Simultaneous intracellular calcium and sodium flux imaging in human vanilloid receptor 1 (VR1)-transfected human embryonic kidney cells: A method to resolve ionic dependence of VR1-mediated cell death

Journal of Pharmacology and Experimental Therapeutics

Volumn 300, Issue 1, 2002, Pages 9-17

  Grant, Elfrida R ^a,b   Dubin, Adrienne E ^a   Zhang, Sui Po ^a   Zivin, Robert A ^a   Zhong, Zhong ^a,c  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b PURDUE PHARMA L P   (United States)

^c Cell and Molecular Technologies   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CAPSAICIN; CAPSAZEPINE; CATION CHANNEL; PROPIDIUM IODIDE; RESINIFERATOXIN; RUTHENIUM; SODIUM ION; VANILLOID RECEPTOR;

ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; KIDNEY CELL; NOCICEPTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY; SODIUM CELL LEVEL; SODIUM TRANSPORT;

BENZOFURANS; CALCIUM; CAPSAICIN; CELL DEATH; CELL LINE; CELLS, CULTURED; CLONING, MOLECULAR; DITERPENES; ETHERS, CYCLIC; FLUORESCENT DYES; FURA-2; HUMANS; HYDROGEN-ION CONCENTRATION; KIDNEY; NEUROTOXINS; REACTIVE OXYGEN SPECIES; RECEPTORS, DRUG; SODIUM; TRANSFECTION;

EID: 0036138248     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.300.1.9     Document Type: Article

References (40)

1. Capsazepine: A competitive antagonist of the sensory neuron excitant capsaicin
2. Impaired nociception and pain sensation in mice lacking the capsaicin receptor
3. The capsaicin receptor: A heat-activated ion channel in the pain pathway
4. Ion channels gated by heat
5. Ionic dependence of glutamate neurotexicity
6. The receptive part of the primary afferent axon is most vulnerable to systemic capsaicin in adult rats
7. Ureteral axon damage following subcutaneous administration of capsaicin in adult rats
8. Protein and cDNA sequences encoding a human vanilloid receptor (VR1) and their applications in drug screening assays and treatment of diseases
9. Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties
10. N-Methyl-D-aspartate receptors expressed in a non-neuronal cell line mediate subunit-specific increases in free intracellular calcium
11. 2+ indicators with greatly improved fluorescence properties
12. Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
13. Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons
14. Degeneration of axons in the ureteric and duodenal nerve plexuses of the adult rat following in vivo treatment with capsaicin
15. +
16. Pathobiological reactions of C-fibre primary sensory neurones to peripheral nerve injury
17. Neurotoxin induced nerve cell degeneration: Possible involvement of calcium
18. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons
19. Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat
20. Appearance of histochemically detectable ionic calcium in degenerating primary sensory neurons
21. Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology
22. Capsaicin, protons and heat: New excitement about nociceptors
23. Collateral sprouting of uninjured primary afferent A-fibers into the superficial dorsal horn of the adult rat spinal cord after topical capsaicin treatment to the sciatic nerve
24. Excitotoxic cell death and delayed rescue in human neurons derived from NT2 cells
25. Glutamate receptor ion channel properties predict vulnerability to cytotoxicity in a transfected nonneuronal cell line
26. Treatment of intractable pain with topical large-dose capsaicin: Preliminary report
27. Topical analgesic agents
28. Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice
29. The endogenous lipid anadamide is a full agonist at the human vanilloid receptor (hVR1)
30. 3H]Resiniferatoxin binding by the vanilloid receptor: Species-related differences, effects of temperature and sulfhydryl reagents
31. Vanilloid receptors: New insights enhance potential as a therapeutic target
32. Vanilloid (capsaicin) receptors and mechanisms
33. The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons
34. Actions of capsaicin on sensory receptors
35. Capsaicin-sensitive sensory nerve terminals with local and systemic efferent functions: Facts and scopes of an unorthodox neuroregulatery mechanism
36. Resiniferatoxin: An ultrapotent neurotoxin of capsaicin-sensitive primary afferent neurons
37. The cloned capsaicin receptor integrates multiple pain-producing stimuli
38. Assessment of neuronal viability with alamar blue in cortical and granule cell cultures
39. Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture
40. NMDA receptor-mediated K+ efflux and neuronal apoptosis