메뉴 건너뛰기




Volumn 11, Issue 1, 2013, Pages

Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity

Author keywords

Heart; Hypertrophy; Leptin; Obesity; Signal transduction; STAT3

Indexed keywords

JANUS KINASE 2; LEPTIN; LEPTIN RECEPTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SERINE; STAT3 PROTEIN; TYROSINE;

EID: 84879997983     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-170     Document Type: Article
Times cited : (44)

References (45)
  • 2
    • 0027984612 scopus 로고
    • Importance of obesity, race and age to the cardiac structural and functional effects of hypertension. The department of veterans affairs cooperative study group on antihypertensive agents
    • 10.1016/0735-1097(94)90145-7, 7930281
    • Gottdiener JS, Reda DJ, Materson BJ, Massie BM, Notargiacomo A, Hamburger RJ, Williams DW, Henderson WG. Importance of obesity, race and age to the cardiac structural and functional effects of hypertension. The department of veterans affairs cooperative study group on antihypertensive agents. J Am Coll Cardiol 1994, 24:1492-1498. 10.1016/0735-1097(94)90145-7, 7930281.
    • (1994) J Am Coll Cardiol , vol.24 , pp. 1492-1498
    • Gottdiener, J.S.1    Reda, D.J.2    Materson, B.J.3    Massie, B.M.4    Notargiacomo, A.5    Hamburger, R.J.6    Williams, D.W.7    Henderson, W.G.8
  • 3
    • 0025773972 scopus 로고
    • The impact of obesity on left ventricular mass and geometry. The framingham heart study
    • 10.1001/jama.1991.03470020057032, 1829117
    • Lauer MS, Anderson KM, Kannel WB, Levy D. The impact of obesity on left ventricular mass and geometry. The framingham heart study. JAMA 1991, 266:231-236. 10.1001/jama.1991.03470020057032, 1829117.
    • (1991) JAMA , vol.266 , pp. 231-236
    • Lauer, M.S.1    Anderson, K.M.2    Kannel, W.B.3    Levy, D.4
  • 6
    • 23044463589 scopus 로고    scopus 로고
    • Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy
    • 10.1210/jc.2004-1963, 15855267
    • Perego L, Pizzocri P, Corradi D, Maisano F, Paganelli M, Fiorina P, Barbieri M, Morabito A, Paolisso G, Folli F, Pontiroli AE. Circulating leptin correlates with left ventricular mass in morbid (grade III) obesity before and after weight loss induced by bariatric surgery: a potential role for leptin in mediating human left ventricular hypertrophy. J Clin Endocrinol Metab 2005, 90:4087-4093. 10.1210/jc.2004-1963, 15855267.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 4087-4093
    • Perego, L.1    Pizzocri, P.2    Corradi, D.3    Maisano, F.4    Paganelli, M.5    Fiorina, P.6    Barbieri, M.7    Morabito, A.8    Paolisso, G.9    Folli, F.10    Pontiroli, A.E.11
  • 7
    • 0041857804 scopus 로고    scopus 로고
    • The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes
    • 10.1161/01.RES.0000089255.37804.72, 12893740
    • Rajapurohitam V, Gan XT, Kirshenbaum LA, Karmazyn M. The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes. Circ Res 2003, 93:277-279. 10.1161/01.RES.0000089255.37804.72, 12893740.
    • (2003) Circ Res , vol.93 , pp. 277-279
    • Rajapurohitam, V.1    Gan, X.T.2    Kirshenbaum, L.A.3    Karmazyn, M.4
  • 8
    • 31344444358 scopus 로고    scopus 로고
    • Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes
    • 10.1016/j.cardiores.2005.11.022, 16376323
    • Madani S, De Girolamo S, Munoz DM, Li RK, Sweeney G. Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovasc Res 2006, 69:716-725. 10.1016/j.cardiores.2005.11.022, 16376323.
    • (2006) Cardiovasc Res , vol.69 , pp. 716-725
    • Madani, S.1    De Girolamo, S.2    Munoz, D.M.3    Li, R.K.4    Sweeney, G.5
  • 9
    • 33746093293 scopus 로고    scopus 로고
    • An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1
    • 10.1016/j.yjmcc.2006.05.001, 16806260
    • Rajapurohitam V, Javadov S, Purdham DM, Kirshenbaum LA, Karmazyn M. An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1. J Mol Cell Cardiol 2006, 41:265-274. 10.1016/j.yjmcc.2006.05.001, 16806260.
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 265-274
    • Rajapurohitam, V.1    Javadov, S.2    Purdham, D.M.3    Kirshenbaum, L.A.4    Karmazyn, M.5
  • 10
    • 54049155806 scopus 로고    scopus 로고
    • Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription
    • 10.1152/ajpheart.00319.2008, 2544483, 18641278
    • Fang CX, Dong F, Thomas DP, Ma H, He L, Ren J. Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription. Am J Physiol Heart Circ Physiol 2008, 295:H1206-H1215. 10.1152/ajpheart.00319.2008, 2544483, 18641278.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Fang, C.X.1    Dong, F.2    Thomas, D.P.3    Ma, H.4    He, L.5    Ren, J.6
  • 11
    • 73349143332 scopus 로고    scopus 로고
    • Dietary-induced obesity hastens the progression from concentric cardiac hypertrophy to pump dysfunction in spontaneously hypertensive rats
    • 10.1161/HYPERTENSIONAHA.108.127514, 19841294
    • Majane OH, Vengethasamy L, du Toit EF, Makaula S, Woodiwiss AJ, Norton GR. Dietary-induced obesity hastens the progression from concentric cardiac hypertrophy to pump dysfunction in spontaneously hypertensive rats. Hypertension 2009, 54:1376-1383. 10.1161/HYPERTENSIONAHA.108.127514, 19841294.
    • (2009) Hypertension , vol.54 , pp. 1376-1383
    • Majane, O.H.1    Vengethasamy, L.2    du Toit, E.F.3    Makaula, S.4    Woodiwiss, A.J.5    Norton, G.R.6
  • 12
    • 0042018759 scopus 로고    scopus 로고
    • Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice
    • 10.1161/01.CIR.0000083716.82622.FD, 12885755
    • Barouch LA, Berkowitz DE, Harrison RW, O'Donnell CP, Hare JM. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 2003, 108:754-759. 10.1161/01.CIR.0000083716.82622.FD, 12885755.
    • (2003) Circulation , vol.108 , pp. 754-759
    • Barouch, L.A.1    Berkowitz, D.E.2    Harrison, R.W.3    O'Donnell, C.P.4    Hare, J.M.5
  • 14
    • 55249127504 scopus 로고    scopus 로고
    • High-fat diet-induced obesity leads to resistance to leptin-induced cardiomyocyte contractile response
    • Ren J, Zhu BH, Relling DP, Esberg LB, Ceylan-Isik AF. High-fat diet-induced obesity leads to resistance to leptin-induced cardiomyocyte contractile response. Obesity (Silver Spring) 2008, 16:2417-2423.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 2417-2423
    • Ren, J.1    Zhu, B.H.2    Relling, D.P.3    Esberg, L.B.4    Ceylan-Isik, A.F.5
  • 15
    • 33847065971 scopus 로고    scopus 로고
    • Induction of cardiac uncoupling protein-2 expression and adenosine 5′-monophosphate-activated protein kinase phosphorylation during early states of diet-induced obesity in mice
    • Somoza B, Guzman R, Cano V, Merino B, Ramos P, Diez-Fernandez C, Fernandez-Alfonso MS, Ruiz-Gayo M. Induction of cardiac uncoupling protein-2 expression and adenosine 5′-monophosphate-activated protein kinase phosphorylation during early states of diet-induced obesity in mice. Endocrinology 2007, 148:924-931.
    • (2007) Endocrinology , vol.148 , pp. 924-931
    • Somoza, B.1    Guzman, R.2    Cano, V.3    Merino, B.4    Ramos, P.5    Diez-Fernandez, C.6    Fernandez-Alfonso, M.S.7    Ruiz-Gayo, M.8
  • 18
    • 0036828842 scopus 로고    scopus 로고
    • Regulation of Jak kinases by intracellular leptin receptor sequences
    • 10.1074/jbc.M205148200, 12196522
    • Kloek C, Haq AK, Dunn SL, Lavery HJ, Banks AS, Myers MG. Regulation of Jak kinases by intracellular leptin receptor sequences. J Biol Chem 2002, 277:41547-41555. 10.1074/jbc.M205148200, 12196522.
    • (2002) J Biol Chem , vol.277 , pp. 41547-41555
    • Kloek, C.1    Haq, A.K.2    Dunn, S.L.3    Lavery, H.J.4    Banks, A.S.5    Myers, M.G.6
  • 19
    • 1642464978 scopus 로고    scopus 로고
    • Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase- and phosphatidylinositol 3-kinase-dependent signaling pathways
    • Tajmir P, Ceddia RB, Li RK, Coe IR, Sweeney G. Leptin increases cardiomyocyte hyperplasia via extracellular signal-regulated kinase- and phosphatidylinositol 3-kinase-dependent signaling pathways. Endocrinology 2004, 145:1550-1555.
    • (2004) Endocrinology , vol.145 , pp. 1550-1555
    • Tajmir, P.1    Ceddia, R.B.2    Li, R.K.3    Coe, I.R.4    Sweeney, G.5
  • 20
    • 38849188633 scopus 로고    scopus 로고
    • Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei
    • Zeidan A, Javadov S, Chakrabarti S, Karmazyn M. Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei. Cardiovasc Res 2008, 77:64-72.
    • (2008) Cardiovasc Res , vol.77 , pp. 64-72
    • Zeidan, A.1    Javadov, S.2    Chakrabarti, S.3    Karmazyn, M.4
  • 22
    • 0242268405 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age
    • 10.1073/pnas.2134694100, 240721, 14566054
    • Jacoby JJ, Kalinowski A, Liu MG, Zhang SS, Gao Q, Chai GX, Ji L, Iwamoto Y, Li E, Schneider M, Russell KS, Fu XY. Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A 2003, 100:12929-12934. 10.1073/pnas.2134694100, 240721, 14566054.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12929-12934
    • Jacoby, J.J.1    Kalinowski, A.2    Liu, M.G.3    Zhang, S.S.4    Gao, Q.5    Chai, G.X.6    Ji, L.7    Iwamoto, Y.8    Li, E.9    Schneider, M.10    Russell, K.S.11    Fu, X.Y.12
  • 28
    • 77953670617 scopus 로고    scopus 로고
    • Leptin signaling in the failing and mechanically unloaded human heart
    • 10.1161/CIRCHEARTFAILURE.109.869909, 2780432, 19919993
    • McGaffin KR, Moravec CS, McTiernan CF. Leptin signaling in the failing and mechanically unloaded human heart. Circ Heart Fail 2009, 2:676-683. 10.1161/CIRCHEARTFAILURE.109.869909, 2780432, 19919993.
    • (2009) Circ Heart Fail , vol.2 , pp. 676-683
    • McGaffin, K.R.1    Moravec, C.S.2    McTiernan, C.F.3
  • 29
    • 0031577546 scopus 로고    scopus 로고
    • Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and, e in different mouse tissues
    • 10.1006/bbrc.1997.7205, 9299568
    • Lollmann B, Gruninger S, Stricker-Krongrad A, Chiesi M. Detection and quantification of the leptin receptor splice variants Ob-Ra, b, and, e in different mouse tissues. Biochem Biophys Res Commun 1997, 238:648-652. 10.1006/bbrc.1997.7205, 9299568.
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 648-652
    • Lollmann, B.1    Gruninger, S.2    Stricker-Krongrad, A.3    Chiesi, M.4
  • 32
    • 34250891864 scopus 로고    scopus 로고
    • Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation
    • 10.1152/ajpheart.00579.2006, 17220191
    • Abe Y, Ono K, Kawamura T, Wada H, Kita T, Shimatsu A, Hasegawa K. Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation. Am J Physiol Heart Circ Physiol 2007, 292:H2387-H2396. 10.1152/ajpheart.00579.2006, 17220191.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Abe, Y.1    Ono, K.2    Kawamura, T.3    Wada, H.4    Kita, T.5    Shimatsu, A.6    Hasegawa, K.7
  • 33
    • 49849103205 scopus 로고    scopus 로고
    • A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart
    • 10.1152/ajpheart.91537.2007, 18469142
    • Purdham DM, Rajapurohitam V, Zeidan A, Huang C, Gross GJ, Karmazyn M. A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart. Am J Physiol Heart Circ Physiol 2008, 295:H441-H446. 10.1152/ajpheart.91537.2007, 18469142.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Purdham, D.M.1    Rajapurohitam, V.2    Zeidan, A.3    Huang, C.4    Gross, G.J.5    Karmazyn, M.6
  • 34
    • 84863559380 scopus 로고    scopus 로고
    • Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice
    • 10.1186/1479-5876-10-145, 3551744, 22784636
    • Wang HT, Liu CF, Tsai TH, Chen YL, Chang HW, Tsai CY, Leu S, Zhen YY, Chai HT, Chung SY, Chua S, Yen CH, Yip HK. Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice. J Transl Med 2012, 10:145. 10.1186/1479-5876-10-145, 3551744, 22784636.
    • (2012) J Transl Med , vol.10 , pp. 145
    • Wang, H.T.1    Liu, C.F.2    Tsai, T.H.3    Chen, Y.L.4    Chang, H.W.5    Tsai, C.Y.6    Leu, S.7    Zhen, Y.Y.8    Chai, H.T.9    Chung, S.Y.10    Chua, S.11    Yen, C.H.12    Yip, H.K.13
  • 35
  • 37
    • 33748030752 scopus 로고    scopus 로고
    • Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects
    • 10.1038/sj.bjp.0706834, 1629412, 16847434
    • Smith CC, Mocanu MM, Davidson SM, Wynne AM, Simpkin JC, Yellon DM. Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects. Br J Pharmacol 2006, 149:5-13. 10.1038/sj.bjp.0706834, 1629412, 16847434.
    • (2006) Br J Pharmacol , vol.149 , pp. 5-13
    • Smith, C.C.1    Mocanu, M.M.2    Davidson, S.M.3    Wynne, A.M.4    Simpkin, J.C.5    Yellon, D.M.6
  • 38
    • 57049120648 scopus 로고    scopus 로고
    • Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice
    • 10.1152/ajpheart.00379.2008, 2759460, 18689499
    • Bouhidel O, Pons S, Souktani R, Zini R, Berdeaux A, Ghaleh B. Myocardial ischemic postconditioning against ischemia-reperfusion is impaired in ob/ob mice. Am J Physiol Heart Circ Physiol 2008, 295:H1580-H1586. 10.1152/ajpheart.00379.2008, 2759460, 18689499.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Bouhidel, O.1    Pons, S.2    Souktani, R.3    Zini, R.4    Berdeaux, A.5    Ghaleh, B.6
  • 40
    • 67650257499 scopus 로고    scopus 로고
    • Leptin attenuates cardiac apoptosis after chronic ischaemic injury
    • 10.1093/cvr/cvp071, 2701718, 19233863
    • McGaffin KR, Zou B, McTiernan CF, O'Donnell CP. Leptin attenuates cardiac apoptosis after chronic ischaemic injury. Cardiovasc Res 2009, 83:313-324. 10.1093/cvr/cvp071, 2701718, 19233863.
    • (2009) Cardiovasc Res , vol.83 , pp. 313-324
    • McGaffin, K.R.1    Zou, B.2    McTiernan, C.F.3    O'Donnell, C.P.4
  • 41
    • 77957255519 scopus 로고    scopus 로고
    • Leptin protects cardiomyocytes from serum-deprivation-induced apoptosis by increasing anti-oxidant defence
    • 10.1111/j.1440-1681.2010.05415.x, 20557321
    • Zheng J, Fang J, Yin YJ, Wang XC, Ren AJ, Bai J, Sun XJ, Yuan WJ, Lin L. Leptin protects cardiomyocytes from serum-deprivation-induced apoptosis by increasing anti-oxidant defence. Clin Exp Pharmacol Physiol 2010, 37:955-962. 10.1111/j.1440-1681.2010.05415.x, 20557321.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 955-962
    • Zheng, J.1    Fang, J.2    Yin, Y.J.3    Wang, X.C.4    Ren, A.J.5    Bai, J.6    Sun, X.J.7    Yuan, W.J.8    Lin, L.9
  • 43
    • 84871341357 scopus 로고    scopus 로고
    • Cardiomyocyte-specific deletion of leptin receptors causes lethal heart failure in Cre-recombinase-mediated cardiotoxicity
    • 10.1152/ajpregu.00292.2012, 23115124
    • Hall ME, Smith G, Hall JE, Stec DE. Cardiomyocyte-specific deletion of leptin receptors causes lethal heart failure in Cre-recombinase-mediated cardiotoxicity. Am J Physiol Regul Integr Comp Physiol 2012, 303:R1241-R1250. 10.1152/ajpregu.00292.2012, 23115124.
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.303
    • Hall, M.E.1    Smith, G.2    Hall, J.E.3    Stec, D.E.4
  • 45
    • 42749090245 scopus 로고    scopus 로고
    • Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts
    • 10.1016/j.yjmcc.2008.03.005, 18436234
    • Schram K, Wong MM, Palanivel R, No EK, Dixon IM, Sweeney G. Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts. J Mol Cell Cardiol 2008, 44:874-881. 10.1016/j.yjmcc.2008.03.005, 18436234.
    • (2008) J Mol Cell Cardiol , vol.44 , pp. 874-881
    • Schram, K.1    Wong, M.M.2    Palanivel, R.3    No, E.K.4    Dixon, I.M.5    Sweeney, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.