Leptin resistance develops spontaneously in mice during adult life in a tissue-specific manner. Consequences for hepatic steatosis

Biochimie

Volumn 93, Issue 10, 2011, Pages 1779-1785

  Stucchi, Paula ^a   Guzmán Ruiz, Rocío ^b   Gil Ortega, Marta ^b   Merino, Beatriz ^b   Somoza, Beatriz ^b   Cano, Victoria ^b   De Castro, Javier ^b   Sevillano, Julio ^b   Ramos, M Pilar ^b   Fernández Alfonso, María S ^a   Ruiz Gayo, Mariano ^b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD SAN PABLO CEU   (Spain)

Author keywords

Akt; Leptin receptors; Leptin resistance; Liver; STAT3

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; PROTEIN KINASE B; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FATTY LIVER; HEART; HEART WEIGHT; HORMONE RESISTANCE; HORMONE RESPONSE; LIVER; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WHITE ADIPOSE TISSUE;

ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; FATTY LIVER; LEPTIN; LIPIDS; LIVER; MALE; MICE; MICE, INBRED C57BL; MYOCARDIUM; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

ANIMALIA; MUS;

EID: 80052100000     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.06.020     Document Type: Article

References (23)

1. M. Shimabukuro, K. Koyama, G. Chen, M.-Y. Wang, F. Trieu, Y. Lee, C.B. Newgard, and R.H. Unger Direct antidiabetic effect of leptin through triglyceride depletion of tissues PNAS USA 94 1997 4637 4661
2. Y.-T. Zhou, P. Grayburn, A. Karim, M. Shimabukuro, M. Higa, D. Baetens, L. Orci, and R.H. Unger Lipotoxic heart disease in obese rats: implications for human obesity PNAS USA 97 2000 1784 1789 (Pubitemid 30118520)
3. N. Sáinz, A. Rodríguez, V. Catalán, S. Becerril, B. Ramírez, J. Gómez-Ambrosi, and G. Frühbeck Leptin administration favors muscle mass accretion by decreasing FoxO3a and increasing PGC-1α in ob/ob mice Plos One 4 2009 e6808
4. Z.W. Wang, Y.T. Zhou, T. Kakuma, Y. Lee, M. Higa, S.P. Kalra, M.G. Dube, P.S. Kalra, and R.H. Unger Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia PNAS USA 96 1999 10373 10378 (Pubitemid 29422565)
5. Y. Lee, M.-Y. Wang, T. Kakuma, Z.-W. Wang, E. Babcock, K. McCorkle, M. Higa, Y.-T. Zhou, and R.H. Unger Liporegulation in diet-induced obesity J. Biol. Chem. 276 2001 5629 5635
6. R.H. Unger, and L. Orci Diseases of liporegulation: new perspective on obesity and related disorders FASEB J. 15 2001 312 321 (Pubitemid 32141423)
7. B. Somoza, R. Guzmán, V. Cano, B. Merino, P. Ramos, C. Díez-Fernández, M.S. Fernández-Alfonso, and M. Ruiz-Gayo Induction of cardiac uncoupling protein-2 expression and adenosine 5′-monophosphate-activated protein kinase phosphorylation during early states of diet-induced obesity in mice Endocrinology 148 2007 924 931
8. R. Guzmán-Ruiz, B. Somoza, M. Gil-Ortega, B. Merino, V. Cano, C. Attané, I. Castan-Laurell, P. Valet, M.S. Fernández-Alfonso, and M. Ruiz-Gayo Sensitivity of cardiac carnitine palmitoyltransferase to malonyl-CoA is regulated by leptin. Similarities with a model of endogenous hyperleptinemia Endocrinology 151 2010 1010 1018
9. H. Münzberg, J.S. Flier, and C. Bjorbaek Region-specific leptin resistance within the hypothalamus of diet-induced obese mice Endocrinology 145 2004 4880 4889 (Pubitemid 39551104)
10. L.L. Listenberger, X. Han, S.E. Lewis, S. Cases, R.V. Farese, D.S. Ory, and J.E. Shaffer Triglyceride accumulation protects against fatty acid-induced lipotoxicity PNAS USA 100 2003 3077 3082 (Pubitemid 36356542)
11. R.H. Unger Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome Endocrinology 144 2003 5159 5165 (Pubitemid 37476041)
12. B. Ahren, S. Mansson, R.L. Gingerich, and P.J. Havel Regulation of plasma leptin in mice: influence of age, high-fat diet, and fasting Am. J. Physiol. Regul. Comp. Physiol. 273 1997 R113 R120
13. J. Cacho, J. Sevillano, J. de Castro, E. Herrera, and M.P. Ramos Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats Am. J. Physiol. Endocrinol. Metab. 295 2008 E1269 E1276
14. E. Herrera, and A. Ayanz Calculation of lipolysis and esterification from glycerol metabolism in rat adipose tissue J. Lipids Res. 13 1972 802 809
15. J. You, Y. Yu, L. Jiang, W. Li, X. Yu, L. Gonzalez, G. Yang, Z. Ke, W. Li, C. Li, and Y. Liu Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance Mol. Cell. Biol. 30 2010 1650 1659
16. M.B. Ernst, C.M. Wunderlich, S. Hess, M. Paehler, A. Mesaros, S.B. Koralov, A. Kleinridders, A. Husch, H. Münzberg, B. Hampel, J. Alber, P. Kloppenburg, J.C. Brüning, and F.T. Wunderlich Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity J. Neurosci. 29 2009 11582 11593
17. S. Fishman, R.H. Muzumdar, G. Atzmon, X. Ma, X. Yang, F.H. Einstein, and N. Barzilai Resistance to leptin action is the major determinant of hepatic triglyceride accumulation in vivo FASEB J. 21 2007 53 60 (Pubitemid 46061355)
18. F. Kim, M. Pham, E. Maloney, N.O. Rizzo, G.J. Morton, B.E. Wisse, E.A. Kirk, A. Chait, and M.W. Schwartz Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance Arterioscler. Thromb. Vasc. Biol. 28 2008 1982 1988
19. L. He, X. Hou, G. Kanel, N. Zeng, V. Galicia, Y. Wang, J. Yang, H. Wu, M.J. Birnbaum, and B.L. Stiles The critical role of Akt2 in hepatic steatosis induced by PTEN loss Am. J. Pathol. 176 2010 2302 2308
20. M.A. Abdul-Ghani, D. Tripathy, and R.A. DeFronzo Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose Diabetes Care 29 2006 1130 1139 (Pubitemid 44115261)
21. P. Björntorp Endocrine abnormalities of obesity Metabolism 44 1995 21 23
22. T. Goto, T. Onuma, K. Takebe, and J.G. Kral The influence of fatty liver on insulin clearance and insulin resistance in non-diabetic Japanese subjects Int. J. Obes. Relat. Metab. Disord. 19 1995 841 845 (Pubitemid 26003018)
23. L. Ryysy, A.M. Häkkinen, T. Goto, S. Vehkavaara, J. Westerbacka, J. Halavaara, and H. Yki-Järvinen Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients Diabetes 49 2000 749 758 (Pubitemid 30339990)