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Volumn 8, Issue , 2009, Pages

Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ANDROGEN RECEPTOR; CASPASE 3; CYTOCHALASIN B; TESTOSTERONE; TUBULIN; MEMBRANE PROTEIN;

EID: 73249146094     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-8-114     Document Type: Article
Times cited : (67)

References (36)
  • 1
    • 0032830850 scopus 로고    scopus 로고
    • Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages
    • 25566, 10512854
    • Benten WP, Lieberherr M, Stamm O, Wrehlke C, Guo Z, Wunderlich F. Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages. Mol Biol Cell 1999, 10:3113-3123. 25566, 10512854.
    • (1999) Mol Biol Cell , vol.10 , pp. 3113-3123
    • Benten, W.P.1    Lieberherr, M.2    Stamm, O.3    Wrehlke, C.4    Guo, Z.5    Wunderlich, F.6
  • 3
    • 0036717596 scopus 로고    scopus 로고
    • The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton
    • Kampa M, Papakonstanti EA, Hatzoglou A, Stathopoulos EN, Stournaras C, Castanas E. The human prostate cancer cell line LNCaP bears functional membrane testosterone receptors that increase PSA secretion and modify actin cytoskeleton. Faseb J 2002, 16:1429-1431.
    • (2002) Faseb J , vol.16 , pp. 1429-1431
    • Kampa, M.1    Papakonstanti, E.A.2    Hatzoglou, A.3    Stathopoulos, E.N.4    Stournaras, C.5    Castanas, E.6
  • 4
    • 54249108482 scopus 로고    scopus 로고
    • Rapid membrane effect of testosterone in LNCaP cells
    • 10.1159/000151418, 18931557
    • Wang Z, Liu L, Hou J, Wen D, Yan C, Pu J, Ouyang J, Pan H. Rapid membrane effect of testosterone in LNCaP cells. Urol Int 2008, 81(3):353-359. 10.1159/000151418, 18931557.
    • (2008) Urol Int , vol.81 , Issue.3 , pp. 353-359
    • Wang, Z.1    Liu, L.2    Hou, J.3    Wen, D.4    Yan, C.5    Pu, J.6    Ouyang, J.7    Pan, H.8
  • 6
    • 35848947564 scopus 로고    scopus 로고
    • Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells
    • 10.1159/000110458, 17982280
    • Kallergi G, Agelaki S, Markomanolaki H, Georgoulias V, Stournaras C. Activation of FAK/PI3K/Rac1 signaling controls actin reorganization and inhibits cell motility in human cancer cells. Cell Physiol Biochem 2007, 20:977-986. 10.1159/000110458, 17982280.
    • (2007) Cell Physiol Biochem , vol.20 , pp. 977-986
    • Kallergi, G.1    Agelaki, S.2    Markomanolaki, H.3    Georgoulias, V.4    Stournaras, C.5
  • 8
    • 53249107178 scopus 로고    scopus 로고
    • Rho/ROCK/Actin signaling regualtes membrane androgen receptor induced apoptosis in prostate cancer cells
    • 10.1016/j.yexcr.2008.07.012, 18694745
    • Papadopoulou N, Charalampopoulos I, Alevizopoulos K, Gravanis A, Stournaras C. Rho/ROCK/Actin signaling regualtes membrane androgen receptor induced apoptosis in prostate cancer cells. Exp Cell Res 2008, 314:3162-3174. 10.1016/j.yexcr.2008.07.012, 18694745.
    • (2008) Exp Cell Res , vol.314 , pp. 3162-3174
    • Papadopoulou, N.1    Charalampopoulos, I.2    Alevizopoulos, K.3    Gravanis, A.4    Stournaras, C.5
  • 9
    • 59049095926 scopus 로고    scopus 로고
    • Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU-145 prostate cancer cells
    • Papadopoulou N, Charalampopoulos I, Anagnostopoulou V, Konstantinidis G, Föller M, Gravanis A, Alevizopoulos K, Lang F, Stournaras C. Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU-145 prostate cancer cells. Mol Canc 2008, 7:88.
    • (2008) Mol Canc , vol.7 , pp. 88
    • Papadopoulou, N.1    Charalampopoulos, I.2    Anagnostopoulou, V.3    Konstantinidis, G.4    Föller, M.5    Gravanis, A.6    Alevizopoulos, K.7    Lang, F.8    Stournaras, C.9
  • 10
    • 33645519245 scopus 로고    scopus 로고
    • Dihydrotestosterone differentially modulates the mitogen-activated protein kinase and the phosphoinositide 3-kinase/Akt pathways through the nuclear and novel membrane androgen receptor in C6 cells
    • 10.1210/en.2005-1395, 16410299
    • Gatson JW, Kaur P, Singh M. Dihydrotestosterone differentially modulates the mitogen-activated protein kinase and the phosphoinositide 3-kinase/Akt pathways through the nuclear and novel membrane androgen receptor in C6 cells. Endocrinology 2006, 147:2028-2034. 10.1210/en.2005-1395, 16410299.
    • (2006) Endocrinology , vol.147 , pp. 2028-2034
    • Gatson, J.W.1    Kaur, P.2    Singh, M.3
  • 12
    • 0842303571 scopus 로고    scopus 로고
    • Role of putative membrane receptors in the effect of androgens on human vascular cell growth
    • 10.1677/joe.0.1800097, 14709148
    • Somjen D, Kohen F, Gayer B, Kulik T, Knoll E, Stern N. Role of putative membrane receptors in the effect of androgens on human vascular cell growth. J Endocrinol 2004, 180:97-106. 10.1677/joe.0.1800097, 14709148.
    • (2004) J Endocrinol , vol.180 , pp. 97-106
    • Somjen, D.1    Kohen, F.2    Gayer, B.3    Kulik, T.4    Knoll, E.5    Stern, N.6
  • 13
    • 2342558431 scopus 로고    scopus 로고
    • Androgen receptor in prostate cancer
    • 10.1210/er.2002-0032, 15082523
    • Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev 2004, 25:276-308. 10.1210/er.2002-0032, 15082523.
    • (2004) Endocr Rev , vol.25 , pp. 276-308
    • Heinlein, C.A.1    Chang, C.2
  • 14
    • 44549085837 scopus 로고    scopus 로고
    • Membrane-initiated steroid action in breast and prostate cancer
    • 10.1016/j.steroids.2007.12.009, 18249430
    • Kampa M, Pelekanou V, Castanas E. Membrane-initiated steroid action in breast and prostate cancer. Steroids 2008, 73(9-10):953-960. 10.1016/j.steroids.2007.12.009, 18249430.
    • (2008) Steroids , vol.73 , Issue.9-10 , pp. 953-960
    • Kampa, M.1    Pelekanou, V.2    Castanas, E.3
  • 15
    • 41549099554 scopus 로고    scopus 로고
    • Rapid actions of androgens
    • 10.1016/j.yfrne.2007.08.004, 17983646
    • Michels G, Hoppe UC. Rapid actions of androgens. Front Neuroendocrinol 2008, 29(2):182-198. 10.1016/j.yfrne.2007.08.004, 17983646.
    • (2008) Front Neuroendocrinol , vol.29 , Issue.2 , pp. 182-198
    • Michels, G.1    Hoppe, U.C.2
  • 16
    • 41549163339 scopus 로고    scopus 로고
    • Non-genomic actions of androgens
    • 2386261, 18093638
    • Foradori CD, Weiser MJ, Handa RJ. Non-genomic actions of androgens. Front Neuroendocrinol 2008, 29(2):169-181. 2386261, 18093638.
    • (2008) Front Neuroendocrinol , vol.29 , Issue.2 , pp. 169-181
    • Foradori, C.D.1    Weiser, M.J.2    Handa, R.J.3
  • 17
    • 62149119309 scopus 로고    scopus 로고
    • Membrane androgen receptor activation in prostate and breast tumor cells: Molecular signaling and clinical impact
    • 10.1002/iub.150, 19109827
    • Papadopoulou N, Papakonstanti EA, Kallergi G, Alevizopoulos K, Stournaras C. Membrane androgen receptor activation in prostate and breast tumor cells: Molecular signaling and clinical impact. IUBMB Life 2009, 61(1):56-61. 10.1002/iub.150, 19109827.
    • (2009) IUBMB Life , vol.61 , Issue.1 , pp. 56-61
    • Papadopoulou, N.1    Papakonstanti, E.A.2    Kallergi, G.3    Alevizopoulos, K.4    Stournaras, C.5
  • 18
    • 0038636338 scopus 로고    scopus 로고
    • A rapid, nongenomic, signaling pathway regulates the actin reorganization induced by activation of membrane testosterone receptors
    • 10.1210/me.2002-0253, 12554777
    • Papakonstanti EA, Kampa M, Castanas E, Stournaras C. A rapid, nongenomic, signaling pathway regulates the actin reorganization induced by activation of membrane testosterone receptors. Mol Endocrinol 2003, 17:870-881. 10.1210/me.2002-0253, 12554777.
    • (2003) Mol Endocrinol , vol.17 , pp. 870-881
    • Papakonstanti, E.A.1    Kampa, M.2    Castanas, E.3    Stournaras, C.4
  • 20
    • 44449138033 scopus 로고    scopus 로고
    • Nuclear receptors, intestinal architecture and colon cancer: an intriguing lin
    • 10.1007/s00018-008-7552-1, 18278436
    • D'Errico I, Moschetta A. Nuclear receptors, intestinal architecture and colon cancer: an intriguing lin. Cell Mol Life Sci 2008, 65(10):1523-1543. 10.1007/s00018-008-7552-1, 18278436.
    • (2008) Cell Mol Life Sci , vol.65 , Issue.10 , pp. 1523-1543
    • D'Errico, I.1    Moschetta, A.2
  • 23
    • 0021710528 scopus 로고
    • Effects of steroid hormone therapy on primarily xenotransplanted human colorectal adenocarcinomas
    • 10.1007/BF00390470, 6511808
    • Izbicki JR, Schmitz R, Hoppen HO, Izbicki W, Troidl H. Effects of steroid hormone therapy on primarily xenotransplanted human colorectal adenocarcinomas. J Cancer Res Clin Oncol 1984, 108(3):345-350. 10.1007/BF00390470, 6511808.
    • (1984) J Cancer Res Clin Oncol , vol.108 , Issue.3 , pp. 345-350
    • Izbicki, J.R.1    Schmitz, R.2    Hoppen, H.O.3    Izbicki, W.4    Troidl, H.5
  • 24
    • 33947126402 scopus 로고    scopus 로고
    • Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice
    • 10.1007/s10495-006-0026-8, 17260186
    • Dimas K, Hatziantoniou S, Tseleni S, Khan K, Georgopoulos A, Alevizopoulos K, Wyche JH, Pantazis P, Demetzos C. Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice. Apoptosis 2007, 12(4):685-694. 10.1007/s10495-006-0026-8, 17260186.
    • (2007) Apoptosis , vol.12 , Issue.4 , pp. 685-694
    • Dimas, K.1    Hatziantoniou, S.2    Tseleni, S.3    Khan, K.4    Georgopoulos, A.5    Alevizopoulos, K.6    Wyche, J.H.7    Pantazis, P.8    Demetzos, C.9
  • 25
    • 35748959354 scopus 로고    scopus 로고
    • Actin Cytoskeleton architecture and signalling in osmosensing
    • 10.1016/S0076-6879(07)28012-7, 17875420
    • Papakonstanti EA, Stournaras C. Actin Cytoskeleton architecture and signalling in osmosensing. Methods in Enzymology 2007, 428:227-240. 10.1016/S0076-6879(07)28012-7, 17875420.
    • (2007) Methods in Enzymology , vol.428 , pp. 227-240
    • Papakonstanti, E.A.1    Stournaras, C.2
  • 26
    • 4644300602 scopus 로고    scopus 로고
    • A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium
    • Wang JG, Wang DF, Lv BJ, Si JM. A novel mouse model for colitis-associated colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sulfate sodium. World J Gastroenterol 2004, 10:2958-2962.
    • (2004) World J Gastroenterol , vol.10 , pp. 2958-2962
    • Wang, J.G.1    Wang, D.F.2    Lv, B.J.3    Si, J.M.4
  • 27
    • 0030988624 scopus 로고    scopus 로고
    • Dexamethasone induces actin polymerization in human endometrial cells without affecting its synthesis
    • 10.1002/(SICI)1097-4644(19970615)65:4<492::AID-JCB5>3.0.CO;2-J, 9178099
    • Koukouritaki S, Margioris A, Gravanis A, Hartig R, Stournaras C. Dexamethasone induces actin polymerization in human endometrial cells without affecting its synthesis. J Cell Biochem 1997, 65:492-500. 10.1002/(SICI)1097-4644(19970615)65:4<492::AID-JCB5>3.0.CO;2-J, 9178099.
    • (1997) J Cell Biochem , vol.65 , pp. 492-500
    • Koukouritaki, S.1    Margioris, A.2    Gravanis, A.3    Hartig, R.4    Stournaras, C.5
  • 28
    • 21744445111 scopus 로고    scopus 로고
    • The actin cytoskeleton: a key regulator of apoptosis and ageing?
    • Gourlay CW, Ayscough KR. The actin cytoskeleton: a key regulator of apoptosis and ageing?. Nat Rev Mol Cell Biol 2005, 6(7):6583-589.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.7 , pp. 6583-6589
    • Gourlay, C.W.1    Ayscough, K.R.2
  • 29
    • 48249107981 scopus 로고    scopus 로고
    • A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals
    • 10.1042/BJ20080320, 18613816
    • Franklin-Tong VE, Gourlay CW. A role for actin in regulating apoptosis/programmed cell death: evidence spanning yeast, plants and animals. Biochem J 2008, 413(3):389-404. 10.1042/BJ20080320, 18613816.
    • (2008) Biochem J , vol.413 , Issue.3 , pp. 389-404
    • Franklin-Tong, V.E.1    Gourlay, C.W.2
  • 30
    • 0030575907 scopus 로고    scopus 로고
    • Altered actin polymerization dynamics in various malignant cell types: evidence for differential sensitivity to cytochalasin B
    • 10.1016/S0006-2952(96)00389-9, 8937443
    • Stournaras C, Stiakaki E, Koukouritaki SB, Theodoropoulos PA, Kalmanti M, Fostinis Y, Gravanis A. Altered actin polymerization dynamics in various malignant cell types: evidence for differential sensitivity to cytochalasin B. Biochem Pharmacol 1996, 52(9):1339-1346. 10.1016/S0006-2952(96)00389-9, 8937443.
    • (1996) Biochem Pharmacol , vol.52 , Issue.9 , pp. 1339-1346
    • Stournaras, C.1    Stiakaki, E.2    Koukouritaki, S.B.3    Theodoropoulos, P.A.4    Kalmanti, M.5    Fostinis, Y.6    Gravanis, A.7
  • 31
    • 28344456900 scopus 로고    scopus 로고
    • Membrane testosterone binding sites in prostate carcinoma as a potential new marker and therapeutic target: study in paraffin tissue sections
    • 10.1186/1471-2407-5-148, 1318463, 16293185
    • Dambaki C, Kogia C, Kampa M, Darivianaki K, Nomikos M, Anezinis P, Theodoropoulos PA, Castanas E, Stathopoulos EN. Membrane testosterone binding sites in prostate carcinoma as a potential new marker and therapeutic target: study in paraffin tissue sections. BMC Cancer 2005, 5:148. 10.1186/1471-2407-5-148, 1318463, 16293185.
    • (2005) BMC Cancer , vol.5 , pp. 148
    • Dambaki, C.1    Kogia, C.2    Kampa, M.3    Darivianaki, K.4    Nomikos, M.5    Anezinis, P.6    Theodoropoulos, P.A.7    Castanas, E.8    Stathopoulos, E.N.9
  • 32
    • 3142729195 scopus 로고    scopus 로고
    • Biochemical characterization of a membrane androgen receptor in the ovary of the atlantic croaker (Micropogonias undulatus)
    • 10.1095/biolreprod.103.025825, 14985249
    • Braun AM, Thomas P. Biochemical characterization of a membrane androgen receptor in the ovary of the atlantic croaker (Micropogonias undulatus). Biol Reprod 2004, 71(1):146-55. 10.1095/biolreprod.103.025825, 14985249.
    • (2004) Biol Reprod , vol.71 , Issue.1 , pp. 146-155
    • Braun, A.M.1    Thomas, P.2
  • 33
    • 23044504053 scopus 로고    scopus 로고
    • Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer
    • 10.1016/j.tem.2005.06.002, 16002302
    • Freeman MR, Cinar B, Lu ML. Membrane rafts as potential sites of nongenomic hormonal signaling in prostate cancer. Trends Endocrinol Metab 2005, 16:273-279. 10.1016/j.tem.2005.06.002, 16002302.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 273-279
    • Freeman, M.R.1    Cinar, B.2    Lu, M.L.3
  • 34
    • 0028290639 scopus 로고
    • Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein
    • Lieberherr M, Grosse B. Androgens increase intracellular calcium concentration and inositol 1,4,5-trisphosphate and diacylglycerol formation via a pertussis toxin-sensitive G-protein. J Biol Chem 1994, 269:7217-7223.
    • (1994) J Biol Chem , vol.269 , pp. 7217-7223
    • Lieberherr, M.1    Grosse, B.2
  • 35
    • 33749487659 scopus 로고    scopus 로고
    • Androgens induce increases in intracellular calcium via a G protein-coupled receptor in LNCaP prostate cancer cells
    • 10.2164/jandrol.106.000554, 16728719
    • Sun YH, Gao X, Tang YJ, Xu CL, Wang LH. Androgens induce increases in intracellular calcium via a G protein-coupled receptor in LNCaP prostate cancer cells. J Androl 2006, 27:671-678. 10.2164/jandrol.106.000554, 16728719.
    • (2006) J Androl , vol.27 , pp. 671-678
    • Sun, Y.H.1    Gao, X.2    Tang, Y.J.3    Xu, C.L.4    Wang, L.H.5
  • 36
    • 49449089292 scopus 로고    scopus 로고
    • Actin associated proteins function as androgen receptor coregulators: an implication of androgen receptor's roles in skeletal muscle
    • 10.1016/j.jsbmb.2008.06.001, 18590822
    • Ting HJ, Chang C. Actin associated proteins function as androgen receptor coregulators: an implication of androgen receptor's roles in skeletal muscle. J Steroid Biochem Mol Biol 2008, 111(3-5):157-163. 10.1016/j.jsbmb.2008.06.001, 18590822.
    • (2008) J Steroid Biochem Mol Biol , vol.111 , Issue.3-5 , pp. 157-163
    • Ting, H.J.1    Chang, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.