Enzymatic detoxication, conformational selection, and the role of molten globule active sites

Journal of Biological Chemistry

Volumn 288, Issue 25, 2013, Pages 18599-18611

  Honaker, Matthew T ^a   Acchione, Mauro ^a   Zhang, Wei ^b   Mannervik, Bengt ^b   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL SELECTION; ENZYME CONFORMATIONS; INDUCED FIT; MOLTEN GLOBULE; PRE-STEADY STATE; SUBSTRATE-FREE; THERMO DYNAMIC ANALYSIS; THERMODYNAMIC PARAMETER;

THERMOANALYSIS;

ENZYMES;

GLUTATHIONE TRANSFERASE A1; PROTEIN VARIANT;

ARTICLE; BIOENGINEERING; BIOLOGICAL MODEL; CATALYSIS; DETOXIFICATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME SUBSTRATE; PRIORITY JOURNAL; STEADY STATE; THERMODYNAMICS;

CALORIMETRY; DRUG METABOLISM; ENERGY LANDSCAPE; ENZYME CATALYSIS; ENZYME CONFORMATION; GLUTATHION; PROMISCUITY; XENOBIOTICS;

BIOCATALYSIS; CALORIMETRY, DIFFERENTIAL SCANNING; CATALYTIC DOMAIN; GLUTATHIONE TRANSFERASE; HUMANS; KINETICS; METABOLIC DETOXICATION, DRUG; MUTATION; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 84880052696     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.445767     Document Type: Article

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