Divalent heavy metal cations block the TRPV1 Ca2+ channel

Biological Trace Element Research

Volumn 151, Issue 3, 2013, Pages 451-461

  Pecze, László ^a,b   Winter, Zoltán ^a   Jósvay, Katalin ^a,b   Ötvös, Ferenc ^b,f   Kolozsi, Csongor ^a,b   Vizler, Csaba ^b   Budai, Dénes ^c   Letoha, Tamás ^a,e   Dombi, György ^a   Szakonyi, Gerda ^a   Oláh, Zoltán ^a,d  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c Kation Europe   (Hungary)

^d Acheuron Hungary Ltd   (Hungary)

^e Pharmacoidea Ltd   (Hungary)

^f Greenformatix Nonprofit Ltd   (Hungary)

Author keywords

Calciumchannel; Cobalt; Heavy metals; Pain; Somatosensory system; TRPV1

Indexed keywords

CADMIUM; COBALT; COPPER ION; LANTHANIDE; MAGNESIUM ION; MANGANESE; NICKEL; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR AGONIST; ZINC ION;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; CALCIUM TRANSPORT; CELL TRANSFER; CHANNEL GATING; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENTIATION; EMBRYO; GENE FUNCTION; HEAT TREATMENT; IC 50; MOUSE; NOCICEPTION; NONHUMAN; PAIN; POINT MUTATION; RAT; RECEPTOR BLOCKING; SPINAL GANGLION;

MUS; RATTUS;

3T3 CELLS; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CATIONS, DIVALENT; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; METALS, HEAVY; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 84880135361     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-012-9570-y     Document Type: Article

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