메뉴 건너뛰기




Volumn 102, Issue 6, 2012, Pages 1341-1351

Molecular dynamics simulations of the Cx26 hemichannel: Insights into voltage-dependent loop-gating

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CONNEXIN 26; GAP JUNCTION PROTEIN; ION CHANNEL;

EID: 84858777446     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2012.02.009     Document Type: Article
Times cited : (31)

References (30)
  • 2
    • 0033909785 scopus 로고    scopus 로고
    • Stoichiometry of transjunctional voltage-gating polarity reversal by a negative charge substitution in the amino terminus of a connexin32 chimera
    • DOI 10.1085/jgp.116.1.13
    • S. Oh, and C.K. Abrams T.A. Bargiello Stoichiometry of transjunctional voltage-gating polarity reversal by a negative charge substitution in the amino terminus of a connexin32 chimera J. Gen. Physiol. 116 2000 13 31 (Pubitemid 30458360)
    • (2000) Journal of General Physiology , vol.116 , Issue.1 , pp. 13-31
    • Oh, S.1    Abrams, C.K.2    Verselis, V.K.3    Bargiello, T.A.4
  • 4
    • 50449110491 scopus 로고    scopus 로고
    • Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating
    • V.K. Verselis, and M. Srinivas Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating J. Gen. Physiol. 132 2008 315 327
    • (2008) J. Gen. Physiol. , vol.132 , pp. 315-327
    • Verselis, V.K.1    Srinivas, M.2
  • 6
    • 0030777706 scopus 로고    scopus 로고
    • Changes in permeability caused by connexin 32 mutations underlie X- linked Charcot-Marie-Tooth disease
    • DOI 10.1016/S0896-6273(00)80973-3
    • S. Oh, and Y. Ri T.A. Bargiello Changes in permeability caused by connexin 32 mutations underlie X-linked Charcot-Marie-Tooth disease Neuron 19 1997 927 938 (Pubitemid 27471396)
    • (1997) Neuron , vol.19 , Issue.4 , pp. 927-938
    • Oh, S.1    Ri, Y.2    Bennett, M.V.L.3    Trexler, E.B.4    Verselis, V.K.5    Bargiello, T.A.6
  • 9
    • 33845673269 scopus 로고    scopus 로고
    • Species specificity of mammalian connexin-26 to form open voltage-gated hemichannels
    • DOI 10.1096/fj.06-5828com
    • D. Gonzalez, J.M. Gomez-Hernandez, and L.C. Barrio Species specificity of mammalian connexin-26 to form open voltage-gated hemichannels FASEB J. 20 2006 2329 2338 (Pubitemid 44953863)
    • (2006) FASEB Journal , vol.20 , Issue.13 , pp. 2329-2338
    • Gonzalez, D.1    Gomez-Hernandez, J.M.2    Barrio, L.C.3
  • 10
    • 77954320871 scopus 로고    scopus 로고
    • 2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome
    • 2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome J. Gen. Physiol. 136 2010 47 62
    • (2010) J. Gen. Physiol. , vol.136 , pp. 47-62
    • Sánchez, H.A.1    Mese, G.2    Verselis, V.K.3
  • 11
    • 0019350755 scopus 로고
    • Kinetic properties of a voltage-dependent junctional conductance
    • DOI 10.1085/jgp.77.1.95
    • A.L. Harris, D.C. Spray, and M.V. Bennett Kinetic properties of a voltage-dependent junctional conductance J. Gen. Physiol. 77 1981 95 117 (Pubitemid 11179579)
    • (1981) Journal of General Physiology , vol.77 , Issue.1 , pp. 95-117
    • Harris, A.L.1    Spray, D.C.2    Bennett, M.V.L.3
  • 12
    • 66749134986 scopus 로고    scopus 로고
    • Voltage-gating mechanisms of connexin channels
    • A.L. Harris, D. Locke, Humana Press Totowa, NJ
    • T. Bargiello, and P. Brink Voltage-gating mechanisms of connexin channels A.L. Harris, D. Locke, Connexins 2009 Humana Press Totowa, NJ 103 128
    • (2009) Connexins , pp. 103-128
    • Bargiello, T.1    Brink, P.2
  • 13
    • 63249084923 scopus 로고    scopus 로고
    • Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain
    • V.K. Verselis, and M.P. Trelles M. Srinivas Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain J. Biol. Chem. 284 2009 4484 4493
    • (2009) J. Biol. Chem. , vol.284 , pp. 4484-4493
    • Verselis, V.K.1    Trelles, M.P.2    Srinivas, M.3
  • 14
    • 66749118906 scopus 로고    scopus 로고
    • Conformational changes in a pore-forming region underlie voltage-dependent "loop gating" of an unapposed connexin hemichannel
    • Q. Tang, and T.L. Dowd T.A. Bargiello Conformational changes in a pore-forming region underlie voltage-dependent "loop gating" of an unapposed connexin hemichannel J. Gen. Physiol. 133 2009 555 570
    • (2009) J. Gen. Physiol. , vol.133 , pp. 555-570
    • Tang, Q.1    Dowd, T.L.2    Bargiello, T.A.3
  • 15
    • 80555135976 scopus 로고    scopus 로고
    • Molecular dynamics simulations of the Cx26 hemichannel: Evaluation of structural models with Brownian dynamics
    • T. Kwon, and A.L. Harris T.A. Bargiello Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics J. Gen. Physiol. 138 2011 475 493
    • (2011) J. Gen. Physiol. , vol.138 , pp. 475-493
    • Kwon, T.1    Harris, A.L.2    Bargiello, T.A.3
  • 16
    • 63849141447 scopus 로고    scopus 로고
    • Structure of the connexin 26 gap junction channel at 3.5 resolution
    • S. Maeda, and S. Nakagawa T. Tsukihara Structure of the connexin 26 gap junction channel at 3.5 resolution Nature 458 2009 597 602
    • (2009) Nature , vol.458 , pp. 597-602
    • Maeda, S.1    Nakagawa, S.2    Tsukihara, T.3
  • 17
    • 77749336161 scopus 로고    scopus 로고
    • Ion selectivity of α-hemolysin with β-cyclodextrin adapter. II. Multi-ion effects studied with grand canonical Monte Carlo/Brownian dynamics simulations
    • B. Egwolf, and Y. Luo B. Roux Ion selectivity of α-hemolysin with β-cyclodextrin adapter. II. Multi-ion effects studied with grand canonical Monte Carlo/Brownian dynamics simulations J. Phys. Chem. B 114 2010 2901 2909
    • (2010) J. Phys. Chem. B , vol.114 , pp. 2901-2909
    • Egwolf, B.1    Luo, Y.2    Roux, B.3
  • 18
    • 79551659527 scopus 로고    scopus 로고
    • Brownian dynamics simulations of ion transport through the VDAC
    • K.I. Lee, and H. Rui W. Im Brownian dynamics simulations of ion transport through the VDAC Biophys. J. 100 2011 611 619
    • (2011) Biophys. J. , vol.100 , pp. 611-619
    • Lee, K.I.1    Rui, H.2    Im, W.3
  • 19
    • 0033884302 scopus 로고    scopus 로고
    • A grand canonical Monte Carlo-Brownian Dynamics algorithm for simulating ion channels
    • W. Im, S. Seefeld, and B. Roux A grand canonical Monte Carlo-Brownian dynamics algorithm for simulating ion channels Biophys. J. 79 2000 788 801 (Pubitemid 30626174)
    • (2000) Biophysical Journal , vol.79 , Issue.2 , pp. 788-801
    • Im, W.1    Seefeld, S.2    Roux, B.3
  • 20
    • 15244338641 scopus 로고    scopus 로고
    • Ion permeation through the α-hemolysin channel: Theoretical studies based on Brownian dynamics and Poisson-Nernst-Plank electrodiffusion theory
    • DOI 10.1529/biophysj.104.044008
    • S.Y. Noskov, W. Im, and B. Roux Ion permeation through the alpha-hemolysin channel: theoretical studies based on Brownian dynamics and Poisson-Nernst-Plank electrodiffusion theory Biophys. J. 87 2004 2299 2309 (Pubitemid 41071331)
    • (2004) Biophysical Journal , vol.87 , Issue.4 , pp. 2299-2309
    • Noskov, S.Yu.1    Im, W.2    Roux, B.3
  • 21
    • 73149098341 scopus 로고    scopus 로고
    • Post-translational modifications of connexin26 revealed by mass spectrometry
    • D. Locke, and S. Bian A.L. Harris Post-translational modifications of connexin26 revealed by mass spectrometry Biochem. J. 424 2009 385 398
    • (2009) Biochem. J. , vol.424 , pp. 385-398
    • Locke, D.1    Bian, S.2    Harris, A.L.3
  • 24
    • 84986512474 scopus 로고
    • CHARMM: A program for macromolecular energy, minimization, and dynamics calculations
    • B.R. Brooks, and R.E. Bruccoleri M. Karplus CHARMM: a program for macromolecular energy, minimization, and dynamics calculations J. Comput. Chem. 4 1983 187 217
    • (1983) J. Comput. Chem. , vol.4 , pp. 187-217
    • Brooks, B.R.1    Bruccoleri, R.E.2    Karplus, M.3
  • 26
    • 0034677524 scopus 로고    scopus 로고
    • Mapping the conformational wave of acetylcholine receptor channel gating
    • DOI 10.1038/35001586
    • C. Grosman, M. Zhou, and A. Auerbach Mapping the conformational wave of acetylcholine receptor channel gating Nature 403 2000 773 776 (Pubitemid 30111838)
    • (2000) Nature , vol.403 , Issue.6771 , pp. 773-776
    • Grosman, C.1    Zhou, M.2    Auerbach, A.3
  • 27
    • 0038149197 scopus 로고    scopus 로고
    • Life at the top: The transition state of AChR gating
    • A. Auerbach Life at the top: the transition state of AChR gating Sci. STKE 2003 2003 re11
    • (2003) Sci. STKE , vol.2003 , pp. 11
    • Auerbach, A.1
  • 28
    • 36549080807 scopus 로고    scopus 로고
    • Acetylcholine receptor gating: Movement in the α-subunit extracellular domain
    • DOI 10.1085/jgp.200709858
    • P. Purohit, and A. Auerbach Acetylcholine receptor gating: movement in the α-subunit extracellular domain J. Gen. Physiol. 130 2007 569 579 (Pubitemid 350179575)
    • (2007) Journal of General Physiology , vol.130 , Issue.6 , pp. 569-579
    • Purohit, P.1    Auerbach, A.2
  • 29
    • 36549039473 scopus 로고    scopus 로고
    • Acetylcholine receptor gating at extracellular transmembrane domain interface: The "pre-M1" linker
    • DOI 10.1085/jgp.200709857
    • P. Purohit, and A. Auerbach Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker J. Gen. Physiol. 130 2007 559 568 (Pubitemid 350179574)
    • (2007) Journal of General Physiology , vol.130 , Issue.6 , pp. 559-568
    • Purohit, P.1    Auerbach, A.2
  • 30
    • 0030404988 scopus 로고    scopus 로고
    • HOLE: A program for the analysis of the pore dimensions of ion channel structural models
    • DOI 10.1016/S0263-7855(97)00009-X, PII S026378559700009X
    • O.S. Smart, and J.G. Neduvelil M.S. Sansom HOLE: a program for the analysis of the pore dimensions of ion channel structural models J. Mol. Graph. 14 1996 354 360 376 (Pubitemid 27302826)
    • (1996) Journal of Molecular Graphics , vol.14 , Issue.6 , pp. 354-360
    • Smart, O.S.1    Neduvelil, J.G.2    Wang, X.3    Wallace, B.A.4    Sansom, M.S.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.