Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity

Molecular Biology of the Cell

Volumn 22, Issue 24, 2011, Pages 4706-4715

  Choo, Yin Yin ^a   Boh, Boon Kim ^a,b   Lou, Jessica Jie Wei ^a   Eng, Jolane ^a   Leck, Yee Chin ^a   Anders, Benjamin ^a   Smith, Peter G ^c   Hagen, Thilo ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; COP9 SIGNALOSOME; CULLIN; CULLIN 1; CULLIN 3; F BOX PROTEIN; PROLINE; S PHASE KINASE ASSOCIATED PROTEIN 2; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; UBIQUITINATION;

CULLIN PROTEINS; HEK293 CELLS; HUMANS; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; REPRESSOR PROTEINS; UBIQUITINATION; UBIQUITINS;

EID: 84055200369     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E11-03-0251     Document Type: Article

References (47)

1. Cdh1 ubiquitin ligase. Nature 428, 190-193.
2. Boh BK, Smith PG, Hagen T (2011). Neddylation-induced conformational control regulates Cullin RING ligase activity in vivo. J Mol Biol 409, 136-145.
3. Bornstein G, Ganoth D, Hershko A (2006). Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate. Proc Natl Acad Sci USA 103, 11515-11520. (Pubitemid 44182483)
4. Bosu DR, Kipreos ET (2008). Cullin-RING ubiquitin ligases: global regulation and activation cycles. Cell Div 3, 7.
5. Brownell JE et al. (2010). Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. Mol Cell 37, 102-111.
6. Chamovitz DA, Wei N, Osterlund MT, von Arnim AG, Staub JM, Matsui M, Deng XW (1996). The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. Cell 86, 115-121. (Pubitemid 26256583)
7. Chew EH, Hagen T (2007). Substrate-mediated regulation of cullin neddylation. J Biol Chem 282, 17032-17040.
8. Chew EH, Poobalasingam T, Hawkey CJ, Hagen T (2007). Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells-evidence for cullin dimerization. Cell Signal 19, 1071-1080. (Pubitemid 46436442)
9. Chua YS, Boh BK, Ponyeam W, Hagen T (2011). Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo. PLoS One 6, e6071.
10. Cope GA, Deshaies RJ (2003). COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell 114, 663-671. (Pubitemid 37186763)
11. Cope GA, Suh GS, Aravind L, Schwarz SE, Zipursky SL, Koonin EV, Deshaies RJ (2002). Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298, 608-611. (Pubitemid 35215316)
12. Culbert AA, Brown MJ, Frame SM, Hagen T, Cross DAE, Bax B, Reith AD (2001). GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β-catenin stabilisation without elevation of glycogen synthase activity. FEBS Lett 507, 288-294. (Pubitemid 33030251)
13. Dohmann EM, Levesque MP, De Veylder L, Reichardt I, Jürgens G, Schmid M, Schwechheimer C (2008). The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability. Development 135, 2013-2022. (Pubitemid 351943365)
14. Duda DM, Borg LA, Scott DC, Hunt HW, Hammel M, Schulman BA (2008). Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation. Cell 134, 995-1006.
15. Djagaeva I, Doronkin S (2009). COP9 limits dendritic branching via Cullin3-dependent degradation of the actin-crosslinking BTB-domain protein Kelch. PLoS One 4, e7598.
16. Freilich S, Oron E, Kapp Y, Nevo-Caspi Y, Orgad S, Segal D, Chamovitz DA (1999). The COP9 signalosome is essential for development of Drosophila melanogaster. Curr Biol 9, 1187-1190. (Pubitemid 29527106)
17. Gan FF, Chua YS, Scarmagnani S, Palaniappan P, Franks M, Poobalasingam T, Bradshaw TD, Westwell AD, Hagen T (2009). Structure-activity analysis of 2′-modified cinnamaldehyde analogues as potential anticancer agents. Biochem Biophys Res Commun 387, 741-747.
18. Haan S, Ferguson P, Sommer U, Hiremath M, McVicar DW, Heinrich PC, Johnston JA, Cacalano NA (2003). Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation. J Biol Chem 278, 31972-31979. (Pubitemid 37048385)
19. Hetfeld BK, Helfrich A, Kapelari B, Scheel H, Hofmann K, Guterman A, Glickman M, Schade R, Kloetzel PM, Dubiel W (2005). The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1. Curr Biol 15, 1217-1221. (Pubitemid 40950520)
20. Kamura T, Brower CS, Conaway RC, Conaway JW (2002). A molecular basis for stabilization of the von Hippel-Lindau (VHL) tumor suppressor protein by components of the VHL ubiquitin ligase. J Biol Chem 277, 30388-30393.
21. Kawakami T et al. (2001). NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J 20, 4003-4012. (Pubitemid 32751817)
22. Lo SC, Hannink M (2006). CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1. Mol Cell Biol 26, 1235-1244.
23. Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001). Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science 292, 1382-1385. (Pubitemid 32476226)
24. Min KW, Kwon MJ, Park HS, Park Y, Yoon SK, Yoon JB (2005). CAND1 enhances deneddylation of CUL1 by COP9 signalosome. Biochem Biophys Res Commun 334, 867-874. (Pubitemid 41033201)
25. Miyauchi Y, Kato M, Tokunaga F, Iwai K (2008). The COP9/signalosome increases the efficiency of von Hippel-Lindau protein ubiquitin ligase-mediated hypoxia-inducible factor-α ubiquitination. J Biol Chem 283, 16622-16631.
26. Orsborn AM, Li W, McEwen TJ, Mizuno T, Kuzmin E, Matsumoto K, Bennett KL (2007). GLH-1, the C. elegans P granule protein, is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5. Development 134, 3383-3392. (Pubitemid 350018438)
27. Petroski MD, Deshaies RJ (2005). Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 6, 9-20. (Pubitemid 40064895)
28. βTrCP- dependent ubiquitination of IBα. Mol Cell Biol 20, 2326-2333.
29. Saha A, Deshaies RJ (2008). Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell 32, 21-31.
30. Sakata E, Yamaguchi Y, Miyauchi Y, Iwai K, Chiba T, Saeki Y, Matsuda N, Tanaka K, Kato K (2007). Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity. Nat Struct Mol Biol 14, 167-168.
31. Schmidt MW, McQuary PR, Wee S, Hofmann K, Wolf DA (2009). F-box-directed CRL complex assembly and regulation by the CSN and CAND1. Mol Cell 35, 586-597.
32. Schoenfeld AR, Davidowitz EJ, Burk RD (2000). Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products. Proc Natl Acad Sci USA 97, 8507-8512. (Pubitemid 30639703)
33. Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ER, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP (2000). Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature 408, 381-386.
34. Schwechheimer C (2004). The COP9 signalosome (CSN): an evolutionary conserved proteolysis regulator in eukaryotic development. Biochim Biophys Acta 1695, 45-54.
35. Soucy TA et al. (2009). An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 458, 732-737.
36. Spoel SH, Mou Z, Tada Y, Spivey NW, Genschik P, Dong X (2009). Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity. Cell 137, 860-872.
37. Sufan RI, Ohh M (2006). Role of the NEDD8 modification of Cul2 in the sequential activation of ECV complex. Neoplasia 8, 956-963. (Pubitemid 44706246)
38. Uhle S et al. (2003). Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. EMBO J 22, 1302-1312. (Pubitemid 36362694)
39. Wei N, Serino G, Deng XW (2008). The COP9 signalosome: more than a protease. Trends Biochem Sci 33, 592-600.
40. Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr (2004). Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428, 194-198. (Pubitemid 38374317)
41. Wolf DA, Zhou C, Wee S (2003). The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?. Nat Cell Biol 5, 1029-1033. (Pubitemid 37509104)
42. Wu K, Chen A, Tan P, Pan ZQ (2002). The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34. J Biol Chem 277, 516-527. (Pubitemid 34952087)
43. Yamoah K, Oashi T, Sarikas A, Gazdoiu S, Osman R, Pan ZQ (2008). Auto-inhibitory regulation of SCF-mediated ubiquitination by human cullin1's C-terminal tail. Proc Natl Acad Sci USA 105, 12230-12235.
44. Yan J, Walz K, Nakamura H, Carattini-Rivera S, Zhao Q, Vogel H, Wei N, Justice MJ, Bradley A, Lupski JR (2003). COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Mol Cell Biol 23, 6798-6808. (Pubitemid 37214651)
45. Yoshida A, Yoneda-Kato N, Panattoni M, Pardi R, Kato J (2010). YCSN5/Jab1 controls multiple events in the mammalian cell cycle. FEBS Lett 584, 4545-4552.
46. Zheng J, Yang X, Harrell JM, Ryzhikov S, Shim EH, Lykke-Andersen K, Wei N, Sun H, Kobayashi R, Zhang H (2002). CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex. Mol Cell 10, 1519-1526. (Pubitemid 36050892)
47. Zhou C, Wee S, Rhee E, Naumann M, Dubiel W, Wolf DA (2003). Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Mol Cell 11, 927-938. (Pubitemid 36566315)