Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells

Molecular Cancer

Volumn 8, Issue , 2009, Pages

  Kumar, Sanjeev ^b,c   Bryant, Christopher S ^c   Chamala, Sreedhar ^a,b   Qazi, Aamer ^a,c   Seward, Shelly ^b,c   Pal, Jagannath ^a,c   Steffes, Christopher P ^c   Weaver, Donald W ^a,c   Morris, Robert ^b,c   Malone, John M ^b,c   Shammas, Masood A ^a,c   Prasad, Madhu ^a,c   Batchu, Ramesh B ^a,c  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PACLITAXEL; PROTEIN BCL 2; PROTEIN KINASE B; RITONAVIR; SOMATOMEDIN C; AKT1 PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASPASE 3; CYCLIN DEPENDENT KINASE; CYCLINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEINASE INHIBITOR; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; TUMOR MARKER;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG POTENTIATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; MIGRATION INHIBITION; OVARY CANCER; PHARMACOLOGICAL BLOCKING; SIGNAL TRANSDUCTION; CELL CYCLE; CELL MOTION; DNA MICROARRAY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; OVARY TUMOR; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL CULTURE; WESTERN BLOTTING; WOUND HEALING;

HUMAN IMMUNODEFICIENCY VIRUS;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; CYCLINS; FEMALE; GENE EXPRESSION PROFILING; HIV PROTEASE INHIBITORS; HUMANS; NEOPLASM INVASIVENESS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARIAN NEOPLASMS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; RETINOBLASTOMA PROTEIN; RITONAVIR; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; WOUND HEALING;

EID: 67549134670     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-8-26     Document Type: Article

References (42)

1. Jemal A Siegel R Ward E Murray T Xu J Thun MJ Cancer statistics, 2007 CA: A Cancer Journal for Clinicians 2007, 57:43-66. 10.3322/ canjclin.57.1.43 17237035
2. Bertone-Johnson ER Epidemiology of ovarian cancer: A status report Lancet 2005, 365:101-102. 10.1016/S0140-6736(05)17716-2 15639276
3. Panos G Samonis G Alexiou VG Kavarnou GA Charatsis G Falagas ME Mortality and morbidity of HIV infected patients receiving HAART: A cohort study Current HIV Research 2008, 6:257-260. 10.2174/ 157016208784324976 18473789
4. Cheung TW AIDS-related cancer in the era of highly active antiretroviral therapy (HAART): A model of the interplay of the immune system, virus, and cancer. "On the offensive-the Trojan Horse is being destroyed"-Part A: Kaposi's sarcoma Cancer Investigation 2004, 22:774-786. 10.1081/CNV-200032788 15581058
5. Laurence J Impact of HAART on HIV-linked malignancies AIDS Reader 2003, 13:202. 12800820
6. Monini P Toschi E Sgadari C Bacigalupo I Palladino C Carlei D Barillari G Ensoli B The use of HAART for biological tumour therapy Journal of HIV Therapy 2006, 11:53-56. 17580499
7. Clifford GM Polesel J Rickenbach M Dal Maso L Keiser O Kofler A Rapiti E Levi F Jundt G Fisch T et al Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency, smoking, and highly active antiretroviral therapy. [see comment] Journal of the National Cancer Institute 2005, 97:425-432. 15770006
8. Kincaid L Modern HAART decreases cancers in children with HIV Lancet Oncology 2007, 8:103. 10.1016/S1470-2045(07)70021-9 17290505
9. Laurence J Impact of HAART on HIV-linked malignancies AIDS Reader 13:202. 12800820
10. Long JL Engels EA Moore RD Gebo KA Incidence and outcomes of malignancy in the HAART era in an urban cohort of HIV-infected individuals AIDS 2008, 22:489-496. 2553213 18301061 10.1097/QAD.0b013e3282f47082
11. Dewan MZ Uchihara JN Terashima K Honda M Sata T Ito M Fujii N Uozumi K Tsukasaki K Tomonaga M et al Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir Blood 2006, 107:716-724. 10.1182/blood-2005-02-0735 16174765
12. Ikezoe T Daar ES Hisatake J Taguchi H Koeffler HP HIV-1 protease inhibitors decrease proliferation and induce differentiation of human myelocytic leukemia cells Blood 2000, 96:3553-3559. 11071654
13. Gaedicke S Firat-Geier E Constantiniu O Lucchiari-Hartz M Freudenberg M Galanos C Niedermann G Antitumor effect of the human immunodeficiency virus protease inhibitor ritonavir: Induction of tumor-cell apoptosis associated with perturbation of proteasomal proteolysis Cancer Research 2002, 62:6901-6908. 12460905
14. Pati S Pelser CB Dufraine J Bryant JL Reitz MS Jr Weichold FF Antitumorigenic effects of HIV protease inhibitor ritonavir: Inhibition of Kaposi sarcoma Blood 2002, 99:3771-3779. 10.1182/blood.V99.10.3771 11986235
15. Testa JR Bellacosa A AKT plays a central role in tumorigenesis.[comment] Proceedings of the National Academy of Sciences of the United States of America 2001, 98:10983-10985. 58668 11572954 10.1073/pnas.211430998
16. Vivanco I Sawyers CL The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nature Reviews Cancer 2002, 2:489-501. 10.1038/nrc839 12094235
17. Caplen NJ Parrish S Imani F Fire A Morgan RA Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems Proceedings of the National Academy of Sciences of the United States of America 2001, 98:9742-9747. 55523 11481446 10.1073/ pnas.171251798
18. McManus MT Sharp PA Gene silencing in mammals by small interfering RNAs Nature Reviews Genetics 2002, 3:737-747. 10.1038/nrg908 12360232
19. Vermes I Haanen C Steffens-Nakken H Reutelingsperger C A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V Journal of Immunological Methods 1995, 184:39-51. 10.1016/0022-1759(95)00072-I 7622868
20. Soldani C Scovassi AI Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: An update Apoptosis 2002, 7:321-328. 10.1023/A:1016119328968 12101391
21. Hajduch E Litherland GJ Hundal HS Protein kinase B (PKB/Akt)-a key regulator of glucose transport? FEBS Letters 2001, 492:199-203. 10.1016/ S0014-5793(01)02242-6 11257494
22. Gills JJ Lopiccolo J Tsurutani J Shoemaker RH Best CJM Abu-Asab MS Borojerdi J Warfel NA Gardner ER Danish M et al Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo Clinical Cancer Research 2007, 13:5183-5194. 10.1158/ 1078-0432.CCR-07-0161 17785575
23. Gupta AK Cerniglia GJ Mick R McKenna WG Muschel RJ HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo Cancer Research 2005, 65:8256-8265. 10.1158/ 0008-5472.CAN-05-1220 16166302
24. Srirangam A Mitra R Wang M Gorski JC Badve S Baldridge L Hamilton J Kishimoto H Hawes J Li L et al Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer Clinical Cancer Research 2006, 12:1883-1896. 10.1158/1078-0432.CCR-05-1167 16551874
25. O'Connor KA Roth BL Finding new tricks for old drugs: An efficient route for public-sector drug discovery Nature Reviews Drug Discovery 2005, 4:1005-1014. 10.1038/nrd1900 16341065
26. Falco P Cavallo F Larocca A Liberati AM Musto P Boccadoro M Palumbo A Falco P Cavallo F Larocca A et al Lenalidomide and its role in the management of multiple myeloma Expert Review of Anticancer Therapy 2008, 8:865-874. 10.1586/14737140.8.6.865 18533796
27. Stumvoll M Stumvoll M Thiazolidinediones - some recent developments Expert Opinion on Investigational Drugs 2003, 12:1179-1187. 10.1517/ 13543784.12.7.1179 12831352
28. Cruzado JM Cruzado JM Nonimmunosuppressive effects of mammalian target of rapamycin inhibitors Transplantation Reviews 2008, 22:73-81. 10.1016/ j.trre.2007.09.003 18631860
29. Yamashita JI Ogawa M Medroxyprogesterone acetate and cancer cachexia: interleukin-6 involvement Breast Cancer 2000, 7:130-135. 10.1007/ BF02967444 11029784
30. Oldfield V Plosker GL Lopinavir/ritonavir: A review of its use in the management of HIV infection Drugs 2006, 66:1275-1299. 10.2165/ 00003495-200666090-00012 16827606
31. Agarwal R Kaye SB Agarwal R Kaye SB Ovarian cancer: Strategies for overcoming resistance to chemotherapy Nature Reviews Cancer 2003, 3:502-516. 10.1038/nrc1123 12835670
32. DiCiommo D Gallie BL Bremner R Retinoblastoma: The disease, gene and protein provide critical leads to understand cancer Seminars in Cancer Biology 2000, 10:255-269. 10.1006/scbi.2000.0326 10966849
33. Sherr CJ The Pezcoller lecture: Cancer cell cycles revisited Cancer Research 2000, 60:3689-3695. 10919634
34. La Thangue NB DP and E2F proteins: Components of a heterodimeric transcription factor implicated in cell cycle control Current Opinion in Cell Biology 1994, 6:443-450. 10.1016/0955-0674(94)90038-8 7917337
35. Muller R Transcriptional regulation during the mammalian cell cycle Trends in Genetics 1995, 11:173-178. 10.1016/S0168-9525(00)89039-3 7785076
36. Morgan DO Principles of CDK regulation Nature 1995, 374:131-134. 10.1038/ 374131a0 7877684
37. Bellacosa A de Feo D Godwin AK Bell DW Cheng JQ Altomare DA Wan M Dubeau L Scambia G Masciullo V et al Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas International Journal of Cancer 1995, 64:280-285. 10.1002/ijc.2910640412
38. Cheng JQ Lindsley CW Cheng GZ Yang H Nicosia SV The Akt/PKB pathway: molecular target for cancer drug discovery Oncogene 2005, 24:7482-7492. 10.1038/sj.onc.1209088 16288295
39. Mackus WJM Kater AP Grummels A Evers LM Hooijbrink B Kramer MHH Castro JE Kipps TJ van Lier RAW van Oers MHJ Eldering E Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation Leukemia 2005, 19:427-434. 10.1038/sj.leu.2403623 15674362
40. Rochet N Jensen AD Sterzing F Munter MW Eichbaum MH Schneeweiss A Sohn C Debus J Harms W Adjuvant whole abdominal intensity modulated radiotherapy (IMRT) for high risk stage FIGO III patients with ovarian cancer (OVAR-IMRT-01) - Pilot trial of a phase I/II study: Study protocol BMC Cancer 2007, 7:227. 2212657 18093313 10.1186/1471-2407-7-227
41. Gatti G Di Biagio A Casazza R De Pascalis C Bassetti M Cruciani M Vella S Bassetti D The relationship between ritonavir plasma levels and side-effects: Implications for therapeutic drug monitoring AIDS 1999, 13:2083-2089. 10.1097/00002030-199910220-00011 10546861
42. Norvir Ritonavir product monograph North Chicago IL, Abbott laboratories 2007.