Peroxisome proliferator-activated receptor δ limits the expansion of pathogenic Th cells during central nervous system autoimmunity

Journal of Experimental Medicine

Volumn 207, Issue 8, 2010, Pages 1599-1608

  Dunn, Shannon E ^a,d   Bhat, Roopa ^a   Straus, Daniel S ^c   Sobel, Raymond A ^b   Axtell, Robert ^a   Johnson, Amanda ^a   Nguyen, Kim ^a   Mukundan, Lata ^b   Moshkova, Marina ^d   Dugas, Jason C ^a   Chawla, Ajay ^b   Steinman, Lawrence ^a  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12P35; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR; [4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; GLYCOPROTEIN; HOMEODOMAIN PROTEIN; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); PEPTIDE FRAGMENT; RAG-1 PROTEIN; RETINOID RELATED ORPHAN RECEPTOR GAMMA; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21; THIAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CELL EXPANSION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD; TH1 CELL; TH17 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; C57BL MOUSE; CELL PROLIFERATION; DRUG EFFECTS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENE EXPRESSION; GENETICS; HELPER CELL; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; PERITONEUM MACROPHAGE; TRANSPLANTATION;

ANIMALS; BRAIN; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GENE EXPRESSION; GLYCOPROTEINS; HOMEODOMAIN PROTEINS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKIN-17; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; MYELOID CELLS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PEPTIDE FRAGMENTS; PPAR DELTA; SPINAL CORD; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER; TH1 CELLS; THIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955343205     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20091663     Document Type: Article

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