-
1
-
-
77951644400
-
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
-
Olsen, J.V., Vermeulen, M., Santamaria, A., Kumar, C., Miller, M.L., Jensen, L.J., Gnad, F., Cox, J., Jensen, T.S., Nigg, E.A. et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signaling 3, ra3
-
(2010)
Sci. Signaling
, vol.3
-
-
Olsen, J.V.1
Vermeulen, M.2
Santamaria, A.3
Kumar, C.4
Miller, M.L.5
Jensen, L.J.6
Gnad, F.7
Cox, J.8
Jensen, T.S.9
Nigg, E.A.10
-
2
-
-
79952832468
-
How protein kinases co-ordinate mitosis in animal cells
-
Ma, H.T. and Poon, R.Y. (2011) How protein kinases co-ordinate mitosis in animal cells. Biochem. J. 435, 17-31
-
(2011)
Biochem. J.
, vol.435
, pp. 17-31
-
-
Ma, H.T.1
Poon, R.Y.2
-
3
-
-
84874306548
-
On the molecular mechanisms of mitotic kinase activation
-
Bayliss, R., Fry, A., Haq, T. and Yeoh, S. (2012) On the molecular mechanisms of mitotic kinase activation. Open Biol. 2, 120136
-
(2012)
Open Biol.
, vol.2
, pp. 120136
-
-
Bayliss, R.1
Fry, A.2
Haq, T.3
Yeoh, S.4
-
4
-
-
0026342401
-
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase
-
Knighton, D.R., Zheng, J.H., Ten Eyck, L.F., Ashford, V.A., Xuong, N.H., Taylor, S.S. and Sowadski, J.M. (1991) Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science 253, 407-414
-
(1991)
Science
, vol.253
, pp. 407-414
-
-
Knighton, D.R.1
Zheng, J.H.2
Ten Eyck, L.F.3
Ashford, V.A.4
Xuong, N.H.5
Taylor, S.S.6
Sowadski, J.M.7
-
5
-
-
0029993727
-
Active and inactive protein kinases: Structural basis for regulation
-
Johnson, L.N., Noble, M.E. and Owen, D.J. (1996) Active and inactive protein kinases: structural basis for regulation. Cell 85, 149-158
-
(1996)
Cell
, vol.85
, pp. 149-158
-
-
Johnson, L.N.1
Noble, M.E.2
Owen, D.J.3
-
6
-
-
0037013143
-
The conformational plasticity of protein kinases
-
Huse, M. and Kuriyan, J. (2002) The conformational plasticity of protein kinases. Cell 109, 275-282
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
7
-
-
84861859600
-
The structural basis for control of eukaryotic protein kinases
-
Endicott, J.A., Noble, M.E. and Johnson, L.N. (2012) The structural basis for control of eukaryotic protein kinases. Annu. Rev. Biochem. 81, 587-613
-
(2012)
Annu. Rev. Biochem.
, vol.81
, pp. 587-613
-
-
Endicott, J.A.1
Noble, M.E.2
Johnson, L.N.3
-
8
-
-
33845197964
-
Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism
-
Kornev, A.P., Haste, N.M., Taylor, S.S. and Eyck, L.F. (2006) Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proc. Natl. Acad. Sci. U.S.A. 103, 17783-17788
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 17783-17788
-
-
Kornev, A.P.1
Haste, N.M.2
Taylor, S.S.3
Eyck, L.F.4
-
9
-
-
55749102720
-
A helix scaffold for the assembly of active protein kinases
-
Kornev, A.P., Taylor, S.S. and Ten Eyck, L.F. (2008) A helix scaffold for the assembly of active protein kinases. Proc. Natl. Acad. Sci. U.S.A. 105, 14377-14382
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 14377-14382
-
-
Kornev, A.P.1
Taylor, S.S.2
Ten Eyck, L.F.3
-
10
-
-
0027182223
-
Crystal structure of cyclin-dependent kinase 2
-
De Bondt, H.L., Rosenblatt, J., Jancarik, J., Jones, H.D., Morgan, D.O. and Kim, S.H. (1993) Crystal structure of cyclin-dependent kinase 2. Nature 363, 595-602
-
(1993)
Nature
, vol.363
, pp. 595-602
-
-
De Bondt, H.L.1
Rosenblatt, J.2
Jancarik, J.3
Jones, H.D.4
Morgan, D.O.5
Kim, S.H.6
-
11
-
-
34948901399
-
Aurora-A: The maker and breaker of spindle poles
-
Barr, A.R. and Gergely, F. (2007) Aurora-A: the maker and breaker of spindle poles. J. Cell Sci. 120, 2987-2996
-
(2007)
J. Cell Sci.
, vol.120
, pp. 2987-2996
-
-
Barr, A.R.1
Gergely, F.2
-
12
-
-
84873721726
-
Aurora A kinase (AURKA) in normal and pathological cell division
-
Nikonova, A.S., Astsaturov, I., Serebriiskii, I.G., Dunbrack, Jr, R.L. and Golemis, E.A. (2012) Aurora A kinase (AURKA) in normal and pathological cell division. Cell. Mol. Life Sci. 70, 661-687
-
(2012)
Cell. Mol. Life Sci.
, vol.70
, pp. 661-687
-
-
Nikonova, A.S.1
Astsaturov, I.2
Serebriiskii, I.G.3
Dunbrack Jr., R.L.4
Golemis, E.A.5
-
13
-
-
0242330123
-
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle
-
Bayliss, R., Sardon, T., Vernos, I. and Conti, E. (2003) Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol. Cell 12, 851-862
-
(2003)
Mol. Cell
, vol.12
, pp. 851-862
-
-
Bayliss, R.1
Sardon, T.2
Vernos, I.3
Conti, E.4
-
14
-
-
0037446847
-
A novel mechanism for activation of the protein kinase Aurora A
-
Eyers, P.A., Erikson, E., Chen, L.G. and Maller, J.L. (2003) A novel mechanism for activation of the protein kinase Aurora A. Curr. Biol. 13, 691-697
-
(2003)
Curr. Biol.
, vol.13
, pp. 691-697
-
-
Eyers, P.A.1
Erikson, E.2
Chen, L.G.3
Maller, J.L.4
-
15
-
-
84855494872
-
Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic
-
Dodson, C.A. and Bayliss, R. (2012) Activation of Aurora-A kinase by protein partner binding and phosphorylation are independent and synergistic. J. Biol. Chem. 287, 1150-1157
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 1150-1157
-
-
Dodson, C.A.1
Bayliss, R.2
-
16
-
-
67650061988
-
Discovery and exploitation of inhibitor-resistant aurora and Polo kinase mutants for the analysis of mitotic networks
-
Scutt, P.J., Chu, M.L., Sloane, D.A., Cherry, M., Bignell, C.R., Williams, D.H. and Eyers, P.A. (2009) Discovery and exploitation of inhibitor-resistant aurora and Polo kinase mutants for the analysis of mitotic networks. J. Biol. Chem. 284, 15880-15893
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 15880-15893
-
-
Scutt, P.J.1
Chu, M.L.2
Sloane, D.A.3
Cherry, M.4
Bignell, C.R.5
Williams, D.H.6
Eyers, P.A.7
-
17
-
-
77953850924
-
Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237
-
Sloane, D.A., Trikic, M.Z., Chu, M.L., Lamers, M.B., Mason, C.S., Mueller, I., Savory, W.J., Williams, D.H. and Eyers, P.A. (2010) Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237. ACS Chem. Biol. 5, 563-576
-
(2010)
ACS Chem. Biol.
, vol.5
, pp. 563-576
-
-
Sloane, D.A.1
Trikic, M.Z.2
Chu, M.L.3
Lamers, M.B.4
Mason, C.S.5
Mueller, I.6
Savory, W.J.7
Williams, D.H.8
Eyers, P.A.9
-
18
-
-
78650745657
-
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
-
Zeng, K., Bastos, R.N., Barr, F.A. and Gruneberg, U. (2010) Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2. J. Cell Biol. 191, 1315-1332
-
(2010)
J. Cell Biol.
, vol.191
, pp. 1315-1332
-
-
Zeng, K.1
Bastos, R.N.2
Barr, F.A.3
Gruneberg, U.4
-
19
-
-
81855224627
-
Nek9, Nek6, Nek7 and the separation of centrosomes
-
Sdelci, S., Bertran, M.T. and Roig, J. (2011) Nek9, Nek6, Nek7 and the separation of centrosomes. Cell Cycle 10, 3816-3817
-
(2011)
Cell Cycle
, vol.10
, pp. 3816-3817
-
-
Sdelci, S.1
Bertran, M.T.2
Roig, J.3
-
20
-
-
67650021805
-
The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis
-
O'Regan, L. and Fry, A.M. (2009) The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. Mol. Cell. Biol. 29, 3975-3990
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 3975-3990
-
-
O'Regan, L.1
Fry, A.M.2
-
21
-
-
33750972565
-
Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression
-
Yissachar, N., Salem, H., Tennenbaum, T. and Motro, B. (2006) Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression. FEBS Lett. 580, 6489-6495
-
(2006)
FEBS Lett.
, vol.580
, pp. 6489-6495
-
-
Yissachar, N.1
Salem, H.2
Tennenbaum, T.3
Motro, B.4
-
22
-
-
84872171489
-
Cell cycle regulation by the NEK family of protein kinases
-
Fry, A.M., O'Regan, L., Sabir, S.R. and Bayliss, R. (2012) Cell cycle regulation by the NEK family of protein kinases. J. Cell Sci. 125, 4423-4433
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4423-4433
-
-
Fry, A.M.1
O'Regan, L.2
Sabir, S.R.3
Bayliss, R.4
-
23
-
-
0042317229
-
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases
-
Belham, C., Roig, J., Caldwell, J.A., Aoyama, Y., Kemp, B.E., Comb, M. and Avruch, J. (2003) A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J. Biol. Chem. 278, 34897-34909
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34897-34909
-
-
Belham, C.1
Roig, J.2
Caldwell, J.A.3
Aoyama, Y.4
Kemp, B.E.5
Comb, M.6
Avruch, J.7
-
24
-
-
70449646933
-
An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9
-
Richards, M.W., O'Regan, L., Mas-Droux, C., Blot, J.M., Cheung, J., Hoelder, S., Fry, A.M. and Bayliss, R. (2009) An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9. Mol. Cell 36, 560-570
-
(2009)
Mol. Cell
, vol.36
, pp. 560-570
-
-
Richards, M.W.1
O'Regan, L.2
Mas-Droux, C.3
Blot, J.M.4
Cheung, J.5
Hoelder, S.6
Fry, A.M.7
Bayliss, R.8
-
25
-
-
0034665713
-
Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase
-
Schindler, T., Bornmann, W., Pellicena, P., Miller, W.T., Clarkson, B. and Kuriyan, J. (2000) Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase. Science 289, 1938-1942
-
(2000)
Science
, vol.289
, pp. 1938-1942
-
-
Schindler, T.1
Bornmann, W.2
Pellicena, P.3
Miller, W.T.4
Clarkson, B.5
Kuriyan, J.6
-
26
-
-
77950878509
-
Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: Insights into selectivity and drug design
-
Dodson, C.A., Kosmopoulou, M., Richards, M.W., Atrash, B., Bavetsias, V., Blagg, J. and Bayliss, R. (2010) Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design. Biochem. J. 427, 19-28
-
(2010)
Biochem. J.
, vol.427
, pp. 19-28
-
-
Dodson, C.A.1
Kosmopoulou, M.2
Richards, M.W.3
Atrash, B.4
Bavetsias, V.5
Blagg, J.6
Bayliss, R.7
-
27
-
-
78149250139
-
Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization
-
Whelligan, D.K., Solanki, S., Taylor, D., Thomson, D.W., Cheung, K.M., Boxall, K., Mas-Droux, C., Barillari, C., Burns, S., Grummitt, C.G. et al. (2010) Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization. J. Med. Chem. 53, 7682-7698
-
(2010)
J. Med. Chem.
, vol.53
, pp. 7682-7698
-
-
Whelligan, D.K.1
Solanki, S.2
Taylor, D.3
Thomson, D.W.4
Cheung, K.M.5
Boxall, K.6
Mas-Droux, C.7
Barillari, C.8
Burns, S.9
Grummitt, C.G.10
-
28
-
-
34247375933
-
Structure and regulation of the human Nek2 centrosomal kinase
-
Rellos, P., Ivins, F.J., Baxter, J.E., Pike, A., Nott, T.J., Parkinson, D.M., Das, S., Howell, S., Fedorov, O., Shen, Q.Y. et al. (2007) Structure and regulation of the human Nek2 centrosomal kinase. J. Biol. Chem. 282, 6833-6842
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 6833-6842
-
-
Rellos, P.1
Ivins, F.J.2
Baxter, J.E.3
Pike, A.4
Nott, T.J.5
Parkinson, D.M.6
Das, S.7
Howell, S.8
Fedorov, O.9
Shen, Q.Y.10
-
29
-
-
79952782394
-
Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship
-
Solanki, S., Innocenti, P., Mas-Droux, C., Boxall, K., Barillari, C., van Montfort, R.L., Aherne, G.W., Bayliss, R. and Hoelder, S. (2011) Benzimidazole inhibitors induce a DFG-out conformation of never in mitosis gene A-related kinase 2 (Nek2) without binding to the back pocket and reveal a nonlinear structure-activity relationship. J. Med. Chem. 54, 1626-1639
-
(2011)
J. Med. Chem.
, vol.54
, pp. 1626-1639
-
-
Solanki, S.1
Innocenti, P.2
Mas-Droux, C.3
Boxall, K.4
Barillari, C.5
Van Montfort, R.L.6
Aherne, G.W.7
Bayliss, R.8
Hoelder, S.9
-
30
-
-
59149104834
-
Insights into the conformational variability and regulation of human Nek2 kinase
-
Westwood, I., Cheary, D.M., Baxter, J.E., Richards, M.W., van Montfort, R.L., Fry, A.M. and Bayliss, R. (2009) Insights into the conformational variability and regulation of human Nek2 kinase. J. Mol. Biol. 386, 476-485
-
(2009)
J. Mol. Biol.
, vol.386
, pp. 476-485
-
-
Westwood, I.1
Cheary, D.M.2
Baxter, J.E.3
Richards, M.W.4
Van Montfort, R.L.5
Fry, A.M.6
Bayliss, R.7
|