A new facile procedure for the preparation of pyrrolo[2,1-c][1,4]benzodiazepines : Synthesis of the antibiotic DC-81 and its thio analogue

Tetrahedron Letters

Volumn 37, Issue 13, 1996, Pages 2281-2284

  Kamal, Ahmed ^a   Reddy, B S Praveen ^a   Reddy, B S Narayan ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,11A TETRAHYDRO 8 HYDROXY 7 METHOXY 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE; BENZODIAZEPINE DERIVATIVE; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; TECHNIQUE;

EID: 0029964629     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00243-2     Document Type: Article

References (20)

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18. +, 20).
19. Typical procedure: To a solution of nitroaldehyde 5a (500mg) in toluene (15ml) was added an equimolar amount of Lawesson's reagent (630mg) and the mixture was heated to 70-80°C for 2-3h. After reaction was complete by TLC, the toluene was evaparated in vacuo. The residue was purified by flash chromatography using ethyl acetate: hexane ( 1:1) on silica gel column to yield 70% of 6a.
20. +, 30).