A comparison of the ability of a 4:1 ketogenic diet and a 6.3:1 ketogenic diet to elevate seizure thresholds in adult and young rats

Epilepsia

Volumn 46, Issue 8, 2005, Pages 1198-1204

  Nylen, Kirk ^a   Likhodii, Sergei ^a   Abdelmalik, Peter A ^a   Clarke, Jasper ^a   Burnham, W McIntyre ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Epilepsy; Glucose; Ketogenic diet; Ketosis; Pentylenetetrazole; Seizure

Indexed keywords

3 HYDROXYBUTYRIC ACID; CASEIN; CELLULOSE; CYSTINE; DEXTRIN; GLUCOSE; HYDROQUININE; LARD; PENTETRAZOLE; SOYBEAN OIL; STARCH; SUCROSE; TERT BUTYLHYDROQUININE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BODY WEIGHT; BUTTER; COMPARATIVE STUDY; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; KETOGENIC DIET; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SEIZURE THRESHOLD; WEIGHT GAIN; AGE; ANIMAL; BLOOD; CHEMICALLY INDUCED DISORDER; DIET THERAPY; DISEASE MODEL; DOSE RESPONSE; FAT INTAKE; KETOACIDOSIS; METABOLISM; PHYSIOLOGY; RANDOMIZATION; TREATMENT OUTCOME; WISTAR RAT;

3-HYDROXYBUTYRIC ACID; AGE FACTORS; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIETARY FATS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; KETOSIS; MALE; PENTYLENETETRAZOLE; RANDOM ALLOCATION; RATS; RATS, WISTAR; SEIZURES; TREATMENT OUTCOME;

EID: 23944516360     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2005.71204.x     Document Type: Article

References (34)

1. Thiele E. Assessing the efficacy of antiepileptic treatments: the ketogenic diet. Epilepsia 2003;44(suppl 7):26-69.
2. Kossoff EH. More fat and fewer seizures: dietary therapies for epilepsy. Lancet Neural 2004;3:415-20.
3. Lefevre F, Aronson N. Ketogenic diet for the treatment of refractory epilepsy in children: a systematic review of efficacy. Pediatrics 2000;105:E46.
4. Nordli DR Jr, DeVivo DC. Classification of infantile seizures: implications for identification and treatment of inborn errors of metabolism. J Child Neurol 2002;17(suppl 3):3S3-7.
5. Vining E. Clinical efficacy of the ketogenic diet. Epilepsy Res 1999;37:181-90.
6. Sirven J, Whedon B, Caplan D, et al. The ketogenic diet for intractable epilepsy in adults: preliminary results. Epilepsia 1999;40:1721-6.
7. Kwiterovich PO Jr, Vining EP, Pyzik P, et al. Effect of a high-fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children. JAMA 2003;290:912-20.
8. Stafstrom CE, Bough KJ. The ketogenic diet for the treatment of epilepsy: a challenge for nutritional neuroscientists. Nutr Neurosci 2003;6:67-79.
9. Bough KJ, Eagles DA. A ketogenic diet increases resistance to pentylenetetrazole-induced seizures in the rat. Epilepsia 1999;40:138-43.
10. Likhodii SS, Musa K, Mendonca A. et al. Dietary fat, ketosis, and seizure resistance in rats on the ketogenic diet. Epilepsia 2000;41:1400-10.
11. Likhodii SS. Experiments in the rat pentylenetetrazole infusion threshold model of the ketogenic diet. Epilepsy Res 2001;44:83-6.
12. Fuehrlein BS, Rutenberg MS, Silver JN, et al. Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets. J Clin Endocrinol Metab 2004;89:1641-5.
13. Huttenlocher PR. Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy. Pediatr Res 1976;10:536-40.
14. Swink TD, Vining EPG, Freeman JM. The ketogenic diet: 1997. Adv Pediatr 1997;44:297-329.
15. Bough KJ, Chen RS, Eagles DA. Path analysis shows that increasing ketogenic ratio, but not beta-hydroxybutyrate, elevates seizure threshold in the rat. Dev Neurosci 1999;21:400-6.
16. Bough KJ, Matthews PJ, Eagles DA. A ketogenic diet has different effects upon seizures induced by maximal electroshock and by pentylenetetrazole infusion. Epilepsy Res 2000;38:105-14.
17. Thavendiranathan P, Chow C, Cunnane S, et al. The effect of the "classic" ketogenic diet on animal seizure models. Brain Res 2003;959:206-13.
18. Rogers AE. Nutrition. In: Baker HJ, Lindsey JR, Weisbroth SH, eds. The laboratory rat. Orlando: Academic Press, 1979:123-52.
19. Bough KJ, Yao SG, Eagles DA. Higher ketogenic ratios confer protection from seizures without neurotoxicity. Epilepsy Res 2000;38:15-25.
20. Thavendiranathan P, Mendonca A, Dell C, et al. The MCT ketogenic diet: effects on animal seizure models. Exp Neurol 2000;161:696-703.
21. Uhlemann ER, Neims AH. Anticonvulsant properties of the ketogenic diet in mice. J Pharmacol Exp Ther 1972;180:231-8.
22. Pollack GM, Shen DD. A timed intravenous pentylenetetrazole infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat. J Pharmacol Methods 1985;13:135-46.
23. Bough KJ, Eagles DA. Comparison of the anticonvulsant efficacies and neurotoxic effects of valproic acid, phenytoin, and the ketogenic diet. Epilepsia 2001;42:1345-53.
24. Harney JP, Madara J, Madara J, et al. Effects of acute inhibition of fatty acid oxidation on latency to seizure and concentrations of beta hydroxybutyrate in plasma of rats maintained on calorie restriction and/or the ketogenic diet. Epilepsy Res 2002;49:239-46.
25. Eagles DA, Boyd SJ, Kotak A, et al. Calorie restriction of a high-carbohydrate diet elevates the threshold of PTZ-induced seizures to values equal to those seen with a ketogenic diet. Epilepsy Res 2003;54:41-52.
26. Freeman JM, Vining EP, Pyzik PL. Beta-hydroxybutyrate levels in blood correlate with seizure control in children on the ketogenic diet. Epilepsia 1998;39(suppl 6):167.
27. Todorova MT, Tandon P, Madore RA, et al. The ketogenic diet inhibits epileptogenesis in EL mice: a genetic model for idiopathic epilepsy. Epilepsia 2000;41:933-40.
28. Schwechter EM, Veliskova J, Velisek L. Correlation between extracellular glucose and seizure susceptibility in adult rats. Ann Neurol 2003;53:91-101.
29. Mantis JG, Centeno NA, Todorova MT, et al. Management of multi-factorial idiopathic epilepsy in EL mice with caloric restriction and the ketogenic diet: role of glucose and ketone bodies. Nutr Metab 2004;1:11.
30. Appleton DB, DeVivo DC. An animal model of the ketogenic diet. Epilepsia 1974;15:211-27.
31. Zhao Q, Stafstrom CE, Fu DD, et al. Detrimental effects of the ketogenic diet on cognitive function in rats. Pediatr Res 2004;55:498-506.
32. Likhodii SS, Burnham WM. Calorie restriction may not elevate the threshold of PTZ-induced seizures. Epilepsy Res 2003;57:77-8.
33. Likhodii SS, Serbanescu I, Cortez MA, et al. Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet. Ann Neurol 2003;54:219-26.
34. Likhodii SS, Burnham WM. The effects of ketone bodies on neuronal excitability. In: Stafstrom CE, Rho JM, eds. Epilepsy and the ketogenic diet. New Jersey: Humana Press, 2004:217-28.