DNA repair is crucial for maintaining hematopoietic stem cell function

DNA Repair

Volumn 7, Issue 3, 2008, Pages 523-529

  Niedernhofer, Laura J ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Aging; Endogenous damage; Oxidative stress; Progeria

Indexed keywords

TELOMERASE;

AGING; ARTICLE; BONE MARROW CELL; CELL COUNT; CELL FUNCTION; CELL RENEWAL; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; EXCISION REPAIR; GENETIC MODEL; GENOTOXICITY; GROWTH RETARDATION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; HUMAN; IMMUNE DEFICIENCY; LIGASE IV SYNDROME; LYMPHOID CELL; NONHOMOLOGOUS END JOINING; NONHUMAN; PRIORITY JOURNAL; SYNDROME; TELOMERE;

AGING; ANIMALS; DNA DAMAGE; DNA REPAIR; HEMATOPOIETIC STEM CELLS; HUMANS;

MUS;

EID: 39149133141     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2007.11.012     Document Type: Article

References (39)

1. D'Errico M., Lemma T., Calcagnile A., Proietti De Santis L., and Dogliotti E. Cell type and DNA damage specific response of human skin cells to environmental agents. Mutat. Res. 614 (2007) 37-47
2. Nouspikel T. DNA repair in differentiated cells: some new answers to old questions. Neuroscience 145 (2007) 1213-1221
3. Bracker T.U., Giebel B., Spanholtz J., Sorg U.R., Klein-Hitpass L., Moritz T., and Thomale J. Stringent regulation of DNA repair during human hematopoietic differentiation: a gene expression and functional analysis. Stem Cells 24 (2006) 722-730
4. Chen M.F., Lin C.T., Chen W.C., Yang C.T., Chen C.C., Liao S.K., Liu J.M., Lu C.H., and Lee K.D. The sensitivity of human mesenchymal stem cells to ionizing radiation. Int. J. Radiat. Oncol. Biol. Phys. 66 (2006) 244-253
5. Weissman I.L. Stem cells: units of development, units of regeneration, and units in evolution. Cell 100 (2000) 157-168
6. Rossi D.J., Bryder D., and Weissman I.L. Hematopoietic stem cell aging: mechanism and consequence. Exp. Gerontol. 42 (2007) 385-390
7. Kirkwood T.B. Understanding the odd science of aging. Cell 120 (2005) 437-447
8. Schlessinger D., and Van Zant G. Does functional depletion of stem cells drive aging?. Mech. Ageing Dev. 122 (2001) 1537-1553
9. Van Zant G., and Liang Y. The role of stem cells in aging. Exp. Hematol. 31 (2003) 659-672
10. Reya T., Morrison S.J., Clarke M.F., and Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 414 (2001) 105-111
11. Barnes D.J., and Melo J.V. Primitive, quiescent and difficult to kill: the role of non-proliferating stem cells in chronic myeloid leukemia. Cell Cycle 5 (2006) 2862-2866
12. Nijnik A., Woodbine L., Marchetti C., Dawson S., Lambe T., Liu C., Rodrigues N.P., Crockford T.L., Cabuy E., Vindigni A., Enver T., Bell J.I., Slijepcevic P., Goodnow C.C., Jeggo P.A., and Cornall R.J. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 447 (2007) 686-690
13. Rossi D.J., Bryder D., Seita J., Nussenzweig A., Hoeijmakers J., and Weissman I.L. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447 (2007) 725-729
14. de Boer J., de Wit J., van Steeg H., Berg R.J., Morreau H., Visser P., Lehmann A.R., Duran M., Hoeijmakers J.H., and Weeda G.A. A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy. Mol. Cell 1 (1998) 981-990
15. Nussenzweig A., Chen C., da Costa Soares V., Sanchez M., Sokol K., Nussenzweig M.C., and Li G.C. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382 (1996) 551-555
16. Ribes-Zamora A., Mihalek I., Lichtarge O., and Bertuch A.A. Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions. Nat. Struct. Mol. Biol. 14 (2007) 301-307
17. Blasco M.A., Lee H.W., Rizen M., Hanahan D., DePinho R., and Greider C.W. Mouse models for the study of telomerase. Ciba Found Symp. 211 (1997) 160-170
18. Barnes D.E., Stamp G., Rosewell I., Denzel A., and Lindahl T. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr. Biol. 8 (1998) 1395-1398
19. Frank K.M., Sharpless N.E., Gao Y., Sekiguchi J.M., Ferguson D.O., Zhu C., Manis J.P., Horner J., DePinho R.A., and Alt F.W. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol. Cell 5 (2000) 993-1002
20. Rogakou E.P., Boon C., Redon C., and Bonner W.M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell. Biol. 146 (1999) 905-916
21. Rao V.A., Conti C., Guirouilh-Barbat J., Nakamura A., Miao Z.H., Davies S.L., Sacca B., Hickson I.D., Bensimon A., and Pommier Y. Endogenous γ-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks. Mol. Cancer Res. 5 (2007) 713-724
22. Bender C.F., Sikes M.L., Sullivan R., Huye L.E., Le Beau M.M., Roth D.B., Mirzoeva O.K., Oltz E.M., and Petrini J.H. Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev. 16 (2002) 2237-2251
23. Ito K., Hirao A., Arai F., Matsuoka S., Takubo K., Hamaguchi I., Nomiyama K., Hosokawa K., Sakurada K., Nakagata N., Ikeda Y., Mak T.W., and Suda T. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431 (2004) 997-1002
24. Navarro S., Meza N.W., Quintana-Bustamante O., Casado J.A., Jacome A., McAllister K., Puerto S., Surralles J., Segovia J.C., and Bueren J.A. Hematopoietic dysfunction in a mouse model for Fanconi anemia group D1. Mol. Ther. 14 (2006) 525-535
25. Dumble M., Moore L., Chambers S.M., Geiger H., Van Zant G., Goodell M.A., and Donehower L.A. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood 109 (2007) 1736-1742
26. Takata M., Sasaki M.S., Sonoda E., Morrison C., Hashimoto M., Utsumi H., Yamaguchi-Iwai Y., Shinohara A., and Takeda S. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J. 17 (1998) 5497-5508
27. Park Y., and Gerson S.L. DNA repair defects in stem cell function and aging. Annu. Rev. Med. 56 (2005) 495-508
28. Liang Y., Van Zant G., and Szilvassy S.J. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 106 (2005) 1479-1487
29. Azuma E., Hirayama M., Yamamoto H., and Komada Y. The role of donor age in naive T-cell recovery following allogeneic hematopoietic stem cell transplantation: the younger the better. Leuk. Lymphoma. 43 (2002) 735-739
30. Kollman C., Howe C.W., Anasetti C., Antin J.H., Davies S.M., Filipovich A.H., Hegland J., Kamani N., Kernan N.A., King R., Ratanatharathorn V., Weisdorf D., and Confer D.L. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 98 (2001) 2043-2051
31. Pipes B.L., Tsang T., Peng S.X., Fiederlein R., Graham M., and Harris D.T. Telomere length changes after umbilical cord blood transplant. Transfusion 46 (2006) 1038-1043
32. van der Horst G.T., van Steeg H., Berg R.J., van Gool A.J., de Wit J., Weeda G., Morreau H., Beems R.B., van Kreijl C.F., de Gruijl F.R., Bootsma D., and Hoeijmakers J.H. Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition. Cell 89 (1997) 425-435
33. de Vries A., van Oostrom C.T., Hofhuis F.M., Dortant P.M., Berg R.J., de Gruijl F.R., Wester P.W., van Kreijl C.F., Capel P.J., van Steeg H., et al. Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature 377 (1995) 169-173
34. O'Driscoll M., Cerosaletti K.M., Girard P.M., Dai Y., Stumm M., Kysela B., Hirsch B., Gennery A., Palmer S.E., Seidel J., Gatti R.A., Varon R., Oettinger M.A., Neitzel H., Jeggo P.A., and Concannon P. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol. Cell 8 (2001) 1175-1185
35. Salob S.P., Webb D.K., and Atherton D.J. A child with xeroderma pigmentosum and bone marrow failure. Br. J. Dermatol. 126 (1992) 372-374
36. Hoover R.N. Cancer-nature, nurture, or both. N. Engl. J. Med. 343 (2000) 135-136
37. Carreau M., Gan O.I., Liu L., Doedens M., Dick J.E., and Buchwald M. Hematopoietic compartment of Fanconi anemia group C null mice contains fewer lineage-negative CD34+ primitive hematopoietic cells and shows reduced reconstruction ability. Exp. Hematol. 27 (1999) 1667-1674
38. Haneline L.S., Gobbett T.A., Ramani R., Carreau M., Buchwald M., Yoder M.C., and Clapp D.W. Loss of FancC function results in decreased hematopoietic stem cell repopulating ability. Blood 94 (1999) 1-8
39. Reese J.S., Liu L., and Gerson S.L. Repopulating defect of mismatch repair-deficient hematopoietic stem cells. Blood 102 (2003) 1626-1633