-
1
-
-
85030490517
-
-
WHO. URL: http://www.who.int/csr/disease/hepatitis/whocdscsrlyo2003/en/ index2.html.
-
-
-
-
2
-
-
80053264773
-
Turning hepatitis C into a real virus
-
Murray CL, Rice CM: Turning hepatitis C into a real virus. Annu Rev Microbiol 2011, 65:307-327.
-
(2011)
Annu Rev Microbiol
, vol.65
, pp. 307-327
-
-
Murray, C.L.1
Rice, C.M.2
-
4
-
-
0034623816
-
Efficient initiation of HCV RNA replication in cell culture
-
Blight KJ, Kolykhalov AA, Rice CM: Efficient initiation of HCV RNA replication in cell culture. Science 2000, 290:1972-1974.
-
(2000)
Science
, vol.290
, pp. 1972-1974
-
-
Blight, K.J.1
Kolykhalov, A.A.2
Rice, C.M.3
-
5
-
-
0345188811
-
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
-
Lohmann V, Korner F, Koch JO, Herian U, Theilmann L, Bartenschlager R: Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999, 285:110-113.
-
(1999)
Science
, vol.285
, pp. 110-113
-
-
Lohmann, V.1
Korner, F.2
Koch, J.O.3
Herian, U.4
Theilmann, L.5
Bartenschlager, R.6
-
6
-
-
0030864915
-
Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA
-
Kolykhalov AA, Agapov EV, Blight KJ, Mihalik K, Feinstone SM, Rice CM: Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA. Science 1997, 277:570-574.
-
(1997)
Science
, vol.277
, pp. 570-574
-
-
Kolykhalov, A.A.1
Agapov, E.V.2
Blight, K.J.3
Mihalik, K.4
Feinstone, S.M.5
Rice, C.M.6
-
7
-
-
23844479936
-
Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication
-
Welbourn S, Green R, Gamache I, Dandache S, Lohmann V, Bartenschlager R, Meerovitch K, Pause A: Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication. J Biol Chem 2005, 280:29604-29611.
-
(2005)
J Biol Chem
, vol.280
, pp. 29604-29611
-
-
Welbourn, S.1
Green, R.2
Gamache, I.3
Dandache, S.4
Lohmann, V.5
Bartenschlager, R.6
Meerovitch, K.7
Pause, A.8
-
8
-
-
34547734952
-
Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
-
Jones CT, Murray CL, Eastman DK, Tassello J, Rice CM: Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J Virol 2007, 81:8374-8383.
-
(2007)
J Virol
, vol.81
, pp. 8374-8383
-
-
Jones, C.T.1
Murray, C.L.2
Eastman, D.K.3
Tassello, J.4
Rice, C.M.5
-
9
-
-
79953905045
-
Nonstructural protein 3-4A: The Swiss army knife of hepatitis C virus
-
Morikawa K, Lange CM, Gouttenoire J, Meylan E, Brass V, Penin F, Moradpour D: Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus. J Viral Hepat 2011, 18:305-315.
-
(2011)
J Viral Hepat
, vol.18
, pp. 305-315
-
-
Morikawa, K.1
Lange, C.M.2
Gouttenoire, J.3
Meylan, E.4
Brass, V.5
Penin, F.6
Moradpour, D.7
-
10
-
-
77954931489
-
Hepatitis C virus non-structural protein 3 (HCV NS3): A multifunctional antiviral target
-
Raney KD, Sharma SD, Moustafa IM, Cameron CE: Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target. J Biol Chem 2010, 285:22725-22731.
-
(2010)
J Biol Chem
, vol.285
, pp. 22725-22731
-
-
Raney, K.D.1
Sharma, S.D.2
Moustafa, I.M.3
Cameron, C.E.4
-
11
-
-
80053144268
-
Single-base pair unwinding and asynchronous RNA release by the hepatitis C virus NS3 helicase
-
Cheng W, Arunajadai SG, Moffitt JR, Tinoco R, Bustamante C: Single-base pair unwinding and asynchronous RNA release by the hepatitis C virus NS3 helicase. Science 2011, 333:1746-1749.
-
(2011)
Science
, vol.333
, pp. 1746-1749
-
-
Cheng, W.1
Arunajadai, S.G.2
Moffitt, J.R.3
Tinoco, R.4
Bustamante, C.5
-
12
-
-
76249111702
-
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
-
Gu M, Rice CM: Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism. Proc Natl Acad Sci U S A 2010, 107:521-528.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 521-528
-
-
Gu, M.1
Rice, C.M.2
-
13
-
-
34547595373
-
Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase
-
Myong S, Bruno MM, Pyle AM, Ha T: Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase. Science 2007, 317:513-516.
-
(2007)
Science
, vol.317
, pp. 513-516
-
-
Myong, S.1
Bruno, M.M.2
Pyle, A.M.3
Ha, T.4
-
14
-
-
78751584740
-
Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV
-
Appleby TC, Anderson R, Fedorova O, Pyle AM, Wang R, Liu X, Brendza KM, Somoza JR: Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV. J Mol Biol 2011, 405:1139-1153.
-
(2011)
J Mol Biol
, vol.405
, pp. 1139-1153
-
-
Appleby, T.C.1
Anderson, R.2
Fedorova, O.3
Pyle, A.M.4
Wang, R.5
Liu, X.6
Brendza, K.M.7
Somoza, J.R.8
-
15
-
-
78651399012
-
The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly
-
Phan T, Kohlway A, Dimberu P, Pyle AM, Lindenbach BD: The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly. J Virol 2011, 85:1193-1204.
-
(2011)
J Virol
, vol.85
, pp. 1193-1204
-
-
Phan, T.1
Kohlway, A.2
Dimberu, P.3
Pyle, A.M.4
Lindenbach, B.D.5
-
16
-
-
77649175920
-
Hepatitis C virus nonstructural protein 4B: A journey into unexplored territory
-
Gouttenoire J, Penin F, Moradpour D: Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory. Rev Med Virol 2010, 20:117-129.
-
(2010)
Rev Med Virol
, vol.20
, pp. 117-129
-
-
Gouttenoire, J.1
Penin, F.2
Moradpour, D.3
-
17
-
-
77957957039
-
Organelle-like membrane compartmentalization of positive-strand RNA virus replication factories
-
den Boon JA, Ahlquist P: Organelle-like membrane compartmentalization of positive-strand RNA virus replication factories. Annu Rev Microbiol 2010, 64:241-256.
-
(2010)
Annu Rev Microbiol
, vol.64
, pp. 241-256
-
-
Den Boon, J.A.1
Ahlquist, P.2
-
19
-
-
0030051777
-
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus
-
Behrens SE, Tomei L, De Francesco R: Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J 1996, 15:12-22.
-
(1996)
EMBO J
, vol.15
, pp. 12-22
-
-
Behrens, S.E.1
Tomei, L.2
De Francesco, R.3
-
20
-
-
16044364658
-
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide
-
Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET et al.: Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell 1996, 87:343-355.
-
(1996)
Cell
, vol.87
, pp. 343-355
-
-
Kim, J.L.1
Morgenstern, K.A.2
Lin, C.3
Fox, T.4
Dwyer, M.D.5
Landro, J.A.6
Chambers, S.P.7
Markland, W.8
Lepre, C.A.9
O'Malley, E.T.10
-
21
-
-
55749102288
-
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex
-
Brass V, Berke JM, Montserret R, Blum HE, Penin F, Moradpour D: Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex. Proc Natl Acad Sci U S A 2008, 105:14545-14550.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 14545-14550
-
-
Brass, V.1
Berke, J.M.2
Montserret, R.3
Blum, H.E.4
Penin, F.5
Moradpour, D.6
-
22
-
-
84864602817
-
The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors
-
Romano KP, Ali A, Aydin C, Soumana D, Ozen A, Deveau LM, Silver C, Cao H, Newton A, Petropoulos CJ et al.: The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors. PLoS Pathog 2012, 8:e1002832.
-
(2012)
PLoS Pathog
, vol.8
-
-
Romano, K.P.1
Ali, A.2
Aydin, C.3
Soumana, D.4
Ozen, A.5
Deveau, L.M.6
Silver, C.7
Cao, H.8
Newton, A.9
Petropoulos, C.J.10
-
23
-
-
77950178001
-
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: A change in direction in the search for a second generation HCV NS3 protease inhibitor
-
Bennett F, Huang Y, Hendrata S, Lovey R, Bogen SL, Pan W, Guo Z, Prongay A, Chen KX, Arasappan A et al.: The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor. Bioorg Med Chem Lett 2010, 20:2617-2621.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 2617-2621
-
-
Bennett, F.1
Huang, Y.2
Hendrata, S.3
Lovey, R.4
Bogen, S.L.5
Pan, W.6
Guo, Z.7
Prongay, A.8
Chen, K.X.9
Arasappan, A.10
-
24
-
-
21644463166
-
Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase
-
Zhang C, Cai Z, Kim YC, Kumar R, Yuan F, Shi PY, Kao C, Luo G: Stimulation of hepatitis C virus (HCV) nonstructural protein 3 (NS3) helicase activity by the NS3 protease domain and by HCV RNA-dependent RNA polymerase. J Virol 2005, 79:8687-8697.
-
(2005)
J Virol
, vol.79
, pp. 8687-8697
-
-
Zhang, C.1
Cai, Z.2
Kim, Y.C.3
Kumar, R.4
Yuan, F.5
Shi, P.Y.6
Kao, C.7
Luo, G.8
-
25
-
-
57649217269
-
Hepatitis C viral NS3-4A protease activity is enhanced by the NS3 helicase
-
Beran RK, Pyle AM: Hepatitis C viral NS3-4A protease activity is enhanced by the NS3 helicase. J Biol Chem 2008, 283:29929-29937.
-
(2008)
J Biol Chem
, vol.283
, pp. 29929-29937
-
-
Beran, R.K.1
Pyle, A.M.2
-
26
-
-
36849075152
-
The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate
-
Beran RK, Serebrov V, Pyle AM: The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate. J Biol Chem 2007, 282:34913-34920.
-
(2007)
J Biol Chem
, vol.282
, pp. 34913-34920
-
-
Beran, R.K.1
Serebrov, V.2
Pyle, A.M.3
-
27
-
-
0346463036
-
The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently
-
Frick DN, Rypma RS, Lam AM, Gu B: The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently. J Biol Chem 2004, 279:1269-1280.
-
(2004)
J Biol Chem
, vol.279
, pp. 1269-1280
-
-
Frick, D.N.1
Rypma, R.S.2
Lam, A.M.3
Gu, B.4
-
28
-
-
0033571623
-
Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase
-
Yao N, Reichert P, Taremi SS, Prosise WW, Weber PC: Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase. Structure 1999, 7:1353-1363.
-
(1999)
Structure
, vol.7
, pp. 1353-1363
-
-
Yao, N.1
Reichert, P.2
Taremi, S.S.3
Prosise, W.W.4
Weber, P.C.5
-
29
-
-
65349178926
-
Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein
-
Hara H, Aizaki H, Matsuda M, Shinkai-Ouchi F, Inoue Y, Murakami K, Shoji I, Kawakami H, Matsuura Y, Lai MM et al.: Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein. J Virol 2009, 83:5137-5147.
-
(2009)
J Virol
, vol.83
, pp. 5137-5147
-
-
Hara, H.1
Aizaki, H.2
Matsuda, M.3
Shinkai-Ouchi, F.4
Inoue, Y.5
Murakami, K.6
Shoji, I.7
Kawakami, H.8
Matsuura, Y.9
Lai, M.M.10
-
30
-
-
34548188701
-
The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication
-
Lindenbach BD, Prágai BM, Montserret R, Beran RK, Pyle AM, Penin F, Rice CM: The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication. J Virol 2007, 81:8905-8918.
-
(2007)
J Virol
, vol.81
, pp. 8905-8918
-
-
Lindenbach, B.D.1
Prágai, B.M.2
Montserret, R.3
Beran, R.K.4
Pyle, A.M.5
Penin, F.6
Rice, C.M.7
-
31
-
-
80052056964
-
Conserved GXXXGand S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication
-
Han Q, Aligo J, Manna D, Belton K, Chintapalli SV, Hong Y, Patterson RL, van Rossum DB, Konan KV: Conserved GXXXGand S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication. J Virol 2011, 85:6464-6479.
-
(2011)
J Virol
, vol.85
, pp. 6464-6479
-
-
Han, Q.1
Aligo, J.2
Manna, D.3
Belton, K.4
Chintapalli, S.V.5
Hong, Y.6
Patterson, R.L.7
Van Rossum, D.B.8
Konan, K.V.9
-
32
-
-
4644222500
-
A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication
-
Einav S, Elazar M, Danieli T, Glenn JS: A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication. J Virol 2004, 78:11288-11295.
-
(2004)
J Virol
, vol.78
, pp. 11288-11295
-
-
Einav, S.1
Elazar, M.2
Danieli, T.3
Glenn, J.S.4
-
33
-
-
61449111949
-
Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: Evidence for ATP/GTP hydrolysis and adenylate kinase activity
-
Thompson AA, Zou A, Yan J, Duggal R, Hao W, Molina D, Cronin CN, Wells PA: Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity. Biochemistry 2009, 48:906-916.
-
(2009)
Biochemistry
, vol.48
, pp. 906-916
-
-
Thompson, A.A.1
Zou, A.2
Yan, J.3
Duggal, R.4
Hao, W.5
Molina, D.6
Cronin, C.N.7
Wells, P.A.8
-
34
-
-
0037369066
-
Viral and cellular determinants of hepatitis C virus RNA replication in cell culture
-
Lohmann V, Hoffmann S, Herian U, Penin F, Bartenschlager R: Viral and cellular determinants of hepatitis C virus RNA replication in cell culture. J Virol 2003, 77:3007-3019.
-
(2003)
J Virol
, vol.77
, pp. 3007-3019
-
-
Lohmann, V.1
Hoffmann, S.2
Herian, U.3
Penin, F.4
Bartenschlager, R.5
-
35
-
-
66149132203
-
Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B
-
Gouttenoire J, Castet V, Montserret R, Arora N, Raussens V, Ruysschaert JM, Diesis E, Blum HE, Penin F, Moradpour D: Identification of a novel determinant for membrane association in hepatitis C virus nonstructural protein 4B. J Virol 2009, 83:6257-6268.
-
(2009)
J Virol
, vol.83
, pp. 6257-6268
-
-
Gouttenoire, J.1
Castet, V.2
Montserret, R.3
Arora, N.4
Raussens, V.5
Ruysschaert, J.M.6
Diesis, E.7
Blum, H.E.8
Penin, F.9
Moradpour, D.10
-
36
-
-
70350330475
-
An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association
-
Gouttenoire J, Montserret R, Kennel A, Penin F, Moradpour D: An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association. J Virol 2009, 83:11378-11384.
-
(2009)
J Virol
, vol.83
, pp. 11378-11384
-
-
Gouttenoire, J.1
Montserret, R.2
Kennel, A.3
Penin, F.4
Moradpour, D.5
-
37
-
-
79960406328
-
NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes
-
Paul D, Romero-Brey I, Gouttenoire J, Stoitsova S, Krijnse-Locker J, Moradpour D, Bartenschlager R: NS4B self-interaction through conserved C-terminal elements is required for the establishment of functional hepatitis C virus replication complexes. J Virol 2011, 85:6963-6976.
-
(2011)
J Virol
, vol.85
, pp. 6963-6976
-
-
Paul, D.1
Romero-Brey, I.2
Gouttenoire, J.3
Stoitsova, S.4
Krijnse-Locker, J.5
Moradpour, D.6
Bartenschlager, R.7
-
38
-
-
79955647061
-
New opportunities in anti-hepatitis C virus drug discovery: Targeting NS4B
-
Rai R, Deval J: New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B. Antiviral Res 2011, 90:93-101.
-
(2011)
Antiviral Res
, vol.90
, pp. 93-101
-
-
Rai, R.1
Deval, J.2
-
39
-
-
51349138269
-
Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis
-
Einav S, Gerber D, Bryson PD, Sklan EH, Elazar M, Maerkl SJ, Glenn JS, Quake SR: Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol 2008, 26:1019-1027.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 1019-1027
-
-
Einav, S.1
Gerber, D.2
Bryson, P.D.3
Sklan, E.H.4
Elazar, M.5
Maerkl, S.J.6
Glenn, J.S.7
Quake, S.R.8
-
40
-
-
42949130180
-
Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly
-
Appel N, Zayas M, Miller S, Krijnse-Locker J, Schaller T, Friebe P, Kallis S, Engel U, Bartenschlager R: Essential role of domain III of nonstructural protein 5A for hepatitis C virus infectious particle assembly. PLoS Pathog 2008, 4:e1000035.
-
(2008)
PLoS Pathog
, vol.4
-
-
Appel, N.1
Zayas, M.2
Miller, S.3
Krijnse-Locker, J.4
Schaller, T.5
Friebe, P.6
Kallis, S.7
Engel, U.8
Bartenschlager, R.9
-
41
-
-
73449126883
-
Apolipoprotein e interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles
-
Benga WJ, Krieger SE, Dimitrova M, Zeisel MB, Parnot M, Lupberger J, Hildt E, Luo G, McLauchlan J, Baumert TF et al.: Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. Hepatology 2010, 51:43-53.
-
(2010)
Hepatology
, vol.51
, pp. 43-53
-
-
Benga, W.J.1
Krieger, S.E.2
Dimitrova, M.3
Zeisel, M.B.4
Parnot, M.5
Lupberger, J.6
Hildt, E.7
Luo, G.8
McLauchlan, J.9
Baumert, T.F.10
-
42
-
-
1542287547
-
Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon
-
Shimakami T, Hijikata M, Luo H, Ma YY, Kaneko S, Shimotohno K, Murakami S: Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon. J Virol 2004, 78:2738-2748.
-
(2004)
J Virol
, vol.78
, pp. 2738-2748
-
-
Shimakami, T.1
Hijikata, M.2
Luo, H.3
Ma, Y.Y.4
Kaneko, S.5
Shimotohno, K.6
Murakami, S.7
-
43
-
-
79953221885
-
Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIa and regulates viral propagation
-
Lim YS, Hwang SB: Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIa and regulates viral propagation. J Biol Chem 2011, 286:11290-11298.
-
(2011)
J Biol Chem
, vol.286
, pp. 11290-11298
-
-
Lim, Y.S.1
Hwang, S.B.2
-
44
-
-
79960422127
-
Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner
-
Foster TL, Gallay P, Stonehouse NJ, Harris M: Cyclophilin A interacts with domain II of hepatitis C virus NS5A and stimulates RNA binding in an isomerase-dependent manner. J Virol 2011, 85:7460-7464.
-
(2011)
J Virol
, vol.85
, pp. 7460-7464
-
-
Foster, T.L.1
Gallay, P.2
Stonehouse, N.J.3
Harris, M.4
-
45
-
-
4644260669
-
Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A
-
Penin F, Brass V, Appel N, Ramboarina S, Montserret R, Ficheux D, Blum HE, Bartenschlager R, Moradpour D: Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J Biol Chem 2004, 279:40835-40843.
-
(2004)
J Biol Chem
, vol.279
, pp. 40835-40843
-
-
Penin, F.1
Brass, V.2
Appel, N.3
Ramboarina, S.4
Montserret, R.5
Ficheux, D.6
Blum, H.E.7
Bartenschlager, R.8
Moradpour, D.9
-
46
-
-
19644393931
-
Structure of the zincbinding domain of an essential component of the hepatitis C virus replicase
-
Tellinghuisen TL, Marcotrigiano J, Rice CM: Structure of the zincbinding domain of an essential component of the hepatitis C virus replicase. Nature 2005, 435:374-379.
-
(2005)
Nature
, vol.435
, pp. 374-379
-
-
Tellinghuisen, T.L.1
Marcotrigiano, J.2
Rice, C.M.3
-
47
-
-
66149115122
-
Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C
-
Love RA, Brodsky O, Hickey MJ, Wells PA, Cronin CN: Crystal structure of a novel dimeric form of NS5A domain I protein from hepatitis C. J Virol 2009, 83:4395-4403.
-
(2009)
J Virol
, vol.83
, pp. 4395-4403
-
-
Love, R.A.1
Brodsky, O.2
Hickey, M.J.3
Wells, P.A.4
Cronin, C.N.5
-
48
-
-
77952035218
-
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
-
Gao M, Nettles RE, Belema M, Snyder LB, Nguyen VN, Fridell RA, Serrano-Wu MH, Langley DR, Sun JH, O'Boyle DR 2nd et al.: Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 2010, 465:96-100.
-
(2010)
Nature
, vol.465
, pp. 96-100
-
-
Gao, M.1
Nettles, R.E.2
Belema, M.3
Snyder, L.B.4
Nguyen, V.N.5
Fridell, R.A.6
Serrano-Wu, M.H.7
Langley, D.R.8
Sun, J.H.9
O'Boyle II, D.R.10
-
49
-
-
79958018094
-
Domain 3 of NS5A protein from the hepatitis C virus has intrinsic a-helical propensity and is a substrate of cyclophilin A
-
Verdegem D, Badillo A, Wieruszeski JM, Landrieu I, Leroy A, Bartenschlager R, Penin F, Lippens G, Hanoulle X: Domain 3 of NS5A protein from the hepatitis C virus has intrinsic a-helical propensity and is a substrate of cyclophilin A. J Biol Chem 2011, 286:20441-20454.
-
(2011)
J Biol Chem
, vol.286
, pp. 20441-20454
-
-
Verdegem, D.1
Badillo, A.2
Wieruszeski, J.M.3
Landrieu, I.4
Leroy, A.5
Bartenschlager, R.6
Penin, F.7
Lippens, G.8
Hanoulle, X.9
-
50
-
-
77956028043
-
All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding
-
Foster TL, Belyaeva T, Stonehouse NJ, Pearson AR, Harris M: All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding. J Virol 2010, 84:9267-9277.
-
(2010)
J Virol
, vol.84
, pp. 9267-9277
-
-
Foster, T.L.1
Belyaeva, T.2
Stonehouse, N.J.3
Pearson, A.R.4
Harris, M.5
-
51
-
-
62649145466
-
Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded
-
Hanoulle X, Verdegem D, Badillo A, Wieruszeski JM, Penin F, Lippens G: Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded. Biochem Biophys Res Commun 2009, 381:634-638.
-
(2009)
Biochem Biophys Res Commun
, vol.381
, pp. 634-638
-
-
Hanoulle, X.1
Verdegem, D.2
Badillo, A.3
Wieruszeski, J.M.4
Penin, F.5
Lippens, G.6
-
52
-
-
77958037203
-
The domain 2 of the HCV NS5A protein is intrinsically unstructured
-
Hanoulle X, Badillo A, Verdegem D, Penin F, Lippens G: The domain 2 of the HCV NS5A protein is intrinsically unstructured. Protein Pept Lett 2010, 17:1012-1018.
-
(2010)
Protein Pept Lett
, vol.17
, pp. 1012-1018
-
-
Hanoulle, X.1
Badillo, A.2
Verdegem, D.3
Penin, F.4
Lippens, G.5
-
53
-
-
35348891616
-
Domain 2 of nonstructural protein 5A (NS5A) of hepatitis C virus is natively unfolded
-
Liang Y, Ye H, Kang CB, Yoon HS: Domain 2 of nonstructural protein 5A (NS5A) of hepatitis C virus is natively unfolded. Biochemistry 2007, 46:11550-11558.
-
(2007)
Biochemistry
, vol.46
, pp. 11550-11558
-
-
Liang, Y.1
Ye, H.2
Kang, C.B.3
Yoon, H.S.4
-
54
-
-
34249664478
-
Phosphorylation of hepatitis C virus NS5A nonstructural protein: A new paradigm for phosphorylation-dependent viral RNA replication?
-
Huang Y, Staschke K, De Francesco R, Tan SL: Phosphorylation of hepatitis C virus NS5A nonstructural protein: a new paradigm for phosphorylation- dependent viral RNA replication? Virology 2007, 364:1-9.
-
(2007)
Virology
, vol.364
, pp. 1-9
-
-
Huang, Y.1
Staschke, K.2
De Francesco, R.3
Tan, S.L.4
-
55
-
-
84872002097
-
A Hepatitis C virus NS5A phosphorylation site that regulates RNA replication
-
Lemay KL, Treadaway J, Angulo-Herrera I, Tellinghuisen TL: A Hepatitis C Virus NS5A Phosphorylation Site that Regulates RNA Replication. J Virol 2013, 87:1255-1260.
-
(2013)
J Virol
, vol.87
, pp. 1255-1260
-
-
Lemay, K.L.1
Treadaway, J.2
Angulo-Herrera, I.3
Tellinghuisen, T.L.4
-
56
-
-
77956868159
-
Identification of a novel phosphorylation site in hepatitis C virus NS5A
-
Nordle Gilliver A, Griffin S, Harris M: Identification of a novel phosphorylation site in hepatitis C virus NS5A. J Gen Virol 2010, 91:2428-2432.
-
(2010)
J Gen Virol
, vol.91
, pp. 2428-2432
-
-
Nordle Gilliver, A.1
Griffin, S.2
Harris, M.3
-
57
-
-
70549094435
-
RNA-dependent RNA polymerases from Flaviviridae
-
Choi KH, Rossmann MG: RNA-dependent RNA polymerases from Flaviviridae. Curr Opin Struct Biol 2009, 19:746-751
-
(2009)
Curr Opin Struct Biol
, vol.19
, pp. 746-751
-
-
Choi, K.H.1
Rossmann, M.G.2
-
58
-
-
23744436747
-
Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors
-
Biswal BK, Cherney MM, Wang M, Chan L, Yannopoulos CG, Bilimoria D, Nicolas O, Bedard J, James MN: Crystal structures of the RNA-dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors. J Biol Chem 2005, 280:18202-18210.
-
(2005)
J Biol Chem
, vol.280
, pp. 18202-18210
-
-
Biswal, B.K.1
Cherney, M.M.2
Wang, M.3
Chan, L.4
Yannopoulos, C.G.5
Bilimoria, D.6
Nicolas, O.7
Bedard, J.8
James, M.N.9
-
59
-
-
0036120573
-
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
-
Bressanelli S, Tomei L, Rey FA, De Francesco R: Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides. J Virol 2002, 76:3482-3492.
-
(2002)
J Virol
, vol.76
, pp. 3482-3492
-
-
Bressanelli, S.1
Tomei, L.2
Rey, F.A.3
De Francesco, R.4
-
60
-
-
77958464322
-
Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis
-
Harrus D, Ahmed-El-Sayed N, Simister PC, Miller S, Triconnet M, Hagedorn CH, Mahias K, Rey FA, Astier-Gin T, Bressanelli S: Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis. J Biol Chem 2010, 285:32906-32918.
-
(2010)
J Biol Chem
, vol.285
, pp. 32906-32918
-
-
Harrus, D.1
Ahmed-El-Sayed, N.2
Simister, P.C.3
Miller, S.4
Triconnet, M.5
Hagedorn, C.H.6
Mahias, K.7
Rey, F.A.8
Astier-Gin, T.9
Bressanelli, S.10
-
61
-
-
7644227543
-
De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities
-
Ranjith-Kumar CT, Sarisky RT, Gutshall L, Thomson M, Kao CC: De novo initiation pocket mutations have multiple effects on hepatitis C virus RNA-dependent RNA polymerase activities. J Virol 2004, 78:12207-12217.
-
(2004)
J Virol
, vol.78
, pp. 12207-12217
-
-
Ranjith-Kumar, C.T.1
Sarisky, R.T.2
Gutshall, L.3
Thomson, M.4
Kao, C.C.5
-
62
-
-
0037470586
-
Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): Structural evidence for nucleotide import and de-novo initiation
-
O'Farrell D, Trowbridge R, Rowlands D, Jäger J: Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation. J Mol Biol 2003, 326:1025-1035.
-
(2003)
J Mol Biol
, vol.326
, pp. 1025-1035
-
-
O'Farrell, D.1
Trowbridge, R.2
Rowlands, D.3
Jäger, J.4
-
63
-
-
84860470225
-
Hepatitis C RNA-dependent RNA polymerase inhibitors: A review of structure-activity and resistance relationships; Different scaffolds and mutations
-
Mayhoub AS: Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations. Bioorg Med Chem 2012, 20:3150-3161.
-
(2012)
Bioorg Med Chem
, vol.20
, pp. 3150-3161
-
-
Mayhoub, A.S.1
-
64
-
-
8644265138
-
Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication
-
Moradpour D, Brass V, Bieck E, Friebe P, Gosert R, Blum HE, Bartenschlager R, Penin F, Lohmann V: Membrane association of the RNA-dependent RNA polymerase is essential for hepatitis C virus RNA replication. J Virol 2004, 78:13278-13284.
-
(2004)
J Virol
, vol.78
, pp. 13278-13284
-
-
Moradpour, D.1
Brass, V.2
Bieck, E.3
Friebe, P.4
Gosert, R.5
Blum, H.E.6
Bartenschlager, R.7
Penin, F.8
Lohmann, V.9
-
65
-
-
1842562346
-
The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo
-
Lee KJ, Choi J, Ou JH, Lai MM: The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo. J Virol 2004, 78:3797-3802.
-
(2004)
J Virol
, vol.78
, pp. 3797-3802
-
-
Lee, K.J.1
Choi, J.2
Ou, J.H.3
Lai, M.M.4
-
66
-
-
77957957374
-
Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNA-dependent RNA polymerase
-
Brass V, Gouttenoire J, Wahl A, Pal Z, Blum HE, Penin F, Moradpour D: Hepatitis C virus RNA replication requires a conserved structural motif within the transmembrane domain of the NS5B RNA-dependent RNA polymerase. J Virol 2010, 84:11580-11584.
-
(2010)
J Virol
, vol.84
, pp. 11580-11584
-
-
Brass, V.1
Gouttenoire, J.2
Wahl, A.3
Pal, Z.4
Blum, H.E.5
Penin, F.6
Moradpour, D.7
-
67
-
-
1842289764
-
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
-
Lohmann V, Körner F, Herian U, Bartenschlager R: Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity. J Virol 1997, 71:8416-8428.
-
(1997)
J Virol
, vol.71
, pp. 8416-8428
-
-
Lohmann, V.1
Körner, F.2
Herian, U.3
Bartenschlager, R.4
-
68
-
-
34548783857
-
Host factors involved in the replication of hepatitis C virus
-
Moriishi K, Matsuura Y: Host factors involved in the replication of hepatitis C virus. Rev Med Virol 2007, 17:343-354.
-
(2007)
Rev Med Virol
, vol.17
, pp. 343-354
-
-
Moriishi, K.1
Matsuura, Y.2
-
69
-
-
70349513508
-
A genome-wide genetic screen for host factors required for hepatitis C virus propagation
-
Li Q, Brass AL, Ng A, Hu Z, Xavier RJ, Liang TJ, Elledge SJ: A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc Natl Acad Sci U S A 2009, 106:16410-16415.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 16410-16415
-
-
Li, Q.1
Brass, A.L.2
Ng, A.3
Hu, Z.4
Xavier, R.J.5
Liang, T.J.6
Elledge, S.J.7
|