Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats

Toxicology and Applied Pharmacology

Volumn 243, Issue 3, 2010, Pages 332-339

  Minor, Robin K ^a   Smith Jr , Daniel L ^b   Sossong, Alex M ^a   Kaushik, Susmita ^c   Poosala, Suresh ^a   Spangler, Edward L ^a   Roth, George S ^d   Lane, Mark ^e   Allison, David B ^b   de Cabo, Rafael ^a   Ingram, Donald K ^f   Mattison, Julie A ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d GeroScience Inc   (United States)

^e MEDIMMUNE   (United States)

^f PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Calorie restriction; Cardiac vacuolarization; Deoxyglucose; Lifespan; Mortality

Indexed keywords

CATHEPSIN D; DEOXYGLUCOSE; GLUCOSE; GLYCOGEN; INSULIN; LIPID;

ADRENAL MEDULLA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BODY TEMPERATURE; BROWN NORWAY RAT; CARDIOTOXICITY; CELL VACUOLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; FISCHER 344 RAT; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEART ATRIUM ENLARGEMENT; HEART ATRIUM THROMBOSIS; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; IN VIVO STUDY; INCIDENCE; INSULIN BLOOD LEVEL; LIVER CONGESTION; LUNG CONGESTION; MALE; MORTALITY; NONHUMAN; PHENOTYPE; PHEOCHROMOCYTOMA; RAT; STRAIN DIFFERENCE; WEIGHT REDUCTION;

ADRENAL GLANDS; ANIMALS; AUTOPHAGY; BLOTTING, WESTERN; BODY TEMPERATURE; BODY WEIGHT; DEOXYGLUCOSE; GLUCOSE; GLYCOGEN; HEART; INSULIN; LIPID METABOLISM; MALE; MYOCARDIUM; RATS; RATS, INBRED BN; RATS, INBRED F344; SURVIVAL ANALYSIS; VACUOLES;

ANIMALIA; MAMMALIA; RATTUS; RATTUS NORVEGICUS; RODENTIA;

EID: 77049113736     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.11.025     Document Type: Article

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