Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals

Biochemistry

Volumn 48, Issue 32, 2009, Pages 7698-7704

  Balogh, Larissa M ^a   Le Trong, Isolde ^a   Kripps, Kimberly A ^a   Tars, Kaspars ^b   Stenkamp, Ronald E ^a   Mannervik, Bengt ^b   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALKENALS; CATALYTIC EFFICIENCIES; GLUTATHIONE TRANSFERASE; HYDROPHOBIC BINDING; LOCALIZED STRUCTURES; STRUCTURAL DETERMINANTS; STRUCTURAL DIFFERENCES; STRUCTURAL ELEMENTS; TERMINAL RESIDUES;

CRYSTAL STRUCTURE; ENZYMES; STRUCTURAL ANALYSIS; SYSTEM THEORY;

BINDING SITES;

GLUTATHIONE; GLUTATHIONE TRANSFERASE A1; MUTANT PROTEIN; PHENYLALANINE; TYROSINE;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME LOCALIZATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE MUTATION; HYDROPHOBICITY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL;

ALKENES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 68849094537     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900895b     Document Type: Article

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