Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase

Biochimica et Biophysica Acta - General Subjects

Volumn 1780, Issue 12, 2008, Pages 1458-1463

  Blikstad, Cecilia ^a   Shokeer, Abeer ^a   Kurtovic, Sanela ^a   Mannervik, Bengt ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Multivariate data analysis; Protein evolution; Rational design; Substrate selectivity

Indexed keywords

ANDROSTENEDIONE; CUMENE; CUMENE HYDROPEROXIDE; ETACRYNIC ACID; GIMFHELIX ENZYME; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE A1; GLUTATHIONE TRANSFERASE A4; HYDROPEROXIDE; PHENETHYL ISOTHIOCYANATE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ISOMERIZATION; MICHAEL ADDITION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CATALYSIS; CATALYTIC DOMAIN; ESCHERICHIA COLI; GLUTATHIONE TRANSFERASE; HUMANS; KINETICS; MULTIVARIATE ANALYSIS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 52949090842     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2008.07.007     Document Type: Article

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