Inhibitory effect of α-Lipoic acid on platelet aggregation is mediated by PPARs

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 7, 2011, Pages 3050-3059

  Chou, Tz Chong ^a   Shih, Ching Yu ^a   Chen, Ying Tsung ^b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TUNGS' TAICHUNG METROHARBOR HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PLATELETS; ANTI-PLATELET ACTIVITIES; ARACHIDONIC ACIDS; CYCLOOXYGENASES; DEPENDENT PROCESS; INHIBITION OF PLATELET AGGREGATION; INHIBITORY EFFECT; INTRACELLULAR CA; ISOFORMS; LIPOIC ACIDS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PLATELET AGGREGATION; PROTEIN KINASE C;

CYTOLOGY;

PLATELETS;

ANTIOXIDANT; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; CYCLIC AMP; CYCLOOXYGENASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE C ALPHA; THIOCTIC ACID;

ANIMAL; BLOOD; CONFERENCE PAPER; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; RABBIT; THROMBOCYTE; THROMBOCYTE AGGREGATION;

ANIMALS; ANTIOXIDANTS; ARACHIDONIC ACID; BLOOD PLATELETS; CYCLIC AMP; CYCLOOXYGENASE 1; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PPAR ALPHA; PPAR GAMMA; PROTEIN KINASE C-ALPHA; RABBITS; THIOCTIC ACID;

ORYCTOLAGUS CUNICULUS;

EID: 79953890808     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf103940u     Document Type: Article

References (40)

1. Spinelli, S. L.; O'Brien, J. J.; Bancos, S.; Lehmann, G. M.; Springer, D. L.; Blumberg, N.; Francis, C. W.; Taubman, M. B.; Phipps, R. P. The PPAR-platelet connection: modulators of inflammation and potential cardiovascular effects PPAR Res. 2008, 328172
2. Smith, T.; Dhunnoo, G.; Mohan, I.; Charlton-Menys, V. A pilot study showing an association between platelet hyperactivity and the severity of peripheral arterial disease Platelets. 2007, 18, 245-248 (Pubitemid 46854819)
3. Tan, K. T.; Lip, G. Y. The potential role of platelet microparticles in atherosclerosis Thromb Haemost. 2005, 94, 488-492 (Pubitemid 41300840)
4. Willoughby, S.; Holmes, A.; Loscalzo, J. Platelets and cardiovascular disease Eur. J. Cardiovasc. Nurs. 2002, 1, 273-288 (Pubitemid 36857068)
5. Jennings, L. K. Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis Thromb. Haemost. 2009, 102, 248-257
6. Hamblin, M.; Chang, L.; Fan, Y.; Zhang, J.; Chen, Y. E. PPARs and the cardiovascular system Antioxid. Redox Signal. 2009, 11, 1415-1452
7. Duez, H.; Fruchart, J. C.; Staels, B. PPARS in inflammation, atherosclerosis and thrombosis J. Cardiovasc. Risk 2001, 8, 187-194 (Pubitemid 32803672)
8. Hegele, R. A. Retinoid X receptor heterodimers in the metabolic syndrome N. Engl. J. Med. 2005, 353, 2088-2088
9. Ali, F. Y.; Davidson, S. J.; Moraes, L. A.; Traves, S. L.; Paul-Clark, M.; Bishop-Bailey, D.; Warner, T. D.; Mitchell, J. A. Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARβ FASEB J. 2006, 20, 326-328 (Pubitemid 46671159)
10. Ali, F. Y.; Armstrong, P. C.; Dhanji, A. R.; Tucker, A. T.; Paul-Clark, M. J.; Mitchell, J. A.; Warner, T. D. Antiplatelet actions of statins and fibrates are mediated by PPARs Arterioscler. Thromb. Vasc. Biol. 2009, 29, 706-711
11. Moini, H.; Packer, L.; Saris, N. E. Antioxidant and prooxidant activities of α-lipoic acid and dihydrolipoic acid Toxicol. Appl. Pharmacol. 2002, 182, 84-90 (Pubitemid 34775480)
12. Smith, A. R.; Shenvi, S. V.; Widlansky, M.; Suh, J. H.; Hagen, T. M. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress Curr. Med. Chem. 2004, 11, 1135-1146 (Pubitemid 38585058)
13. Zhang, W. J.; Bird, K. E.; McMillen, T. S.; LeBoeuf, R. C.; Hagen, T. M.; Frei, B. Dietary α-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice Circulation 2008, 117, 421-428
14. Lai, Y. S.; Shih, C. Y.; Huang, Y. F.; Chou, T. C. Antiplatelet activity of α-lipoic acid J. Agric. Food Chem. 2010, 58, 8596-8603
15. Pershadsingh, H. A.; Ho, C. I.; Rajamani, J.; Chittiboyina, A. G.; Deshpande, R.; Kurtz, T. W.; Chan, J. Y.; Avery, M. A.; Benson, S. C. α-Lipoic acid is a weak dual PPARα/γ agonist: an ester derivative with increased PPAR activity J. Appl. Res. 2005, 5, 510-523 (Pubitemid 44713376)
16. Xu, H. E.; Stanley, T. B.; Montana, V. G.; Lambert, M. H.; Shearer, B. G.; Cobb, J. E.; McKee, D. D.; Galardi, C. M.; Plunket, K. D.; Nolte, R. T.; Parks, D. J.; Moore, J. T.; Kliewer, S. A.; Willson, T. M.; Stimmel, J. B. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPAR Nature 2002, 415, 813-817 (Pubitemid 34150506)
17. Shearer, B. G.; Steger, D. J.; Way, J. M.; Stanley, T. B.; Lobe, D. C.; Grillot, D. A.; Iannone, M A.; Lazar, M. A.; Willson, T. M.; Billin, A. N. Identification and characterization of a selective peroxisome proliferator-activated receptor β/δ (NR1C2) antagonist Mol. Endocrinol. 2008, 22, 523-529 (Pubitemid 351185947)
18. Baier, P. C.; Koch, J. M.; Seeck-Hirschner, M.; Ohlmeyer, K.; Wilms, S.; Aldenhoff, J. B.; Hinze-Selch, D. A flow-cytometric method to investigate glutamate-receptor-sensitivity in whole blood platelets-results from healthy controls and patients with schizophrenia J. Psychiatr. Res. 2009, 43, 585-591
19. Ray, D. M.; Spinelli, S. L.; O'Brien, J. J.; Blumberg, N.; Phipps, R. P. Platelets as a novel target for PPARgamma ligands: implications for inflammation, diabetes, and cardiovascular disease BioDrugs 2006, 20, 231-241 (Pubitemid 44050431)
20. Tharakan, B.; Holder-Haynes, J. G.; Hunter, F. A.; Childs, E. W. α-Lipoic acid attenuates microvascular endothelial cell hyperpermeability by inhibiting the intrinsic apoptotic signaling Am. J. Surg. 2008, 195, 174-178
21. Guo, Q.; Tirosh, O.; Packer, L. Inhibitory effect of α-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophages Biochem. Pharmacol. 2001, 61, 547-554 (Pubitemid 32178488)
22. Lee, C. K.; Lee, E. Y.; Kim, Y. G.; Mun, S. H.; Moon, H. B.; Yoo, B. α-Lipoic acid inhibits TNF-α induced NF-κ B activation through blocking of MEKK1-MKK4-IKK signaling cascades Int. Immunopharmacol. 2008, 8, 362-370
23. Ogborne, R. M.; Rushworth, S. A.; O'Connell, M. A. α-Lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells Arterioscler. Thromb. Vasc. Biol. 2005, 25, 2100-2105 (Pubitemid 41416307)
24. Takaishi, N.; Yoshida, K.; Satsu, H.; Shimizu, M. Transepithelial transport of α-lipoic acid across uman intestinal Caco-2 cell monolayers J. Agric. Food Chem. 2007, 55, 5253-5259 (Pubitemid 47056084)
25. Prasad, P. D.; Wang, H.; Kekuda, R.; Fujita, T.; Fei, Y. J.; Devoe., L. D.; Leibach, F H.; Ganapathy, V. Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate J. Biol. Chem. 1998, 273, 7501-7506
26. Moraes, L. A.; Spyridon, M.; Kaiser, W. J.; Jones, C. I.; Sage, T.; Atherton, R. E.; Gibbins, J. M. Non-genomic effects of PPARγ ligands: inhibition of GPVI-stimulated platelet activation J. Thromb. Haemost. 2010, 8, 577-587
27. Schwarz, U. R.; Walter, U.; Eigenthaler, M. Taming platelets with cyclic nucleotides Biochem. Pharmacol. 2001, 62, 1153-1161 (Pubitemid 33055619)
28. Kim, S. P.; Ha, J. M.; Yun, S. J.; Kim, E. K.; Chung, S. W.; Hong, K. W.; Kim, C. D.; Bae, S. S. Transcriptional activation of peroxisome proliferator-activated receptor-γ requires activation of both protein kinase A and Akt during adipocyte differentiation Biochem. Biophys. Res. Commun. 2010, 399, 55-59
29. Simmoteit, R.; Schulzki, H. D.; Palm, D.; Mollner, S.; Pfeuffer, T. Chemical and functional analysis of components of adenylyl cyclase from human platelets treated with phorbolesters FEBS Lett. 1991, 285, 99-103
30. Lazarowski, E. R.; Lapetina, E. G. Activation of platelet phospholipase C by fluoride is inhibited by elevation of cyclic AMP Biochem. Biophys. Res. Commun. 1989, 158, 440-444 (Pubitemid 19053949)
31. Walter, U.; Eigenthaler, M.; Geiger, J.; Reinhard, M. Role of cyclic nucleotide-dependent protein kinases and their common substrate VASP in the regulation of human platelets Adv. Exp. Med. Biol. 1993, 344, 237-249
32. Konopatskaya, O.; Gilio, K.; Harper, M. T.; Zhao, Y.; Cosemans, J. M.; Karim, Z. A.; Whiteheart, S. W.; Molkentin, J. D.; Verkade, P.; Watson, S. P.; Heemskerk, J. W.; Poole, A. W. PKCα regulates platelet granule secretion and thrombus formation in mice J. Clin. Invest. 2009, 119, 399-407
33. Pula, G.; Crosby, D.; Baker, J.; Poole, A. W. Functional interaction of protein kinase Cα with the tyrosine kinases Syk and Src in human platelets J. Biol. Chem. 2005, 280, 7194-7205 (Pubitemid 40341277)
34. Ali, F. Y.; Hall, M. G.; Desvergne, B.; Warner, T. D.; Mitchell, J. A. PPARb/d agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCα Arterioscler. Thromb. Vasc. Biol. 2009, 29, 1871-1873
35. Paumelle, R.; Blanquart, C.; Briand, O.; Barbier, O.; Duhem, C.; Woerly, G.; Percevault, F.; Fruchart, J. C.; Dombrowicz, D.; Glineur, C.; Staels, B. Acute antiinflammatory properties of statins involve peroxisome proliferator-activated receptor-α via inhibition of the protein kinase C signaling pathway Circ. Res. 2006, 98, 361-369
36. Paul, B. Z.; Jin, J.; Kunapuli, S. P. Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and α(2a) receptors J. Biol. Chem. 1999, 274, 29108-29114
37. Ray, D. M.; Spinelli, S. L.; Pollock, S. J.; Murant, T. I.; O'Brien, J. J.; Blumberg, N.; Francis, C. W.; Taubman, M. B.; Phipps, R. P. Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles Thromb. Haemost. 2008, 99, 86-95
38. Schafer, A.; Flierl, U.; Pfortsch, S.; Seydelmann, N.; Micka, J.; Bauersachs, J. The H(2)-receptor antagonist ranitidine interferes with clopidogrel-mediated P2Y(12) inhibition in platelets Pharmacol. Res. 2010, 62, 352-356
39. Salinthone, S.; Schillace, R. V.; Tsang, C.; Regan, J. W.; Bourdette, D. N.; Carr, D. W. Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and-independent mechanisms. J. Nutr. Biochem. 2011, in press.
40. Salinthone, S.; Schillace, R. V.; Marracci, G. H.; Bourdette, D. N.; Carr, D. W. Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN γ synthesis and cellular cytotoxicity in NK cells J. Neuroimmunol. 2008, 199, 46-55