Leptin signalling reduces the severity of cardiac dysfunction and remodelling after chronic ischaemic injury

Cardiovascular Research

Volumn 77, Issue 1, 2008, Pages 54-63

  McGaffin, Kenneth R ^a   Sun, Cheuk Kwan ^a,b   Rager, Jennifer J ^a   Romano, Lia C ^a   Zou, Baobo ^a   Mathier, Michael A ^a   O'Doherty, Robert M ^a   McTiernan, Charles F ^a   O'Donnell, Christopher P ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Cytokines; Gene expression; Heart failure; Ischaemia; Signal transduction

Indexed keywords

HEAT SHOCK PROTEIN 70; STAT3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE SEVERITY; DNA BINDING; ECHOCARDIOGRAPHY; HEART DISEASE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; LEAN BODY WEIGHT; LEFT CORONARY ARTERY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; SHAM PROCEDURE; SIGNAL TRANSDUCTION; SURVIVAL; THORAX SURGERY; TISSUE STRUCTURE; WESTERN BLOTTING; WILD TYPE;

ANIMALS; CARDIOMEGALY; HEART; HEART FAILURE; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; VENTRICULAR FUNCTION, LEFT;

EID: 38849090085     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvm023     Document Type: Article

References (33)

1. Ren J. Leptin and hyperletinemia-from friend to foe for cardiovascular function. J Endocrinol 2004;181:1-10.
2. Purdham D, Zou MX, Rajapurohitam V, Karmazyn M. Rat heart is a site of leptin production and action. Am J Physiol Heart Circ Physiol 2004;287:H2877-H2884.
3. Barouch L, Berkowitz DE, Harrison RW, O'Donnell CP, Hare JM. Disruption of leptin signalling contributes to cardiac hypertrophy independently of body weight in mice. Circulation 2003;108:754-759.
4. Raju S, Zhengm M, Schuleri KH, Phan AC, Bedja D, Saraiva RM et al. Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity. Proc Natl Acad Sci USA 2006;103:4222-4227.
5. Madani S, De Girolamo S, Munzo DM, Li RK, Sweeny G. Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovasc Res 2005;69:716-725.
6. Pinieiro R, Iglesias MJ, Eiras S, Vinuela J, Lago F, Gonzalez-Juanatey JR. Leptin does not induce hypertrophy, cell cycle alterations, or production of MCP-1 in cultured rat and mouse cardiomyocytes. Endocr Res 2005;31:375-386.
7. Zeidan A, Javadov S, Karmazyn M. Essential role of Rho/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes. Cardiovasc Res 2006;72:101-111.
8. Struthers A. Pathophysiology of heart failure following myocardial infarction. Heart 2005;91:ii14-ii16.
9. Greer J, Ware DP, Lefer DJ. Myocardial infarction and heart failure in the db/db diabetic mouse. Am J Physiol Heart Circ Physiol 2006;290:H146-H453.
10. Erkasap N, Ikizler M, Shneyvays V, Zinman T, Mamedova LK, Uyar R et al. Leptin protects the cardiac myocyte cultures from hypoxic damage. Life Sci 2006;78:1098-1102.
11. Meisel S, Ellis M, Pariente C, Pauzner H, Liebowitz M, David D et al. Serum leptin levels increase following acute myocardial infarction. Cardiology 2001;95:206-211.
12. Schulze P, Kratzsch J, Linke A, Schoene N, Adams V, Gielen S et al. Elevated serum levels of leptin and soluble receptor in patients with advanced chronic heart failure. Eur J Heart Fail 2003;5:33-40.
13. Scarpace PJ, Zhang Y. Elevated leptin: consequence or cause of obesity? Front Biosci 2007;12:3531-3544.
14. Banks A, Davis SM, Bates SH, Myers MG. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000;275: 14563-14572.
15. Barry S, Townsend PA, Latchman DS, Stephanou A. Role of the JAK-STAT pathway in myocardial injury. Trends Mol Med 2007;13:82-89.
16. Yamauchi-Takihara K, Kishimoto T. A novel role for STAT3 in cardiac remodeling. Trends Cardiovasc Med 2000;10:298-303.
17. Ramani R, Mathier M, Wang P, Gibson G, Togel S, Dawson J et al. Inhibition of tumor necrosis factor receptor-1-mediated pathways has beneficial effects in a murine model of postischemic remodeling. Am J Physiol Heart Circ Physiol 2004;287:H1369-H1377.
18. Stephanou A, Latchman DS. Transcriptional regulation of the heat shock protein genes by STAT family transcription factors. Gene Expr 1999;7:311-319.
19. Cao Q, Mak KM, Ren C, Lieber CS. Leptin stimulates tissue inhibitor of metalloprotinease-1 in human hepatic stellate cells: rspective roles of the JAK/STAT and JAK mediated H2O2-dependant MAPK pathways. J Biol Chem 2004;279:4292-4304.
20. Schulze PC, Kratzsch J. Leptin as a new diagnostic tool in chronic heart failure. Clin Chim Acta 2005;362:1-11.
21. Madiehe A, Schaffhauser AO, Braymer DH, Bray GA, York DA. Differential expression of leptin receptor in high- and low-fat-fed osborne-mendel and S5B/Pl rats. Obes Res 2000;8:467-474.
22. Peiser C, McGregor GP, Lang RE. Leptin receptor expression and suppressor of cytokine signaling transcript levels in high-fat-fed rats. Life Sci 2000;67:2971-2981.
23. Barr V, Lane K, Taylor SI. Subcellular localization and internalization of the four human leptin receptor isoforms. J Biol Chem 1999;274:21416-21424.
24. Gao X-M, Dart AM, Dewar E, Jennings G, Du X-J. Serial echocardiographic assessment of left ventricular dimensions and function after myocardial infarction in mice. Cardiovasc Res 2000;45:330-338.
25. Pons S, Fornes P, Hagege AA, Heudes D, Giudicelli J-F, Richer C. Survival, haemodynamics and cardiac remodelling follow up in mice after myocardial infarction. Clin Exp Pharmacol Physiol 2003;30:25-31.
26. Soond S, Latchman DS, Stephanou A. STAT signalling in the heart and cardioprotection. Expert Rev Mol Med 2006;8:1-16.
27. Hilfinker-Kleiner D, Hilfinker A, Fuchs M, Kaminski K, Schaefer A, Schieffer B et al. Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and protection from ischemic injury. Circ Res 2004;95:187-195.
28. Creemers E, Davis JN, Parkhurst AM, Leenders P, Dowdy KB, Hapke E et al. Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction in mice. Am J Physiol Heart Circ Physiol 2003;284:H364- H371.
29. Jayakumar J, Suzuki K, Sammut IA, Smolenski RT, Khan M, Latif N et al. Heat shock protein 70 gene transfection protects mitochondrial and ventricular function against ischemia-reperfusion injury. Circulation 2001;104:I303-I307.
30. Delogu G, Signore M, Mechelli A, Famularo G. Heat shock proteins and their role in heart injury. Curr Opin Crit Care 2002;8:411-416.
31. Buchanan J, Mazumder PK, Hu P, Chakrabarti G, Roberts MW, Yun UJ et al. Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology 2005;146:5341-5349.
32. Sharma AM. Obesity and cardiovascular risk. Growth Horm IGF Res 2003;13:S10-S17.
33. Curtis J, Selter JG, Wang Y, Rathore SS, Jovin IS, Jadbabaie F et al. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 2005;165:55-61.