Liver X receptor is a therapeutic target for photoaging and chronological skin aging

Molecular Endocrinology

Volumn 22, Issue 11, 2008, Pages 2407-2419

  Chang, Ken C N ^a   Shen, Qi ^a   Inn, Gyung Oh ^b   Jelinsky, Scott A ^a   Jenkins, Susan F ^a   Wang, Wei ^a   Wang, Yihe ^a   LaCava, Margaret ^a   Yudt, Matthew R ^a   Thompson, Catherine C ^a   Freedman, Leonard P ^a   Jin, Ho Chung ^b   Nagpal, Sunil ^a  

^a PFIZER INC   (United States)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; CYTOKINE; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; METALLOPROTEINASE; T 1317; T 137; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CUTANEOUS PARAMETERS; DOWN REGULATION; ENZYME SYNTHESIS; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; LIPOGENESIS; MOUSE; NONHUMAN; PHOTOAGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN FIBROBLAST; SKIN INFLAMMATION; SKINFOLD; ULTRAVIOLET RADIATION; WRINKLE;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA-BINDING PROTEINS; FEMALE; HUMANS; KERATINOCYTES; LIGANDS; LIPID METABOLISM; MICE; MICE, HAIRLESS; MICE, KNOCKOUT; MODELS, BIOLOGICAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SKIN AGING;

MURINAE;

EID: 55049135861     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2008-0232     Document Type: Article

References (54)

1. Makrantonaki E, Zouboulis CC 2007 Molecular mechanisms of skin aging: state of the art. Ann NY Acad Sci 1119:40-50
2. Fisher GJ, Kang S, Varani J, Bata-Sorgo Z, Wan Y, Datta, S, Voorhees JJ 2002 Mechanisms of photoaging and chronological skin aging. Arch Dermatol 138:1462-1470
3. Rijken F, Kiekens RC, Bruijnzeel PL 2005 Skin-infiltrating neutrophils following exposure to solar-simulated radiation could play an important role in photoageing of human skin. Br J Dermatol 152:321-328
4. Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, Voorhees, JJ 1996 Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 379:335-339
5. Fagot D, Asselineau D, Bernard F 2004 Matrix metalloproteinase-1 production observed after solar-simulated radiation exposure is assumed by dermal fibroblasts but involves a paracrine activation through epidermal keratinocytes. Photochem Photobiol 79:499-505
6. Makrantonaki E, Zouboulis CC 2007 William J Cunliffe Scientific Awards. Characteristics and pathomechanisms of endogenously aged skin. Dermatology 214:352-360
7. Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM 1995 The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest 95:2281-2290
8. Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM 1997 Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol 37:403-408
9. Campisi J 1998 The role of cellular senescence in skin aging. J Investig Dermatol Symp Proc 3:1-5
10. Han JH, Roh MS, Park CH, Park KC, Cho KH, Kim KH, Eun HC, Chung JH 2004 Selective COX-2 inhibitor, NS-398, inhibits the replicative senescence of cultured dermal fibroblasts. Mech Ageing Dev 125:359-366
11. Hashizume H 2004 Skin aging and dry skin. J Dermatol 31:603-609
12. Seo JY, Kim EK, Lee SH, Park KC, Kim KH, Eun HC, Chung JH 2003 Enhanced expression of cylooxygenase-2 by UV in aged human skin in vivo. Mech Ageing Dev 124:903-910
13. Kim HH, Cho S, Lee S, Kim KH, Cho KH, Eun HC, Chung JH 2006 Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo. J Lipid Res 47:921-930
14. Polte T, Tyrrell RM 2004 Involvement of lipid peroxidation and organic peroxides in UVA-induced matrix metalloproteinase-1 expression. Free Radic Biol Med 36:1566-1574
15. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ 2001 Nuclear receptors and lipid physiology: opening the X-files. Science 294:1866-1870
16. Zelcer N, Tontonoz P 2006 Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 116:607-614
17. Zelcer N, Khanlou N, Clare R, Jiang Q, Reed-Geaghan EG, Landreth GE, Vinters HV, Tontonoz P 2007 Attenuation of neuroinflammation and Alzheimer's disease pathology by liver X receptors. Proc Natl Acad Sci USA 104:10601-10606
18. Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hseuh WA, Law RE, Collins JL, Willson TM, Tontonoz P 2002 Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci USA 99:7604-7609
19. Tontonoz P, Mangelsdorf DJ 2003 Liver X receptor signaling pathways in cardiovascular disease. Mol Endocrinol 17:985-993
20. Chintalacharuvu SR, Sandusky GE, Burris TP, Burmer GC, Nagpal S 2007 Liver X receptor is a therapeutic target in collagen-induced arthritis. Arthritis Rheum 56:1365-1367
21. Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW, Rhein L, Collins JL, Willson TL, Mangelsdorf DJ, Elias PM, Feingold KR 2003 Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol 120:246-255
22. Kömüves LG, Schmuth M, Fowler AJ, Elias PM, Hanley K, Man MQ, Moser AH, Lobaccaro JM, Williams ML, Mangelsdorf DJ, Feingold KR 2002 Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-β in murine epidermis. J Invest Dermatol 118:25-34
23. Man MQ, Choi EH, Schmuth M, Crumrine D, Uchida Y, Elias PM, Holleran WM, Feingold KR 2006 Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing. J Invest Dermatol 126:386-392
24. Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Scwendner S, Wang S, Thoolen M, Mangelsdorf DJ, Lusting KD, Shan B 2000 Role of LXRs in control of lipogenesis. Genes Dev 14:2831-2838
25. Jiang YJ, Lu B, Kim P, Elias PM, Feingold KR 2006 Regulation of ABCA1 expression in human keratinocytes and murine epidermis. J Lipid Res 47:2248-2258
26. Schmuth M, Elias PM, Hanley K, Lau P, Moser A, Willson TM, Bikle DD, Feiongold KR 2004 The effect of LXR activators on AP-1 proteins in keratinocytes. J Invest Dermatol 123:41-48
27. Inomata S, Matsunaga Y, Amano S, Takada K, Kobayashi K, Tsunenaga M, Nishiyama T, Kohno Y, Fukuda M 2003 Possible involvement of gelatinases in basement membrane damage and wrinkle formation in chronically ultraviolet B-exposed hairless mouse. J Invest Dermatol 120:128-134
28. Ghadially R, Brown BE, Hanley K, Reed JT, Feingold KR, Elias PM 1996 Decreased epidermal lipid synthesis accounts for altered barrier function in aged mice. J Invest Dermatol 106:1064-1069
29. Jensen JM, Förl M, Winoto-Morbach S, Seita S, Schunck M, Proksch E, Schutze H 2005 Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging. Exp Dermatol 14:609-618
30. Crish JF, Eckert RL 2008 Synergistic activation of human involucrin gene expression by Fra-1 and p300: evidence for the presence of a multiprotein complex. J Invest Dermatol 128:530-541
31. Hanley K, Ng DC, He SS, Lau P, Min K, Elias PM, Bikle DD, Mangelsdorf DJ, Williams ML, Feingold KR 2000 Oxysterols induce differentiation in human keratinocytes and increase Ap-1-dependent involucrin transcription. J Invest Dermatol 114:545-553
32. Jang SI, Steinert PM 2002 Loricrin expression in cultured human keratinocytes is controlled by a complex interplay between transcription factors of the Sp1, CREB, AP1, and AP2 families. J Biol Chem 277:42268-42279
33. Jang SI, Steinert PM, Markova NG 1996 Activator protein 1 activity is involved in the regulation of the cell type-specific expression from the proximal promoter of the human profilaggrin gene. J Biol Chem 271:24105-24114
34. Jiang YJ, Lu B, Kim P, Paragh G, Schmitz G, Elias PM, Feingold KR 2007 PPAR and LXR activators regulate ABCA12 expression in human keratinocytes. J Invest Dermatol 128:370-377
35. Tian L, Greenberg SA, Kong SW, Altschuler J, Kohane IS, Park PJ 2005 Discovering statistically significant pathways in expression profiling studies. Proc Natl Acad Sci USA 102:13544-13549
36. Ly DH, Lockhart DJ, Lerner RA, Schultz PG 2000 Mitotic misregulation and human aging. Science 287:2486-2492
37. Zhang Z, Hirano K, Tsukamoto K, Ikegami C, Koseki M, Saijo K, Ohno T, Sakai N, Hiraoka H, Shimomura I, Yamashita H 2005 Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase. Exp Gerontol 40:286-294
38. Chung JH, Seo JY, Choi HR, Lee MK, Youn CS, Rhie G, Cho KH, Kim KH, Park KC, Eun HC 2001 Modulation of skin collagen metabolism in aged and photoaged human skin in vivo. J Invest Dermatol 117:1218-1224
39. Park CH, Lee MJ, Kim JP, Yoo ID, Chung JH 2006 Prevention of UV radiation-induced premature skin aging in hairless mice by the novel compound melanocin A. Photochem Photobiol 82:574-578
40. Singh M, Griffiths C 2006 The use of retinoids in the treatment of photoaging. Dermatol Ther 19:297-305
41. Nagpal S, Chandraratna RA 2000 Recent developments in receptor-selective retinoids. Curr Pharm Des 6:919-931
42. Schäcke H, Berger M, Rehwinkel H, Asadullah K 2007 Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index. Mol Cell Endocrinol 275:109-117
43. Jiang YJ, Kim P, Elias PM, Feingold KR 2005 LXR and PPAR activators stimulate cholesterol sulfotransferase type 2 isoform 1b in human keratinocytes. J Lipid Res 46:2657-2666
44. Nagpal S 2003 An orphan meets family members in skin. J Invest Dermatol 120:viii-x
45. Tanaka K, Hasegawa J, Asamitsu K, Okamoto T 2005 Prevention of the ultraviolet B-mediated skin photoaging by a nuclear factor κB inhibitor, parthenolide. J Pharmacol Exp Ther 315:624-630
46. Joseph SB, Castrillo A, Laffitte BA, Mangelsdorf DJ, Tontonoz P 2003 Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 9:213-219
47. Zeng G, McCue HM, Mastrangelo L, Millis AJ 1996 Endogenous TGF-β activity is modified during cellular aging: effects on metalloproteinase and TIMP-1 expression. Exp Cell Res 228:271-276
48. Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ, Voorhees JJ 2006 Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol 168:1861-1868
49. Thornfeldt CR 2008 Chronic inflammation is etiology of extrinsic aging. J Cosmet Dermatol 7:78-82
50. Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY 2007 Motif module map reveals enforcement of aging by continual NF-κB activity. Genes Dev 21:3244-3257
51. Draelos ZD 2007 The latest cosmeceutical approaches for anti-aging. J Cosmet Dermatol 6:2-6
52. Choi EH, Man MQ, Xu P, Xin S, Liu Z, Crumrine DA, Jiang YJ, Fluhr JW, Feingold KR, Elias PM, Mauro TM 2007 Stratum corneum acidification is impaired in moderately aged human and murine skin. J Invest Dermatol 127:2847-2856
53. Zheng Y, Du X, Wang W, Boucher M, Parimoo S, Stenn KS 2005 Organogenesis from dissociated cells: generation of mature cycling hair follicles from skin-derived cells. J Invest Dermatol 124:867-876
54. T method. Methods 25:402-408