Non-genomic actions of sex steroid hormones

European Journal of Endocrinology

Volumn 148, Issue 3, 2003, Pages 281-292

  Simoncini, Tommaso ^a   Genazzani, Andrea R ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; HORMONE RECEPTOR; ION CHANNEL; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; REGULATOR PROTEIN; SEX HORMONE;

CARDIOVASCULAR SYSTEM; CELL MEMBRANE; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MEMBRANE BINDING; MOLECULAR MECHANICS; NERVE CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SYNTHESIS; RECEPTOR BINDING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VASODILATATION;

ANIMALS; CELL MEMBRANE; GONADAL STEROID HORMONES; GTP-BINDING PROTEINS; HUMANS; ION CHANNELS; PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 0037355797     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1480281     Document Type: Review

References (93)

1. Truss M & Beato M. Steroid hormone receptors: interaction with deoxyribonucleic acid and transcription factors. Endocrine Reviews 1993 14 459-479.
2. Pietras RJ & Szego CM. Specific binding sites for oestrogen at the outer surfaces of isolated endometrial cells. Nature 1977 265 69-72.
3. Pietras RJ & Szego CM. Partial purification and characterization of oestrogen receptors in subfractions of hepatocyte plasma membranes. Biochemical Journal 1980 191 743-760.
4. Moggs JG & Orphanides G. Estrogen receptors: orchestrators of pleiotropic cellular responses. EMBO Report 2001 2 775-781.
5. Levin ER. Cellular Functions of the plasma membrane estrogen receptor. Trends in Endocrinology and Metabolism 1999 10 374-377.
6. Tesarik J & Mendoza C. Nongenomic effects of 17 beta-estradiol on maturing human oocytes: relationship to oocyte developmental potential. Journal of Clinical Endocrinology and Metabolism 1995 80 1438-1443.
7. 2+ currents in aortic smooth muscle cells. European Journal of Pharmacology 1995 294 625-635.
8. Valverde MA, Rojas P, Amigo J, Cosmelli D, Orio P, Bahamonde MI et al. Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit. Science 1999 285 1929-1931.
9. Kelly MJ & Wagner EJ. Estrogen modulation of G-protein-coupled receptors. Trends in Endocrinology and Metabolism 1999 10 369-374.
10. Migliaccio A, Di Domenico M, Castoria G, de Falco A, Bontempo P, Nola E et al. Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells. EMBO Journal 1996 15 1292-1300.
11. Watters JJ, Campbell JS, Cunningham MJ, Krebs EG & Dorsa DM. Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. Endocrinology 1997 138 4030-4033.
12. Aronica SM, Kraus WL & Katzenellenbogen BS. Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. PNAS 1994 91 8517-8521.
13. Le Mellay V, Grosse B & Lieberherr M. Phospholipase C beta and membrane action of calcitriol and estradiol. Journal of Biological Chemistry 1997 272 11902-11907.
14. Razandi M, Pedram A, Greene GL & Levin ER. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERalpha and ERbeta expressed in Chinese hamster ovary cells. Molecular Endocrinology 1999 13 307-319.
15. Pyo Kim H, Young Lee J, Kim Jeong J, Won Bae S, Kyu Lee H & Jo I. Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae. Biochemical and Biophysical Research Communications 1999 263 257-262.
16. Chambliss KL, Yuhanna IS, Anderson RGW, Mendelsohn ME & Shaul PW. ER beta has nongenomic action in caveolae. Molecular Endocrinology 2002 16 938-946.
17. Lieberherr M & Grosse B. Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein. Journal of Biological Chemistry 1994 269 7217-7223.
18. Guo Z, Benten WP, Krucken J & Wunderlich F. Nongenomic testosterone calcium signaling. Genotropic actions in androgen receptor-free macrophages. Journal of Biological Chemistry 2002 277 29600-29607.
19. Benten WP, Lieberherr M, Giese G, Wrehlke C, Stamm O, Sekeris CE et al. Functional testosterone receptors in plasma membranes of T cells. FASEB Journal 1999 13 123-133.
20. Kampa M, Papakonstanti EA, Hatzoglou A, Stathopoulos EN, Stournaras C & Castanas E. The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton. FASEB Journal 2002 16 1429-1431.
21. Figueroa-Valverde L, Luna H, Castillo-Henkel C, Munoz-Garcia O, Morato-Cartagena T & Ceballos-Reyes G. Synthesis and evaluation of the cardiovascular effects of two, membrane impermeant, macromolecular complexes of dextran-testosterone. Steroids 2002 67 611-619.
22. Tesarik J, Moos J & Mendoza C. Stimulation of protein tyrosine phosphorylation by a progesterone receptor on the cell surface of human sperm. Endocrinology 1993 133 328-335.
23. Grosse B, Kachkache M, Le Mellay V & Lieberherr M. Membrane signalling and progesterone in female and male osteoblasts. I. Involvement of intracellular Ca(2+), inositol trisphosphate, and diacylglycerol, but not cAMP. Journal of Cellular Biochemistry 2000 79 334-345.
24. Machelon V, Nome F, Grosse B & Lieberherr M. Progesterone triggers rapid transmembrane calcium influx and/or calcium mobilization from endoplasmic reticulum, via a pertussis-insensitive G-protein in granulosa cells in relation to luteinization process. Journal of Cellular Biochemistry 1996 61 619-628.
25. Bagowski CP, Myers JW & Ferrell JE Jr. The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes. Journal of Biological Chemistry 2001 276 37708-37714.
26. Mendelsohn ME & Karas RH. The protective effects of estrogen on the cardiovascular system. New England Journal of Medicine 1999 340 1801-1811.
27. McEwen BS & Alves SE. Estrogen actions in the central nervous system. Endocrine Reviews 1999 20 279-307.
28. Watson CS. Signaling themes shared between peptide and steroid hormones at the plasma membrane. Science's STKE 1999 1999 PE1.
29. Castoria G, Barone MV, Di Domenico M, Bilancio A, Ametrano D, Migliaccio A et al. Non-transcriptional action of oestradiol and progestin triggers DNA synthesis. EMBO Journal 1999 18 2500-2510.
30. Wyckoff MH, Chambliss KL, Mineo C, Yuhanna IS, Mendelsohn ME, Mumby SM et al. Plasma membrane estrogen receptors are coupled to endothelial nitric-oxide synthase through Galpha(i). Journal of Biological Chemistry 2001 276 27071-27076.
31. Le Mellay V, Lasmoles F & Lieberherr M. Ga(q/11) and Gbg proteins and membrane signaling of calcitriol and estradiol. Journal of Cellular Biochemistry 1999 75 138-146.
32. Grazzini E, Guillon G, Mouillac B & Zingg HH. Inhibition of oxytocin receptor function by direct binding of progesterone. Nature 1998 392 509-512.
33. Burger K, Fahrenholz F & Gimpl G. Non-genomic effects of progesterone on the signaling function of G protein-coupled receptors. FEBS Letters 1999 464 25-29.
34. Heinlein CA & Chang C. The roles of androgen receptors and androgen-binding proteins in nongenomic androgen actions. Molecular Endocrinology 2002 16 2181-2187.
35. Benten WP, Lieberherr M, Stamm O, Wrehlke C, Guo Z & Wunderlich F. Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages. Molecular Biology of the Cell 1999 10 3113-3123.
36. Estrada M, Liberona JL, Miranda M & Jaimovich E. Aldosterone and testosterone-mediated intracellular calcium response in skeletal muscle cell cultures. American Journal of Physiology 2000 279 E132-E139.
37. Kelly MJ, Lagrange AH, Wagner EJ & Ronnekleiv OK. Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways. Steroids 1999 64 64-75.
38. White RE, Darkow DJ & Lang JL. Estrogen relaxes coronary arteries by opening BKCa channels through a cGMP-dependent mechanism. Circulation Research 1995 77 936-942.
39. Mendoza C, Soler A & Tesarik J. Nongenomic steroid action: independent targeting of a plasma membrane calcium channel and a tyrosine kinase. Biochemical and Biophysical Research Communications 1995 210 518-523.
40. Revelli A, Massobrio M & Tesarik J. Nongenomic actions of steroid hormones in reproductive tissues. Endocrine Reviews 1998 19 3-17.
41. Barbagallo M, Dominguez LJ, Licata G, Shan J, Bing L, Karpinski E et al. Vascular effects of progesterone: role of cellular calcium regulation. Hypertension 2001 37 142-147.
42. Minshall RD, Pavcnik D, Browne DL & Hermsmeyer K. Nongenomic vasodilator action of progesterone on primate coronary arteries. Journal of Applied Physiology 2002 92 701-708.
43. 2+ entry mechanisms of coronary vasoconstriction. Arteriosclerosis, Thrombosis and Vascular Biology 1999 19 1034-1040.
44. Deenadayalu VP, White RE, Stallone JN, Gao X & Garcia AJ. Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. American Journal of Physiology 2001 281 H1720-H1727.
45. + channel activation. Journal of Applied Physiology 2001 91 2742-2750.
46. Chang L & Karin M. Mammalian MAP kinase signalling cascades. Nature 2001 410 37-40.
47. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K et al. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocrine Reviews 2001 22 153-183.
48. Weigel NL & Zhang Y. Ligand-independent activation of steroid hormone receptors. Journal of Molecular Medicine 1998 76 469-479.
49. Kato S, Endoh H, Masuhiro Y, Kitamoto T, Uchiyama S, Sasaki H et al. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995 270 1491-1494.
50. Endoh H, Sasaki H, Maruyama K, Takeyama K, Waga I, Shimizu T et al. Rapid activation of MAP kinase by estrogen in the bone cell line. Biochemical and Biophysical Research Communications 1997 235 99-102.
51. Garcia Dos Santos E, Dieudonne MN, Pecquery R, Le Moal V, Giudicelli Y & Lacasa D. Rapid nongenomic E2 effects on p42/p44 MAPK, activator protein-1, and cAMP response element binding protein in rat white adipocytes. Endocrinology 2002 143 930-940.
52. Keshamouni VG, Mattingly RR & Reddy KB. Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells a role for HER2 and PKC-delta. Journal of Biological Chemistry 2002 277 22558-22565.
53. Yue W, Wang J-P, Conaway M, Masamura S, Li Y & Santen RJ. Activation of the MAPK pathway enhances sensitivity of MCF-7 breast cancer cells to the mitogenic effect of estradiol. Endocrinology 2002 143 3221-3229.
54. Migliaccio A, Piccolo D, Castoria G, Di Domenico M, Bilancio A, Lombardi M et al. Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor. EMBO Journal 1998 17 2008-2018.
55. Razandi M, Pedram A & Levin ER. Estrogen signals to the preservation of endothelial cell form and function. Journal of Biological Chemistry 2000 275 38540-38546.
56. Srivastava S, Weitzmann MN, Cenci S, Ross FP, Adler S & Pacifici R. Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. Journal of Clinical Investigation 1999 104 503-513.
57. Razandi M, Pedram A & Levin ER. Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. Molecular Endocrinology 2000 14 1434-1447.
58. Brubaker KD & Gay CV. Estrogen stimulates protein tyrosine phosphorylation and Src kinase activity in avian osteoclasts. Journal of Cellular Biochemistry 1999 76 206-216.
59. Filardo EJ, Quinn JA, Bland KI & Frackelton AR Jr. Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF. Molecular Endocrinology 2000 14 1649-1660.
60. Filardo EJ. Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. Journal of Steroid Biochemistry and Molecular Biology 2002 80 231-238.
61. Marquez DC, Lee J, Lin T & Pietras RJ. Epidermal growth factor receptor and tyrosine phosphorylation of estrogen receptor. Endocrine 2001 16 73-81.
62. Bi R, Broutman G, Foy MR, Thompson RF & Baudry M. The tyrosine kinase and mitogen-activated protein kinase pathways mediate multiple effects of estrogen in hippocampus. PNAS 2000 97 3602-3607.
63. Boonyaratanakornkit V, Scott MP, Ribon V, Sherman L, Anderson SM, Maller JL et al. Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. Molecular Cell 2001 8 269-280.
64. Simoncini T, Hafezi-Moghadam A, Brazil D, Ley K, Chin WW & Liao JK. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature 2000 407 538-541.
65. Castoria G, Migliaccio A, Bilancio A, Di Domenico M, de Falco A, Lombardi M et al. PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO Journal 2001 20 6050-6059.
66. Hafezi-Moghadam A, Simoncini T, Yang E, Limbourg FP, Plumier JC, Rebsamen MC et al. Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nature Medicine 2002 8 473-479.
67. Ciocca DR & Roig LM. Estrogen receptors in human nontarget tissues: biological and clinical implications. Endocrine Reviews 1995 16 35-62.
68. Manolagas SC & Kousteni S. Perspective: nonreproductive sites of action of reproductive hormones. Endocrinology 2001 142 2200-2204.
69. Simoncini T & Genazzani AR. Direct vascular effects of estrogens and selective estrogen receptor modulators. Current Opinion in Obstetrics and Gynecology 2000 12 181-187.
70. Gilligan DM, Quyyumi AA & Cannon RO III. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation 1994 89 2545-2551.
71. Liao JK. Endothelial nitric oxide and vascular inflammation. In Endothelium, Nitric Oxide and Atherosclerosis, pp 119-132. Eds JA Panza & ROI Cannon. Armonk, NY: Futura Publishing Co. Inc., 1999.
72. Guetta V, Quyyumi AA, Prasad A, Panza JA, Waclawiw M & Cannon RO III. The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women. Circulation 1997 96 2795-2801.
73. Chen Z, Yuhanna IS, Galcheva-Gargova Z, Karas RH, Mendelsohn ME & Shaul PW. Estrogen receptor alpha mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen. Journal of Clinical Investigation 1999 103 401-406.
74. Garcia-Cardena G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A et al. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 1998 392 821-824.
75. Chou TM, Sudhir K, Hutchison SJ, Ko E, Amidon TM, Collins P et al. Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Circulation 1996 94 2614-2619.
76. Gee KW. Steroid modulation of the GABA/benzodiazepine receptor-linked chloride ionophore. Molecular Neurobiology 1988 2 291-317.
77. McEwen BS. Non-genomic and genomic effects of steroids on neural activity. Trends in Pharmacological Sciences 1991 12 141-147.
78. Vincens M, Shu C, Moguilewsky M & Philibert D. A progesterone metabolite enhances the activity of the GABAA receptor complex at the pituitary level. European Journal of Pharmacology 1989 168 15-21.
79. Kelly MJ, Moss RL & Dudley CA. The effects of microelectrophoretically applied estrogen, cortisol and acetylcholine on medial preoptic-septal unit activity throughout the estrous cycle of the female rat. Experimental Brain Research 1977 30 53-64.
80. Dufy B, Vincent JD, Fleury H, Du Pasquier P, Gourdji D & Tixier-Vidal A. Membrane effects of thyrotropin-releasing hormone and estrogen shown by intracellular recording from pituitary cells. Science 1979 204 509-511.
81. Shakil T, Hoque ANE, Husain M & Belsham DD. Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: membrane versus nuclear receptor activation. Molecular Endocrinology 2002 16 2592-2602.
82. Mermelstein PG, Becker JB & Surmeier DJ. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor. Journal of Neuroscience 1996 16 595-604.
83. Minami T, Oomura Y, Nabekura J & Fukuda A. 17 beta-estradiol depolarization of hypothalamic neurons is mediated by cyclic AMP. Brain Research 1990 519 301-307.
84. Roof RL & Hall ED. Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone. Journal of Neurotrauma 2000 17 367-388.
85. Chowen JA, Torres-Aleman I & Garcia-Segura LM. Trophic effects of estradiol on fetal rat hypothalamic neurons. Neuroendocrinology 1992 56 895-901.
86. Behl C, Skutella T, Lezoualc'h F, Post A, Widmann M, Newton CJ et al. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Molecular Pharmacology 1997 51 535-541.
87. Simpkins JW, Rajakumar G, Zhang YQ, Simpkins CE, Greenwald D, Yu CJ et al. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. Journal of Neurosurgery 1997 87 724-730.
88. Hawk T, Zhang YQ, Rajakumar G, Day AL & Simpkins JW. Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats. Brain Research 1998 796 296-298.
89. Simpkins JW, Green PS, Gridley KE, Singh M de Fiebre NC & Rajakumar G. Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease. American Journal of Medicine 1997 103 19S-25S.
90. Resnick SM, Metter EJ & Zonderman AB. Estrogen replacement therapy and longitudinal decline in visual memory. A possible protective effect? Neurology 1997 49 1491-1497.
91. Jakacka M, Ito M, Weiss J, Chien PY, Gehm BD & Jameson JL. Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP1 pathway. Journal of Biological Chemistry 2001 276 13615-13621.
92. Jakacka M, Ito M, Martinson F, Ishikawa T, Lee EJ & Jameson JL. An estrogen receptor (ER) (alpha) deoxyribonucleic acid-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo. Molecular Endocrinology 2002 16 2188-2201.
93. Bjornstrom L & Sjoberg M. Signal transducers and activators of transcription as downstream targets of nongenomic estrogen receptor actions. Molecular Endocrinology 2002 16 2202-2214.