Structure and regulation of the human Nek2 centrosomal kinase

Journal of Biological Chemistry

Volumn 282, Issue 9, 2007, Pages 6833-6842

  Rellos, Peter ^a   Ivins, Frank J ^b   Baxter, Joanne E ^c   Pike, Ashley ^a   Nott, Timothy J ^b   Parkinson, Donna Marie ^c   Das, Sanjan ^a   Howell, Steven ^b   Fedorov, Oleg ^a   Qi, Yu Shen ^c   Fry, Andrew M ^c   Knapp, Stefan ^a   Smerdon, Stephen J ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CENTROSOME COHESION; INHIBITORY HELICAL MOTIFS; KINASE ACTIVITY;

CELL CULTURE; MASS SPECTROMETRY; ONCOLOGY; PHOSPHORYLATION; SEPARATION;

ENZYME ACTIVITY;

CYCLIN DEPENDENT KINASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; NEK2 KINASE; PROTEIN SERINE THREONINE KINASE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; NEK2 PROTEIN, HUMAN;

ARTICLE; AUTOPHOSPHORYLATION; CANCER CELL CULTURE; CELL MATURATION; CENTROSOME; CONTROLLED STUDY; CORRELATION ANALYSIS; DIMERIZATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IN VIVO STUDY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; ALLOSTERISM; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION;

ALLOSTERIC REGULATION; BINDING SITES; CENTROSOME; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DNA MUTATIONAL ANALYSIS; HUMANS; MASS SPECTROMETRY; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 34247375933     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609721200     Document Type: Article

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