1.3-Å resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site

Proteins: Structure, Function and Genetics

Volumn 48, Issue 4, 2002, Pages 618-627

  Le Trong, Isolde ^a   Stenkamp, Ronald E ^a   Ibarra, Catherine ^a   Atkins, William M ^a   Adman, Elinor T ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Glutathione; Glutathione S transferase; Ligandin; Water structure; X ray structure

Indexed keywords

GLUTATHIONE TRANSFERASE; LIGANDIN; S HEXYLGLUTATHIONE; APOENZYME; DRUG DERIVATIVE; ENZYME INHIBITOR; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE ALPHA; GLYCEROL; HEXYLGLUTATHIONE; ISOENZYME; LIGAND; TYROSINE; WATER;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; ENZYME SUBUNIT; HUMAN; HYDROPHOBICITY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; HYDROGEN BOND; METABOLISM; PROTEIN CONFORMATION; SENSITIVITY AND SPECIFICITY;

APOENZYMES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLYCEROL; HUMANS; HYDROGEN BONDING; HYDROPHOBICITY; ISOENZYMES; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SENSITIVITY AND SPECIFICITY; TYROSINE; WATER;

EID: 0036719369     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10162     Document Type: Article

References (31)

1. Structure, catalytic mechanism, and evolution of the glutathione transferases
2. The isoenzymes of glutathione transferase
3. Glutathione transferases - Structure and catalytic activity
4. Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes
5. Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate
6. Role of the C-terminal helix 9 in the stability and ligandin function of class A glutathione transferase A1-1
7. Folding and assembly of dimeric human glutathione transferase A1-1
8. Localization of the C-terminus of rat glutathione S-transferase A1-1: Crystal structure of mutants W21F and W21F/F220Y
9. Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products
10. Contribution of aromaticaromatic interactions to the anomolous pKa of Tyr-9 and the C-terminal dynamics ofglutathione S-transferase A1-1
11. Oscillation data reduction program
12. Processing of x-ray diffraction data collected in oscillation mode
13. Collaborative Computational Project 4. The CCP4 suite: Programs for protein crystallography
14. SHELXL: High resolution refinement
15. A visual protein crystallographic software system for X11/Xview
16. Assessment of phase accuracy by cross validation: The free R value. Methods and applications
17. Improved Fourier coefficients for maps using phases from partial structures with errors
18. Expanding the model: Anisotropic displacement parameters in protein structure refinement
19. A natural grouping of motifs with an aspartate or asparagine residue forming two hydrogen bonds to residues ahead in sequence: Their occurrence at a-helical N termini and in other situations
20. The protein data bank
21. High resolution crystal structure ofcytochrome P450cam
22. Large-scale networks of hydration water molecules around bovine β-trypsin revealed by cryogenic x-ray crystal structure analysis
23. The identity of glutathione S-transferase B with ligandin, a major binding protein in liver
24. The binding of porphyrins by ligandin
25. Interaction of hemin with placental glutathione S-transferases
26. The inhibition of glutathione S-transferases: Mechanisms, toxic consequences, and therapeutic benefits
27. The structures of human glutathione S-transferase P1-1 in complex with glutathione and various inhibitors at high resolution
28. Molscript: A program to produce both detailed and schematic plots of protein structures
29. Raster3D Version 2.0. A program for photorealistic molecular graphics