MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression

Diabetes Research and Clinical Practice

Volumn 91, Issue 1, 2011, Pages 94-100

  Sun, Liang Liang ^a   Jiang, Bei Ge ^b   Li, Wen Tong ^c   Zou, Jun Jie ^a   Shi, Yong Quan ^a   Liu, Zhi Min ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c No 1 Outpatient Clinic of Shanghai Garrison   (China)

Author keywords

Insulin biosynthesis; MiR 15a; UCP 2

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; INSULIN; LUCIFERASE; MICRORNA; MICRORNA 15A; OXYGEN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE ACTIVITY; INHIBITION KINETICS; INSULIN SYNTHESIS; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PROTEIN EXPRESSION; REPORTER GENE; UPREGULATION; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE; GENE EXPRESSION REGULATION; GENES, REPORTER; HEK293 CELLS; HUMANS; HYPERGLYCEMIA; INSULIN; ION CHANNELS; ISLETS OF LANGERHANS; MICE; MICE, INBRED C57BL; MICRORNAS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; ORGAN CULTURE TECHNIQUES; OXYGEN; RNA, MESSENGER; TIME FACTORS; UNCOUPLING AGENTS;

EID: 78650554763     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2010.11.006     Document Type: Article

References (32)

1. Cnop M., Welsh N., Jonas J.C., Jorns A., Lenzen S., Eizirik D.L. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 2005, 54(Suppl. 2):S97-107.
2. Fred R.G., Bang-Berthelsen C.H., Mandrup-Poulsen T., Grunnet L.G., Welsh N. High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expression. PLoS One 2010, 5:e10843.
3. Khanna P., Strom J.A., Malone J.I., Bhansali S. Microneedle-based automated therapy for diabetes mellitus. J Diabetes Sci Technol 2008, 2:1122-1129.
4. Melloul D., Ben-Neriah Y., Cerasi E. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci USA 1993, 90:3865-3869.
5. Tillmar L., Carlsson C., Welsh N. Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence. J Biol Chem 2002, 277:1099-1106.
6. Ashcroft F.M., Rorsman P. Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol 1989, 54:87-143.
7. Blixt M., Niklasson B., Sandler S. Pancreatic islets of bank vole show signs of dysfunction after prolonged exposure to high glucose concentrations in vitro. J Endocrinol 2010, 206:47-54.
8. Eizirik D.L., Korbutt G.S., Hellerstrom C. Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. J Clin Invest 1992, 90:1263-1268.
9. Ashcroft F.M., Gribble F.M. ATP-sensitive K+ channels and insulin secretion: their role in health and disease. Diabetologia 1999, 42:903-919.
10. Zhang C.Y., Baffy G., Perret P., Krauss S., Peroni O., Grujic D., et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 2001, 105:745-755.
11. Green K., Brand M.D., Murphy M.P. Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes 2004, 53(Suppl. 1):S110-118.
12. Piconi L., Quagliaro L., Assaloni R., Da Ros R., Maier A., Zuodar G., et al. Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction. Diabetes Metab Res Rev 2006, 22:198-203.
13. Bouillaud F., Ricquier D., Thibault J., Weissenbach J. Molecular approach to thermogenesis in brown adipose tissue: cDNA cloning of the mitochondrial uncoupling protein. Proc Natl Acad Sci USA 1985, 82:445-448.
14. Bordone L., Motta M.C., Picard F., Robinson A., Jhala U.S., Apfeld J., et al. Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol 2006, 4:e31.
15. Chan C.B., De Leo D., Joseph J.W., McQuaid T.S., Ha X.F., Xu F., et al. Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes 2001, 50:1302-1310.
16. Chan C.B., MacDonald P.E., Saleh M.C., Johns D.C., Marban E., Wheeler M.B. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 1999, 48:1482-1486.
17. Zampetaki A., Kiechl S., Drozdov I., Willeit P., Mayr U., Prokopi M., et al. Plasma microRNA profiling reveals loss of endothelial MiR-126 and other microRNAs in type 2 diabetes. Circ Res 2010, 107:810-817.
18. Poy M.N., Eliasson L., Krutzfeldt J., Kuwajima S., Ma X., Macdonald P.E., et al. A pancreatic islet-specific microRNA regulates insulin secretion. Nature 2004, 432:226-230.
19. Herrera B.M., Lockstone H.E., Taylor J.M., Ria M., Barrett A., Collins S., et al. Global microRNA expression profiles in insulin target tissues in a spontaneous rat model of type 2 diabetes. Diabetologia 2010, 53:1099-1109.
20. Xia H.Q., Pan Y., Peng J., Lu G.X. Over-expression of miR375 reduces glucose-induced insulin secretion in Nit-1 cells. Mol Biol Rep 2010.
21. Li Y., Xu X., Liang Y., Liu S., Xiao H., Li F., et al. miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression. Int J Clin Exp Pathol 2010, 3:254-264.
22. Lipson K.L., Fonseca S.G., Ishigaki S., Nguyen L.X., Foss E., Bortell R., et al. Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab 2006, 4:245-254.
23. Matthias A., Ohlson K.B., Fredriksson J.M., Jacobsson A., Nedergaard J., Cannon B. Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty scid-induced thermogenesis. J Biol Chem 2000, 275:25073-25081.
24. Kapinas K., Kessler C.B., Ricks T., Gronowicz G., Delany A.M. miR-29 modulates WNT signaling in human osteoblasts through a positive feedback loop. J Biol Chem 2010.
25. Lu H., Buchan R.J., Cook S.A. MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism. Cardiovasc Res 2010, 86:410-420.
26. Zhao H., Guan J., Lee H.M., Sui Y., He L., Siu J.J., et al. Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition. Pancreas 2010, 39:843-846.
27. Wang B., Herman-Edelstein M., Koh P., Burns W., Jandeleit-Dahm K., Watson A., et al. E-cadherin expression is regulated by miR-192/215 by a mechanism that is independent of the profibrotic effects of transforming growth factor-beta. Diabetes 2010, 59:1794-1802.
28. Andersen D.C., Jensen C.H., Schneider M., Nossent A.Y., Eskildsen T., Hansen J.L., et al. MicroRNA-15a fine-tunes the level of Delta-like 1 homolog (DLK1) in proliferating 3T3-L1 preadipocytes. Exp Cell Res 2010, 316:1681-1691.
29. Yang J., Cao Y., Sun J., Zhang Y. Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells. Med Oncol 2009.
30. Bhattacharya R., Nicoloso M., Arvizo R., Wang E., Cortez A., Rossi S., et al. MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer. Cancer Res 2009, 69:9090-9095.
31. Arsenijevic D., Onuma H., Pecqueur C., Raimbault S., Manning B.S., Miroux B., et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 2000, 26:435-439.
32. Dulloo A.G., Samec S. Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered. Br J Nutr 2001, 86:123-139.