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Volumn 17, Issue 8, 2013, Pages 951-963

Targeting membrane androgen receptors in tumors

Author keywords

Actin cytoskeleton; Androgens; Apoptosis; Cell proliferation; MAR expression; MAR ligands; MAR signaling; Migration; SGK1

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CYPROTERONE ACETATE; FLUTAMIDE; G PROTEIN COUPLED RECEPTOR; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PROCYANIDIN; PROCYANIDIN B2; PROTEIN KINASE B; TEMOZOLOMIDE; TESTOSTERONE; TESTOSTERONE ALBUMIN CONJUGATE; UNCLASSIFIED DRUG;

EID: 84880371610     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2013.806491     Document Type: Review
Times cited : (32)

References (105)
  • 3
    • 0037355797 scopus 로고    scopus 로고
    • Non-genomic actions of sex steroid hormones
    • DOI 10.1530/eje.0.1480281
    • Simoncini T, Genazzani AR. Non-genomic actions of sex steroid hormones. Eur J Endocrinol 2003;148:281-92 (Pubitemid 36410713)
    • (2003) European Journal of Endocrinology , vol.148 , Issue.3 , pp. 281-292
    • Simoncini, T.1    Genazzani, A.R.2
  • 4
    • 0345874610 scopus 로고    scopus 로고
    • Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
    • Norman AW, Mizwicki MT, Norman DP. Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov 2004;3:27-41 (Pubitemid 38088696)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.1 , pp. 27-41
    • Norman, A.W.1    Mizwicki, M.T.2    Norman, D.P.G.3
  • 5
    • 0017722384 scopus 로고
    • Activities of the androgen responsive receptor of the prostatic plasma membrane
    • Farnsworth WE. Activities of the androgen-responsive receptor of the prostatic plasma membrane. Invest Urol 1977;15:75-7 (Pubitemid 8163526)
    • (1977) Investigative Urology , vol.15 , Issue.1 , pp. 75-77
    • Farnsworth, W.E.1
  • 6
    • 0025415515 scopus 로고
    • The prostate plasma membrane as an androgen receptor
    • Farnsworth WE. The prostate plasma membrane as an androgen receptor. Membr Biochem 1990;9:141-62
    • (1990) Membr Biochem , vol.9 , pp. 141-162
    • Farnsworth, W.E.1
  • 7
    • 0026337341 scopus 로고
    • Prostate plasma membrane receptor: A hypothesis
    • Farnsworth WE. Prostate plasma membrane receptor: a hypothesis. Prostate 1991;19:329-52
    • (1991) Prostate , vol.19 , pp. 329-352
    • Farnsworth, W.E.1
  • 8
    • 0027444941 scopus 로고
    • Na+K(+)-ATPase: The actual androgen receptor of the prostate?
    • Farnsworth WE. Na+,K(+)-ATPase: the actual androgen receptor of the prostate? Med Hypotheses 1993;41:358-62
    • (1993) Med Hypotheses , vol.41 , pp. 358-362
    • Farnsworth, W.E.1
  • 9
    • 0029890498 scopus 로고    scopus 로고
    • Membrane receptors for estrogen, progesterone, and testosterone in the rat brain: Fantasy or reality
    • DOI 10.1007/BF02088175
    • Ramirez VD, Zheng J, Siddique KM. Membrane receptors for estrogen, progesterone, and testosterone in the rat brain: fantasy or reality. Cell Mol Neurobiol 1996;16:175-98 (Pubitemid 26158376)
    • (1996) Cellular and Molecular Neurobiology , vol.16 , Issue.2 , pp. 175-198
    • Ramirez, V.D.1    Zheng, J.2    Siddique, K.M.3
  • 12
    • 0037119394 scopus 로고    scopus 로고
    • Nongenomic testosterone calcium signaling: Genotropic actions in androgen receptor-free macrophages
    • DOI 10.1074/jbc.M202997200
    • Guo Z, Benten WP, Krucken J, et al. Nongenomic testosterone calcium signaling. Genotropic actions in androgen receptor-free macrophages. J Biol Chem 2002;277:29600-7 (Pubitemid 41079249)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.33 , pp. 29600-29607
    • Guo, Z.1    Benten, W.P.M.2    Krucken, J.3    Wunderlich, F.4
  • 14
    • 84864441029 scopus 로고    scopus 로고
    • Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes
    • ElBaradie K, Wang Y, Boyan BD, et al. Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes. J Steroid Biochem Mol Biol 2012;132:15-23
    • (2012) J Steroid Biochem Mol Biol , vol.132 , pp. 15-23
    • Elbaradie, K.1    Wang, Y.2    Boyan, B.D.3
  • 15
    • 34249824292 scopus 로고    scopus 로고
    • Activation of a membrane-associated androgen receptor promotes cell death in primary cortical astrocytes
    • DOI 10.1210/en.2006-1443
    • Gatson JW, Singh M. Activation of a membrane-associated androgen receptor promotes cell death in primary cortical astrocytes. Endocrinology 2007;148:2458-64 (Pubitemid 46997068)
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2458-2464
    • Gatson, J.W.1    Singh, M.2
  • 16
    • 33747333308 scopus 로고    scopus 로고
    • Neuronal differentiation of PC12 cells abolishes the expression of membrane androgen receptors
    • Alexaki VI, Dermitzaki E, Charalampopoulos I, et al. Neuronal differentiation of PC12 cells abolishes the expression of membrane androgen receptors. Exp Cell Res 2006;312:2745-56
    • (2006) Exp Cell Res , vol.312 , pp. 2745-2756
    • Alexaki, V.I.1    Dermitzaki, E.2    Charalampopoulos, I.3
  • 17
    • 0842303571 scopus 로고    scopus 로고
    • Role of putative membrane receptors in the effects of androgens on human vascular cell growth
    • DOI 10.1677/joe.0.1800097
    • Somjen D, Kohen F, Gayer B, et al. Role of putative membrane receptors in the effect of androgens on human vascular cell growth. J Endocrinol 2004;180:97-106 (Pubitemid 38180761)
    • (2004) Journal of Endocrinology , vol.180 , Issue.1 , pp. 97-106
    • Somjen, D.1    Kohen, F.2    Gayer, B.3    Kulik, T.4    Knoll, E.5    Stern, N.6
  • 19
    • 0042315340 scopus 로고    scopus 로고
    • Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells
    • DOI 10.1210/en.2002-0164
    • Estrada M, Espinosa A, Muller M, et al. Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells. Endocrinology 2003;144:3586-97 (Pubitemid 36904438)
    • (2003) Endocrinology , vol.144 , Issue.8 , pp. 3586-3597
    • Estrada, M.1    Espinosa, A.2    Muller, M.3    Jaimovich, E.4
  • 20
    • 0028942387 scopus 로고
    • Androgens rapidly increase the cytosolic calcium concentration in Sertoli cells
    • Gorczynska E, Handelsman DJ. Androgens rapidly increase the cytosolic calcium concentration in Sertoli cells. Endocrinology 1995;136:2052-9
    • (1995) Endocrinology , vol.136 , pp. 2052-2059
    • Gorczynska, E.1    Handelsman, D.J.2
  • 22
    • 0033785921 scopus 로고    scopus 로고
    • Simultaneous detection and functional response of testosterone and estradiol receptors in osteoblast plasma membranes
    • Armen TA, Gay CV. Simultaneous detection and functional response of testosterone and estradiol receptors in osteoblast plasma membranes. J Cell Biochem 2000;79:620-7
    • (2000) J Cell Biochem , vol.79 , pp. 620-627
    • Armen, T.A.1    Gay, C.V.2
  • 23
  • 24
    • 35748980862 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains
    • DOI 10.1074/jbc.M703310200
    • Cinar B, Mukhopadhyay NK, Meng G, et al. Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. J Biol Chem 2007;282:29584-93 (Pubitemid 350043392)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.40 , pp. 29584-29593
    • Cinar, B.1    Mukhopadhyay, N.K.2    Meng, G.3    Freeman, M.R.4
  • 25
    • 0036717596 scopus 로고    scopus 로고
    • The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton
    • Kampa M, Papakonstanti EA, Hatzoglou A, et al. The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton. FASEB J 2002;16:1429-31
    • (2002) FASEB J , vol.16 , pp. 1429-1431
    • Kampa, M.1    Papakonstanti, E.A.2    Hatzoglou, A.3
  • 26
    • 0034675994 scopus 로고    scopus 로고
    • Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation
    • Migliaccio A, Castoria G, Di Domenico M, et al. Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. EMBO J 2000;19:5406-17
    • (2000) EMBO J , vol.19 , pp. 5406-5417
    • Migliaccio, A.1    Castoria, G.2    Di Domenico, M.3
  • 27
    • 0038636338 scopus 로고    scopus 로고
    • A rapid, nongenomic, signaling pathway regulates the actin reorganization induced by activation of membrane testosterone receptors
    • DOI 10.1210/me.2002-0253
    • Papakonstanti EA, Kampa M, Castanas E, et al. A rapid, nongenomic, signaling pathway regulates the actin reorganization induced by activation of membrane testosterone receptors. Mol Endocrinol 2003;17:870-81 (Pubitemid 36539577)
    • (2003) Molecular Endocrinology , vol.17 , Issue.5 , pp. 870-881
    • Papakonstanti, E.A.1    Kampa, M.2    Castanas, E.3    Stournaras, C.4
  • 28
    • 33749487659 scopus 로고    scopus 로고
    • Androgens induce increases in intracellular calcium via a G protein-coupled receptor in LNCaP prostate cancer cells
    • DOI 10.2164/jandrol.106.000554
    • Sun YH, Gao X, Tang YJ, et al. Androgens induce increases in intracellular calcium via a G protein-coupled receptor in LNCaP prostate cancer cells. J Androl 2006;27:671-8 (Pubitemid 44520808)
    • (2006) Journal of Andrology , vol.27 , Issue.5 , pp. 671-678
    • Sun, Y.-H.1    Gao, X.2    Tang, Y.-J.3    Xu, C.-L.4    Wang, L.-H.5
  • 30
    • 53249107178 scopus 로고    scopus 로고
    • Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells
    • Papadopoulou N, Charalampopoulos I, Alevizopoulos K, et al. Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells. Exp Cell Res 2008;314:3162-74
    • (2008) Exp Cell Res , vol.314 , pp. 3162-3174
    • Papadopoulou, N.1    Charalampopoulos, I.2    Alevizopoulos, K.3
  • 31
    • 77956555910 scopus 로고    scopus 로고
    • Paxillin regulates androgen-and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells
    • Sen A, O'Malley K, Wang Z, et al. Paxillin regulates androgen-and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells. J Biol Chem 2010;285:28787-95
    • (2010) J Biol Chem , vol.285 , pp. 28787-28795
    • Sen, A.1    O'Malley, K.2    Wang, Z.3
  • 32
    • 77949275201 scopus 로고    scopus 로고
    • Testosterone membrane-initiated action in breast cancer cells: Interaction with the androgen signaling pathway and EPOR
    • Pelekanou V, Notas G, Sanidas E, et al. Testosterone membrane-initiated action in breast cancer cells: interaction with the androgen signaling pathway and EPOR. Mol Oncol 2010;4:135-49
    • (2010) Mol Oncol , vol.4 , pp. 135-149
    • Pelekanou, V.1    Notas, G.2    Sanidas, E.3
  • 33
  • 34
    • 33645519245 scopus 로고    scopus 로고
    • Dihydrotestosterone differentially modulates the mitogen-activated protein kinase and the phosphoinositide 3-kinase/Akt pathways through the nuclear and novel membrane androgen receptor in C6 cells
    • Gatson JW, Kaur P, Singh M. Dihydrotestosterone differentially modulates the mitogen-activated protein kinase and the phosphoinositide 3-kinase/Akt pathways through the nuclear and novel membrane androgen receptor in C6 cells. Endocrinology 2006;147:2028-34
    • (2006) Endocrinology , vol.147 , pp. 2028-2034
    • Gatson, J.W.1    Kaur, P.2    Singh, M.3
  • 36
    • 73249146094 scopus 로고    scopus 로고
    • Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo
    • Gu S, Papadopoulou N, Gehring EM, et al. Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo. Mol Cancer 2009;8:114
    • (2009) Mol Cancer , vol.8 , pp. 114
    • Gu, S.1    Papadopoulou, N.2    Gehring, E.M.3
  • 37
    • 78651490702 scopus 로고    scopus 로고
    • Activation of membrane androgen receptors in colon cancer inhibits the prosurvival signals Akt/bad in vitro and in vivo and blocks migration via vinculin/actin signaling
    • Gu S, Papadopoulou N, Nasir O, et al. Activation of membrane androgen receptors in colon cancer inhibits the prosurvival signals Akt/bad in vitro and in vivo and blocks migration via vinculin/actin signaling. Mol Med 2011;17:48-58
    • (2011) Mol Med , vol.17 , pp. 48-58
    • Gu, S.1    Papadopoulou, N.2    Nasir, O.3
  • 39
    • 59049095926 scopus 로고    scopus 로고
    • Membrane androgen receptor activation triggers down-regulation of PI3K/Akt/NFkappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells
    • Papadopoulou N, Charalampopoulos I, Anagnostopoulou V, et al. Membrane androgen receptor activation triggers down-regulation of PI3K/Akt/NFkappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells. Mol Cancer 2008;7:88
    • (2008) Mol Cancer , vol.7 , pp. 88
    • Papadopoulou, N.1    Charalampopoulos, I.2    Anagnostopoulou, V.3
  • 40
    • 46749155783 scopus 로고    scopus 로고
    • Testosterone and dihydrotestosterone inhibit gallbladder motility through multiple signalling pathways
    • Kline LW, Karpinski E. Testosterone and dihydrotestosterone inhibit gallbladder motility through multiple signalling pathways. Steroids 2008;73:1174-80
    • (2008) Steroids , vol.73 , pp. 1174-1180
    • Kline, L.W.1    Karpinski, E.2
  • 41
    • 84859100828 scopus 로고    scopus 로고
    • Serum-and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor
    • Schmidt EM, Gu S, Anagnostopoulou V, et al. Serum-and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor. FEBS J 2012;279:1231-42
    • (2012) FEBS J , vol.279 , pp. 1231-1242
    • Schmidt, E.M.1    Gu, S.2    Anagnostopoulou, V.3
  • 42
    • 34247557419 scopus 로고    scopus 로고
    • Receptor mechanisms mediating non-genomic actions of sex steroids
    • DOI 10.1055/s-2007-973427
    • Boonyaratanakornkit V, Edwards DP. Receptor mechanisms mediating non-genomic actions of sex steroids. Semin Reprod Med 2007;25:139-53 (Pubitemid 46676901)
    • (2007) Seminars in Reproductive Medicine , vol.25 , Issue.3 , pp. 139-153
    • Boonyaratanakornkit, V.1    Edwards, D.P.2
  • 45
    • 82355163442 scopus 로고    scopus 로고
    • Minireview: Recent advances in extranuclear steroid receptor actions
    • Hammes SR, Levin ER. Minireview: recent advances in extranuclear steroid receptor actions. Endocrinology 2011;152:4489-95
    • (2011) Endocrinology , vol.152 , pp. 4489-4495
    • Hammes, S.R.1    Levin, E.R.2
  • 46
    • 44549085837 scopus 로고    scopus 로고
    • Membrane-initiated steroid action in breast and prostate cancer
    • Kampa M, Pelekanou V, Castanas E. Membrane-initiated steroid action in breast and prostate cancer. Steroids 2008;73:953-60
    • (2008) Steroids , vol.73 , pp. 953-960
    • Kampa, M.1    Pelekanou, V.2    Castanas, E.3
  • 47
    • 33947401482 scopus 로고    scopus 로고
    • Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer
    • DOI 10.1146/annurev.physiol.69.031905.160319
    • Lange CA, Gioeli D, Hammes SR, et al. Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer. Annu Rev Physiol 2007;69:171-99 (Pubitemid 46457640)
    • (2007) Annual Review of Physiology , vol.69 , pp. 171-199
    • Lange, C.A.1    Gioeli, D.2    Hammes, S.R.3    Marker, P.C.4
  • 49
    • 62149119309 scopus 로고    scopus 로고
    • Membrane androgen receptor activation in prostate and breast tumor cells: Molecular signaling and clinical impact
    • Papadopoulou N, Papakonstanti EA, Kallergi G, et al. Membrane androgen receptor activation in prostate and breast tumor cells: molecular signaling and clinical impact. IUBMB Life 2009;61:56-61
    • (2009) IUBMB Life , vol.61 , pp. 56-61
    • Papadopoulou, N.1    Papakonstanti, E.A.2    Kallergi, G.3
  • 50
    • 36248981484 scopus 로고    scopus 로고
    • Non-classical actions of testosterone: an update
    • DOI 10.1016/j.tem.2007.09.004, PII S1043276007001750
    • Rahman F, Christian HC. Non-classical actions of testosterone: an update. Trends Endocrinol Metab 2007;18:371-8 (Pubitemid 350137764)
    • (2007) Trends in Endocrinology and Metabolism , vol.18 , Issue.10 , pp. 371-378
    • Rahman, F.1    Christian, H.C.2
  • 51
    • 80052780494 scopus 로고    scopus 로고
    • Role of 17beta-estradiol and testosterone in apoptosis
    • Vasconsuelo A, Pronsato L, Ronda AC, et al. Role of 17beta-estradiol and testosterone in apoptosis. Steroids 2011;76:1223-31
    • (2011) Steroids , vol.76 , pp. 1223-1231
    • Vasconsuelo, A.1    Pronsato, L.2    Ronda, A.C.3
  • 52
    • 0031589011 scopus 로고    scopus 로고
    • 2+ influx via non-genomic surface receptors in activated T cells
    • DOI 10.1016/S0014-5793(97)00346-3, PII S0014579397003463
    • Benten WP, Lieberherr M, Sekeris CE, et al. Testosterone induces Ca2+ influx via non-genomic surface receptors in activated T cells. FEBS Lett 1997;407:211-14 (Pubitemid 27199494)
    • (1997) FEBS Letters , vol.407 , Issue.2 , pp. 211-214
    • Benten, W.P.M.1    Lieberherr, M.2    Sekeris, C.E.3    Wunderlich, F.4
  • 53
    • 77954243029 scopus 로고    scopus 로고
    • Androgens are powerful non-genomic inducers of calcium sensitization in visceral smooth muscle
    • Gonzalez-Montelongo MC, Marin R, Gomez T, et al. Androgens are powerful non-genomic inducers of calcium sensitization in visceral smooth muscle. Steroids 2010;75:533-8
    • (2010) Steroids , vol.75 , pp. 533-538
    • Gonzalez-Montelongo, M.C.1    Marin, R.2    Gomez, T.3
  • 55
    • 84867625987 scopus 로고    scopus 로고
    • Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells
    • Gu S, Kounenidakis M, Schmidt EM, et al. Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells. Cell Signal 2013;25:66-73
    • (2013) Cell Signal , vol.25 , pp. 66-73
    • Gu, S.1    Kounenidakis, M.2    Schmidt, E.M.3
  • 56
    • 33646417329 scopus 로고    scopus 로고
    • DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation
    • DOI 10.1016/j.febslet.2006.03.041, PII S0014579306003565
    • Alimirah F, Chen J, Basrawala Z, et al. DU145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation. FEBS Lett 2006;580:2294-300 (Pubitemid 43675636)
    • (2006) FEBS Letters , vol.580 , Issue.9 , pp. 2294-2300
    • Alimirah, F.1    Chen, J.2    Basrawala, Z.3    Xin, H.4    Choubey, D.5
  • 57
    • 0344626940 scopus 로고    scopus 로고
    • Phenotypic and genotypic characterization of commonly used human prostatic cell lines
    • DOI 10.1046/j.1464-410X.2000.00606.x
    • Mitchell S, Abel P, Ware M, et al. Phenotypic and genotypic characterization of commonly used human prostatic cell lines. BJU Int 2000;85:932-44 (Pubitemid 30242804)
    • (2000) BJU International , vol.85 , Issue.7 , pp. 932-944
    • Mitchell, S.1    Abel, P.2    Ware, M.3    Stamp, G.4    Lalani, E.-N.5
  • 58
    • 77956140003 scopus 로고    scopus 로고
    • Colorectal carcinoma cells-regulation of survival and growth by SGK1
    • Lang F, Perrotti N, Stournaras C. Colorectal carcinoma cells-regulation of survival and growth by SGK1. Int J Biochem Cell Biol 2010;42:1571-5
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1571-1575
    • Lang, F.1    Perrotti, N.2    Stournaras, C.3
  • 59
    • 84878233480 scopus 로고    scopus 로고
    • Therapeutic potential of serum and glucocorticoid inducible kinase inhibition
    • Lang F, Voelkl J. Therapeutic potential of serum and glucocorticoid inducible kinase inhibition. Expert Opin Investig Drugs 2013
    • (2013) Expert Opin Investig Drugs
    • Lang, F.1    Voelkl, J.2
  • 61
    • 84873149747 scopus 로고    scopus 로고
    • SGK3 regulates Ca(2+) entry and migration of dendritic cells
    • Schmid E, Bhandaru M, Nurbaeva MK, et al. SGK3 regulates Ca(2+) entry and migration of dendritic cells. Cell Physiol Biochem 2012;30:1423-35
    • (2012) Cell Physiol Biochem , vol.30 , pp. 1423-1435
    • Schmid, E.1    Bhandaru, M.2    Nurbaeva, M.K.3
  • 62
    • 84859914401 scopus 로고    scopus 로고
    • Effect of azathioprine on Na(+)/H(+) exchanger activity in dendritic cells
    • Bhandaru M, Pasham V, Yang W, et al. Effect of azathioprine on Na(+)/H(+) exchanger activity in dendritic cells. Cell Physiol Biochem 2012;29:533-42
    • (2012) Cell Physiol Biochem , vol.29 , pp. 533-542
    • Bhandaru, M.1    Pasham, V.2    Yang, W.3
  • 63
    • 80052079645 scopus 로고    scopus 로고
    • Influence of dexamethasone on Na+/H+ exchanger activity in dendritic cells
    • Rotte A, Pasham V, Eichenmuller M, et al. Influence of dexamethasone on Na+/H+ exchanger activity in dendritic cells. Cell Physiol Biochem 2011;28:305-14
    • (2011) Cell Physiol Biochem , vol.28 , pp. 305-314
    • Rotte, A.1    Pasham, V.2    Eichenmuller, M.3
  • 64
    • 0036343938 scopus 로고    scopus 로고
    • Possible interrelationship between changes in F-actin and myosin II, protein phosphorylation, and cell volume regulation in Ehrlich ascites tumor cells
    • DOI 10.1006/excr.2002.5529
    • Pedersen SF, Hoffmann EK. Possible interrelationship between changes in F-actin and myosin II, protein phosphorylation, and cell volume regulation in Ehrlich ascites tumor cells. Exp Cell Res 2002;277:57-73 (Pubitemid 34948340)
    • (2002) Experimental Cell Research , vol.277 , Issue.1 , pp. 57-73
    • Pedersen, S.F.1    Hoffmann, E.K.2
  • 65
    • 33750562162 scopus 로고    scopus 로고
    • Cell volume regulatory ion transport in the regulation of cell migration
    • DOI 10.1159/000096322, Mechanisms and Significance of Cell Volume Regulation
    • Jakab M, Ritter M. Cell volume regulatory ion transport in the regulation of cell migration. Contrib Nephrol 2006;152:161-80 (Pubitemid 44672107)
    • (2006) Contributions to Nephrology , vol.152 , pp. 161-180
    • Jakab, M.1    Ritter, M.2
  • 66
    • 33744832157 scopus 로고    scopus 로고
    • + exchanger NHE1 in cell migration
    • DOI 10.1111/j.1748-1716.2006.01543.x
    • Stock C, Schwab A. Role of the Na/H exchanger NHE1 in cell migration. Acta Physiol (Oxf) 2006;187:149-57 (Pubitemid 43828772)
    • (2006) Acta Physiologica , vol.187 , Issue.1-2 , pp. 149-157
    • Stock, C.1    Schwab, A.2
  • 67
    • 84863293173 scopus 로고    scopus 로고
    • NHE-1: A promising target for novel anti-cancer therapeutics
    • Loo SY, Chang MK, Chua CS, et al. NHE-1: a promising target for novel anti-cancer therapeutics. Curr Pharm Des 2012;18:1372-82
    • (2012) Curr Pharm des , vol.18 , pp. 1372-1382
    • Loo, S.Y.1    Chang, M.K.2    Chua, C.S.3
  • 68
    • 33748059840 scopus 로고    scopus 로고
    • Non-genomic immunosuppressive actions of progesterone inhibits PHA-induced alkalinization and activation in T cells
    • DOI 10.1002/jcb.20858
    • Chien EJ, Chang CP, Lee WF, et al. Non-genomic immunosuppressive actions of progesterone inhibits PHA-induced alkalinization and activation in T cells. J Cell Biochem 2006;99:292-304 (Pubitemid 44297972)
    • (2006) Journal of Cellular Biochemistry , vol.99 , Issue.1 , pp. 292-304
    • Chien, E.J.1    Chang, C.-P.2    Lee, W.-F.3    Su, T.-H.4    Wu, C.-H.5
  • 69
    • 84871883315 scopus 로고    scopus 로고
    • Serumand glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation
    • Schmid E, Gu S, Yang W, et al. Serumand glucocorticoid-inducible kinase SGK1 regulates reorganization of actin cytoskeleton in mast cells upon degranulation. Am J Physiol Cell Physiol 2013;304:C49-55
    • (2013) Am J Physiol Cell Physiol , vol.304
    • Schmid, E.1    Gu, S.2    Yang, W.3
  • 71
    • 23044504053 scopus 로고    scopus 로고
    • Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer
    • DOI 10.1016/j.tem.2005.06.002, PII S1043276005001244
    • Freeman MR, Cinar B, Lu ML. Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trends Endocrinol Metab 2005;16:273-9 (Pubitemid 41058759)
    • (2005) Trends in Endocrinology and Metabolism , vol.16 , Issue.6 , pp. 273-279
    • Freeman, M.R.1    Cinar, B.2    Lu, M.L.3
  • 72
    • 77953460074 scopus 로고    scopus 로고
    • Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane
    • Razandi M, Pedram A, Levin ER. Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane. Mol Cell Biol 2010;30:3249-61
    • (2010) Mol Cell Biol , vol.30 , pp. 3249-3261
    • Razandi, M.1    Pedram, A.2    Levin, E.R.3
  • 73
    • 84864766183 scopus 로고    scopus 로고
    • Src kinase-mediates androgen receptor-dependent non-genomic activation of signaling cascade leading to endothelial nitric oxide synthase
    • Yu J, Akishita M, Eto M, et al. Src kinase-mediates androgen receptor-dependent non-genomic activation of signaling cascade leading to endothelial nitric oxide synthase. Biochem Biophys Res Commun 2012;424:538-43
    • (2012) Biochem Biophys Res Commun , vol.424 , pp. 538-543
    • Yu, J.1    Akishita, M.2    Eto, M.3
  • 74
    • 0028290639 scopus 로고
    • Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein
    • Lieberherr M, Grosse B. Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein. J Biol Chem 1994;269:7217-23
    • (1994) J Biol Chem , vol.269 , pp. 7217-7223
    • Lieberherr, M.1    Grosse, B.2
  • 76
    • 0036140032 scopus 로고    scopus 로고
    • Estrogen action via the G protein-coupled receptor, GPR30: Stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis
    • DOI 10.1210/me.16.1.70
    • Filardo EJ, Quinn JA, Frackelton AR Jr, et al. Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis. Mol Endocrinol 2002;16:70-84 (Pubitemid 34044499)
    • (2002) Molecular Endocrinology , vol.16 , Issue.1 , pp. 70-84
    • Filardo, E.J.1    Quinn, J.A.2    Frackelton Jr., A.R.3    Bland, K.I.4
  • 77
    • 0344885580 scopus 로고    scopus 로고
    • Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
    • DOI 10.1073/pnas.0436133100
    • Zhu Y, Bond J, Thomas P. Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. Proc Natl Acad Sci USA 2003;100:2237-42 (Pubitemid 36297483)
    • (2003) Proceedings of the National Academy of Sciences of the United States of America , vol.100 , Issue.5 , pp. 2237-2242
    • Zhu, Y.1    Bond, J.2    Thomas, P.3
  • 78
    • 84865811924 scopus 로고    scopus 로고
    • Characterization and ligand identification of a membrane progesterone receptor in fungi: Existence of a novel PAQR in Sporothrix schenckii
    • Gonzalez-Velazquez W, Gonzalez-Mendez R, Rodriguez-del Valle N. Characterization and ligand identification of a membrane progesterone receptor in fungi: existence of a novel PAQR in Sporothrix schenckii. BMC Microbiol 2012;12:194
    • (2012) BMC Microbiol , vol.12 , pp. 194
    • Gonzalez-Velazquez, W.1    Gonzalez-Mendez, R.2    Rodriguez-Del Valle, N.3
  • 79
    • 33645389472 scopus 로고    scopus 로고
    • Progestin, estrogen and androgen G-protein coupled receptors in fish gonads
    • Thomas P, Dressing G, Pang Y, et al. Progestin, estrogen and androgen G-protein coupled receptors in fish gonads. Steroids 2006;71:310-16
    • (2006) Steroids , vol.71 , pp. 310-316
    • Thomas, P.1    Dressing, G.2    Pang, Y.3
  • 80
    • 78650038629 scopus 로고    scopus 로고
    • GPRC6A mediates the non-genomic effects of steroids
    • Pi M, Parrill AL, Quarles LD. GPRC6A mediates the non-genomic effects of steroids. J Biol Chem 2010;285:39953-64
    • (2010) J Biol Chem , vol.285 , pp. 39953-39964
    • Pi, M.1    Parrill, A.L.2    Quarles, L.D.3
  • 81
    • 3543041879 scopus 로고    scopus 로고
    • The androgen receptor associates with the epidermal growth factor receptor in androgen-sensitive prostate cancer cells
    • DOI 10.1016/j.steroids.2004.05.011, PII S0039128X04000777
    • Bonaccorsi L, Muratori M, Carloni V, et al. The androgen receptor associates with the epidermal growth factor receptor in androgen-sensitive prostate cancer cells. Steroids 2004;69:549-52 (Pubitemid 39013486)
    • (2004) Steroids , vol.69 , Issue.8-9 , pp. 549-552
    • Bonaccorsi, L.1    Muratori, M.2    Carloni, V.3    Marchiani, S.4    Formigli, L.5    Forti, G.6    Baldi, E.7
  • 82
    • 1542269061 scopus 로고    scopus 로고
    • The opioid agonist ethylketocyclazocine reverts the rapid, non-genomic effects of membrane testosterone receptors in the human prostate LNCaP cell line
    • DOI 10.1016/j.yexcr.2003.11.027, PII S0014482703006426
    • Kampa M, Papakonstanti EA, Alexaki VI, et al. The opioid agonist ethylketocyclazocine reverts the rapid, non-genomic effects of membrane testosterone receptors in the human prostate LNCaP cell line. Exp Cell Res 2004;294:434-45 (Pubitemid 38326742)
    • (2004) Experimental Cell Research , vol.294 , Issue.2 , pp. 434-445
    • Kampa, M.1    Papakonstanti, E.A.2    Alexaki, V.-I.3    Hatzoglou, A.4    Stournaras, C.5    Castanas, E.6
  • 83
    • 2542478192 scopus 로고    scopus 로고
    • The androgen receptor of the prostate plasma membrane - An hypontesis
    • DOI 10.1016/j.mehy.2004.01.024
    • Farnsworth WE. The androgen receptor of the prostate plasma membrane-an hypothesis. Med Hypotheses 2004;62:954-7 (Pubitemid 38680367)
    • (2004) Medical Hypotheses , vol.62 , Issue.6 , pp. 954-957
    • Farnsworth, W.E.1
  • 84
    • 0037962085 scopus 로고    scopus 로고
    • Distinct signaling pathways regulate differential opioid effects on actin cytoskeleton in malignant MCF7 and nonmalignant MCF12A human breast epithelial cells
    • DOI 10.1016/S0014-4827(03)00210-6
    • Kallergi G, Tsapara A, Kampa M, et al. Distinct signaling pathways regulate differential opioid effects on actin cytoskeleton in malignant MCF7 and nonmalignant MCF12A human breast epithelial cells. Exp Cell Res 2003;288:94-109 (Pubitemid 36873805)
    • (2003) Experimental Cell Research , vol.288 , Issue.1 , pp. 94-109
    • Kallergi, G.1    Tsapara, A.2    Kampa, M.3    Papakonstanti, E.A.4    Krasagakis, K.5    Castanas, E.6    Stournaras, C.7
  • 85
    • 0029847569 scopus 로고    scopus 로고
    • Dexamethasone alters rapidly actin polymerization dynamics in human endometrial cells: Evidence for nongenomic actions involving cAMP turnover
    • DOI 10.1002/(SICI)1097-4644(199608)62:2<251::AID-JCB13>3.0.CO;2-O
    • Koukouritaki SB, Theodoropoulos PA, Margioris AN, et al. Dexamethasone alters rapidly actin polymerization dynamics in human endometrial cells: evidence for nongenomic actions involving cAMP turnover. J Cell Biochem 1996;62:251-61 (Pubitemid 26287209)
    • (1996) Journal of Cellular Biochemistry , vol.62 , Issue.2 , pp. 251-261
    • Koukouritaki, S.B.1    Theodoropoulos, P.A.2    Margioris, A.N.3    Gravanis, A.4    Stournaras, C.5
  • 86
    • 0030988624 scopus 로고    scopus 로고
    • Dexamethasone induces rapid actin assembly in human endometrial cells without affecting its synthesis
    • DOI 10.1002/(SICI)1097-4644(19970615)65:4<492::AID-JCB5>3.0.CO;2-J
    • Koukouritaki SB, Margioris AN, Gravanis A, et al. Dexamethasone induces rapid actin assembly in human endometrial cells without affecting its synthesis. J Cell Biochem 1997;65:492-500 (Pubitemid 27240915)
    • (1997) Journal of Cellular Biochemistry , vol.65 , Issue.4 , pp. 492-500
    • Koukouritaki, S.B.1    Margioris, A.N.2    Gravanis, A.3    Hartig, R.4    Stournaras, C.5
  • 87
    • 0033276623 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of focal adhesion kinase and paxillin regulates the signaling mechanism of the rapid nongenomic action of dexamethasone on actin cytoskeleton
    • Koukouritaki SB, Gravanis A, Stournaras C. Tyrosine phosphorylation of focal adhesion kinase and paxillin regulates the signaling mechanism of the rapid nongenomic action of dexamethasone on actin cytoskeleton. Mol Med 1999;5:731-42 (Pubitemid 32937033)
    • (1999) Molecular Medicine , vol.5 , Issue.11 , pp. 731-742
    • Koukouritaki, S.B.1    Gravanis, A.2    Stournaras, C.3
  • 88
    • 23044462488 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfate and allopregnanolone directly stimulate catecholamine production via induction of tyrosine hydroxylase and secretion by affecting actin polymerization
    • DOI 10.1210/en.2005-0263
    • Charalampopoulos I, Dermitzaki E, Vardouli L, et al. Dehydroepiandrosterone sulfate and allopregnanolone directly stimulate catecholamine production via induction of tyrosine hydroxylase and secretion by affecting actin polymerization. Endocrinology 2005;146:3309-18 (Pubitemid 41058102)
    • (2005) Endocrinology , vol.146 , Issue.8 , pp. 3309-3318
    • Charalampopoulos, I.1    Dermitzaki, E.2    Vardouli, L.3    Tsatsanis, C.4    Stournaras, C.5    Margioris, A.N.6    Gravanis, A.7
  • 89
    • 0034102483 scopus 로고    scopus 로고
    • Actin cytoskeleton and cell signaling
    • Carpenter CL. Actin cytoskeleton and cell signaling. Crit Care Med 2000;28:N94-9 (Pubitemid 30262052)
    • (2000) Critical Care Medicine , vol.28 , Issue.4 SUPPL.
    • Carpenter, C.L.1
  • 91
    • 49449089292 scopus 로고    scopus 로고
    • Actin associated proteins function as androgen receptor coregulators: An implication of androgen receptor's roles in skeletal muscle
    • Ting HJ, Chang C. Actin associated proteins function as androgen receptor coregulators: an implication of androgen receptor's roles in skeletal muscle. J Steroid Biochem Mol Biol 2008;111:157-63
    • (2008) J Steroid Biochem Mol Biol , vol.111 , pp. 157-163
    • Ting, H.J.1    Chang, C.2
  • 92
    • 79953013333 scopus 로고    scopus 로고
    • Novel oligomeric proanthocyanidin derivatives interact with membrane androgen sites and induce regression of hormone-independent prostate cancer
    • Kampa M, Theodoropoulou K, Mavromati F, et al. Novel oligomeric proanthocyanidin derivatives interact with membrane androgen sites and induce regression of hormone-independent prostate cancer. J Pharmacol Exp Ther 2011;337:24-32
    • (2011) J Pharmacol Exp Ther , vol.337 , pp. 24-32
    • Kampa, M.1    Theodoropoulou, K.2    Mavromati, F.3
  • 93
    • 48249107981 scopus 로고    scopus 로고
    • A role for actin in regulating apoptosis/programmed cell death: Evidence spanning yeast, plants and animals
    • Franklin-Tong VE, Gourlay CW. A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals. Biochem J 2008;413:389-404
    • (2008) Biochem J , vol.413 , pp. 389-404
    • Franklin-Tong, V.E.1    Gourlay, C.W.2
  • 94
    • 21744445111 scopus 로고    scopus 로고
    • The actin cytoskeleton: A key regulator of apoptosis and ageing?
    • DOI 10.1038/nrm1682
    • Gourlay CW, Ayscough KR. The actin cytoskeleton: a key regulator of apoptosis and ageing? Nat Rev Mol Cell Biol 2005;6:583-9 (Pubitemid 40943049)
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.7 , pp. 583-589
    • Gourlay, C.W.1    Ayscough, K.R.2
  • 95
    • 1542283796 scopus 로고    scopus 로고
    • Tumor Necrosis Factor-α Promotes Survival of Opossum Kidney Cells via Cdc42-induced Phospholipase C-γ1 Activation and Actin Filament Redistribution
    • DOI 10.1091/mbc.E03-07-0491
    • Papakonstanti EA, Stournaras C. Tumor necrosis factor-alpha promotes survival of opossum kidney cells via Cdc42-induced phospholipase C-gamma1 activation and actin filament redistribution. Mol Biol Cell 2004;15:1273-86 (Pubitemid 38316234)
    • (2004) Molecular Biology of the Cell , vol.15 , Issue.3 , pp. 1273-1286
    • Papakonstanti, E.A.1    Stournaras, C.2
  • 96
    • 44449149681 scopus 로고    scopus 로고
    • Cell responses regulated by early reorganization of actin cytoskeleton
    • Papakonstanti EA, Stournaras C. Cell responses regulated by early reorganization of actin cytoskeleton. FEBS Lett 2008;582:2120-7
    • (2008) FEBS Lett , vol.582 , pp. 2120-2127
    • Papakonstanti, E.A.1    Stournaras, C.2
  • 97
    • 37849186467 scopus 로고    scopus 로고
    • The Functional Role of Actin Cytoskeleton Dynamics and Signaling
    • DOI 10.1016/S1569-2558(06)37009-9, PII S1569255806370099, Aspects of the Cytoskeleton
    • Stournaras C. The functional role of actin cytoskeleton dynamics and signaling in early cell responses. In: Khurana S, editor, Advances in molecular and cell biology. Elsevier, London, UK; 2006. p. 181-200 (Pubitemid 44827948)
    • (2006) Advances in Molecular and Cell Biology , vol.37 , pp. 181-200
    • Stournaras, C.1
  • 101
    • 28344456900 scopus 로고    scopus 로고
    • Membrane testosterone binding sites in prostate carcinoma as a potential new marker and therapeutic target: Study in paraffin tissue sections
    • Dambaki C, Kogia C, Kampa M, et al. Membrane testosterone binding sites in prostate carcinoma as a potential new marker and therapeutic target: study in paraffin tissue sections. BMC Cancer 2005;5:148
    • (2005) BMC Cancer , vol.5 , pp. 148
    • Dambaki, C.1    Kogia, C.2    Kampa, M.3
  • 102
    • 1542366176 scopus 로고    scopus 로고
    • Membrane androgen binding sites are preferentially expressed in human prostate carcinoma cells
    • Stathopoulos EN, Dambaki C, Kampa M, et al. Membrane androgen binding sites are preferentially expressed in human prostate carcinoma cells. BMC Clin Pathol 2003;3:1
    • (2003) BMC Clin Pathol , vol.3 , pp. 1
    • Stathopoulos, E.N.1    Dambaki, C.2    Kampa, M.3
  • 104
    • 84894891354 scopus 로고    scopus 로고
    • Membrane androgen receptor ligands; A novel therapeutic approach for the treatment of cancer
    • Alevizopoulos K, Bacopoulos N, Stournaras C. Membrane androgen receptor ligands; a novel therapeutic approach for the treatment of cancer. Cancer Res 2010;70:1728
    • (2010) Cancer Res , vol.70 , pp. 1728
    • Alevizopoulos, K.1    Bacopoulos, N.2    Stournaras, C.3


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