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Volumn 142, Issue 1, 2013, Pages 23-45

Insights on the mechanisms of Ca2+ regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CONNEXIN 26; CYSTEINE; GAP JUNCTION PROTEIN;

EID: 84880000898     PISSN: 00221295     EISSN: 15407748     Source Type: Journal    
DOI: 10.1085/jgp.201210893     Document Type: Article
Times cited : (47)

References (55)
  • 1
    • 0037133669 scopus 로고    scopus 로고
    • Voltage opens unopposed gap junction hemichannels formed by a connexin 32 mutant associated with X-linked Charcot-Marie-Tooth disease
    • Abrams, C.K., M.V. Bennett, V.K. Verselis, and T.A. Bargiello. 2002. Voltage opens unopposed gap junction hemichannels formed by a connexin 32 mutant associated with X-linked Charcot-Marie-Tooth disease. Proc. Natl. Acad. Sci. USA. 99:3980-3984. http://dx.doi.org/10.1073/pnas.261713499
    • (2002) Proc. Natl. Acad. Sci. USA. , vol.99 , pp. 3980-3984
    • Abrams, C.K.1    Bennett, M.V.2    Verselis, V.K.3    Bargiello, T.A.4
  • 2
    • 79959332086 scopus 로고    scopus 로고
    • Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces.
    • Allen, M.J., J. Gemel, E.C. Beyer, and R. Lal. 2011. Atomic force microscopy of Connexin40 gap junction hemichannels reveals calcium-dependent three-dimensional molecular topography and open-closed conformations of both the extracellular and cytoplasmic faces. J. Biol. Chem. 286:22139-22146. http://dx.doi.org/10.1074/jbc.M111.240002
    • (2011) J. Biol. Chem. , vol.286 , pp. 22139-22146
    • Allen, M.J.1    Gemel, J.2    Beyer, E.C.3    Lal, R.4
  • 3
    • 0036218448 scopus 로고    scopus 로고
    • Hemichannel and junctional properties of connexin 50
    • Beahm, D.L., and J.E. Hall. 2002. Hemichannel and junctional properties of connexin 50. Biophys. J. 82:2016-2031. http://dx.doi.org/10.1016/S0006-3495(02)75550-1
    • (2002) Biophys. J. , vol.82 , pp. 2016-2031
    • Beahm, D.L.1    Hall, J.E.2
  • 4
    • 0242380301 scopus 로고    scopus 로고
    • New roles for astrocytes: gap junction hemichannels have something to communicate
    • Bennett, M.V., J.E. Contreras, F.F. Bukauskas, and J.C. Sáez. 2003. New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci. 26:610-617. http://dx.doi.org/10.1016/j.tins.2003.09.008
    • (2003) Trends Neurosci. , vol.26 , pp. 610-617
    • Bennett, M.V.1    Contreras, J.E.2    Bukauskas, F.F.3    Sáez, J.C.4
  • 5
    • 0032199006 scopus 로고    scopus 로고
    • Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
    • Colquhoun, D. 1998. Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br. J. Pharmacol. 125:924-947
    • (1998) Br. J. Pharmacol , vol.125 , pp. 924-947
    • Colquhoun, D.1
  • 6
    • 0037039391 scopus 로고    scopus 로고
    • Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
    • Contreras, J.E., H.A. Sánchez, E.A. Eugenin, D. Speidel, M. Theis, K. Willecke, F.F. Bukauskas, M.V. Bennett, and J.C. Sáez. 2002. Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc. Natl. Acad. Sci. USA. 99:495-500. http://dx.doi.org/10.1073/pnas.012589799
    • (2002) Proc. Natl. Acad. Sci. USA. , vol.99 , pp. 495-500
    • Contreras, J.E.1    Sánchez, H.A.2    Eugenin, E.A.3    Speidel, D.4    Theis, M.5    Willecke, K.6    Bukauskas, F.F.7    Bennett, M.V.8    Sáez, J.C.9
  • 8
    • 9644302728 scopus 로고    scopus 로고
    • Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue.
    • Contreras, J.E., H.A. Sánchez, L.P. Véliz, F.F. Bukauskas, M.V. Bennett, and J.C. Sáez. 2004. Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res. Brain Res. Rev. 47:290-303. http://dx.doi.org/10.1016/j.brainresrev.2004.08.002
    • (2004) Brain Res. Brain Res. Rev. , vol.47 , pp. 290-303
    • Contreras, J.E.1    Sánchez, H.A.2    Véliz, L.P.3    Bukauskas, F.F.4    Bennett, M.V.5    Sáez, J.C.6
  • 9
    • 10344247673 scopus 로고    scopus 로고
    • Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels
    • Craven, K.B., and W.N. Zagotta. 2004. Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels. J. Gen. Physiol. 124:663-677. http://dx.doi.org/10.1085/jgp.200409178
    • (2004) J. Gen. Physiol. , vol.124 , pp. 663-677
    • Craven, K.B.1    Zagotta, W.N.2
  • 11
    • 36649026454 scopus 로고    scopus 로고
    • Some oculodentodigital dysplasia-associated Cx43 mutations cause increased hemichannel activity in addition to deficient gap junction channels
    • Dobrowolski, R., A. Sommershof, and K. Willecke. 2007. Some oculodentodigital dysplasia-associated Cx43 mutations cause increased hemichannel activity in addition to deficient gap junction channels. J. Membr. Biol. 219:9-17. http://dx.doi.org/10.1007/s00232-007-9055-7
    • (2007) J. Membr. Biol. , vol.219 , pp. 9-17
    • Dobrowolski, R.1    Sommershof, A.2    Willecke, K.3
  • 12
    • 0029738650 scopus 로고    scopus 로고
    • Xenopus connexin38 forms hemi-gap-junctional channels in the nonjunctional plasma membrane of Xenopus oocytes
    • Ebihara, L. 1996. Xenopus connexin38 forms hemi-gap-junctional channels in the nonjunctional plasma membrane of Xenopus oocytes. Biophys. J. 71:742-748. http://dx.doi.org/10.1016/S0006-3495(96)79273-1
    • (1996) Biophys. J. , vol.71 , pp. 742-748
    • Ebihara, L.1
  • 13
    • 0038142399 scopus 로고    scopus 로고
    • New roles for connexons. News Physiol. Sci. 18:100-103
    • Ebihara, L. 2003. New roles for connexons. News Physiol. Sci. 18:100-103
    • (2003)
    • Ebihara, L.1
  • 14
    • 0037214571 scopus 로고    scopus 로고
    • Effect of external magnesium and calcium on human connexin46 hemichannels.
    • Ebihara, L., X. Liu, and J.D. Pal. 2003. Effect of external magnesium and calcium on human connexin46 hemichannels. Biophys. J. 84:277-286. http://dx.doi.org/10.1016/S0006-3495(03)74848-6
    • (2003) Biophys. J. , vol.84 , pp. 277-286
    • Ebihara, L.1    Liu, X.2    Pal, J.D.3
  • 15
    • 0029997591 scopus 로고    scopus 로고
    • On the choice of reference mutant states in the application of the double-mutant cycle method
    • Faiman, G.A., and A. Horovitz. 1996. On the choice of reference mutant states in the application of the double-mutant cycle method. Protein Eng. 9:315-316. http://dx.doi.org/10.1093/protein/9.3.31
    • (1996) Protein Eng. , vol.9 , pp. 315-316
    • Faiman, G.A.1    Horovitz, A.2
  • 16
    • 34250807258 scopus 로고    scopus 로고
    • Aberrant hemichannel properties of Cx26 mutations causing skin disease and deafness.
    • Gerido, D.A., A.M. DeRosa, G. Richard, and T.W. White. 2007. Aberrant hemichannel properties of Cx26 mutations causing skin disease and deafness. Am. J. Physiol. Cell Physiol. 293:C337- C345. http://dx.doi.org/10.1152/ajpcell.00626.2006
    • (2007) Am. J. Physiol. Cell Physiol. , vol.293
    • Gerido, D.A.1    DeRosa, A.M.2    Richard, G.3    White, T.W.4
  • 17
    • 58149093958 scopus 로고    scopus 로고
    • An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating
    • Gleitsman, K.R., S.M. Kedrowski, H.A. Lester, and D.A. Dougherty. 2008. An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating. J. Biol. Chem. 283:35638-35643
    • (2008) J. Biol. Chem. , vol.283 , pp. 35638-35643
    • Gleitsman, K.R.1    Kedrowski, S.M.2    Lester, H.A.3    Dougherty, D.A.4
  • 19
    • 0035704411 scopus 로고    scopus 로고
    • Emerging issues of connexin channels: biophysics fills the gap.
    • Harris, A.L. 2001. Emerging issues of connexin channels: biophysics fills the gap. Q. Rev. Biophys. 34:325-472. http://dx.doi.org/10.1017/S0033583501003705
    • (2001) Q. Rev. Biophys. , vol.34 , pp. 325-472
    • Harris, A.L.1
  • 20
    • 0037448581 scopus 로고    scopus 로고
    • Coupling of agonist binding to channel gating in the GABA(A) receptor.
    • Kash, T.L., A. Jenkins, J.C. Kelley, J.R. Trudell, and N.L. Harrison. 2003. Coupling of agonist binding to channel gating in the GABA(A) receptor. Nature. 421:272-275
    • (2003) Nature. , vol.421 , pp. 272-275
    • Kash, T.L.1    Jenkins, A.2    Kelley, J.C.3    Trudell, J.R.4    Harrison, N.L.5
  • 21
    • 0141919839 scopus 로고    scopus 로고
    • Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels
    • Kronengold, J., E.B. Trexler, F.F. Bukauskas, T.A. Bargiello, and V.K. Verselis. 2003. Single-channel SCAM identifies pore-lining residues in the first extracellular loop and first transmembrane domains of Cx46 hemichannels. J. Gen. Physiol. 122:389-405 http://dx.doi.org/10.1085/jgp.200308861
    • (2003) J. Gen. Physiol. , vol.122 , pp. 389-405
    • Kronengold, J.1    Trexler, E.B.2    Bukauskas, F.F.3    Bargiello, T.A.4    Verselis, V.K.5
  • 22
    • 80555135976 scopus 로고    scopus 로고
    • Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics.
    • Kwon, T., A.L. Harris, A. Rossi, and T.A. Bargiello. 2011. Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics. J. Gen. Physiol. 138: 475-493. http://dx.doi.org/10.1085/jgp.201110679
    • (2011) J. Gen. Physiol. , vol.138 , pp. 475-493
    • Kwon, T.1    Harris, A.L.2    Rossi, A.3    Bargiello, T.A.4
  • 23
    • 84858777446 scopus 로고    scopus 로고
    • Molecular dynamics simulations of the Cx26 hemichannel: insights into voltage-dependent loop-gating.
    • Kwon, T., B. Roux, S. Jo, J.B. Klauda, A.L. Harris, and T.A. Bargiello. 2012. Molecular dynamics simulations of the Cx26 hemichannel: insights into voltage-dependent loop-gating. Biophys. J. 102:1341- 1351. http://dx.doi.org/10.1016/j.bpj.2012.02.009
    • (2012) Biophys. J. , vol.102 , pp. 1341-1351
    • Kwon, T.1    Roux, B.2    Jo, S.3    Klauda, J.B.4    Harris, A.L.5    Bargiello, T.A.6
  • 24
    • 84874742226 scopus 로고    scopus 로고
    • Voltage-dependent gating of the Cx32*43E1 hemichannel: conformational changes at the channel entrances.
    • Kwon, T., Q. Tang, and T.A. Bargiello. 2013. Voltage-dependent gating of the Cx32*43E1 hemichannel: conformational changes at the channel entrances. J. Gen. Physiol. 141:243-259. http://dx.doi.org/10.1085/jgp.201210839
    • (2013) J. Gen. Physiol. , vol.141 , pp. 243-259
    • Kwon, T.1    Tang, Q.2    Bargiello, T.A.3
  • 25
    • 79953023119 scopus 로고    scopus 로고
    • A state-dependent salt-bridge interaction exists across the ?/? intersubunit interface of the GABAA receptor
    • Laha, K.T., and D.A. Wagner. 2011. A state-dependent salt-bridge interaction exists across the ?/? intersubunit interface of the GABAA receptor. Mol. Pharmacol. 79:662-671. http://dx.doi.org/10.1124/mol.110.068619
    • (2011) Mol. Pharmacol. , vol.79 , pp. 662-671
    • Laha, K.T.1    Wagner, D.A.2
  • 27
    • 63149198803 scopus 로고    scopus 로고
    • Connexin mutations causing skin disease and deafness increase hemichannel activity and cell death when expressed in Xenopus oocytes
    • Lee, J.R., A.M. Derosa, and T.W. White. 2009. Connexin mutations causing skin disease and deafness increase hemichannel activity and cell death when expressed in Xenopus oocytes. J. Invest. Dermatol. 129:870-878. http://dx.doi.org/10.1038/jid.2008.335
    • (2009) J. Invest. Dermatol. , vol.129 , pp. 870-878
    • Lee, J.R.1    Derosa, A.M.2    White, T.W.3
  • 30
    • 0037324895 scopus 로고    scopus 로고
    • Gating mechanism of BK (Slo1) channels: so near, yet so far.
    • Magleby, K.L. 2003. Gating mechanism of BK (Slo1) channels: so near, yet so far. J. Gen. Physiol. 121:81-96. http://dx.doi.org/10.1085/jgp.20028721
    • (2003) J. Gen. Physiol. , vol.121 , pp. 81-96
    • Magleby, K.L.1
  • 32
    • 44649131935 scopus 로고    scopus 로고
    • A novel M163L mutation in connexin 26 causing cell death and associated with autosomal dominant hearing loss.
    • Matos, T.D., H. Caria, H. Simões-Teixeira, T. Aasen, O. Dias, M. Andrea, D.P. Kelsell, and G. Fialho. 2008. A novel M163L mutation in connexin 26 causing cell death and associated with autosomal dominant hearing loss. Hear. Res. 240:87-92. http://dx.doi.org/10.1016/j.heares.2008.03.004
    • (2008) Hear. Res. , vol.240 , pp. 87-92
    • Matos, T.D.1    Caria, H.2    Simões-Teixeira, H.3    Aasen, T.4    Dias, O.5    Andrea, M.6    Kelsell, D.P.7    Fialho, G.8
  • 33
  • 34
    • 0037099393 scopus 로고    scopus 로고
    • Conformational changes in surface structures of isolated connexin 26 gap junctions
    • Müller, D.J., G.M. Hand, A. Engel, and G.E. Sosinsky. 2002. Conformational changes in surface structures of isolated connexin 26 gap junctions. EMBO J. 21:3598-3607. http://dx.doi.org/10.1093/emboj/cdf365
    • (2009) EMBO J. , vol.21 , pp. 3598-3607
    • Müller, D.J.1    Hand, G.M.2    Engel, A.3    Sosinsky, G.E.4
  • 37
    • 77955142082 scopus 로고    scopus 로고
    • Coupling between residues on S4 and S1 defines the voltage-sensor resting conformation in NaChBac
    • Paldi, T., and M. Gurevitz. 2010. Coupling between residues on S4 and S1 defines the voltage-sensor resting conformation in NaChBac. Biophys. J. 99:456-463. http://dx.doi.org/10.1016/j.bpj.2010.04.053
    • (2010) Biophys. J. , vol.99 , pp. 456-463
    • Paldi, T.1    Gurevitz, M.2
  • 38
    • 0026352039 scopus 로고
    • Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes
    • Paul, D.L., L. Ebihara, L.J. Takemoto, K.I. Swenson, and D.A. Goodenough. 1991. Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes. J. Cell Biol. 115:1077-1089. http://dx.doi.org/10.1083/jcb.115.4.1077
    • (1991) J. Cell Biol. , vol.115 , pp. 1077-1089
    • Paul, D.L.1    Ebihara, L.2    Takemoto, L.J.3    Swenson, K.I.4    Goodenough, D.A.5
  • 39
    • 34548485996 scopus 로고    scopus 로고
    • Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors.
    • Price, K.L., K.S. Millen, and S.C. Lummis. 2007. Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors. J. Biol. Chem. 282:25623-25630
    • (2007) J. Biol. Chem. , vol.282 , pp. 25623-25630
    • Price, K.L.1    Millen, K.S.2    Lummis, S.C.3
  • 40
    • 4043100299 scopus 로고    scopus 로고
    • Properties of connexin26 hemichannels expressed in Xenopus oocytes.
    • Ripps, H., H. Qian, and J. Zakevicius. 2004. Properties of connexin26 hemichannels expressed in Xenopus oocytes. Cell. Mol. Neurobiol. 24:647-665. http://dx.doi.org/10.1023/B:CEMN.0000036403.43484.3d
    • (2004) Cell. Mol. Neurobiol. , vol.24 , pp. 647-665
    • Ripps, H.1    Qian, H.2    Zakevicius, J.3
  • 41
    • 17344390158 scopus 로고    scopus 로고
    • Plasma membrane channels formed by connexins: their regulation and functions.
    • Sáez, J.C., V.M. Berthoud, M.C. Branes, A.D. Martinez, and E.C. Beyer. 2003. Plasma membrane channels formed by connexins: their regulation and functions. Physiol. Rev. 83:1359-1400
    • (2003) Physiol. Rev. , vol.83 , pp. 1359-1400
    • Sáez, J.C.1    Berthoud, V.M.2    Branes, M.C.3    Martinez, A.D.4    Beyer, E.C.5
  • 42
    • 77955087401 scopus 로고    scopus 로고
    • Cell membrane permeabilization via connexin hemichannels in living and dying cells.
    • Sáez, J.C., K.A. Schalper, M.A. Retamal, J.A. Orellana, K.F. Shoji, and M.V. Bennett. 2010. Cell membrane permeabilization via connexin hemichannels in living and dying cells. Exp. Cell Res. 316:2377-2389. http://dx.doi.org/10.1016/j.yexcr.2010.05.026
    • (2010) Exp. Cell Res. , vol.316 , pp. 2377-2389
    • Sáez, J.C.1    Schalper, K.A.2    Retamal, M.A.3    Orellana, J.A.4    Shoji, K.F.5    Bennett, M.V.6
  • 43
    • 77954320871 scopus 로고    scopus 로고
    • 2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome.
    • 2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome. J. Gen. Physiol. 136:47-62. http://dx.doi.org/10.1085/jgp.201010433
    • (2010) J. Gen. Physiol. , vol.136 , pp. 47-62
    • Sánchez, H.A.1    Mese, G.2    Srinivas, M.3    White, T.W.4    Verselis, V.K.5
  • 44
    • 33845505914 scopus 로고    scopus 로고
    • A novel mechanism for connexin 26 mutation linked deafness: cell death caused by leaky gap junction hemichannels.
    • Stong, B.C., Q. Chang, S. Ahmad, and X. Lin. 2006. A novel mechanism for connexin 26 mutation linked deafness: cell death caused by leaky gap junction hemichannels. Laryngoscope. 116:2205-2210. http://dx.doi.org/10.1097/01.mlg.0000241944.77192.d2
    • (2006) Laryngoscope. , vol.116 , pp. 2205-2210
    • Stong, B.C.1    Chang, Q.2    Ahmad, S.3    Lin, X.4
  • 45
    • 66749118906 scopus 로고    scopus 로고
    • Conformational changes in a pore-forming region underlie voltage- dependent "loop gating" of an unapposed connexin hemichannel.
    • Tang, Q., T.L. Dowd, V.K. Verselis, and T.A. Bargiello. 2009. Conformational changes in a pore-forming region underlie voltage- dependent "loop gating" of an unapposed connexin hemichannel. J. Gen. Physiol. 133:555-570. http://dx.doi.org/10.1085/jgp.200910207
    • (2009) J. Gen. Physiol. , vol.133 , pp. 555-570
    • Tang, Q.1    Dowd, T.L.2    Verselis, V.K.3    Bargiello, T.A.4
  • 46
    • 15444367718 scopus 로고    scopus 로고
    • Calciumdependent open/closed conformations and interfacial energy maps of reconstituted hemichannels.
    • Thimm, J., A. Mechler, H. Lin, S. Rhee, and R. Lal. 2005. Calciumdependent open/closed conformations and interfacial energy maps of reconstituted hemichannels. J. Biol. Chem. 280:10646- 10654. http://dx.doi.org/10.1074/jbc.M412749200
    • (2005) J. Biol. Chem. , vol.280 , pp. 10646-10654
    • Thimm, J.1    Mechler, A.2    Lin, H.3    Rhee, S.4    Lal, R.5
  • 47
    • 33748464388 scopus 로고    scopus 로고
    • Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels.
    • Tong, J.J., and L. Ebihara. 2006. Structural determinants for the differences in voltage gating of chicken Cx56 and Cx45.6 gap-junctional hemichannels. Biophys. J. 91:2142-2154. http://dx.doi.org/10.1529/biophysj.106.082859
    • (2006) Biophys. J. , vol.91 , pp. 2142-2154
    • Tong, J.J.1    Ebihara, L.2
  • 48
    • 79955557177 scopus 로고    scopus 로고
    • Different consequences of cataractassociated mutations at adjacent positions in the first extracellular boundary of connexin50.
    • Tong, J.J., P.J. Minogue, W. Guo, T.L. Chen, E.C. Beyer, V.M. Berthoud, and L. Ebihara. 2011. Different consequences of cataractassociated mutations at adjacent positions in the first extracellular boundary of connexin50. Am. J. Physiol. Cell Physiol. 300: C1055-C1064. http://dx.doi.org/10.1152/ajpcell.00384.2010
    • (2011) Am. J. Physiol. Cell Physiol. , vol.300
    • Tong, J.J.1    Minogue, P.J.2    Guo, W.3    Chen, T.L.4    Beyer, E.C.5    Berthoud, V.M.6    Ebihara, L.7
  • 49
    • 84880022477 scopus 로고    scopus 로고
    • Disruption of salt bridge interactions modifies gating kinetics of connexin hemichannels
    • Tong, X., W. Lopez, and Y. Liu. A.L. Harris, and J.E. Contreras. 2013. Disruption of salt bridge interactions modifies gating kinetics of connexin hemichannels. Biophys. J. 104:631a-632a. http://dx.doi.org/10.1016/j.bpj.2012.11.3492
    • (2013) Biophys. J. , vol.104
    • Tong, X.1    Lopez, W.2    Liu, Y.3    Harris, A.L.4    Contreras, J.E.5
  • 50
    • 0033936136 scopus 로고    scopus 로고
    • Electrical properties of gap junction hemichannels identified in transfected HeLa cells.
    • Valiunas, V., and R. Weingart. 2000. Electrical properties of gap junction hemichannels identified in transfected HeLa cells. Pflugers Arch. 440:366-379. http://dx.doi.org/10.1007/s004240000294
    • (2000) Pflugers Arch. , vol.440 , pp. 366-379
    • Valiunas, V.1    Weingart, R.2
  • 51
    • 63249084923 scopus 로고    scopus 로고
    • Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain.
    • Verselis, V.K., M.P. Trelles, C. Rubinos, T.A. Bargiello, and M. Srinivas. 2009. Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain. J. Biol. Chem. 284:4484-4493. http://dx.doi.org/10.1074/jbc.M807430200
    • (2009) J. Biol. Chem. , vol.284 , pp. 4484-4493
    • Verselis, V.K.1    Trelles, M.P.2    Rubinos, C.3    Bargiello, T.A.4    Srinivas, M.5
  • 54
    • 84870064725 scopus 로고    scopus 로고
    • The role of connexins in ear and skin physiology-functional insights from disease-associated mutations.
    • Xu, J., and B.J. Nicholson. 2013. The role of connexins in ear and skin physiology-functional insights from disease-associated mutations. Biochim. Biophys. Acta. 1828:167-178. http://dx.doi.org/10.1016/j.bbamem.2012.06.024
    • (2013) Biochim. Biophys. Acta. , vol.1828 , pp. 167-178
    • Xu, J.1    Nicholson, B.J.2
  • 55
    • 0032903938 scopus 로고    scopus 로고
    • Functional and morphological correlates of connexin50 expressed in Xenopus laevis oocytes.
    • Zampighi, G.A., D.D. Loo, M. Kreman, S. Eskandari, and E.M. Wright. 1999. Functional and morphological correlates of connexin50 expressed in Xenopus laevis oocytes. J. Gen. Physiol. 113:507-524. http://dx.doi.org/10.1085/jgp.113.4.507
    • (1999) J. Gen. Physiol. , vol.113 , pp. 507-524
    • Zampighi, G.A.1    Loo, D.D.2    Kreman, M.3    Eskandari, S.4    Wright, E.M.5


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