AlCl3-NaI assisted cleavage of polymer-bound esters with concomitant amine coupling and azido-reductive cyclization: Synthesis of pyrrolobenzodiazepine derivatives

Tetrahedron Letters

Volumn 54, Issue 33, 2013, Pages 4435-4441

  Kamal, Ahmed ^a   Prabhakar, S ^a   Shankaraiah, Nagula ^b   Markandeya, Nagula ^a   Venkat Reddy, P ^a   Srinivasulu, Vunnam ^a   Sathish, Manda ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

AlCl3 NaI; Azido reductive cyclization; Combinatorial chemistry; Pyrrolobenzodiazepines; SLE method; Solid phase synthesis

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; ALUMINUM CHLORIDE; AMINE; AZIDE; ESTER; LACTAM; MOLECULAR SCAFFOLD; POLYMER; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; PYRROLOBENZODIAZEPINE DERIVATIVE; RESIN; SODIUM IODIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYCLIZATION; DNA BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; LIQUID LIQUID EXTRACTION; ONE POT SOLID PHASE PARALLEL DIVERSITY ORIENTED SYNTHESIS; ONE POT SYNTHESIS; REDUCTION KINETICS; SOLID PHASE SYNTHESIS; SOLID SUPPORTED LIQUID LIQUID EXTRACTION;

EID: 84880042319     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2013.06.033     Document Type: Article

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