DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation

FEBS Letters

Volumn 580, Issue 9, 2006, Pages 2294-2300

  Alimirah, Fatouma ^a   Chen, Jianming ^a   Basrawala, Zane ^a   Xin, Hong ^a   Choubey, Divaker ^a  

^a HINES VA HOSPITAL   (United States)

Author keywords

Androgen receptor; Androgen independent; Androgens; Prostate cancer

Indexed keywords

AMINO ACID; ANDROGEN RECEPTOR; ANDROSTANOLONE; MESSENGER RNA; PEPTIDE ANTIBODY;

AMINO TERMINAL SEQUENCE; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL STRAIN LNCAP; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANABOLIC AGENTS; ANTIBODIES; CELL LINE, TUMOR; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; NEOPLASM PROTEINS; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; RNA, MESSENGER; TESTOSTERONE;

EID: 33646417329     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.03.041     Document Type: Article

References (31)

1. Abate-Shen C., and Shen M.M. Molecular genetics of prostate cancer. Genes Dev. 14 (2000) 2410-2434
2. Abate-Shen C., and Shen M.M. Mouse models of prostate carcinogenesis. Trends Genet. 18 (2002) S1-S5
3. Culig Z., Hobisch A., Cronauer M.V., Radmayer C., Trapman J., Hittmair A., Bartsch G., and Klocker H. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res. 54 (1994) 5474-5478
4. Hobisch A., Eder I.E., Putz T., Horninger W., Bartsch G., Klocker H., and Culig Z. Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor. Cancer Res. 58 (1998) 4640-4645
5. Mitchell S., Abel P., Ware M., Stamp G., and Lalani E.N. Phenotypic and genotypic characterization of commonly used human prostatic cell lines. BJU Int. 85 (2000) 932-944
6. Chlenski A., Nakashiro K., Ketels K.V., Korovaitseva G.I., and Oyasu R. Androgen receptor expression in androgen-independent prostate cancer cell lines. Prostate 47 (2001) 66-75
7. van Bokhoven A., Varella-Garcia M., Korch C., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., and Lucia M.S. Molecular characterization of human prostate carcinoma cell lines. Prostate 57 (2003) 205-225
8. Culig Z., Klocker H., Eberle J., Kaspar F., Hobisch A., Cronauer M.V., and Bartsch G. DNA sequence of the androgen receptor in prostatic tumor cell lines and tissue specimens assessed by means of the polymerase chain reaction. Prostate 22 (1993) 11-22
9. Edelstein R.A., Carr M.C., Caesar R., Young M., Atala A., and Freeman M.R. Detection of human androgen receptor mRNA expression abnormalities by competitive PCR. DNA Cell Biol. 13 (1994) 265-273
10. Tilley W.D., Bentel J.M., Aspinall J.O., Hall R.E., and Horsfall D.J. Evidence for a novel mechanism of androgen resistance in the human prostate cancer cell line, PC-3. Steroids 60 (1995) 180-186
11. Jarrard D.F., Kinoshita H., Shi Y., Sandefur C., Hoff D., Meisner L.F., Chang C., Herman J.G., Isaacs W.B., and Nassif N. Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells. Cancer Res. 58 (1998) 5310-5314
12. Buchanan G., Craft P.S., Yang M., Cheong A., Prescott J., Jia L., Coetzee G.A., and Tilley W.D. PC-3 cells with enhanced androgen receptor signaling: a model for clonal selection in prostate cancer. Prostate 60 (2004) 352-366
13. Stark G.R., Kerr I.M., Williams B.R., Silverman R.H., and Schreiber R.D. How cells respond to interferons. Annu. Rev. Biochem. 67 (1998) 227-264
14. Sica G., Fabbroni L., Dell'Acqua G., Iacopino F., Marchetti P., Cacciatore M., and Pavone-Macaluso M. Natural beta-interferon and androgen receptors in prostatic cancer cells. Urol. Int. 46 (1991) 159-162
15. Sica G., Dell'Acqua G., Iacopino F., Fattorossi A., Marchetti P., van der Kwast T.H., and Pavone-Macaluso M. Androgen receptors and hormone sensitivity of a human prostatic cancer cell line (PC-3) are modulated by natural beta-interferon. Urol. Res. 22 (1994) 33-38
16. Jenster G., de Ruiter P.E., van der Korput H.A., Kuiper G.G., Trapman J., and Brinkmann A.O. Changes in the abundance of androgen receptor isotypes: effects of ligand treatment, glutamine-stretch variation, and mutation of putative phosphorylation sites. Biochemistry 33 (1994) 14064-14072
17. Edwards J., and Bartlett J.M. The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: Modifications to the androgen receptor. BJU Int. 95 (2005) 1320-1326
18. Kuiper G.G., and Brinkmann A.O. Phosphotryptic peptide analysis of the human androgen receptor: detection of a hormone-induced phosphopeptide. Biochemistry 34 (1995) 1851-1857
19. Taneja S.S., Ha S., Swenson N.K., Huang H.Y., Lee P., Melamed J., Shapiro E., Garabedian M.J., and Logan S.K. Cell-specific regulation of androgen receptor phosphorylation in vivo. J. Biol. Chem. 280 (2005) 40916-40924
20. Buchanan G., Irvine R.A., Coetzee G.A., and Tilley W.D. Contribution of the androgen receptor to prostate cancer predisposition and progression. Cancer Metastasis Rev. 20 (2001) 207-223
21. Heinlein C.A., and Chang C. Androgen receptor in prostate cancer. Endocr. Rev. 25 (2004) 276-308
22. Linja M.J., and Visakorpi T. Alterations of androgen receptor in prostate cancer. J. Steroid Biochem. Mol. Biol. 92 (2004) 255-264
23. Choubey D., and Lengyel P. Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kDa protein that is encoded by the Ifi200 gene from the gene 200 cluster. J. Interferon Res. 13 (1993) 43-52
24. Agoulnik I.U., Krause W.C., Bingman W.E., Rahman H.T., Amrikachi M., Ayala G.E., and Weigel N.L. Repressors of androgen and progesterone receptor action. J. Biol. Chem. 278 (2003) 31136-31148
25. Xin H., Curry J., Johnstone R.W., Nickoloff B.J., and Choubey D. Role of IFI16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Oncogene 22 (2003) 4831-4840
26. Gelmann E.P. Molecular biology of the androgen receptor. J. Clin. Oncol. 20 (2002) 3001-3015
27. Lu S., Liu M., Epner D.E., Tsai S.Y., and Tsai M.J. Androgen regulation of the cyclin-dependent kinase inhibitor p21 gene through an androgen response element in the proximal promoter. Mol. Endocrinol. 13 (1999) 376-384
28. Heinlein C.A., and Chang C. Androgen receptor (AR) coregulators: an overview. Endocr. Rev. 23 (2002) 175-200
29. Gnanapragasam V.J., Leung H.Y., Pulimood A.S., Neal D.E., and Robson C.N. Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer. Brit. J. Cancer 85 (2001) 1928-1936
30. Fujimoto N., Mizokami A., Harada S., and Matsumoto T. Different expression of androgen receptor coactivators in human prostate. Urology 58 (2001) 289-294
31. Yuan S., Trachtenberg J., Mills G.B., Brown T.J., Xu F., and Keating A. Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA. Cancer Res. 53 (1993) 1304-1311