Novel oligomeric proanthocyanidin derivatives interact with membrane androgen sites and induce regression of hormone-independent prostate cancer

Journal of Pharmacology and Experimental Therapeutics

Volumn 337, Issue 1, 2011, Pages 24-32

  Kampa, Marilena ^a   Theodoropoulou, Katerina ^a   Mavromati, Fani ^a   Pelekanou, Vassiliki ^a,d   Notas, George ^a   Lagoudaki, Eleni D ^a   Nifli, Artemissia Phoebe ^a,e   Morel Salmi, Cécile ^b   Stathopoulos, Efstathios N ^a   Vercauteren, Joseph ^c   Castanas, Elias ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b Polyphenols Research and Development Societe Anonyme A Responsabilite Limitee   (France)

^c UNIV MONTPELLIER   (France)

^d JULES BORDET INSTITUTE   (Belgium)

^e UNIVERSITY OF THESSALY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN CONJUGATE; ANDROGEN RECEPTOR; ASPARTATE AMINOTRANSFERASE; BOVINE SERUM ALBUMIN; EPICATECHIN; EPICATECHIN GALLATE; FLAVANOL DERIVATIVE; GRAPE SEED EXTRACT; PROANTHOCYANIDIN DERIVATIVE; PROCYANIDIN B1; PROCYANIDIN B2; PROCYANIDIN B3; PROCYANIDIN B4; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CANCER CELL CULTURE; CANCER REGRESSION; CELL PROLIFERATION; CELL STRAIN LNCAP; CONTROLLED STUDY; DRUG STRUCTURE; GRAPE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INHIBITION KINETICS; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPERMATOGENESIS; SPERMATOZOON MATURATION; TESTIS SIZE; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; BINDING SITES; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; GRAPE SEED EXTRACT; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASMS, HORMONE-DEPENDENT; PROANTHOCYANIDINS; PROSTATIC NEOPLASMS; RECEPTORS, ANDROGEN; TESTOSTERONE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79953013333     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.177246     Document Type: Article

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