR, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, Hoeijmakers JH, van der Horst GT, Garinis GA (2008) Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet 4(8):e1000161. doi: 10.1371/journal.pgen.1000161
36. Swindell WR (2008) Genes regulated by caloric restriction have unique roles within transcriptional networks. Mech Ageing Dev 129(10):580-592. doi: 10.1016/j.mad.2008.06.001
37. Tanaka F, Hori N, Sato K (2002) Identification of differentially expressed genes in rat hepatoma cell lines using subtraction and microarray. J Biochem 131(1):39-44
38. Thomas RP, Guigneaux M, Wood T, Evers BM (2002) Age-associated changes in gene expression patterns in the liver. J Gastrointest Surg 6(3):445-453, Discussion, 454
39. Thomas PD, Campbell MJ, Kejariwal A, Mi H, Karlak B, Daverman R, Diemer K, Muruganujan A, Narechania A (2003) PANTHER: a library of protein families and subfamilies indexed by function. Genome Res 13(9):2129-2141
40. Thomas PD, Kejariwal A, Guo N, Mi H, Campbell MJ, Muruganujan A, Lazareva-Ulitsky B (2006) Applications for protein sequence-function evolution data: mRNA/protein expression analysis and coding SNP scoring tools. Nucleic Acids Res 34:W645-W650, Web Server issue
41. Tollet-Egnell P, Flores-Morales A, Stahlberg N, Malek RL, Lee N, Norstedt G (2001) Gene expression profile of the aging process in rat liver: normalizing effects of growth hormone replacement. Mol Endocrinol 15(2):308-318
42. Valle A, Sastre-Serra J, Roca P, Oliver J (2010) Modulation of white adipose tissue proteome by aging and calorie restriction. Aging Cell 9(5):882-894. doi: 10.1111/j.1474-9726.2010.00613.x
43. Wang X, Quail E, Hung NJ, Tan Y, Ye H, Costa RH (2001) Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver. Proc Natl Acad Sci USA 98(20):11468-11473. doi: 10.1073/pnas.20136089898/20/11468
44. Wang MC, Bohmann D, Jasper H (2003) JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell 5(5):811-816
45. Wang MC, Bohmann D, Jasper H (2005) JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 121(1):115-125. doi: 10.1016/j.cell.2005.02.030
46. Wayneforth HB (ed) (1980) Experimental and surgical techniques in the rat. Academic, New York
47. Welle S, Brooks AI, Delehanty JM, Needler N, Thornton CA (2003) Gene expression profile of aging in human muscle. Physiol Genomics 14(2):149-159. doi: 10.1152/physiolgenomics.00049.200300049.2003
48. Wurmbach E, Chen YB, Khitrov G, Zhang W, Roayaie S, Schwartz M, Fiel I, Thung S, Mazzaferro V, Bruix J, Bottinger E, Friedman S, Waxman S, Llovet JM (2007) Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatol (Baltimore, Md) 45(4):938-947
49. Yamaza H, Komatsu T, Wakita S, Kijogi C, Park S, Hayashi H, Chiba T, Mori R, Furuyama T, Mori N, Shimokawa I (2010) FoxO1 is involved in the antineoplastic effect of calorie restriction. Aging Cell 9(3):372-382. doi: 10.1111/j.1474-9726.2010.00563.x
50. Yoshida S, Yashar BM, Hiriyanna S, Swaroop A (2002) Microarray analysis of gene expression in the aging human retina. Invest Ophthalmol Vis Sci 43(8):2554-2560
51. Zahn JM, Sonu R, Vogel H, Crane E, Mazan-Mamczarz K, Rabkin R, Davis RW, Becker KG, Owen AB, Kim SK (2006) Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet 2(7):e115. doi: 10.1371/journal.pgen.0020115.eor