MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells

Journal of Biological Chemistry

Volumn 287, Issue 37, 2012, Pages 31155-31164

  Zhao, Xiaomin ^a,b   Mohan, Ramkumar ^b   Özcan, Sabire ^c   Tang, Xiaoqing ^b  

^a NORTHWEST A F UNIVERSITY   (China)

^b MICHIGAN TECHNOLOGICAL UNIVERSITY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL FUNCTIONS; DATA SUPPORT; DB/DB MOUSE; DOWN-REGULATION; EXPRESSION LEVELS; INSULIN RECEPTOR SUBSTRATE 2; INSULIN SECRETION; MICRORNAS; MITOGEN-ACTIVATED PROTEINS; NON-CODING RNAS; OVER-EXPRESSION; PROINFLAMMATORY CYTOKINES; TARGET GENES;

CELL PROLIFERATION; CELLS; CYTOLOGY; ENZYMES; GENES; GLUCOSE; PHYSIOLOGY; RNA; TRANSCRIPTION; TRANSCRIPTION FACTORS;

INSULIN;

INSULIN; INSULIN RECEPTOR SUBSTRATE 2; MESSENGER RNA; MICRORNA; MICRORNA 30D; MITOGEN ACTIVATED PROTEIN 4 KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR MAFA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RESPONSE; DIABETES MELLITUS; ENZYME ACTIVATION; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; INSULIN RELEASE; INSULIN SYNTHESIS; MAFA GENE; MALE; MAP4K4 GENE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; DIABETES MELLITUS; DOWN-REGULATION; EXOCYTOSIS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; MAF TRANSCRIPTION FACTORS, LARGE; MALE; MICE; MICRORNAS; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84866115684     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.362632     Document Type: Article

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