Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-Mediated Apoptosis in Murine Livers

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Lei, Daoxiong ^a,b   Li, Faqian ^c   Su, Huabo ^a,d   Liu, Jinbao ^a,e   Wei, Ning ^f   Wang, Xuejun ^a  

^a UNIVERSITY OF SOUTH DAKOTA   (United States)

^b TIANJIN FOURTH CENTRAL HOSPITAL   (China)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d MEDICAL COLLEGE OF GEORGIA   (United States)

^e GUANGZHOU MEDICAL UNIVERSITY   (China)

^f YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; COP9 SIGNALOSOME; COP9 SIGNALOSOME SUBUNIT 8 PROTEIN; PROTEASOME; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN CIS; RECEPTOR PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOACCUMULATION; CELL INCLUSION; CONTROLLED STUDY; ENZYME SUBSTRATE; ENZYME SUBUNIT; LIVER CELL; MOUSE; NEDDYLATION; NONHUMAN; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; UBIQUITINATION; UPREGULATION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; GENE KNOCKOUT TECHNIQUES; LIVER; MEMBRANE PROTEINS; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; UBIQUITIN; UBIQUITINS;

EUKARYOTA; MURINAE; VERTEBRATA;

EID: 84879702339     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067793     Document Type: Article

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