Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats

Neuroscience

Volumn 219, Issue , 2012, Pages 33-47

  Huang, X ^a   McMahon, J ^a   Yang, J ^a   Shin, D ^a   Huang, Y ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Development; Epilepsy; MTOR; Rapamycin; Seizure

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; KAINIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; PENTETRAZOLE; PILOCARPINE; POTASSIUM CHLORIDE COTRANSPORTER 2; RAPAMYCIN; UNCLASSIFIED DRUG;

AGE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLONIC SEIZURE; CONTROLLED STUDY; DISEASE DURATION; DISEASE PREDISPOSITION; DOWN REGULATION; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEIZURE; THALAMUS;

ANIMALS; ANTICONVULSANTS; BLOTTING, WESTERN; CONVULSANTS; DISEASE SUSCEPTIBILITY; DOWN-REGULATION; IMMUNOHISTOCHEMISTRY; MALE; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; SIROLIMUS; SYMPORTERS; TOR SERINE-THREONINE KINASES;

EID: 84864000749     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.05.003     Document Type: Article

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