메뉴 건너뛰기




Volumn 125, Issue 7, 2013, Pages 329-340

α-Lipoic acid enhances endogenous peroxisome-proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis in mice

Author keywords

lipoic acid; Experimental autoimmune encephalomyelitis; Immunomodulation; Multipl sclerosis; Proliferator activated receptor ; Regulatory T cell

Indexed keywords

ALPHA THIOCTIC ACID; HEME OXYGENASE 1; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; THIOCTIC ACID; UNCLASSIFIED DRUG;

EID: 84880105696     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20120560     Document Type: Article
Times cited : (52)

References (51)
  • 2
    • 33745321276 scopus 로고    scopus 로고
    • IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    • Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., Sudo, K. and Iwakura, Y. (2006) IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177, 566-573
    • (2006) J. Immunol. , vol.177 , pp. 566-573
    • Komiyama, Y.1    Nakae, S.2    Matsuki, T.3    Nambu, A.4    Ishigame, H.5    Kakuta, S.6    Sudo, K.7    Iwakura, Y.8
  • 3
    • 34548133584 scopus 로고    scopus 로고
    • Multiple sclerosis: a complicated picture of autoimmunity
    • McFarland, H. F. and Martin, R. (2007) Multiple sclerosis: a complicated picture of autoimmunity. Nat. Immunol. 8, 913-919
    • (2007) Nat. Immunol. , vol.8 , pp. 913-919
    • McFarland, H.F.1    Martin, R.2
  • 7
    • 36448981390 scopus 로고    scopus 로고
    • Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology
    • Schreibelt, G., van Horssen, J., van Rossum, S., Dijkstra, C. D., Drukarch, B. and de Vries, H. E. (2007) Therapeutic potential and biological role of endogenous antioxidant enzymes in multiple sclerosis pathology. Brain Res. Rev. 56, 322-330
    • (2007) Brain Res. Rev. , vol.56 , pp. 322-330
    • Schreibelt, G.1    van Horssen, J.2    van Rossum, S.3    Dijkstra, C.D.4    Drukarch, B.5    de Vries, H.E.6
  • 8
    • 0037491616 scopus 로고    scopus 로고
    • Caspasemediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination
    • Hisahara, S., Okano, H. and Miura, M. (2003) Caspasemediated oligodendrocyte cell death in the pathogenesis of autoimmune demyelination. Neurosci. Res. 46, 387-397
    • (2003) Neurosci. Res. , vol.46 , pp. 387-397
    • Hisahara, S.1    Okano, H.2    Miura, M.3
  • 10
    • 0242661909 scopus 로고    scopus 로고
    • a-Lipoic acid and cardiovascular disease
    • Wollin, S. D. and Jones, P. J. (2003) a-Lipoic acid and cardiovascular disease. J. Nutr. 133, 3327-3330
    • (2003) J. Nutr. , vol.133 , pp. 3327-3330
    • Wollin, S.D.1    Jones, P.J.2
  • 12
    • 70350459594 scopus 로고    scopus 로고
    • The nuclear receptor PPAR γ selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
    • Klotz, L., Burgdorf, S., Dani, I., Saijo, K., Flossdorf, J, Hucke, S., Alferink, J., Nowak, N., Beyer, M., Mayer, G. et al. (2009) The nuclear receptor PPAR γ selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity. J. Exp. Med. 206, 2079-2089
    • (2009) J. Exp. Med. , vol.206 , pp. 2079-2089
    • Klotz, L.1    Burgdorf, S.2    Dani, I.3    Saijo, K.4    Flossdorf, J.5    Hucke, S.6    Alferink, J.7    Nowak, N.8    Beyer, M.9    Mayer, G.10
  • 13
    • 33847403883 scopus 로고    scopus 로고
    • Peroxisomeproliferator- activated receptor γ is required for regulatory CD4+ T cell-mediated protection against colitis
    • Hontecillas, R. and Bassaganya-Riera, J. (2007) Peroxisomeproliferator- activated receptor γ is required for regulatory CD4+ T cell-mediated protection against colitis. J. Immunol. 178, 2940-2949
    • (2007) J. Immunol. , vol.178 , pp. 2940-2949
    • Hontecillas, R.1    Bassaganya-Riera, J.2
  • 14
    • 70450223896 scopus 로고    scopus 로고
    • Decoy receptor 3 ameliorates experimental autoimmune encephalomyelitis by directly counteracting local inflammation and downregulating Th17 cells
    • Chen, S. J., Wang, Y. L., Kao, J. H., Wu, S. F., Lo, W. T., Wu, C. C., Tao, P. L., Wang, C. C., Chang, D. M. and Sytwu, H. K. (2009) Decoy receptor 3 ameliorates experimental autoimmune encephalomyelitis by directly counteracting local inflammation and downregulating Th17 cells. Mol. Immunol. 47, 567-574
    • (2009) Mol. Immunol. , vol.47 , pp. 567-574
    • Chen, S.J.1    Wang, Y.L.2    Kao, J.H.3    Wu, S.F.4    Lo, W.T.5    Wu, C.C.6    Tao, P.L.7    Wang, C.C.8    Chang, D.M.9    Sytwu, H.K.10
  • 16
    • 0036790853 scopus 로고    scopus 로고
    • a-Lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis
    • Marracci, G. H., Jones, R. E., McKeon, G. P. and Bourdette, D. N. (2002) a-Lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis. J. Neuroimmunol. 131, 104-114
    • (2002) J. Neuroimmunol. , vol.131 , pp. 104-114
    • Marracci, G.H.1    Jones, R.E.2    McKeon, G.P.3    Bourdette, D.N.4
  • 18
    • 33646050051 scopus 로고    scopus 로고
    • IL-4-induced peroxisome-proliferator-activated receptor gamma activation inhibits NF-γB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: implication for CNS-demyelinating diseases
    • Paintlia, A. S., Paintlia, M. K., Singh, I. and Singh, A. K. (2006) IL-4-induced peroxisome-proliferator-activated receptor gamma activation inhibits NF-γB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: implication for CNS-demyelinating diseases. J. Immunol. 176, 4385-4398
    • (2006) J. Immunol. , vol.176 , pp. 4385-4398
    • Paintlia, A.S.1    Paintlia, M.K.2    Singh, I.3    Singh, A.K.4
  • 19
    • 0035341427 scopus 로고    scopus 로고
    • Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome-proliferator-activated receptor-γ
    • Niino, M., Iwabuchi, K., Kikuchi, S., Ato, M., Morohashi, T., Ogata, A., Tashiro, K. and Onoe, K. (2001) Amelioration of experimental autoimmune encephalomyelitis in C57BL/6 mice by an agonist of peroxisome-proliferator-activated receptor-γ . J. Neuroimmunol. 116, 40-48
    • (2001) J. Neuroimmunol. , vol.116 , pp. 40-48
    • Niino, M.1    Iwabuchi, K.2    Kikuchi, S.3    Ato, M.4    Morohashi, T.5    Ogata, A.6    Tashiro, K.7    Onoe, K.8
  • 20
    • 73449102477 scopus 로고    scopus 로고
    • Modeling multiple sclerosis in laboratory animals
    • Schreiner, B., Heppner, F. L. and Becher, B. (2009) Modeling multiple sclerosis in laboratory animals. Semin. Immunopathol. 31, 479-495
    • (2009) Semin. Immunopathol. , vol.31 , pp. 479-495
    • Schreiner, B.1    Heppner, F.L.2    Becher, B.3
  • 21
    • 0041976916 scopus 로고    scopus 로고
    • a-Lipoic acid decreases thiol reactivity of the insulin receptor and protein tyrosine phosphatase 1B in 3T3-L1 adipocytes
    • Cho, K. J., Moini, H., Shon, H. K., Chung, A. S. and Packer, L. (2003) a-Lipoic acid decreases thiol reactivity of the insulin receptor and protein tyrosine phosphatase 1B in 3T3-L1 adipocytes. Biochem. Pharmacol. 66, 849-858
    • (2003) Biochem. Pharmacol. , vol.66 , pp. 849-858
    • Cho, K.J.1    Moini, H.2    Shon, H.K.3    Chung, A.S.4    Packer, L.5
  • 22
    • 0034773628 scopus 로고    scopus 로고
    • Molecular aspects of lipoic acid in the prevention of diabetes complications
    • Packer, L., Kraemer, K. and Rimbach, G. (2001) Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition 17, 888-895
    • (2001) Nutrition , vol.17 , pp. 888-895
    • Packer, L.1    Kraemer, K.2    Rimbach, G.3
  • 23
    • 33645376729 scopus 로고    scopus 로고
    • Modulation of cardiac and aortic peroxisome-proliferatoractivated receptor-γ expression by oxidative stress in chronically glucose-fed rats
    • El Midaoui, A., Wu, L., Wang, R. and de Champlain, J. (2006) Modulation of cardiac and aortic peroxisome-proliferatoractivated receptor-γ expression by oxidative stress in chronically glucose-fed rats. Am. J. Hypertens. 19, 407-412
    • (2006) Am. J. Hypertens. , vol.19 , pp. 407-412
    • El Midaoui, A.1    Wu, L.2    Wang, R.3    de Champlain, J.4
  • 24
    • 0036182681 scopus 로고    scopus 로고
    • Prevention of hypertension, insulin resistance, and oxidative stress by a-lipoic acid
    • El Midaoui, A. and de Champlain, J. (2002) Prevention of hypertension, insulin resistance, and oxidative stress by a-lipoic acid. Hypertension 39, 303-307
    • (2002) Hypertension , vol.39 , pp. 303-307
    • El Midaoui, A.1    de Champlain, J.2
  • 25
    • 0033080764 scopus 로고    scopus 로고
    • a-Lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve
    • Mitsui, Y., Schmelzer, J. D., Zollman, P. J., Mitsui, M., Tritschler, H. J. and Low, P. A. (1999) a-Lipoic acid provides neuroprotection from ischemia-reperfusion injury of peripheral nerve. J. Neurol. Sci. 163, 11-16
    • (1999) J. Neurol. Sci. , vol.163 , pp. 11-16
    • Mitsui, Y.1    Schmelzer, J.D.2    Zollman, P.J.3    Mitsui, M.4    Tritschler, H.J.5    Low, P.A.6
  • 26
    • 0032788081 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic polyneuropathy with the antioxidant a-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study).ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy
    • Ziegler, D., Hanefeld, M., Ruhnau, K. J., Hasche, H., Lobisch, M., Schutte, K., Kerum, G. and Malessa, R. (1999) Treatment of symptomatic diabetic polyneuropathy with the antioxidant a-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III Study). ALADIN III Study Group. Alpha-Lipoic Acid in Diabetic Neuropathy. Diabetes Care 22, 1296-1301
    • (1999) Diabetes Care , vol.22 , pp. 1296-1301
    • Ziegler, D.1    Hanefeld, M.2    Ruhnau, K.J.3    Hasche, H.4    Lobisch, M.5    Schutte, K.6    Kerum, G.7    Malessa, R.8
  • 28
    • 1242337352 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic polyneuropathy with the antioxidant a-lipoic acid: a meta-analysis
    • Ziegler, D., Nowak, H., Kempler, P., Vargha, P. and Low, P. A. (2004) Treatment of symptomatic diabetic polyneuropathy with the antioxidant a-lipoic acid: a meta-analysis. Diabetic Med. 21, 114-121
    • (2004) Diabetic Med. , vol.21 , pp. 114-121
    • Ziegler, D.1    Nowak, H.2    Kempler, P.3    Vargha, P.4    Low, P.A.5
  • 29
    • 38449099641 scopus 로고    scopus 로고
    • a-Lipoic acid as a new treatment option for Alzheimer's disease - a 48 months follow-up analysis
    • Hager, K., Kenklies, M., McAfoose, J., Engel, J. and Munch, G. (2007) a-Lipoic acid as a new treatment option for Alzheimer's disease - a 48 months follow-up analysis. J. Neural Transm. Suppl. 189-193
    • (2007) J. Neural Transm. Suppl. , pp. 189-193
    • Hager, K.1    Kenklies, M.2    McAfoose, J.3    Engel, J.4    Munch, G.5
  • 32
    • 33746274081 scopus 로고    scopus 로고
    • Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis
    • Chaudhary, P., Marracci, G. H. and Bourdette, D. N. (2006) Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis. J. Neuroimmunol. 175, 87-96
    • (2006) J. Neuroimmunol. , vol.175 , pp. 87-96
    • Chaudhary, P.1    Marracci, G.H.2    Bourdette, D.N.3
  • 33
    • 59049099828 scopus 로고    scopus 로고
    • A cannabinoid agonist interferes with the progression of a chronic model of multiple sclerosis by downregulating adhesion molecules
    • Mestre, L., Docagne, F., Correa, F., Loria, F., Hernangomez, M., Borrell, J. and Guaza, C. (2009) A cannabinoid agonist interferes with the progression of a chronic model of multiple sclerosis by downregulating adhesion molecules. Mol. Cell. Neurosci. 40, 258-266
    • (2009) Mol. Cell. Neurosci. , vol.40 , pp. 258-266
    • Mestre, L.1    Docagne, F.2    Correa, F.3    Loria, F.4    Hernangomez, M.5    Borrell, J.6    Guaza, C.7
  • 34
    • 79953890808 scopus 로고    scopus 로고
    • Inhibitory effect of a-lipoic acid on platelet aggregation is mediated by PPARs
    • Chou, T. C., Shih, C. Y. and Chen, Y. T. (2011) Inhibitory effect of a-lipoic acid on platelet aggregation is mediated by PPARs. J. Agric. Food Chem. 59, 3050-3059
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 3050-3059
    • Chou, T.C.1    Shih, C.Y.2    Chen, Y.T.3
  • 35
    • 0036499074 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor-γ agonist 15-deoxy-(12,14)-prostaglandin J2 ameliorates experimental autoimmune encephalomyelitis
    • Diab, A., Deng, C., Smith, J. D., Hussain, R. Z., Phanavanh, B., Lovett-Racke, A. E., Drew, P. D. and Racke, M. K. (2002) Peroxisome-proliferator-activated receptor-γ agonist 15-deoxy-(12,14)-prostaglandin J2 ameliorates experimental autoimmune encephalomyelitis. J. Immunol. 168, 2508-2515
    • (2002) J. Immunol. , vol.168 , pp. 2508-2515
    • Diab, A.1    Deng, C.2    Smith, J.D.3    Hussain, R.Z.4    Phanavanh, B.5    Lovett-Racke, A.E.6    Drew, P.D.7    Racke, M.K.8
  • 37
    • 14844282813 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor-γ agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis
    • Storer, P. D., Xu, J., Chavis, J. and Drew, P. D. (2005) Peroxisome-proliferator-activated receptor-γ agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosis. J. Neuroimmunol. 161, 113-122
    • (2005) J. Neuroimmunol. , vol.161 , pp. 113-122
    • Storer, P.D.1    Xu, J.2    Chavis, J.3    Drew, P.D.4
  • 38
    • 0032847680 scopus 로고    scopus 로고
    • Peroxisome-proliferatoractivated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction
    • Jackson, S. M., Parhami, F., Xi, X. P., Berliner, J. A, Hsueh, W. A., Law, R. E. and Demer, L. L. (1999) Peroxisome-proliferatoractivated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. Arterioscler. Thromb. Vasc. Biol. 19, 2094-2104
    • (1999) Arterioscler. Thromb. Vasc. Biol. , vol.19 , pp. 2094-2104
    • Jackson, S.M.1    Parhami, F.2    Xi, X.P.3    Berliner, J.A.4    Hsueh, W.A.5    Law, R.E.6    Demer, L.L.7
  • 39
    • 56449084136 scopus 로고    scopus 로고
    • Association of the PPARγ gene polymorphism Pro12Ala with delayed onset of multiple sclerosis
    • Klotz, L., Schmidt, S., Heun, R., Klockgether, T. and Kolsch, H. (2009) Association of the PPARγ gene polymorphism Pro12Ala with delayed onset of multiple sclerosis. Neurosci. Lett. 449, 81-83
    • (2009) Neurosci. Lett. , vol.449 , pp. 81-83
    • Klotz, L.1    Schmidt, S.2    Heun, R.3    Klockgether, T.4    Kolsch, H.5
  • 40
    • 0344153921 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor-γ - deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis
    • Natarajan, C., Muthian, G., Barak, Y., Evans, R. M. and Bright, J. J. (2003) Peroxisome-proliferator-activated receptor-γ - deficient heterozygous mice develop an exacerbated neural antigen-induced Th1 response and experimental allergic encephalomyelitis. J. Immunol. 171, 5743-5750
    • (2003) J. Immunol. , vol.171 , pp. 5743-5750
    • Natarajan, C.1    Muthian, G.2    Barak, Y.3    Evans, R.M.4    Bright, J.J.5
  • 41
    • 26244450392 scopus 로고    scopus 로고
    • a-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells
    • Ogborne, R. M., Rushworth, S. A. and O'Connell, M. A. (2005) a-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells. Arterioscler. Thromb. Vasc. Biol. 25, 2100-2105
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 2100-2105
    • Ogborne, R.M.1    Rushworth, S.A.2    O'Connell, M.A.3
  • 42
    • 78649284975 scopus 로고    scopus 로고
    • Erythropoietin enhances endogenous haem oxygenase-1 and represses immune responses to ameliorate experimental autoimmune encephalomyelitis
    • Chen, S. J., Wang, Y. L., Lo, W. T., Wu, C. C., Hsieh, C. W., Huang, C. F., Lan, Y. H., Wang, C. C., Chang, D. M. and Sytwu, H. K. (2010) Erythropoietin enhances endogenous haem oxygenase-1 and represses immune responses to ameliorate experimental autoimmune encephalomyelitis. Clin. Exp. Immunol. 162, 210-223
    • (2010) Clin. Exp. Immunol. , vol.162 , pp. 210-223
    • Chen, S.J.1    Wang, Y.L.2    Lo, W.T.3    Wu, C.C.4    Hsieh, C.W.5    Huang, C.F.6    Lan, Y.H.7    Wang, C.C.8    Chang, D.M.9    Sytwu, H.K.10
  • 43
    • 0034625485 scopus 로고    scopus 로고
    • Cyclopentenone prostaglandin 15-deoxy-(12,14)-prostaglandin J2 acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells
    • Koppal, T., Petrova, T. V. and Van Eldik, L. J. (2000) Cyclopentenone prostaglandin 15-deoxy-(12,14)-prostaglandin J2 acts as a general inhibitor of inflammatory responses in activated BV-2 microglial cells. Brain Res. 867, 115-121
    • (2000) Brain Res. , vol.867 , pp. 115-121
    • Koppal, T.1    Petrova, T.V.2    Van Eldik, L.J.3
  • 44
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L. and Kuchroo, V. K. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235-238
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 45
    • 56149125346 scopus 로고    scopus 로고
    • Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis
    • O'Connor, R. A., Prendergast, C. T., Sabatos, C. A., Lau, C. W., Leech, M. D., Wraith, D. C. and Anderton, S. M. (2008) Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J. Immunol. 181, 3750-3754
    • (2008) J. Immunol. , vol.181 , pp. 3750-3754
    • O'Connor, R.A.1    Prendergast, C.T.2    Sabatos, C.A.3    Lau, C.W.4    Leech, M.D.5    Wraith, D.C.6    Anderton, S.M.7
  • 46
    • 35148835215 scopus 로고    scopus 로고
    • CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    • Ponomarev, E. D., Maresz, K., Tan, Y. and Dittel, B. N. (2007) CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J. Neurosci. 27, 10714-10721
    • (2007) J. Neurosci. , vol.27 , pp. 10714-10721
    • Ponomarev, E.D.1    Maresz, K.2    Tan, Y.3    Dittel, B.N.4
  • 47
    • 0032525044 scopus 로고    scopus 로고
    • A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice
    • Falcone, M., Rajan, A. J., Bloom, B. R. and Brosnan, C. F. (1998) A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice. J. Immunol. 160, 4822-4830
    • (1998) J. Immunol. , vol.160 , pp. 4822-4830
    • Falcone, M.1    Rajan, A.J.2    Bloom, B.R.3    Brosnan, C.F.4
  • 48
    • 0036838536 scopus 로고    scopus 로고
    • Cutting edge: CD4+ CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
    • Kohm, A. P., Carpentier, P. A., Anger, H. A. and Miller, S. D. (2002) Cutting edge: CD4+ CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J. Immunol. 169, 4712-4716
    • (2002) J. Immunol. , vol.169 , pp. 4712-4716
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 49
    • 65449122461 scopus 로고    scopus 로고
    • Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg
    • Stephens, L. A., Malpass, K. H. and Anderton, S. M. (2009) Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg. Eur. J. Immunol. 39, 1108-1117
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1108-1117
    • Stephens, L.A.1    Malpass, K.H.2    Anderton, S.M.3
  • 50
    • 77955343205 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor d limits the expansion of pathogenic Th cells during central nervous system autoimmunity
    • Dunn, S. E., Bhat, R., Straus, D. S., Sobel, R. A., Axtell, R., Johnson, A., Nguyen, K., Mukundan, L., Moshkova, M., Dugas, J. C. et al. (2010) Peroxisome-proliferator-activated receptor d limits the expansion of pathogenic Th cells during central nervous system autoimmunity. J. Exp. Med. 207, 1599-1608
    • (2010) J. Exp. Med. , vol.207 , pp. 1599-1608
    • Dunn, S.E.1    Bhat, R.2    Straus, D.S.3    Sobel, R.A.4    Axtell, R.5    Johnson, A.6    Nguyen, K.7    Mukundan, L.8    Moshkova, M.9    Dugas, J.C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.