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Volumn 28, Issue 8, 2013, Pages 1027-1033

How does the ketogenic diet work? Four potential mechanisms

Author keywords

ATP sensitive K channel; epilepsy; glucose; ketogenic diet; mammalian target of rapamycin; mechanism of action; Seizure; vesicular glutamate transporters

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; MAMMALIAN TARGET OF RAPAMYCIN;

EID: 84879699812     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073813487598     Document Type: Conference Paper
Times cited : (102)

References (70)
  • 1
    • 84861925298 scopus 로고    scopus 로고
    • Ketogenic diet and other dietary treatments for epilepsy
    • Levy RG, Cooper PN, Giri P.. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev. 2012 ; 3: CD001903
    • (2012) Cochrane Database Syst Rev , vol.3 , pp. 001903
    • Levy, R.G.1    Cooper, P.N.2    Giri, P.3
  • 2
    • 58849155005 scopus 로고    scopus 로고
    • Optimal clinical management of children receiving the ketogenic diet: Recommendations of the International Ketogenic Diet Study Group
    • Kossoff EH, Zupec-Kania BA, Amark PE, et al. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group. Epilepsia. 2009 ; 50: 304-317
    • (2009) Epilepsia , vol.50 , pp. 304-317
    • Kossoff, E.H.1    Zupec-Kania, B.A.2    Amark, P.E.3
  • 3
    • 84866022656 scopus 로고    scopus 로고
    • The ketogenic diet as a treatment paradigm for diverse neurological disorders
    • Stafstrom CE, Rho JM. The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol. 2012 ; 3: 59
    • (2012) Front Pharmacol , vol.3 , pp. 59
    • Stafstrom, C.E.1    Rho, J.M.2
  • 4
    • 77951233713 scopus 로고    scopus 로고
    • Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet
    • Seyfried BT, Kiebish M, Marsh J, Mukherjee P. Targeting energy metabolism in brain cancer through calorie restriction and the ketogenic diet. J Cancer Res Ther. 2009 ; 5 (S1). S7 - S15
    • (2009) J Cancer Res Ther , vol.5 , Issue.S1
    • Seyfried, B.T.1    Kiebish, M.2    Marsh, J.3    Mukherjee, P.4
  • 5
    • 79955383670 scopus 로고    scopus 로고
    • Reversal of diabetic nephropathy by a ketogenic diet
    • Poplawski MM, Mastaitis JW, Isoda F, et al. Reversal of diabetic nephropathy by a ketogenic diet. PLoS One. 2011 ; 6: e18604
    • (2011) PLoS One , vol.6 , pp. 18604
    • Poplawski, M.M.1    Mastaitis, J.W.2    Isoda, F.3
  • 6
    • 0017143254 scopus 로고
    • Ketonemia and seizures: Metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy
    • Huttenlocher PR.. Ketonemia and seizures: Metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res. 1976 ; 10: 536-540
    • (1976) Pediatr Res , vol.10 , pp. 536-540
    • Huttenlocher, P.R.1
  • 7
    • 55349107292 scopus 로고    scopus 로고
    • Seizure suppression via glycolysis inhibition with 2-deoxy-d-glucose
    • Stafstrom CE, Roopra A, Sutula TP. Seizure suppression via glycolysis inhibition with 2-deoxy-d-glucose. Epilepsia. 2008 ; 49 (S8). 97-100
    • (2008) Epilepsia , vol.49 , Issue.S8 , pp. 97-100
    • Stafstrom, C.E.1    Roopra, A.2    Sutula, T.P.3
  • 8
    • 80052943080 scopus 로고    scopus 로고
    • Preictal and ictal neurovascular and metabolic coupling surrounding a seizure focus
    • Zhao M, Nguyen J, Ma H, et al. Preictal and ictal neurovascular and metabolic coupling surrounding a seizure focus. J Neurosci. 2011 ; 31: 13292-13300
    • (2011) J Neurosci , vol.31 , pp. 13292-13300
    • Zhao, M.1    Nguyen, J.2    Ma, H.3
  • 9
    • 33750443292 scopus 로고    scopus 로고
    • 2-Deoxy-d-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure
    • Garriga-Canut M, Schoenike B, Qazi R, et al. 2-Deoxy-d-glucose reduces epilepsy progression by NRSF-CtBP-dependent metabolic regulation of chromatin structure. Nat Neurosci. 2006 ; 9: 1382-1387
    • (2006) Nat Neurosci , vol.9 , pp. 1382-1387
    • Garriga-Canut, M.1    Schoenike, B.2    Qazi, R.3
  • 10
    • 62949110733 scopus 로고    scopus 로고
    • Anticonvulsant and antiepileptic actions of 2-deoxy-d-glucose in epilepsy models
    • Stafstrom CE, Ockuly JC, Murphree L, et al. Anticonvulsant and antiepileptic actions of 2-deoxy-d-glucose in epilepsy models. Ann Neurol. 2009 ; 65: 435-447
    • (2009) Ann Neurol , vol.65 , pp. 435-447
    • Stafstrom, C.E.1    Ockuly, J.C.2    Murphree, L.3
  • 11
    • 35948960395 scopus 로고    scopus 로고
    • Fructose-1,6-biphosphate has anticonvulsant activity in models of acute seizures in adult rats
    • Lian X-Y, Khan FA, Stringer JL.. Fructose-1,6-biphosphate has anticonvulsant activity in models of acute seizures in adult rats. J Neurosci. 2007 ; 27: 12007-12011
    • (2007) J Neurosci , vol.27 , pp. 12007-12011
    • Lian, X.-Y.1    Khan, F.A.2    Stringer, J.L.3
  • 12
    • 77955340185 scopus 로고    scopus 로고
    • Anticonvulsant and proconvulsant actions of 2-deoxy-d-glucose
    • Gasior M, Yankura J, Hartman AL, et al. Anticonvulsant and proconvulsant actions of 2-deoxy-d-glucose. Epilepsia. 2010 ; 5: 1385-1394
    • (2010) Epilepsia , vol.5 , pp. 1385-1394
    • Gasior, M.1    Yankura, J.2    Hartman, A.L.3
  • 13
    • 3242704193 scopus 로고    scopus 로고
    • Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model
    • He XP, Kotloski R, Nef S, et al. Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron. 2004 ; 43: 31-42
    • (2004) Neuron , vol.43 , pp. 31-42
    • He, X.P.1    Kotloski, R.2    Nef, S.3
  • 14
    • 33750452352 scopus 로고    scopus 로고
    • Inhibiting glycolysis to reduce seizures: How it might work
    • Huang YZ, McNamara JO. Inhibiting glycolysis to reduce seizures: how it might work. Nat Neurosci. 2006 ; 9: 1351-1352
    • (2006) Nat Neurosci , vol.9 , pp. 1351-1352
    • Huang, Y.Z.1    McNamara, J.O.2
  • 15
    • 80052553383 scopus 로고    scopus 로고
    • Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet
    • Hu XL, Cheng X, Fei J, Xiong ZQ. Neuron-restrictive silencer factor is not required for the antiepileptic effect of the ketogenic diet. Epilepsia. 2011 ; 52: 1609-1616
    • (2011) Epilepsia , vol.52 , pp. 1609-1616
    • Hu, X.L.1    Cheng, X.2    Fei, J.3    Xiong, Z.Q.4
  • 16
    • 84864088898 scopus 로고    scopus 로고
    • Activity-dependent effects of 2DG influencing synaptic transmission, LTP, LTD, and epileptogenesis
    • Pan YZ, Ockuly JC, Rutecki PA, Sutula TP.. Activity-dependent effects of 2DG influencing synaptic transmission, LTP, LTD, and epileptogenesis. Soc Neurosci Abstr. 2008 ;: 147
    • (2008) Soc Neurosci Abstr , pp. 147
    • Pan, Y.Z.1    Ockuly, J.C.2    Rutecki, P.A.3    Sutula, T.P.4
  • 17
    • 84864092157 scopus 로고    scopus 로고
    • Effect of glycolytic metabolism on synaptic currents in CA3 pyramidal neurons
    • Pan YZ, Devinney MJ, Rutecki PA, Sutula TP. Effect of glycolytic metabolism on synaptic currents in CA3 pyramidal neurons. Soc Neurosci Abstr. 2009 ; 10 (/16). 331
    • (2009) Soc Neurosci Abstr , vol.10 , Issue.16 , pp. 331
    • Pan, Y.Z.1    Devinney, M.J.2    Rutecki, P.A.3    Sutula, T.P.4
  • 18
    • 78650174390 scopus 로고    scopus 로고
    • Dose-response and time course of action of disease-modifying effects of 2DG on kindling progression: Effectiveness of administration after seizures
    • Sutula T, Franzoso S. Dose-response and time course of action of disease-modifying effects of 2DG on kindling progression: effectiveness of administration after seizures. Epilepsia. 2008 ; 49 (suppl 7). 382
    • (2008) Epilepsia , vol.49 , Issue.SUPPL. 7 , pp. 382
    • Sutula, T.1    Franzoso, S.2
  • 19
    • 84866143610 scopus 로고    scopus 로고
    • Behavioral, cognitive, and safety profile of 2-deoxy-2-glucose (2DG) in adult rats
    • Ockuly JC, Gielissen JM, Levenick CV, et al. Behavioral, cognitive, and safety profile of 2-deoxy-2-glucose (2DG) in adult rats. Epilepsy Res. 2012 ; 101: 246-252
    • (2012) Epilepsy Res , vol.101 , pp. 246-252
    • Ockuly, J.C.1    Gielissen, J.M.2    Levenick, C.V.3
  • 20
    • 77049113736 scopus 로고    scopus 로고
    • Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and incre-ases mortality in rats
    • Minor RK, Smith DL, Sossong AM, et al. Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and incre-ases mortality in rats. Toxicol Appl Pharmacol. 2010 ; 243: 332-339
    • (2010) Toxicol Appl Pharmacol , vol.243 , pp. 332-339
    • Minor, R.K.1    Smith, D.L.2    Sossong, A.M.3
  • 21
    • 84864084943 scopus 로고    scopus 로고
    • Modulation of oxidative stress and mitochondrial function by the ketogenic diet
    • Milder J, Patel M. Modulation of oxidative stress and mitochondrial function by the ketogenic diet. Epilepsy Res. 2012 ; 100: 295-303
    • (2012) Epilepsy Res , vol.100 , pp. 295-303
    • Milder, J.1    Patel, M.2
  • 22
    • 34147189503 scopus 로고    scopus 로고
    • Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels
    • Ma W, Berg J, Yellen G. Ketogenic diet metabolites reduce firing in central neurons by opening K(ATP) channels. J Neurosci. 2007 ; 27: 3618-3625
    • (2007) J Neurosci , vol.27 , pp. 3618-3625
    • Ma, W.1    Berg, J.2    Yellen, G.3
  • 23
    • 79958290778 scopus 로고    scopus 로고
    • Single K ATP channel opening in response to action potential firing in mouse dentate granule neurons
    • Tanner GR, Lutas A, Martinez-Francois JR, Yellen G. Single K ATP channel opening in response to action potential firing in mouse dentate granule neurons. J Neurosci. 2011 ; 31: 8689-8696
    • (2011) J Neurosci , vol.31 , pp. 8689-8696
    • Tanner, G.R.1    Lutas, A.2    Martinez-Francois, J.R.3    Yellen, G.4
  • 24
    • 68149107692 scopus 로고    scopus 로고
    • BAD: Undertaker by night, candyman by day
    • Danial NN. BAD: undertaker by night, candyman by day. Oncogene. 2008 ; 27 (suppl 1). S53 - S70
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Danial, N.N.1
  • 25
    • 84861440823 scopus 로고    scopus 로고
    • BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures
    • Gimenez-Cassina A, Martinez-Francois JR, Fisher JK, et al. BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures. Neuron. 2012 ; 74: 719-730
    • (2012) Neuron , vol.74 , pp. 719-730
    • Gimenez-Cassina, A.1    Martinez-Francois, J.R.2    Fisher, J.K.3
  • 26
    • 70350418625 scopus 로고    scopus 로고
    • MTOR signaling at a glance
    • Laplante M, Sabatini DM.. mTOR signaling at a glance. J Cell Sci. 2009 ; 122 (pt 20). 3589-3594
    • (2009) J Cell Sci , vol.122 , Issue.PART 20 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 27
    • 0037039358 scopus 로고    scopus 로고
    • A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
    • Tang SJ, Reis G, Kang H, et al. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A. 2002 ; 99: 467-472
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 467-472
    • Tang, S.J.1    Reis, G.2    Kang, H.3
  • 28
    • 3242724040 scopus 로고    scopus 로고
    • Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
    • Hou L, Klann E. Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. J Neurosci. 2004 ; 24: 6352-6361
    • (2004) J Neurosci , vol.24 , pp. 6352-6361
    • Hou, L.1    Klann, E.2
  • 29
    • 77949882117 scopus 로고    scopus 로고
    • The tuberous sclerosis complex
    • Orlova KA, Crino PB. The tuberous sclerosis complex. Ann N Y Acad Sci. 2010 ; 1184: 87-105
    • (2010) Ann N y Acad Sci , vol.1184 , pp. 87-105
    • Orlova, K.A.1    Crino, P.B.2
  • 30
    • 42949140259 scopus 로고    scopus 로고
    • Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex
    • Zeng LH, Xu L, Gutmann DH, Wong M. Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol. 2008 ; 63: 444-453
    • (2008) Ann Neurol , vol.63 , pp. 444-453
    • Zeng, L.H.1    Xu, L.2    Gutmann, D.H.3    Wong, M.4
  • 31
    • 78651064535 scopus 로고    scopus 로고
    • Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex
    • Zeng LH, Rensing NR, Zhang B, et al. Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. Hum Mol Genet. 2011 ; 20: 445-454
    • (2011) Hum Mol Genet , vol.20 , pp. 445-454
    • Zeng, L.H.1    Rensing, N.R.2    Zhang, B.3
  • 32
    • 68349100270 scopus 로고    scopus 로고
    • Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
    • Ljungberg MC, Sunnen CN, Lugo JN, et al. Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia. Dis Model Mech. 2009 ; 2: 389-398
    • (2009) Dis Model Mech , vol.2 , pp. 389-398
    • Ljungberg, M.C.1    Sunnen, C.N.2    Lugo, J.N.3
  • 33
    • 80155189536 scopus 로고    scopus 로고
    • Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice
    • Sunnen CN, Brewster AL, Lugo JN, et al. Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice. Epilepsia. 2011 ; 52: 2065-2075
    • (2011) Epilepsia , vol.52 , pp. 2065-2075
    • Sunnen, C.N.1    Brewster, A.L.2    Lugo, J.N.3
  • 34
    • 66149169973 scopus 로고    scopus 로고
    • The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy
    • Zeng LH, Rensing NR, Wong M. The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy. J Neurosci. 2009 ; 29: 6964-6972
    • (2009) J Neurosci , vol.29 , pp. 6964-6972
    • Zeng, L.H.1    Rensing, N.R.2    Wong, M.3
  • 35
    • 77955845741 scopus 로고    scopus 로고
    • Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy
    • Huang X, Zhang H, Yang J, et al. Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy. Neurobiol Dis. 2010 ; 40: 193-199
    • (2010) Neurobiol Dis , vol.40 , pp. 193-199
    • Huang, X.1    Zhang, H.2    Yang, J.3
  • 36
    • 84860491069 scopus 로고    scopus 로고
    • The interaction between early life epilepsy and autistic-like behavioral consequences: A role for the mammalian target of rapamycin (mTOR) pathway
    • Talos DM, Sun H, Zhou X, et al. The interaction between early life epilepsy and autistic-like behavioral consequences: a role for the mammalian target of rapamycin (mTOR) pathway. PLoS One. 2012 ; 7: e35885
    • (2012) PLoS One , vol.7 , pp. 35885
    • Talos, D.M.1    Sun, H.2    Zhou, X.3
  • 37
    • 79958184395 scopus 로고    scopus 로고
    • A pulse rapamycin therapy for infantile spasms and associated cognitive decline
    • Raffo E, Coppola A, Ono T, et al. A pulse rapamycin therapy for infantile spasms and associated cognitive decline. Neurobiol Dis. 2011 ; 43: 322-329
    • (2011) Neurobiol Dis , vol.43 , pp. 322-329
    • Raffo, E.1    Coppola, A.2    Ono, T.3
  • 38
    • 79951531485 scopus 로고    scopus 로고
    • Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy
    • Buckmaster PS, Lew FH. Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. J Neurosci. 2011 ; 31: 2337-2347
    • (2011) J Neurosci , vol.31 , pp. 2337-2347
    • Buckmaster, P.S.1    Lew, F.H.2
  • 39
    • 84864000749 scopus 로고    scopus 로고
    • Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats
    • Huang X, McMahon J, Yang J, et al. Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats. Neuroscience. 2012 ; 219: 33-47
    • (2012) Neuroscience , vol.219 , pp. 33-47
    • Huang, X.1    McMahon, J.2    Yang, J.3
  • 40
    • 84856372774 scopus 로고    scopus 로고
    • Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy
    • Sliwa A, Plucinska G, Bednarczyk J, Lukasiuk K. Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy. Neurosci Lett. 2012 ; 509: 105-109
    • (2012) Neurosci Lett , vol.509 , pp. 105-109
    • Sliwa, A.1    Plucinska, G.2    Bednarczyk, J.3    Lukasiuk, K.4
  • 41
    • 78049510428 scopus 로고    scopus 로고
    • Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis
    • Krueger DA, Care MM, Holland K, et al. Everolimus for subependymal giant-cell astrocytomas in tuberous sclerosis. N Engl J Med. 2010 ; 363: 1801-1811
    • (2010) N Engl J Med , vol.363 , pp. 1801-1811
    • Krueger, D.A.1    Care, M.M.2    Holland, K.3
  • 42
    • 84866331178 scopus 로고    scopus 로고
    • The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice
    • Hartman AL, Santos P, Dolce A, Hardwick JM. The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice. PLoS One. 2012 ; 7: e45156
    • (2012) PLoS One , vol.7 , pp. 45156
    • Hartman, A.L.1    Santos, P.2    Dolce, A.3    Hardwick, J.M.4
  • 43
    • 36249023723 scopus 로고    scopus 로고
    • Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
    • Ruegg S, Baybis M, Juul H, et al. Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons. Epilepsy Res. 2007 ; 77: 85-92
    • (2007) Epilepsy Res , vol.77 , pp. 85-92
    • Ruegg, S.1    Baybis, M.2    Juul, H.3
  • 44
    • 33749639034 scopus 로고    scopus 로고
    • Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites
    • Raab-Graham KF, Haddick PC, Jan YN, Jan LY. Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science. 2006 ; 314: 144-148
    • (2006) Science , vol.314 , pp. 144-148
    • Raab-Graham, K.F.1    Haddick, P.C.2    Jan, Y.N.3    Jan, L.Y.4
  • 45
    • 30544449810 scopus 로고    scopus 로고
    • Control of dendritic arborization by the phosphoinositide-3′- kinase-Akt-mammalian target of rapamycin pathway
    • Jaworski J, Spangler S, Seeburg DP, et al. Control of dendritic arborization by the phosphoinositide-3′-kinase-Akt-mammalian target of rapamycin pathway. J Neurosci. 2005 ; 25: 11300-11312
    • (2005) J Neurosci , vol.25 , pp. 11300-11312
    • Jaworski, J.1    Spangler, S.2    Seeburg, D.P.3
  • 46
    • 84864965624 scopus 로고    scopus 로고
    • Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission
    • Weston MC, Chen H, Swann JW.. Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission. J Neurosci. 2012 ; 32: 11441-11452
    • (2012) J Neurosci , vol.32 , pp. 11441-11452
    • Weston, M.C.1    Chen, H.2    Swann, J.W.3
  • 47
    • 0032498882 scopus 로고    scopus 로고
    • Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and rapamycin
    • Terashima A, Nakai M, Hashimoto T, et al. Single-channel activity of the Ca2+-dependent K+ channel is modulated by FK506 and rapamycin. Brain Res. 1998 ; 786: 255-258
    • (1998) Brain Res , vol.786 , pp. 255-258
    • Terashima, A.1    Nakai, M.2    Hashimoto, T.3
  • 48
    • 33646391271 scopus 로고    scopus 로고
    • A role for the mTOR pathway in surface expression of AMPA receptors
    • Wang Y, Barbaro MF, Baraban SC. A role for the mTOR pathway in surface expression of AMPA receptors. Neurosci Lett. 2006 ; 401: 35-39
    • (2006) Neurosci Lett , vol.401 , pp. 35-39
    • Wang, Y.1    Barbaro, M.F.2    Baraban, S.C.3
  • 49
    • 80555125111 scopus 로고    scopus 로고
    • The cell biology of synaptic plasticity
    • Ho VM, Lee JA, Martin KC. The cell biology of synaptic plasticity. Science. 2011 ; 334: 623-628
    • (2011) Science , vol.334 , pp. 623-628
    • Ho, V.M.1    Lee, J.A.2    Martin, K.C.3
  • 50
    • 79952570329 scopus 로고    scopus 로고
    • The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway
    • McDaniel SS, Rensing NR, Thio LL, et al. The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. Epilepsia. 2011 ; 52: e7 - e11
    • (2011) Epilepsia , vol.52
    • McDaniel, S.S.1    Rensing, N.R.2    Thio, L.L.3
  • 51
    • 38649113935 scopus 로고    scopus 로고
    • Efficacy of the ketogenic diet in the 6-Hz seizure test
    • Hartman AL, Lyle M, Rogawski MA, Gasior M. Efficacy of the ketogenic diet in the 6-Hz seizure test. Epilepsia. 2008 ; 49: 334-339
    • (2008) Epilepsia , vol.49 , pp. 334-339
    • Hartman, A.L.1    Lyle, M.2    Rogawski, M.A.3    Gasior, M.4
  • 52
    • 0034484802 scopus 로고    scopus 로고
    • The ketogenic diet: Seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones
    • Gilbert DL, Pyzik PL, Freeman JM. The ketogenic diet: seizure control correlates better with serum beta-hydroxybutyrate than with urine ketones. J Child Neurol. 2000 ; 15: 787-790
    • (2000) J Child Neurol , vol.15 , pp. 787-790
    • Gilbert, D.L.1    Pyzik, P.L.2    Freeman, J.M.3
  • 53
    • 0022213803 scopus 로고
    • Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy
    • Ross DL, Swaiman KF, Torres F, Hansen J. Early biochemical and EEG correlates of the ketogenic diet in children with atypical absence epilepsy. Pediatr Neurol. 1985 ; 1: 104-108
    • (1985) Pediatr Neurol , vol.1 , pp. 104-108
    • Ross, D.L.1    Swaiman, K.F.2    Torres, F.3    Hansen, J.4
  • 54
    • 0037465771 scopus 로고    scopus 로고
    • Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet
    • Fraser DD, Whiting S, Andrew RD, et al. Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet. Neurology. 2003 ; 60: 1026-1029
    • (2003) Neurology , vol.60 , pp. 1026-1029
    • Fraser, D.D.1    Whiting, S.2    Andrew, R.D.3
  • 55
    • 65549152475 scopus 로고    scopus 로고
    • A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy
    • Neal EG, Chaffe H, Schwartz RH, et al. A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia. 2009 ; 50: 1109-1117
    • (2009) Epilepsia , vol.50 , pp. 1109-1117
    • Neal, E.G.1    Chaffe, H.2    Schwartz, R.H.3
  • 56
    • 65549104388 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy
    • Muzykewicz DA, Lyczkowski DA, Memon N, et al. Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy. Epilepsia. 2009 ; 50: 1118-1126
    • (2009) Epilepsia , vol.50 , pp. 1118-1126
    • Muzykewicz, D.A.1    Lyczkowski, D.A.2    Memon, N.3
  • 57
    • 33846216385 scopus 로고    scopus 로고
    • Use of a modified Atkins diet in intractable childhood epilepsy
    • Kang HC, Lee HS, You SJ, et al. Use of a modified Atkins diet in intractable childhood epilepsy. Epilepsia. 2007 ; 48: 182-186
    • (2007) Epilepsia , vol.48 , pp. 182-186
    • Kang, H.C.1    Lee, H.S.2    You, S.J.3
  • 58
    • 33645326867 scopus 로고    scopus 로고
    • A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy
    • Kossoff EH, McGrogan JR, Bluml RM, et al. A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy. Epilepsia. 2006 ; 47: 421-424
    • (2006) Epilepsia , vol.47 , pp. 421-424
    • Kossoff, E.H.1    McGrogan, J.R.2    Bluml, R.M.3
  • 59
    • 73749084917 scopus 로고    scopus 로고
    • Blood beta-hydroxybutyrate correlates better with seizure reduction due to ketogenic diet than do ketones in the urine
    • van Delft R, Lambrechts D, Verschuure P, et al. Blood beta-hydroxybutyrate correlates better with seizure reduction due to ketogenic diet than do ketones in the urine. Seizure. 2010 ; 19: 36-39
    • (2010) Seizure , vol.19 , pp. 36-39
    • Van Delft, R.1    Lambrechts, D.2    Verschuure, P.3
  • 60
    • 0032901064 scopus 로고    scopus 로고
    • A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat
    • Bough KJ, Eagles DA. A ketogenic diet increases the resistance to pentylenetetrazole-induced seizures in the rat. Epilepsia. 1999 ; 40: 138-143
    • (1999) Epilepsia , vol.40 , pp. 138-143
    • Bough, K.J.1    Eagles, D.A.2
  • 61
    • 0032902642 scopus 로고    scopus 로고
    • Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet
    • Bough KJ, Valiyil R, Han FT, Eagles DA. Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet. Epilepsy Res. 1999 ; 35: 21-28
    • (1999) Epilepsy Res , vol.35 , pp. 21-28
    • Bough, K.J.1    Valiyil, R.2    Han, F.T.3    Eagles, D.A.4
  • 62
    • 0033756270 scopus 로고    scopus 로고
    • Dietary fat, ketosis, and seizure resistance in rats on the ketogenic diet
    • Likhodii SS, Musa K, Mendonca A, et al. Dietary fat, ketosis, and seizure resistance in rats on the ketogenic diet. Epilepsia. 2000 ; 41: 1400-1410
    • (2000) Epilepsia , vol.41 , pp. 1400-1410
    • Likhodii, S.S.1    Musa, K.2    Mendonca, A.3
  • 63
    • 23944516360 scopus 로고    scopus 로고
    • A comparison of the ability of a 4:1 ketogenic diet and a 6.3:1 ketogenic diet to elevate seizure thresholds in adult and young rats
    • Nylen K, Likhodii S, Abdelmalik PA, et al. A comparison of the ability of a 4:1 ketogenic diet and a 6.3:1 ketogenic diet to elevate seizure thresholds in adult and young rats. Epilepsia. 2005 ; 46: 1198-1204
    • (2005) Epilepsia , vol.46 , pp. 1198-1204
    • Nylen, K.1    Likhodii, S.2    Abdelmalik, P.A.3
  • 64
    • 38649105197 scopus 로고    scopus 로고
    • Calorie-restricted ketogenic diet increases thresholds to all patterns of pentylenetetrazol-induced seizures: Critical importance of electroclinical assessment
    • Raffo E, Francois J, Ferrandon A, et al. Calorie-restricted ketogenic diet increases thresholds to all patterns of pentylenetetrazol-induced seizures: critical importance of electroclinical assessment. Epilepsia. 2008 ; 49: 320-328
    • (2008) Epilepsia , vol.49 , pp. 320-328
    • Raffo, E.1    Francois, J.2    Ferrandon, A.3
  • 65
    • 0008797454 scopus 로고
    • Factors influencing experimentally produced convulsions
    • Keith HM. Factors influencing experimentally produced convulsions. Arch Neurol Psychiatry. 1933 ; 29: 148-154
    • (1933) Arch Neurol Psychiatry , vol.29 , pp. 148-154
    • Keith, H.M.1
  • 66
    • 0041843792 scopus 로고    scopus 로고
    • Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet
    • Likhodii SS, Serbanescu I, Cortez MA, et al. Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet. Ann Neurol. 2003 ; 54: 219-226
    • (2003) Ann Neurol , vol.54 , pp. 219-226
    • Likhodii, S.S.1    Serbanescu, I.2    Cortez, M.A.3
  • 67
    • 34247100675 scopus 로고    scopus 로고
    • The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid
    • Gasior M, French A, Joy MT, et al. The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid. Epilepsia. 2007 ; 48: 793-800
    • (2007) Epilepsia , vol.48 , pp. 793-800
    • Gasior, M.1    French, A.2    Joy, M.T.3
  • 68
    • 0142136079 scopus 로고    scopus 로고
    • Voltage-dependent block of N-methyl-d-aspartate receptors by the novel anticonvulsant dibenzylamine, a bioactive constituent of l-(+)-beta- hydroxybutyrate
    • Donevan SD, White HS, Anderson GD, Rho JM. Voltage-dependent block of N-methyl-d-aspartate receptors by the novel anticonvulsant dibenzylamine, a bioactive constituent of l-(+)-beta-hydroxybutyrate. Epilepsia. 2003 ; 44: 1274-1279
    • (2003) Epilepsia , vol.44 , pp. 1274-1279
    • Donevan, S.D.1    White, H.S.2    Anderson, G.D.3    Rho, J.M.4
  • 69
    • 0343775830 scopus 로고    scopus 로고
    • Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission
    • Thio LL, Wong M, Yamada KA. Ketone bodies do not directly alter excitatory or inhibitory hippocampal synaptic transmission. Neurology. 2000 ; 54: 325-331
    • (2000) Neurology , vol.54 , pp. 325-331
    • Thio, L.L.1    Wong, M.2    Yamada, K.A.3
  • 70
    • 77957307251 scopus 로고    scopus 로고
    • Metabolic control of vesicular glutamate transport and release
    • Juge N, Gray JA, Omote H, et al. Metabolic control of vesicular glutamate transport and release. Neuron. 2010 ; 68: 99-112
    • (2010) Neuron , vol.68 , pp. 99-112
    • Juge, N.1    Gray, J.A.2    Omote, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.