MicroRNAs: New insights into chronic childhood diseases

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Omran, Ahmed ^a,b   Elimam, Dalia ^a   Yin, Fei ^b  

^a Suez Canal University Faculty of Medicine   (Egypt)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOSE; INSULIN; MICRORNA; MICRORNA 106A; MICRORNA 125A; MICRORNA 126; MICRORNA 133A; MICRORNA 143; MICRORNA 145; MICRORNA 146A; MICRORNA 146B; MICRORNA 155; MICRORNA 15A; MICRORNA 192; MICRORNA 221; MICRORNA 223; MICRORNA 29; MICRORNA 29B; MICRORNA 29C; MICRORNA 375; MICRORNA 377; MICRORNA 483; MICRORNA 503; MICRORNA 574; MICRORNA 5P; MICRORNA 672; MICRORNA 690; MICRORNA 9; MICRORNA 98; UNCLASSIFIED DRUG;

ASTHMA; BRONCHUS MUCOSA; BRONCHUS MUSCLE; CHILD HOSPITALIZATION; CHILDHOOD DISEASE; CHILDHOOD OBESITY; CHRONIC DISEASE; CYSTIC FIBROSIS; DIABETES MELLITUS; EPILEPSY; EPILEPTIC STATE; GLUCOSE METABOLISM; HIPPOCAMPUS; HUMAN; IMMUNE RESPONSE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SYNTHESIS; MORBIDITY; MORTALITY; NERVE CELL PLASTICITY; NONHUMAN; PANCREAS ISLET BETA CELL; PHENOTYPE; PROTEIN SYNTHESIS; QUALITY OF LIFE; REGULATORY T LYMPHOCYTE; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPORAL LOBE EPILEPSY; BIOLOGICAL MODEL; CHILD; FEMALE; GENETICS; INFANT; MALE; NEWBORN; PRESCHOOL CHILD;

ASTHMA; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; CYSTIC FIBROSIS; DIABETES MELLITUS; EPILEPSY; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; MICRORNAS; MODELS, GENETIC;

EID: 84880175244     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/291826     Document Type: Review

References (132)

1. Janse A. J., Uiterwaal C. S., Gemke R. J., Kimpen J. L., Sinnema G., A difference in perception of quality of life in chronically ill children was found between parents and pediatricians. Journal of Clinical Epidemiology 2005 58 5 495 502 2-s2.0-17544382779 10.1016/j.jclinepi.2004.09.010
2. Omran A., Elimam D., Shalaby S., Peng J., Yin F., MicroRNAs: a light into the "Black Box" of neuropediatric diseases. Neuromolecular Medicine 2012 14 4 244 261 10.1007/s12017-012-8193-y
3. Omran A., Elimam D., Webster K., Shehadeh L., Yin F., MicroRNAs: a new piece in the paediatric cardiovascular disease puzzle. Cardiology in the Young 2013 1 14 10.1017/S1047951113000048
4. Bossé Y., Paré P. D., Seow C. Y., Airway wall remodeling in asthma: from the epithelial layer to the adventitia. Current Allergy and Asthma Reports 2008 8 4 357 366 2-s2.0-50349100424 10.1007/s11882-008-0056-0
5. Vignola A. M., Mirabella F., Costanzo G., Di Giorgi R., Gjomarkaj M., Bellia V., Bonsignore G., Airway remodeling in asthma. Chest 2003 123 supplement 3 417S 422S 2-s2.0-0037335980
6. Anderson G. P., Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. The Lancet 2008 372 9643 1107 1119 2-s2.0-52049087356 10.1016/S0140-6736(08)61452-X
7. Akinbami L. J., Moorman J. E., Garbe P. L., Sondik E. J., Status of childhood asthma in the United States, 1980-2007. Pediatrics 2009 123 3 S131 S145 2-s2.0-63449135734 10.1542/peds.2008-2233C
8. Kelley C. F., Mannino D. M., Homa D. M., Savage-Brown A., Holguin F., Asthma phenotypes, risk factors, and measures of severity in a national sample of US children. Pediatrics 2005 115 3 726 731 2-s2.0-20344372908 10.1542/peds.2004-0529
9. Tan Z., Randall G., Fan J., Camoretti-Mercado B., Brockman-Schneider R., Pan L., Solway J., Gern J. E., Lemanske R. F. Jr., Nicolae D., Ober C., Allele-specific targeting of microRNAs to HLA-G and risk of asthma. American Journal of Human Genetics 2007 81 4 829 834 2-s2.0-35348992063 10.1086/521200
10. Su X.-W., Yang Y., Lv M.-L., Li L.-J., Dong W., Miao-Liao M.-L., Gao L.-B., Luo H.-B., Yun-Liu Y.-L., Cong R.-J., Liang W.-B., Li Y.-B., Association between single-nucleotide polymorphisms in pre-mirnas and the risk of asthma in a Chinese population. DNA and Cell Biology 2011 30 11 919 923 2-s2.0-80655128319 10.1089/dna.2010.1164
11. +; T cells of patients with allergic asthma. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2012 28 5 540 543
12. Lu T. X., Munitz A., Rothenberg M. E., MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. Journal of Immunology 2009 182 8 4994 5002 2-s2.0-65249106172 10.4049/jimmunol.0803560
13. Mattes J., Collison A., Plank M., Phipps S., Foster P. S., Antagonism of microRNA-126 suppresses the effector function of T H2 cells and the development of allergic airways disease. Proceedings of the National Academy of Sciences of the United States of America 2009 106 44 18704 18709 2-s2.0-70549095099 10.1073/pnas.0905063106
14. Williams A. E., Larner-Svensson H., Perry M. M., Campbell G. A., Herrick S. E., Adcock I. M., Erjefalt J. S., Chung K. F., Lindsay M. A., MicroRNA expression profiling in mild asthmatic human airways and effect of corticosteroid therapy. PLoS ONE 2009 4 6, article e5889 2-s2.0-67651240360 10.1371/journal.pone.0005889
15. Polikepahad S., Knight J. M., Naghavi A. O., Oplt T., Creighton C. J., Shaw C., Benham A. L., Kim J., Soibam B., Harris R. A., Coarfa C., Zariff A., Milosavljevic A., Batts L. M., Kheradmand F., Gunaratne P. H., Corry D. B., Proinflammatory role for let-7 microRNAS in experimental asthma. Journal of Biological Chemistry 2010 285 39 30139 30149 2-s2.0-77956893155 10.1074/jbc.M110.145698
16. Rodriguez A., Vigorito E., Clare S., Warren M. V., Couttet P., Soond D. R., Van Dongen S., Grocock R. J., Das P. P., Miska E. A., Vetrie D., Okkenhaug K., Enright A. J., Dougan G., Turner M., Bradley A., Requirement of bic/microRNA-155 for normal immune function. Science 2007 316 5824 608 611 2-s2.0-34247584465 10.1126/science.1139253
17. Chiba Y., Tanabe M., Goto K., Sakai H., Misawa M., Down-regulation of miR-133a contributes to up-regulation of RhoA in bronchial smooth muscle cells. American Journal of Respiratory and Critical Care Medicine 2009 180 8 713 719 2-s2.0-70349852575 10.1164/rccm.200903-0325OC
18. Kumar M., Mabalirajan U., Agrawal A., Ghosh B., Proinflammatory role of let-7 miRNAs in experimental asthma? Journal of Biological Chemistry 2010 285 48 le20 2-s2.0-78549261106 10.1074/jbc.L110.145698
19. Garbacki N., di Valentin E., Huynh-Thu V. A., Geurts P., Irrthum A., Crahay C., Arnould T., Deroanne C., Piette J., Cataldo D., Colige A., MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets. PLoS ONE 2011 6 1, article e16509 2-s2.0-79551565924 10.1371/journal.pone.0016509
20. Mayoral R. J., Pipkin M. E., Pachkov M., van Nimwegen E., Rao A., Monticelli S., MicroRNA-221-222 regulate the cell cycle in mast cells. Journal of Immunology 2009 182 1 433 445 2-s2.0-59849122726
21. Mayoral R. J., Deho L., Rusca N., Bartonicek N., Saini H. K., Enright A. J., Monticelli S., MiR-221 influences effector functions and actin cytoskeleton in mast cells. PLoS ONE 2011 6 10, article e26133 2-s2.0-80053981443 10.1371/journal.pone.0026133
22. Walsh G. M., Targeting eosinophils in asthma: current and future state of cytokine-and chemokine-directed monoclonal therapy. Expert Review of Clinical Immunology 2010 6 5 701 704 2-s2.0-77956521264 10.1586/eci.10.58
23. Kim H. Y., Dekruyff R. H., Umetsu D. T., The many paths to asthma:phenotype shaped by innate and adaptive immunity. Nature Immunology 2010 11 7 577 584 2-s2.0-77953794345 10.1038/ni.1892
24. Schroeder J. T., Bieneman A. P., Chichester K. L., Breslin L., Xiao H., Liu M. C., Pulmonary allergic responses augment interleukin-13 secretion by circulating basophils yet suppress interferon- α from plasmacytoid dendritic cells. Clinical and Experimental Allergy 2010 40 5 745 754 2-s2.0-77950948333 10.1111/j.1365-2222.2010.03456.x
25. Liu X., Nelson A., Wang X., Kanaji N., Kim M., Sato T., Nakanishi M., Li Y., Sun J., Michalski J., Patil A., Basma H., Rennard S. I., MicroRNA-146a modulates human bronchial epithelial cell survival in response to the cytokine-induced apoptosis. Biochemical and Biophysical Research Communications 2009 380 1 177 182 2-s2.0-59849087052 10.1016/j.bbrc.2009.01.066
26. Kumar M., Ahmad T., Sharma A., Mabalirajan U., Kulshreshtha A., Agrawal A., Ghosh B., Let-7 microRNA-mediated regulation of IL-13 and allergic airway inflammation. Journal of Allergy and Clinical Immunology 2011 128 5 1077.e10 1085.e10 2-s2.0-80052502658 10.1016/j.jaci.2011.04.034
27. Collison A., Mattes J., Plank M., Foster P. S., Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment. Journal of Allergy and Clinical Immunology 2011 128 1 160 167 2-s2.0-79959828991 10.1016/j.jaci.2011.04.005
28. Radzikinas K., Aven L., Jiang Z., Tran T., Paez-Cortez J., Boppidi K., Lu J., Fine A., Ai X., A Shh/miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. Journal of Neuroscience 2011 31 43 15407 15415 2-s2.0-80054950828 10.1523/JNEUROSCI.2745-11.2011
29. Barnes P. J., Immunology of asthma and chronic obstructive pulmonary disease. Nature Reviews Immunology 2008 8 3 183 192 2-s2.0-40049104892 10.1038/nri2254
30. Hammad H., Lambrecht B. N., Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nature Reviews Immunology 2008 8 3 193 204 2-s2.0-40049088465 10.1038/nri2275
31. Holgate S. T., The epithelium takes centre stage in asthma and atopic dermatitis. Trends in Immunology 2007 28 6 248 251 2-s2.0-34249337763 10.1016/j.it.2007.04.007
32. Schleimer R. P., Kato A., Kern R., Kuperman D., Avila P. C., Epithelium: at the interface of innate and adaptive immune responses. Journal of Allergy and Clinical Immunology 2007 120 6 1279 1284 2-s2.0-36749040998 10.1016/j.jaci.2007.08.046
33. Zhai Y., Zhong Z., Chen C.-Y. A., Xia Z., Song L., Blackburn M. R., Shyu A.-B., Coordinated changes in mRNA turnover, translation, and RNA processing bodies in bronchial epithelial cells following inflammatory stimulation. Molecular and Cellular Biology 2008 28 24 7414 7426 2-s2.0-57349109907 10.1128/MCB.01237-08
34. Chiba Y., Misawa M., MicroRNAs and their therapeutic potential for human diseases: MiR-133a and bronchial smooth muscle hyperresponsiveness in asthma. Journal of Pharmacological Sciences 2010 114 3 264 268 2-s2.0-78649437465 10.1254/jphs.10R10FM
35. Sharma A., Kumar M., Ahmad T., Antagonism of mmu-mir-106a attenuates asthma features in allergic murine model. Journal of Applied Physiology 2012 113 3 459 464 10.1152/japplphysiol.00001.2012
36. + T lymphocytes play proinflammatory roles in a murine model of asthma. International Immunopharmacology 2012 13 3 347 353
37. Schaafsma D., Gosens R., Zaagsma J., Halayko A. J., Meurs H., Rho kinase inhibitors: a novel therapeutical intervention in asthma? European Journal of Pharmacology 2008 585 2-3 398 406 2-s2.0-43049096072 10.1016/j.ejphar.2008.01. 056
38. Kume H., RhoA/Rho-kinase as a therapeutic target in asthma. Current Medicinal Chemistry 2008 15 27 2876 2885 2-s2.0-58149384692 10.2174/ 092986708786242831
39. Patterson C. C., Dahlquist G. G., Gyürüs E., Green A., Soltész G., EURODIAB Study Group, Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. The Lancet 2009 373 9680 2027 2033 2-s2.0-67049159857 10.1016/S0140-6736(09)60568-7
40. Danaei G., Finucane M. M., Lu Y., Singh G. M., Cowan M. J., Paciorek C. J., Lin J. K., Farzadfar F., Khang Y.-H., Stevens G. A., Rao M., Ali M. K., Riley L. M., Robinson C. A., Ezzati M., National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. The Lancet 2011 378 9785 31 40 2-s2.0-79959936188 10.1016/S0140-6736(11)60679-X
41. Baroukh N., Ravier M. A., Loder M. K., Hill E. V., Bounacer A., Scharfmann R., Rutter G. A., Van Obberghen E., MicroRNA-124a regulates foxa2 expression and intracellular signaling in pancreatic β -cell lines. Journal of Biological Chemistry 2007 282 27 19575 19588 2-s2.0-34547126004 10.1074/jbc.M611841200
42. Keller D. M., Clark E. A., Goodman R. H., Regulation of microRNA-375 by cAMP in pancreatic β -cells. Molecular Endocrinology 2012 26 6 989 999 10.1210/me.2011-1205
43. Poy M. N., Hausser J., Trajkovski M., Braun M., Collins S., Rorsman P., Zavolan M., Stoffel M., miR-375 maintains normal pancreatic α-and β -cell mass. Proceedings of the National Academy of Sciences of the United States of America 2009 106 14 5813 5818 2-s2.0-65249093130 10.1073/pnas.0810550106
44. Sun L.-L., Jiang B.-G., Li W.-T., Zou J.-J., Shi Y.-Q., Liu Z.-M., MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression. Diabetes Research and Clinical Practice 2011 91 1 94 100 2-s2.0-78650554763 10.1016/j.diabres.2010.11.006
45. Zhao X., Mohan R., Tang X., MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (Map4k4) in pancreatic β cells. Journal of Biological Chemistry 2012 287 37 31155 31164 10.1074/jbc.M112.362632
46. Bolmeson C., Esguerra J. L. S., Salehi A., Speidel D., Eliasson L., Cilio C. M., Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects. Biochemical and Biophysical Research Communications 2011 404 1 16 22 2-s2.0-78650902669 10.1016/j.bbrc.2010.11.024
47. Fred R. G., Bang-Berthelsen C. H., Mandrup-Poulsen T., Grunnet L. G., Welsh N., High glucose suppresses human islet insulin biosynthesis by inducing mir-133a leading to decreased polypyrimidine tract binding protein-expression. PLoS ONE 2010 5 5, article e10843 2-s2.0-77956276832 10.1371/journal.pone. 0010843
48. Plaisance V., Abderrahmani A., Perret-Menoud V., Jacquemin P., Lemaigre F., Regazzi R., MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells. Journal of Biological Chemistry 2006 281 37 26932 26942 2-s2.0-33748749597 10.1074/jbc.M601225200
49. Ramachandran D., Roy U., Garg S., Ghosh S., Pathak S., Kolthur-Seetharam U., Sirt1 and mir-9 expression is regulated during glucose-stimulated insulin secretion in pancreatic β -islets. FEBS Journal 2011 278 7 1167 1174 2-s2.0-79952846843 10.1111/j.1742-4658.2011.08042.x
50. Poy M. N., Eliasson L., Krutzfeldt J., Kuwajima S., Ma X., MacDonald P. E., Pfeffer S., Tuschl T., Rajewsky N., Rorsman P., Stoffel M., A pancreatic islet-specific microRNA regulates insulin secretion. Nature 2004 432 7014 226 230 2-s2.0-9144270691 10.1038/nature03076
51. Li Y., Xu X., Liang Y., Liu S., Xiao H., Li F., Cheng H., Fu Z., miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression. International Journal of Clinical and Experimental Pathology 2010 3 3 254 264 2-s2.0-77953376194
52. Pullen T. J., da Silva Xavier G., Kelsey G., Rutter G. A., miR-29a and miR-29b contribute to pancreatic β -cell-specific silencing of monocarboxylate transporter 1 (MCT1). Molecular and Cellular Biology 2011 31 15 3182 3194 2-s2.0-79960322580 10.1128/MCB.01433-10
53. Wijesekara N., Zhang L.-H., Kang M. H., Abraham T., Bhattacharjee A., Warnock G. L., Verchere C. B., Hayden M. R., miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets. Diabetes 2012 61 3 653 658 2-s2.0-84857401885 10.2337/db11-0944
54. Roggli E., Britan A., Gattesco S., Lin-Marq N., Abderrahmani A., Meda P., Regazzi R., Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic β -cells. Diabetes 2010 59 4 978 986 2-s2.0-77951158889 10.2337/db09-0881
55. Trajkovski M., Hausser J., Soutschek J., Bhat B., Akin A., Zavolan M., Heim M. H., Stoffel M., MicroRNAs 103 and 107 regulate insulin sensitivity. Nature 2011 474 7353 649 653 2-s2.0-79959845414 10.1038/nature10112
56. Zhu H., Shyh-Chang N., Segr A. V., Shinoda G., Shah S. P., Einhorn W. S., Takeuchi A., Engreitz J. M., Hagan J. P., Kharas M. G., Urbach A., Thornton J. E., Triboulet R., Gregory R. I., Altshuler D., Daley G. Q., The Lin28/let-7 axis regulates glucose metabolism. Cell 2011 147 1 81 94 2-s2.0-80053481600 10.1016/j.cell.2011.08.033
57. Zhou L., He H., Mi J. X., Li C., Lee B., Mi Q.-S., MicroRNA genes: are they susceptibility candidates for human type 1 diabetes? Annals of the New York Academy of Sciences 2008 1150 72 75 2-s2.0-57749203779 10.1196/annals.1447.026
58. Hezova R., Slaby O., Faltejskova P., Mikulkova Z., Buresova I., Raja K. R. M., Hodek J., Ovesna J., Michalek J., microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients. Cellular Immunology 2010 260 2 70 74 2-s2.0-71349083569 10.1016/j.cellimm.2009.10.012
59. Roggli E., Gattesco S., Caille D., Changes in microrna expression contribute to pancreatic β -cell dysfunction in prediabetic nod mice. Diabetes 2012 61 7 1742 1751 10.2337/db11-1086
60. Sebastiani G., Grieco F. A., Spagnuolo I., Galleri L., Cataldo D., Dotta F., Increased expression of microRNA miR-326 in type 1 diabetic patients with ongoing islet autoimmunity. Diabetes/Metabolism Research and Reviews 2011 27 8 862 866 2-s2.0-80855124151 10.1002/dmrr.1262
61. Bang-Berthelsen C. H., Pedersen L., Fløyel T., Hagedorn P. H., Gylvin T., Pociot F., Independent component and pathway-based analysis of miRNA-regulated gene expression in a model of type 1 diabetes. BMC Genomics 2011 12, article 97 2-s2.0-79551598113 10.1186/1471-2164-12-97
62. Lynn F. C., Skewes-Cox P., Kosaka Y., McManus M. T., Harfe B. D., German M. S., MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes 2007 56 12 2938 2945 2-s2.0-36248978699 10.2337/db07-0175
63. Melkman-Zehavi T., Oren R., Kredo-Russo S., Shapira T., Mandelbaum A. D., Rivkin N., Nir T., Lennox K. A., Behlke M. A., Dor Y., Hornstein E., miRNAs control insulin content in pancreatic β -cells via downregulation of transcriptional repressors. EMBO Journal 2011 30 5 835 845 2-s2.0-79952259862 10.1038/emboj.2010.361
64. Kalis M., Bolmeson C., Esguerra J. L. S., Gupta S., Edlund A., Tormo-Badia N., Speidel D., Holmberg D., Mayans S., Khoo N. K. S., Wendt A., Eliasson L., Cilio C. M., Beta-cell specific deletion of dicer1 leads to defective insulin secretion and diabetes mellitus. PLoS ONE 2011 6 12, article e29166 2-s2.0-84455161954 10.1371/journal.pone.0029166
65. Gilad S., Meiri E., Yogev Y., Benjamin S., Lebanony D., Yerushalmi N., Benjamin H., Kushnir M., Cholakh H., Melamed N., Bentwich Z., Hod M., Goren Y., Chajut A., Serum microRNAs are promising novel biomarkers. PLoS ONE 2008 3 9, article e3148 2-s2.0-52349083651 10.1371/journal.pone.0003148
66. Johnson J. D., Proteomic identification of carboxypeptidase E connects lipid-induced β -cell apoptosis and dysfunction in type 2 diabetes. Cell Cycle 2009 8 1 38 42 2-s2.0-60749119458
67. 2+ homeostasis in β -cells. American Journal of Physiology-Endocrinology and Metabolism 2009 296 4 E690 E701 2-s2.0-65649140089 10.1152/ajpendo.90525.2008
68. Jordan S. D., Krüger M., Willmes D. M., Redemann N., Wunderlich F. T., Brönneke H. S., Merkwirth C., Kashkar H., Olkkonen V. M., Böttger T., Braun T., Seibler J., Brüning J. C., Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nature Cell Biology 2011 13 4 434 448 2-s2.0-79953317808 10.1038/ncb2211
69. Balasubramanyam M., Aravind S., Gokulakrishnan K., Prabu P., Sathishkumar C., Ranjani H., Mohan V., Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes. Molecular and Cellular Biochemistry 2011 351 1-2 197 205 2-s2.0-79953726990 10.1007/s11010-011-0727-3
70. Herrera B. M., Lockstone H. E., Taylor J. M., Wills Q. F., Kaisaki P. J., Barrett A., Camps C., Fernandez C., Ragoussis J., Gauguier D., McCarthy M. I., Lindgren C. M., MicroRNA-125a is over-expressed in insulin target tissues in a spontaneous rat model of Type 2 Diabetes. BMC Medical Genomics 2009 2, article no. 54 2-s2.0-70350637814 10.1186/1755-8794-2-54
71. Fujishiro M., Gotoh Y., Katagiri H., Sakoda H., Ogihara T., Anai M., Onishi Y., Ono H., Abe M., Shojima N., Fukushima Y., Kikuchi M., Oka Y., Asano T., Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes. Molecular Endocrinology 2003 17 3 487 497 2-s2.0-0037339991 10.1210/me.2002-0131
72. Engelman J. A., Berg A. H., Lewis R. Y., Lisanti M. P., Scherer P. E., Tumor necrosis factor α -mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. Molecular Endocrinology 2000 14 10 1557 1569 2-s2.0-0033773334
73. Kong L., Zhu J., Han W., Jiang X., Xu M., Zhao Y., Dong Q., Pang Z., Guan Q., Gao L., Zhao J., Zhao L., Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: A Clinical Study. Acta Diabetologica 2011 48 1 61 69 2-s2.0-79953327099 10.1007/s00592-010-0226-0
74. He A., Zhu L., Gupta N., Chang Y., Fang F., Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes. Molecular Endocrinology 2007 21 11 2785 2794 2-s2.0-35649011441 10.1210/me.2007-0167
75. Lovis P., Roggli E., Laybutt D. R., Gattesco S., Yang J.-Y., Widmann C., Abderrahmani A., Regazzi R., Alterations in MicroRNA expression contribute to fatty Acid-Induced pancreatic β -Cell dysfunction. Diabetes 2008 57 10 2728 2736 2-s2.0-58149350340 10.2337/db07-1252
76. Karolina D. S., Armugam A., Tavintharan S., Wong M. T. K., Lim S. C., Sum C. F., Jeyaseelan K., MicroRNA 144 impairs insulin signaling by inhibiting the expression of insulin receptor substrate 1 in type 2 diabetes mellitus. PLoS ONE 2011 6 8, article e22839 2-s2.0-79960932477 10.1371/journal.pone.0022839
77. Zampetaki A., Kiechl S., Drozdov I., Willeit P., Mayr U., Prokopi M., Mayr A., Weger S., Oberhollenzer F., Bonora E., Shah A., Willeit J., Mayr M., Plasma microRNA profiling reveals loss of endothelial miR-126 and other MicroRNAs in type 2 diabetes. Circulation Research 2010 107 6 810 817 2-s2.0-77957259803 10.1161/CIRCRESAHA.110.226357
78. Kato M., Zhang J., Wang M., Lanting L., Yuan H., Rossi J. J., Natarajan R., MicroRNA-192 in diabetic kidney glomeruli and its function in TGF- β -induced collagen expression via inhibition of E-box repressors. Proceedings of the National Academy of Sciences of the United States of America 2007 104 9 3432 3437 2-s2.0-33847682663 10.1073/pnas.0611192104
79. Kato M., Wang L., Putta S., Wang M., Yuan H., Sun G., Lanting L., Todorov I., Rossi J. J., Natarajan R., Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF- β -induced collagen expression in kidney cells. Journal of Biological Chemistry 2010 285 44 34004 34015 2-s2.0-77958583070 10.1074/jbc.M110.165027
80. Kato M., Arce L., Wang M., Putta S., Lanting L., Natarajan R., A microRNA circuit mediates transforming growth factor- β 1 autoregulation in renal glomerular mesangial cells. Kidney International 2011 80 4 358 368 2-s2.0-80052248898 10.1038/ki.2011.43
81. Kato M., Putta S., Wang M., Yuan H., Lanting L., Nair I., Gunn A., Nakagawa Y., Shimano H., Todorov I., Rossi J. J., Natarajan R., TGF- β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN. Nature Cell Biology 2009 11 7 881 889 2-s2.0-67650085171 10.1038/ncb1897
82. Wang Q., Wang Y., Minto A. W., Wang J., Shi Q., Li X., Quigg R. J., MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB Journal 2008 22 12 4126 4135 2-s2.0-57349186092 10.1096/fj.08-112326
83. Putta S., Lanting L., Sun G., Lawson G., Kato M., Natarajan R., Inhibiting microRNA-192 ameliorates renal fibrosis in diabetic nephropathy. Journal of the American Society of Nephrology 2012 23 3 458 469 2-s2.0-84857979740 10.1681/ASN.2011050485
84. Kovacs B., Lumayag S., Cowan C., Xu S., MicroRNAs in early diabetic retinopathy in streptozotocin-induced diabetic rats. Investigative Ophthalmology & Visual Science 2011 52 7 4402 4409 2-s2.0-80052333875
85. Silva V. A. O., Polesskaya A., Sousa T. A., Corrêa V. M. A., André N. D., Reis R. I., Kettelhut I. C., Harel-Bellan A., De Lucca F. L., Expression and cellular localization of microRNA-29b and RAX, an activator of the RNA-dependent protein kinase (PKR), in the retina of streptozotocin- induced diabetic rats. Molecular Vision 2011 17 2228 2240 2-s2.0-80053027076
86. Wu J.-H., Gao Y., Ren A.-J., Zhao S.-H., Zhong M., Peng Y.-J., Shen W., Jing M., Liu L., Altered microRNA expression profiles in retinas with diabetic retinopathy. Ophthalmic Research 2012 47 4 195 201 2-s2.0-82955161737 10.1159/000331992
87. Hermeking H., The miR-34 family in cancer and apoptosis. Cell Death and Differentiation 2010 17 2 193 199 2-s2.0-74249123570 10.1038/cdd.2009.56
88. Suárez Y., Sessa W. C., MicroRNAs as novel regulators of angiogenesis. Circulation Research 2009 104 4 442 454 2-s2.0-61949361268 10.1161/CIRCRESAHA.108.191270
89. Urbich C., Kuehbacher A., Dimmeler S., Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovascular Research 2008 79 4 581 588 2-s2.0-52449100144 10.1093/cvr/cvn156
90. Xie S., Xie N., Li Y., Wang P., Zhang C., Li Q., Liu X., Deng J., Zhang C., Lv C., Upregulation of TRB2 induced by miR-98 in the early lesions of large artery of type-2 diabetic rat. Molecular and Cellular Biochemistry 2012 361 1-2 305 314 2-s2.0-84860233217
91. Caporali A., Meloni M., Völlenkle C., Bonci D., Sala-Newby G. B., Addis R., Spinetti G., Losa S., Masson R., Baker A. H., Agami R., Le Sage C., Condorelli G., Madeddu P., Martelli F., Emanueli C., Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after Limb Ischemia. Circulation 2011 123 3 282 291 2-s2.0-79251534433 10.1161/CIRCULATIONAHA.110.952325
92. Meng S., Cao J. T., Zhang B., Zhou Q., Shen C. X., Wang C. Q., Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1. Journal of Molecular and Cellular Cardiology 2012 53 1 64 72 10.1016/j.yjmcc.2012.04.003
93. Chen B.-Z., Yu S.-L., Singh S., Kao L.-P., Tsai Z.-Y., Yang P.-C., Chen B.-H., Li S. S.-L., Identification of microRNAs expressed highly in pancreatic islet-like cell clusters differentiated from human embryonic stem cells. Cell Biology International 2011 35 1 29 37 2-s2.0-78649640379 10.1042/CBI20090081
94. Ruan Q., Wang T., Kameswaran V., Wei Q., Johnson D. S., Matschinsky F., Shi W., Chen Y. H., The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic β cell death. Proceedings of the National Academy of Sciences of the United States of America 2011 108 29 12030 12035 2-s2.0-79961065195 10.1073/pnas.1101450108
95. Liang F., Kume S., Koya D., SIRT1 and insulin resistance. Nature Reviews Endocrinology 2009 5 7 367 373 2-s2.0-69449106304 10.1038/nrendo.2009.101
96. Zhou B., Li C., Qi W., Zhang Y., Zhang F., Wu J. X., Hu Y. N., Wu D. M., Liu Y., Yan T. T., Jing Q., Liu M. F., Zhai Q. W., Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity. Diabetologia 2012 55 7 2032 2043 2-s2.0-84859177860 10.1007/s00125-012-2539-8
97. Geerts A., Brouwer O., Stroink H., Van Donselaar C., Peters B., Peeters E., Arts W. F., Onset of intractability and its course over time: The Dutch Study of Epilepsy in Childhood. Epilepsia 2012 53 4 741 751 2-s2.0-84859422280 10.1111/j.1528-1167.2012.03429.x
98. Perry M. S., Duchowny M., Surgical management of intractable childhood epilepsy: curative and palliative procedures. Seminars in Pediatric Neurology 2011 18 3 195 202 2-s2.0-80655125250 10.1016/j.spen.2011.06.006
99. Russ S. A., Larson K., Halfon N., A national profile of childhood epilepsy and seizure disorder. Pediatrics 2012 129 2 256 264 2-s2.0-84856532346 10.1542/peds.2010-1371
100. Tao J., Wu H., Lin Q., Deletion of astroglial dicer causes non-cell autonomous neuronal dysfunction and degeneration. Journal of Neuroscience 2011 31 22 8306 8319 2-s2.0-79958020894 10.1523/JNEUROSCI.0567-11.2011
101. McKiernan R. C., Jimenez-Mateos E. M., Bray I., Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis. PLoS ONE 2012 7 5, article e35921 10.1371/journal.pone. 0035921
102. Hu K., Zhang C., Long L., Long X., Feng L., Li Y., Xiao B., Expression profile of microRNAs in rat hippocampus following lithium-pilocarpine-induced status epilepticus. Neuroscience Letters 2011 488 3 252 257 2-s2.0-78650837680 10.1016/j.neulet.2010.11.040
103. Risbud R. M., Lee C., Porter B. E., Neurotrophin-3 mRNA a putative target of miR21 following status epilepticus. Brain Research 2011 1424 53 59 2-s2.0-80455143568 10.1016/j.brainres.2011.09.039
104. Peng J., Omran A., Ashhab M. U., Expression patterns of miR-124, miR-134, miR-132, and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy. Journal of Molecular Neuroscience 2013 50 2 291 297 10.1007/s12031-013-9953-3
105. Song Y.-J., Tian X.-B., Zhang S., Zhang Y.-X., Li X., Li D., Cheng Y., Zhang J.-N., Kang C.-S., Zhao W., Temporal lobe epilepsy induces differential expression of hippocampal miRNAs including let-7e and miR-23a/b. Brain Research 2011 1387 134 140 2-s2.0-79954422928 10.1016/j.brainres.2011.02.073
106. Aronica E., Fluiter K., Iyer A., Zurolo E., Vreijling J., Van Vliet E. A., Baayen J. C., Gorter J. A., Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. European Journal of Neuroscience 2010 31 6 1100 1107 2-s2.0-77949549835 10.1111/j.1460-9568.2010.07122.x
107. Omran A., Peng J., Zhang C., Interleukin-1 β and microRNA-146a in an immature rat model and children with mesial temporal lobe epilepsy. Epilepsia 2012 53 7 1215 1224 10.1111/j.1528-1167.2012.03540.x
108. Ashhab M. U., Omran A., Kong H., Expressions of tumor necrosis factor-alpha and microrna-155 in immature rat model of status epilepticus and children with mesial temporal lobe epilepsy. Journal of Molecular Neuroscience 2013 10.1007/s12031-013-0013-9
109. Kan A. A., van Erp S., Derijck A. A. H. A., de Wit M., Hessel E. V. S., O'Duibhir E., de Jager W., Van Rijen P. C., Gosselaar P. H., de Graan P. N. E., Pasterkamp R. J., Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. Cellular and Molecular Life Sciences 2012 69 18 3127 3145 2-s2.0-84859936903 10.1007/s00018-012-0992-7
110. Brooks-Kayal A., Molecular mechanisms of cognitive and behavioral comorbidities of epilepsy in children. Epilepsia 2011 52 1 13 20 2-s2.0-78651293102 10.1111/j.1528-1167.2010.02906.x
111. Wu L., Peng J., Wei C., Liu G., Wang G., Li K., Yin F., Characterization, using comparative proteomics, of differentially expressed proteins in the hippocampus of the mesial temporal lobe of epileptic rats following treatment with valproate. Amino Acids 2011 40 1 221 238 2-s2.0-78751582250 10.1007/s00726-010-0638-8
112. Ashraf S. I., McLoon A. L., Sclarsic S. M., Kunes S., Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila. Cell 2006 124 1 191 205 2-s2.0-30344449514 10.1016/j.cell.2005.12.017
113. Rajasethupathy P., Fiumara F., Sheridan R., Betel D., Puthanveettil S. V., Russo J. J., Sander C., Tuschl T., Kandel E., Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. Neuron 2009 63 6 803 817 2-s2.0-70349117273 10.1016/j.neuron.2009. 05.029
114. Pichardo-Casas I., Goff L. A., Swerdel M. R., Athie A., Davila J., Ramos-Brossier M., Lapid-Volosin M., Friedman W. J., Hart R. P., Vaca L., Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced dynamic modulation. Brain Research 2012 1436 20 33 2-s2.0-84855986489 10.1016/j.brainres.2011.12.001
115. Nudelman A. S., Dirocco D. P., Lambert T. J., Garelick M. G., Le J., Nathanson N. M., Storm D. R., Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo. Hippocampus 2010 20 4 492 498 2-s2.0-77950111923 10.1002/hipo.20646
116. Liu D.-Z., Tian Y., Ander B. P., Xu H., Stamova B. S., Zhan X., Turner R. J., Jickling G., Sharp F. R., Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. Journal of Cerebral Blood Flow and Metabolism 2010 30 1 92 101 2-s2.0-73949091031 10.1038/jcbfm.2009.186
117. Jimenez-Mateos E. M., Bray I., Sanz-Rodriguez A., Engel T., McKiernan R. C., Mouri G., Tanaka K., Sano T., Saugstad J. A., Simon R. P., Stallings R. L., Henshall D. C., miRNA expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132. American Journal of Pathology 2011 179 5 2519 2532 2-s2.0-80054998780 10.1016/j.ajpath.2011.07.036
118. Jimenez-Mateos E. M., Engel T., Merino-Serrais P., Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nature Medicine 2012 18 7 1087 1094 10.1038/nm.2834
119. Ratjen F., Döring G., Cystic fibrosis. The Lancet 2003 361 9358 681 689 2-s2.0-0037460729 10.1016/S0140-6736(03)12567-6
120. Dodge J. A., Lewis P. A., Stanton M., Wilsher J., Cystic fibrosis mortality and survival in the UK: 1947-2003. European Respiratory Journal 2007 29 3 522 526 2-s2.0-33847711906 10.1183/09031936.00099506
121. Hodson M. E., Simmonds N. J., Warwick W. J., Tullis E., Castellani C.,
122. Gibson R. L., Burns J. L., Ramsey B. W., Pathophysiology and management of pulmonary infections in cystic fibrosis. American Journal of Respiratory and Critical Care Medicine 2003 168 8 918 951 2-s2.0-0142043977 10.1164/rccm.200304- 505SO
123. Xu W., Hui C., Yu S. S. B., Jing C., Chan H. C., MicroRNAs and cystic fibrosis-an epigenetic perspective. Cell Biology International 2011 35 5 463 466 2-s2.0-79960985619 10.1042/CBI20100664
124. Oglesby I. K., Bray I. M., Chotirmall S. H., Stallings R. L., O'Neill S. J., McElvaney N. G., Greene C. M., miR-126 is downregulated in cystic fibrosis airway epithelial cells and regulates TOM1 expression. Journal of Immunology 2010 184 4 1702 1709 2-s2.0-77949890696 10.4049/jimmunol.0902669
125. Bazett M., Paun A., Haston C. K., MicroRNA profiling of cystic fibrosis intestinal disease in mice. Molecular Genetics and Metabolism 2011 103 1 38 43 2-s2.0-79955133428 10.1016/j.ymgme.2011.01.012
126. Bhattacharyya S., Balakathiresan N. S., Dalgard C., Gutti U., Armistead D., Jozwik C., Srivastava M., Pollard H. B., Biswas R., Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8. Journal of Biological Chemistry 2011 286 13 11604 11615 2-s2.0-79953171192 10.1074/jbc.M110.198390
127. Kuhn A. R., Schlauch K., Lao R., Halayko A. J., Gerthoffer W. T., Singer C. A., MicroRNA expression in human airway smooth muscle cells: Role of miR-25 in regulation of airway smooth muscle phenotype. American Journal of Respiratory Cell and Molecular Biology 2010 42 4 506 513 2-s2.0-77950467511 10.1165/rcmb.2009-0123OC
128. Moschos S. A., Williams A. E., Perry M. M., Birrell M. A., Belvisi M. G., Lindsay M. A., Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids. BMC Genomics 2007 8, article 240 2-s2.0-34547774686 10.1186/1471-2164-8-240
129. Ramachandran S., Karp P. H., Jiang P., A microRNA network regulates expression and biosynthesis of wild-type and ΔF508 mutantcystic fibrosis transmembrane conductance regulator. Proceedings of the National Academy of Sciences of the United States of America, 2012 109 33 13362 13367 10.1073/pnas.1210906109
130. Gillen A. E., Gosalia N., Leir S.-H., Harris A., MicroRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene. Biochemical Journal 2011 438 1 25 32 2-s2.0-79960807167 10.1042/BJ20110672
131. Megiorni F., Cialfi S., Dominici C., Quattrucci S., Pizzuti A., Synergistic post-transcriptional regulation of the cystic fibrosis transmembrane conductance regulator (CFTR) by miR-101 and miR-494 specific binding. PLoS ONE 2011 6 10, article e26601 2-s2.0-80054777791 10.1371/journal.pone.0026601
132. Rao J. R., Nelson D., Moore J. E., Millar B. C., Goldsmith C. E., Rendall J., Elborn J. S., Non-coding small (micro) RNAs of Pseudomonas aeruginosa isolated from clinical isolates from adult patients with cystic fibrosis. British Journal of Biomedical Science 2010 67 3 126 132 2-s2.0-77957008535