Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations

Journal of Biological Chemistry

Volumn 285, Issue 40, 2010, Pages 30752-30758

  Yamasaki, Masayuki ^a   Sendall, Timothy J ^a   Harris, Laura E ^a   Lewis, Giles M W ^a   Huntington, James A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ORGANIC ACIDS; POLYMERIZATION;

ANTITRYPSIN; ASPARTIC ACIDS; ENDOPLASMIC RETICULUM; FOLDING MECHANISM; META-STABLE STATE; POINT MUTATIONS; PROTEASE INHIBITION; REACTIVE CENTER LOOPS; SECRETORY CELLS; SERPINS;

POLYMERS;

ASPARTIC ACID; GUANIDINE; SERINE PROTEINASE INHIBITOR; ALPHA 1 ANTITRYPSIN; ALPHA 1-ANTITRYPSIN SIIYAMA;

AMINO ACID SUBSTITUTION; ARTICLE; BETA SHEET; CELL STRAIN COS7; CONTROLLED STUDY; HEAT TREATMENT; HYDROPHOBICITY; MUTATION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN POLYMERIZATION; PROTEIN STRUCTURE; REACTIVE LOOP CENTER; ANIMAL; CHEMICAL MODEL; CHEMICAL PHENOMENA; CHEMISTRY; CHLOROCEBUS AETHIOPS; GENETICS; HUMAN; MISSENSE MUTATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE;

ALPHA 1-ANTITRYPSIN; ANIMALS; CERCOPITHECUS AETHIOPS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, CHEMICAL; MUTATION, MISSENSE; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY;

EID: 77957251912     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.156042     Document Type: Article

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