Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

Journal of Molecular Biology

Volumn 386, Issue 2, 2009, Pages 476-485

  Westwood, Isaac ^a,b   Cheary, Donna Marie ^c   Baxter, Joanne E ^c   Richards, Mark W ^a   van Montfort, Rob L M ^a,b   Fry, Andrew M ^c   Bayliss, Richard ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

cancer; Nek2 kinase; structure based drug design; X ray crystallography

Indexed keywords

ADENOSINE DIPHOSPHATE; AURORA A KINASE; CYCLIN DEPENDENT KINASE 2; NEK2 KINASE; NUCLEOTIDE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME STRUCTURE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; WILD TYPE;

EID: 59149104834     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.12.033     Document Type: Article

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