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Volumn 453, Issue 2, 2013, Pages 167-178

Brown adipose tissue: Development, metabolism and beyond

Author keywords

Adipocyte; Brown adipose tissue; Obesity; Thermogenesis; White adipose tissue

Indexed keywords

BETA 3 ADRENERGIC RECEPTOR; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CD137 ANTIGEN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 4; MYOD PROTEIN; MYOGENIC FACTOR 5; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR PAX7; TRANSFORMING GROWTH FACTOR BETA; UNCOUPLING PROTEIN 1; WNT PROTEIN;

EID: 84879590350     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130457     Document Type: Review
Times cited : (138)

References (152)
  • 2
    • 77953169046 scopus 로고    scopus 로고
    • Cellular bioenergetics as a target for obesity therapy
    • Tseng, Y. H., Cypess, A. M. and Kahn, C. R. (2010) Cellular bioenergetics as a target for obesity therapy. Nat. Rev. Drug Discovery 9, 465-482
    • (2010) Nat. Rev. Drug Discovery , vol.9 , pp. 465-482
    • Tseng, Y.H.1    Cypess, A.M.2    Kahn, C.R.3
  • 3
    • 35348874911 scopus 로고    scopus 로고
    • Developmental Origin of Fat: Tracking Obesity to Its Source
    • DOI 10.1016/j.cell.2007.10.004, PII S009286740701272X
    • Gesta, S., Tseng, Y. H. and Kahn, C. R. (2007) Developmental origin of fat: tracking obesity to its source. Cell 131, 242-256 (Pubitemid 47576146)
    • (2007) Cell , vol.131 , Issue.2 , pp. 242-256
    • Gesta, S.1    Tseng, Y.-H.2    Kahn, C.R.3
  • 4
    • 84861037753 scopus 로고    scopus 로고
    • The holy grail of metabolic disease: Brown adipose tissue
    • Bartelt, A. and Heeren, J. (2012) The holy grail of metabolic disease: brown adipose tissue. Curr. Opin. Lipidol. 23, 190-195
    • (2012) Curr. Opin. Lipidol. , vol.23 , pp. 190-195
    • Bartelt, A.1    Heeren, J.2
  • 6
    • 77953809603 scopus 로고    scopus 로고
    • Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans)
    • Cannon, B. and Nedergaard, J. (2010) Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int. J. Obes. 34 (Suppl. 1), S7-S16
    • (2010) Int. J. Obes. , vol.34 , Issue.SUPPL. 1
    • Cannon, B.1    Nedergaard, J.2
  • 7
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann, H. M., Golozoubova, V., Cannon, B. and Nedergaard, J. (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 9, 203-209
    • (2009) Cell Metab. , vol.9 , pp. 203-209
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 8
    • 0027731309 scopus 로고
    • Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
    • DOI 10.1038/366740a0
    • Lowell, B. B., Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P. and Flier, J. S. (1993) Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742 (Pubitemid 24038513)
    • (1993) Nature , vol.366 , Issue.6457 , pp. 740-742
    • Lowell, B.B.1    S-Susulic, V.2    Hamann, A.3    Lawitts, J.A.4    Himms-Hagen, J.5    Boyer, B.B.6    Kozak, L.P.7    Flier, J.S.8
  • 9
    • 33748942837 scopus 로고    scopus 로고
    • Transcriptional control of adipocyte formation
    • Farmer, S. R. (2006) Transcriptional control of adipocyte formation. Cell Metab. 4, 263-273
    • (2006) Cell Metab. , vol.4 , pp. 263-273
    • Farmer, S.R.1
  • 10
    • 44149120984 scopus 로고    scopus 로고
    • Molecular determinants of brown adipocyte formation and function
    • Farmer, S. R. (2008) Molecular determinants of brown adipocyte formation and function. Genes Dev. 22, 1269-1275
    • (2008) Genes Dev. , vol.22 , pp. 1269-1275
    • Farmer, S.R.1
  • 11
    • 77950245008 scopus 로고    scopus 로고
    • Transcriptional control of brown fat development
    • Kajimura, S., Seale, P. and Spiegelman, B. M. (2010) Transcriptional control of brown fat development. Cell Metab. 11, 257-262
    • (2010) Cell Metab. , vol.11 , pp. 257-262
    • Kajimura, S.1    Seale, P.2    Spiegelman, B.M.3
  • 12
    • 33845325476 scopus 로고    scopus 로고
    • Adipocyte differentiation from the inside out
    • DOI 10.1038/nrm2066, PII NRM2066
    • Rosen, E. D. and MacDougald, O. A. (2006) Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 7, 885-896 (Pubitemid 44871415)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.12 , pp. 885-896
    • Rosen, E.D.1    MacDougald, O.A.2
  • 13
    • 64349121056 scopus 로고    scopus 로고
    • Transcriptional control of brown adipocyte development and physiological function: Of mice and men
    • Seale, P., Kajimura, S. and Spiegelman, B. M. (2009) Transcriptional control of brown adipocyte development and physiological function: of mice and men. Genes Dev. 23, 788-797
    • (2009) Genes Dev. , vol.23 , pp. 788-797
    • Seale, P.1    Kajimura, S.2    Spiegelman, B.M.3
  • 14
    • 79952115255 scopus 로고    scopus 로고
    • Brown adipose tissue: A promising target to combat obesity
    • Vernochet, C., McDonald, M. E. and Farmer, S. R. (2010) Brown adipose tissue: a promising target to combat obesity. Drug News Perspect. 23, 409-417
    • (2010) Drug News Perspect , vol.23 , pp. 409-417
    • Vernochet, C.1    McDonald, M.E.2    Farmer, S.R.3
  • 15
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR γ2, a lipid-activated transcription factor
    • Tontonoz, P., Hu, E. and Spiegelman, B. M. (1994) Stimulation of adipogenesis in fibroblasts by PPAR γ2, a lipid-activated transcription factor. Cell 79, 1147-1156
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 17
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • DOI 10.1016/S0092-8674(00)81410-5
    • Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M. and Spiegelman, B. M. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839 (Pubitemid 28155321)
    • (1998) Cell , vol.92 , Issue.6 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 18
    • 69349088117 scopus 로고    scopus 로고
    • Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-β transcriptional complex
    • Kajimura, S., Seale, P., Kubota, K., Lunsford, E., Frangioni, J. V., Gygi, S. P. and Spiegelman, B. M. (2009) Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-β transcriptional complex. Nature 460, 1154-1158
    • (2009) Nature , vol.460 , pp. 1154-1158
    • Kajimura, S.1    Seale, P.2    Kubota, K.3    Lunsford, E.4    Frangioni, J.V.5    Gygi, S.P.6    Spiegelman, B.M.7
  • 26
    • 0015332110 scopus 로고
    • The distribution of brown adipose tissue in the human
    • Heaton, J. M. (1972) The distribution of brown adipose tissue in the human. J. Anat. 112, 35-39
    • (1972) J. Anat. , vol.112 , pp. 35-39
    • Heaton, J.M.1
  • 27
    • 0021081298 scopus 로고
    • Uncoupling protein in human brown adipose tissue mitochondria. Isolation and detection by specific antiserum
    • DOI 10.1016/0014-5793(83)80826-6
    • Lean, M. E. and James, W. P. (1983) Uncoupling protein in human brown adipose tissue mitochondria. Isolation and detection by specific antiserum. Growth Regul. 163, 235-240 (Pubitemid 14248842)
    • (1983) FEBS Letters , vol.163 , Issue.2 , pp. 235-240
    • Lean, M.E.J.1    James, W.P.T.2
  • 29
    • 0020466632 scopus 로고
    • Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma
    • Ricquier, D., Nechad, M. and Mory, G. (1982) Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma. J. Clin. Endocrinol. Metab. 54, 803-807 (Pubitemid 13240843)
    • (1982) Journal of Clinical Endocrinology and Metabolism , vol.54 , Issue.4 , pp. 803-807
    • Ricquier, D.1    Nechad, M.2    Mory, G.3
  • 31
    • 77953010087 scopus 로고    scopus 로고
    • Medicine. Beige can be slimming
    • Ishibashi, J. and Seale, P. (2010) Medicine. Beige can be slimming. Science 328, 1113-1114
    • (2010) Science , vol.328 , pp. 1113-1114
    • Ishibashi, J.1    Seale, P.2
  • 32
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B. and Nedergaard, J. (2009) Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 285, 7153-7164
    • (2009) J. Biol. Chem. , vol.285 , pp. 7153-7164
    • Petrovic, N.1    Walden, T.B.2    Shabalina, I.G.3    Timmons, J.A.4    Cannon, B.5    Nedergaard, J.6
  • 33
    • 0032528169 scopus 로고    scopus 로고
    • Emergence of brown adipocytes in white fat in mice is under genetic control effects on body weight and adiposity
    • Guerra, C., Koza, R. A., Yamashita, H., Walsh, K. and Kozak, L. P. (1998) Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 102, 412-420 (Pubitemid 28335201)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.2 , pp. 412-420
    • Guerra, C.1    Koza, R.A.2    Yamashita, H.3    Walsh, K.4    Kozak, L.P.5
  • 35
    • 65649111494 scopus 로고    scopus 로고
    • The origins of brown adipose tissue
    • Enerback, S. (2009) The origins of brown adipose tissue. N. Engl. J. Med. 360, 2021-2023
    • (2009) N. Engl. J. Med. , vol.360 , pp. 2021-2023
    • Enerback, S.1
  • 36
    • 84879577791 scopus 로고    scopus 로고
    • Reference deleted
    • Reference deleted
  • 37
    • 79951560291 scopus 로고    scopus 로고
    • Between brown and white: Novel aspects of adipocyte differentiation
    • Cinti, S. (2011) Between brown and white: novel aspects of adipocyte differentiation. Ann. Med. 43, 104-115
    • (2011) Ann. Med. , vol.43 , pp. 104-115
    • Cinti, S.1
  • 38
    • 84859465056 scopus 로고    scopus 로고
    • In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding
    • Lee, Y. H., Petkova, A. P., Mottillo, E. P. and Granneman, J. G. (2012) In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding. Cell Metab. 15, 480-491
    • (2012) Cell Metab. , vol.15 , pp. 480-491
    • Lee, Y.H.1    Petkova, A.P.2    Mottillo, E.P.3    Granneman, J.G.4
  • 41
    • 0028246730 scopus 로고
    • Neural crest cell formation and migration in the developing embryo
    • Bronner-Fraser, M. (1994) Neural crest cell formation and migration in the developing embryo. FASEB J. 8, 699-706
    • (1994) FASEB J. , vol.8 , pp. 699-706
    • Bronner-Fraser, M.1
  • 42
    • 53349160483 scopus 로고    scopus 로고
    • Developmental origin of adipocytes: New insights into a pending question
    • Billon, N., Monteiro, M. C. and Dani, C. (2008) Developmental origin of adipocytes: new insights into a pending question. Biol. Cell 100, 563-575
    • (2008) Biol. Cell , vol.100 , pp. 563-575
    • Billon, N.1    Monteiro, M.C.2    Dani, C.3
  • 44
    • 0025939597 scopus 로고
    • Expression of p53 during mouse embryogenesis
    • Schmid, P., Lorenz, A., Hameister, H. and Montenarh, M. (1991) Expression of p53 during mouse embryogenesis. Development 113, 857-865 (Pubitemid 21900325)
    • (1991) Development , vol.113 , Issue.3 , pp. 857-865
    • Schmid, P.1    Lorenz, A.2    Hameister, H.3    Montenarh, M.4
  • 49
    • 53549134683 scopus 로고    scopus 로고
    • Identification of white adipocyte progenitor cells in vivo
    • Rodeheffer, M. S., Birsoy, K. and Friedman, J. M. (2008) Identification of white adipocyte progenitor cells in vivo. Cell 135, 240-249
    • (2008) Cell , vol.135 , pp. 240-249
    • Rodeheffer, M.S.1    Birsoy, K.2    Friedman, J.M.3
  • 50
    • 75949130333 scopus 로고    scopus 로고
    • Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle
    • Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S. and Tsuchida, K. (2010) Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat. Cell Biol. 12, 143-152
    • (2010) Nat. Cell Biol. , vol.12 , pp. 143-152
    • Uezumi, A.1    Fukada, S.2    Yamamoto, N.3    Takeda, S.4    Tsuchida, K.5
  • 51
    • 84874657953 scopus 로고    scopus 로고
    • Characterization of the adipocyte cellular lineage in vivo
    • Berry, R. and Rodeheffer, M. S. (2013) Characterization of the adipocyte cellular lineage in vivo. Nat. Cell Biol. 15, 302-308
    • (2013) Nat. Cell Biol. , vol.15 , pp. 302-308
    • Berry, R.1    Rodeheffer, M.S.2
  • 55
    • 33846152299 scopus 로고    scopus 로고
    • Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade
    • DOI 10.1128/MCB.01557-06
    • Jimenez, M. A., Akerblad, P., Sigvardsson, M. and Rosen, E. D. (2007) Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade. Mol. Cell. Biol. 27, 743-757 (Pubitemid 46080139)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.2 , pp. 743-757
    • Jimenez, M.A.1    Akerblad, P.2    Sigvardsson, M.3    Rosen, E.D.4
  • 56
    • 50049097319 scopus 로고    scopus 로고
    • Developmental biology: Neither fat nor flesh
    • Cannon, B. and Nedergaard, J. (2008) Developmental biology: neither fat nor flesh. Nature 454, 947-948
    • (2008) Nature , vol.454 , pp. 947-948
    • Cannon, B.1    Nedergaard, J.2
  • 57
    • 77954741222 scopus 로고    scopus 로고
    • Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells
    • Lepper, C. and Fan, C. M. (2010) Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells. Genesis 48, 424-436
    • (2010) Genesis , vol.48 , pp. 424-436
    • Lepper, C.1    Fan, C.M.2
  • 59
    • 0027258162 scopus 로고
    • Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
    • DOI 10.1038/364501a0
    • Hasty, P., Bradley, A., Morris, J. H., Edmondson, D. G., Venuti, J. M., Olson, E. N. and Klein, W. H. (1993) Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature 364, 501-506 (Pubitemid 23273093)
    • (1993) Nature , vol.364 , Issue.6437 , pp. 501-506
    • Hasty, P.1    Bradley, A.2    Morris, J.H.3    Edmondson, D.G.4    Venuti, J.M.5    Olson, E.N.6    Klein, W.H.7
  • 60
    • 0038206882 scopus 로고    scopus 로고
    • Myf5 and MyoD activation define independent myogenic compartments during embryonic development
    • DOI 10.1016/S0012-1606(03)00139-8
    • Kablar, B., Krastel, K., Tajbakhsh, S. and Rudnicki, M. A. (2003) Myf5 and MyoD activation define independent myogenic compartments during embryonic development. Dev. Biol. 258, 307-318 (Pubitemid 36683133)
    • (2003) Developmental Biology , vol.258 , Issue.2 , pp. 307-318
    • Kablar, B.1    Krastel, K.2    Tajbakhsh, S.3    Rudnicki, M.A.4
  • 61
    • 84865792944 scopus 로고    scopus 로고
    • PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors
    • Sanchez-Gurmaches, J., Hung, C. M., Sparks, C. A., Tang, Y., Li, H. and Guertin, D. A. (2012) PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. Cell Metab. 16, 348-362
    • (2012) Cell Metab. , vol.16 , pp. 348-362
    • Sanchez-Gurmaches, J.1    Hung, C.M.2    Sparks, C.A.3    Tang, Y.4    Li, H.5    Guertin, D.A.6
  • 62
    • 0035366502 scopus 로고    scopus 로고
    • Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype
    • DOI 10.1042/0264-6021:3560659
    • Moulin, K., Truel, N., Andre, M., Arnauld, E., Nibbelink, M., Cousin, B., Dani, C., Penicaud, L. and Casteilla, L. (2001) Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype. Biochem. J. 356, 659-664 (Pubitemid 32532380)
    • (2001) Biochemical Journal , vol.356 , Issue.2 , pp. 659-664
    • Moulin, K.1    Truel, N.2    Andre, M.3    Arnauld, E.4    Nibbelink, M.5    Cousin, B.6    Dani, C.7    Penicaud8    Casteilla, L.9
  • 63
    • 46149102685 scopus 로고    scopus 로고
    • Highly Efficient, Functional Engraftment of Skeletal Muscle Stem Cells in Dystrophic Muscles
    • DOI 10.1016/j.cell.2008.05.049, PII S0092867408007551
    • Cerletti, M., Jurga, S., Witczak, C. A., Hirshman, M. F., Shadrach, J. L., Goodyear, L. J. and Wagers, A. J. (2008) Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Cell 134, 37-47 (Pubitemid 351905744)
    • (2008) Cell , vol.134 , Issue.1 , pp. 37-47
    • Cerletti, M.1    Jurga, S.2    Witczak, C.A.3    Hirshman, M.F.4    Shadrach, J.L.5    Goodyear, L.J.6    Wagers, A.J.7
  • 64
    • 54049143270 scopus 로고    scopus 로고
    • Reversible transdifferentiation in the adipose organ
    • Cinti, S. (2008) Reversible transdifferentiation in the adipose organ. Int. J. Pediatr. Obes. 3 (Suppl. 2), 21-26
    • (2008) Int. J. Pediatr. Obes. , vol.3 , Issue.SUPPL. 2 , pp. 21-26
    • Cinti, S.1
  • 65
    • 77949327079 scopus 로고    scopus 로고
    • Reversible physiological transdifferentiation in the adipose organ
    • Cinti, S. (2009) Reversible physiological transdifferentiation in the adipose organ. Proc. Nutr. Soc. 68, 340-349
    • (2009) Proc. Nutr. Soc. , vol.68 , pp. 340-349
    • Cinti, S.1
  • 66
    • 70350443275 scopus 로고    scopus 로고
    • Transdifferentiation properties of adipocytes in the adipose organ
    • Cinti, S. (2009) Transdifferentiation properties of adipocytes in the adipose organ. Am. J. Physiol. Endocrinol. Metab. 297, E977-E986
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297
    • Cinti, S.1
  • 67
    • 70649109834 scopus 로고    scopus 로고
    • Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism
    • Schulz, T. J. and Tseng, Y. H. (2009) Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism. Cytokine Growth Factor Rev. 20, 523-531
    • (2009) Cytokine Growth Factor Rev. , vol.20 , pp. 523-531
    • Schulz, T.J.1    Tseng, Y.H.2
  • 69
    • 0034697007 scopus 로고    scopus 로고
    • Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes
    • DOI 10.1074/jbc.275.16.12119
    • Konishi, M., Mikami, T., Yamasaki, M., Miyake, A. and Itoh, N. (2000) Fibroblast growth factor-16 is a growth factor for embryonic brown adipocytes. J. Biol. Chem. 275, 12119-12122 (Pubitemid 30237788)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.16 , pp. 12119-12122
    • Konishi, M.1    Mikami, T.2    Yamasaki, M.3    Miyake, A.4    Itoh, N.5
  • 72
  • 76
    • 34250019537 scopus 로고
    • Bone: Formation by autoinduction
    • Urist, M. R. (1965) Bone: formation by autoinduction. Science 150, 893-899
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 77
    • 0031093601 scopus 로고    scopus 로고
    • Bone morphogenetic protein: The molecularization of skeletal system development
    • Urist, M. R. (1997) Bone morphogenetic protein: the molecularization of skeletal system development. J. Bone Miner. Res. 12, 343-346
    • (1997) J. Bone Miner. Res. , vol.12 , pp. 343-346
    • Urist, M.R.1
  • 78
    • 21344433063 scopus 로고    scopus 로고
    • BMP signaling and early embryonic patterning
    • DOI 10.1016/j.cytogfr.2005.04.002, PII S1359610105000444
    • Kishigami, S. and Mishina, Y. (2005) BMP signaling and early embryonic patterning. Cytokine Growth Factor Rev. 16, 265-278 (Pubitemid 40910316)
    • (2005) Cytokine and Growth Factor Reviews , vol.16 , Issue.3 SPEC. ISS. , pp. 265-278
    • Kishigami, S.1    Mishina, Y.2
  • 80
    • 33846146325 scopus 로고    scopus 로고
    • BMP-4 treatment of C3H10T1/2 stem cells blocks expression of MMP-3 and MMP-13
    • DOI 10.1016/j.bbrc.2006.12.170, PII S0006291X06028452
    • Otto, T. C., Bowers, R. R. and Lane, M. D. (2006) BMP-4 treatment of C3H10T1/2 stem cells blocks expression of MMP-3 and MMP-13. Biochem. Biophys. Res. Commun. 353, 1097-1104 (Pubitemid 46080411)
    • (2007) Biochemical and Biophysical Research Communications , vol.353 , Issue.4 , pp. 1097-1104
    • Otto, T.C.1    Bowers, R.R.2    Lane, M.D.3
  • 81
    • 0027185702 scopus 로고
    • Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells
    • Wang, E. A., Israel, D. I., Kelly, S. and Luxenberg, D. P. (1993) Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 9, 57-71 (Pubitemid 23241842)
    • (1993) Growth Factors , vol.9 , Issue.1 , pp. 57-71
    • Wang, E.A.1    Israel, D.I.2    Kelly, S.3    Luxenberg, D.P.4
  • 83
    • 0028832707 scopus 로고
    • A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
    • Dudley, A. T., Lyons, K. M. and Robertson, E. J. (1995) A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev. 9, 2795-2807
    • (1995) Genes Dev. , vol.9 , pp. 2795-2807
    • Dudley, A.T.1    Lyons, K.M.2    Robertson, E.J.3
  • 88
    • 65349151258 scopus 로고    scopus 로고
    • Have we entered the brown adipose tissue renaissance?
    • Ravussin, E. and Kozak, L. P. (2009) Have we entered the brown adipose tissue renaissance? Obes. Rev. 10, 265-268
    • (2009) Obes. Rev. , vol.10 , pp. 265-268
    • Ravussin, E.1    Kozak, L.P.2
  • 89
    • 4544357340 scopus 로고    scopus 로고
    • Learning new tricks from old dogs: β-adrenergic receptors teach new lessons on firing up adipose tissue metabolism
    • DOI 10.1210/me.2004-0193
    • Collins, S., Cao, W. and Robidoux, J. (2004) Learning new tricks from old dogs: β-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. Mol. Endocrinol. 18, 2123-2131 (Pubitemid 39215245)
    • (2004) Molecular Endocrinology , vol.18 , Issue.9 , pp. 2123-2131
    • Collins, S.1    Cao, W.2    Robidoux, J.3
  • 90
    • 78449266620 scopus 로고    scopus 로고
    • Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks
    • Collins, S., Yehuda-Shnaidman, E. and Wang, H. (2010) Positive and negative control of Ucp1 gene transcription and the role of β-adrenergic signaling networks. Int. J. Obes. 34 (Suppl. 1), S28-S33
    • (2010) Int. J. Obes. , vol.34 , Issue.SUPPL. 1
    • Collins, S.1    Yehuda-Shnaidman, E.2    Wang, H.3
  • 91
    • 84874413612 scopus 로고    scopus 로고
    • β-Adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure
    • Collins, S. (2012) β-Adrenoceptor signaling networks in adipocytes for recruiting stored fat and energy expenditure. Front. Endocrinol. 2, 102
    • (2012) Front. Endocrinol. , vol.2 , pp. 102
    • Collins, S.1
  • 92
    • 79955032433 scopus 로고    scopus 로고
    • Brown fat biology and thermogenesis
    • Richard, D. and Picard, F. (2011) Brown fat biology and thermogenesis. Front. Biosci. 16, 1233-1260
    • (2011) Front. Biosci. , vol.16 , pp. 1233-1260
    • Richard, D.1    Picard, F.2
  • 93
    • 84871252686 scopus 로고    scopus 로고
    • Brown adipose tissue: Recent insights into development, metabolic function, and therapeutic potential
    • Townsend, K. L. and Tseng, Y. H. (2012) Brown adipose tissue: recent insights into development, metabolic function, and therapeutic potential. Adipocyte 1, 13-24
    • (2012) Adipocyte , vol.1 , pp. 13-24
    • Townsend, K.L.1    Tseng, Y.H.2
  • 95
    • 33751172559 scopus 로고    scopus 로고
    • The role of brown adipose tissue in human obesity
    • Cinti, S. (2006) The role of brown adipose tissue in human obesity. Nutr. Metab. Cardiovasc. Dis. 16, 569-574
    • (2006) Nutr. Metab. Cardiovasc. Dis. , vol.16 , pp. 569-574
    • Cinti, S.1
  • 96
    • 77950190436 scopus 로고    scopus 로고
    • Distribution and development of brown adipocytes in the murine and human adipose organ
    • Frontini, A. and Cinti, S. (2010) Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab. 11, 253-256
    • (2010) Cell Metab. , vol.11 , pp. 253-256
    • Frontini, A.1    Cinti, S.2
  • 99
    • 77952243631 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure
    • Wang, C., Bomberg, E., Billington, C. J., Levine, A. S. and Kotz, C. M. (2010) Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure. Brain Res. 1336, 66-77
    • (2010) Brain Res. , vol.1336 , pp. 66-77
    • Wang, C.1    Bomberg, E.2    Billington, C.J.3    Levine, A.S.4    Kotz, C.M.5
  • 100
    • 80052739107 scopus 로고    scopus 로고
    • White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis
    • Cao, L., Choi, E. Y., Liu, X., Martin, A., Wang, C., Xu, X. and During, M. J. (2011) White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis. Cell Metab. 14, 324-338
    • (2011) Cell Metab. , vol.14 , pp. 324-338
    • Cao, L.1    Choi, E.Y.2    Liu, X.3    Martin, A.4    Wang, C.5    Xu, X.6    During, M.J.7
  • 101
    • 84879548972 scopus 로고    scopus 로고
    • Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake
    • doi:10.1089/ars.2012.4536
    • Townsend, K. L., An, D., Lynes, M. D., Huang, T. L., Zhang, H., Goodyear, L. J. and Tseng, Y. H. (2012) Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake. Antioxid. Redox. Signaling, doi:10.1089/ars.2012.4536
    • (2012) Antioxid. Redox. Signaling
    • Townsend, K.L.1    An, D.2    Lynes, M.D.3    Huang, T.L.4    Zhang, H.5    Goodyear, L.J.6    Tseng, Y.H.7
  • 104
    • 80053928150 scopus 로고    scopus 로고
    • Orexin is required for brown adipose tissue development, differentiation, and function
    • Sellayah, D., Bharaj, P. and Sikder, D. (2011) Orexin is required for brown adipose tissue development, differentiation, and function. Cell Metab. 14, 478-490
    • (2011) Cell Metab. , vol.14 , pp. 478-490
    • Sellayah, D.1    Bharaj, P.2    Sikder, D.3
  • 105
    • 77956030149 scopus 로고    scopus 로고
    • The endogenous actions of hypothalamic peptides on brown adipose tissue thermogenesis in the rat
    • Verty, A. N., Allen, A. M. and Oldfield, B. J. (2010) The endogenous actions of hypothalamic peptides on brown adipose tissue thermogenesis in the rat. Endocrinology 151, 4236-4246
    • (2010) Endocrinology , vol.151 , pp. 4236-4246
    • Verty, A.N.1    Allen, A.M.2    Oldfield, B.J.3
  • 106
    • 18844401648 scopus 로고    scopus 로고
    • Dual regulatory effects of orexins on sympathetic nerve activity innervating brown adipose tissue in rats
    • DOI 10.1210/en.2004-1226
    • Yasuda, T., Masaki, T., Kakuma, T., Hara, M., Nawata, T., Katsuragi, I. and Yoshimatsu, H. (2005) Dual regulatory effects of orexins on sympathetic nerve activity innervating brown adipose tissue in rats. Endocrinology 146, 2744-2748 (Pubitemid 40695578)
    • (2005) Endocrinology , vol.146 , Issue.6 , pp. 2744-2748
    • Yasuda, T.1    Masaki, T.2    Kakuma, T.3    Hara, M.4    Nawata, T.5    Katsuragi, I.6    Yoshimatsu, H.7
  • 108
    • 46149086585 scopus 로고    scopus 로고
    • Central control of thermogenesis in mammals
    • DOI 10.1113/expphysiol.2007.041848
    • Morrison, S. F., Nakamura, K. and Madden, C. J. (2008) Central control of thermogenesis in mammals. Exp. Physiol. 93, 773-797 (Pubitemid 351904256)
    • (2008) Experimental Physiology , vol.93 , Issue.7 , pp. 773-797
    • Morrison, S.F.1    Nakamura, K.2    Madden, C.J.3
  • 111
    • 77957279363 scopus 로고    scopus 로고
    • The T3 receptor β1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes
    • Martinez, D. M., Scanlan, T. S. and Obregon, M. J. (2010) The T3 receptor β1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes. Endocrinology 151, 5074-5083
    • (2010) Endocrinology , vol.151 , pp. 5074-5083
    • Martinez, D.M.1    Scanlan, T.S.2    Obregon, M.J.3
  • 112
    • 79955010740 scopus 로고    scopus 로고
    • Brown adipose tissue growth and development: Significance and nutritional regulation
    • Satterfield, M. C. and Wu, G. (2011) Brown adipose tissue growth and development: significance and nutritional regulation. Front. Biosci. 16, 1589-1608
    • (2011) Front. Biosci. , vol.16 , pp. 1589-1608
    • Satterfield, M.C.1    Wu, G.2
  • 113
    • 1342282912 scopus 로고    scopus 로고
    • Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation
    • DOI 10.1128/MCB.24.5.1918-1929.2004
    • Tseng, Y. H., Kriauciunas, K. M., Kokkotou, E. and Kahn, C. R. (2004) Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol. Cell. Biol. 24, 1918-1929 (Pubitemid 38248933)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.5 , pp. 1918-1929
    • Tseng, Y.-H.1    Kriauciunas, K.M.2    Kokkotou, E.3    Kahn, C.R.4
  • 115
    • 77249099832 scopus 로고    scopus 로고
    • Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    • Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Iglesias, R. and Villarroya, F. (2010) Hepatic FGF21 expression is induced at birth via PPARα in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab. 11, 206-212
    • (2010) Cell Metab. , vol.11 , pp. 206-212
    • Hondares, E.1    Rosell, M.2    Gonzalez, F.J.3    Giralt, M.4    Iglesias, R.5    Villarroya, F.6
  • 118
    • 34249677947 scopus 로고    scopus 로고
    • FGF21: A missing link in the biology of fasting
    • Reitman, M. L. (2007) FGF21: a missing link in the biology of fasting. Cell Metab. 5, 405-407
    • (2007) Cell Metab. , vol.5 , pp. 405-407
    • Reitman, M.L.1
  • 124
    • 78651313711 scopus 로고    scopus 로고
    • Nonshivering thermogenesis and its adequate measurement in metabolic studies
    • Cannon, B. and Nedergaard, J. (2011) Nonshivering thermogenesis and its adequate measurement in metabolic studies. J. Exp. Biol. 214, 242-253
    • (2011) J. Exp. Biol. , vol.214 , pp. 242-253
    • Cannon, B.1    Nedergaard, J.2
  • 125
    • 0024362168 scopus 로고
    • Role of thermogenesis in the regulation of energy balance in relation to obesity
    • Himms-Hagen, J. (1989) Role of thermogenesis in the regulation of energy balance in relation to obesity. Can. J. Physiol. Pharmacol. 67, 394-401
    • (1989) Can. J. Physiol. Pharmacol. , vol.67 , pp. 394-401
    • Himms-Hagen, J.1
  • 126
    • 0023622433 scopus 로고
    • Effect of high fat diets on energy balance and thermogenesis in brown adipose tissue of lean and genetically obese ob/ob mice
    • Mercer, S. W. and Trayhurn, P. (1987) Effect of high fat diets on energy balance and thermogenesis in brown adipose tissue of lean and genetically obese ob /ob mice. J. Nutr. 117, 2147-2153 (Pubitemid 18030601)
    • (1987) Journal of Nutrition , vol.117 , Issue.12 , pp. 2147-2153
    • Mercer, S.W.1    Trayhurn, P.2
  • 127
    • 0018646453 scopus 로고
    • A role for brown adipose tissue in diet-induced thermogenesis
    • DOI 10.1038/281031a0
    • Rothwell, N. J. and Stock, M. J. (1979) A role for brown adipose tissue in diet-induced thermogenesis. Nature 281, 31-35 (Pubitemid 9247988)
    • (1979) Nature , vol.281 , Issue.5726 , pp. 31-35
    • Rothwell, N.J.1    Stock, M.J.2
  • 128
    • 0020693920 scopus 로고
    • Luxuskonsumption, diet-induced thermogenesis and brown fat: The case in favour
    • Rothwell, N. J. and Stock, M. J. (1983) Luxuskonsumption, diet-induced thermogenesis and brown fat: the case in favour. Clin. Sci. 64, 19-23 (Pubitemid 13207247)
    • (1983) Clinical Science , vol.64 , Issue.1 , pp. 19-23
    • Rothwell, N.J.1    Stock, M.J.2
  • 129
    • 84965083278 scopus 로고
    • Role of adrenaline and noradrenaline in chemical regulation of heat production
    • Hsieh, A. C. and Alson, L. D. (1957) Role of adrenaline and noradrenaline in chemical regulation of heat production. Am. J. Physiol. 190, 243-246
    • (1957) Am. J. Physiol. , vol.190 , pp. 243-246
    • Hsieh, A.C.1    Alson, L.D.2
  • 130
    • 0000426830 scopus 로고
    • The calorigenic response of cold-acclimated white rats to infused noradrenaline
    • Depocas, F. (1960) The calorigenic response of cold-acclimated white rats to infused noradrenaline. Can. J. Biochem. Physiol. 38, 107-114
    • (1960) Can. J. Biochem. Physiol. , vol.38 , pp. 107-114
    • Depocas, F.1
  • 131
    • 0028224485 scopus 로고
    • Effect of CL-316,243, a thermogenic β3-agonist, on energy balance and brown and white adipose tissues in rats
    • Himms-Hagen, J., Cui, J., Danforth, Jr, E., Taatjes, D. J., Lang, S. S., Waters, B. L. and Claus, T. H. (1994) Effect of CL-316,243, a thermogenic β3-agonist, on energy balance and brown and white adipose tissues in rats. Am. J. Physiol. 266, R1371-R1382
    • (1994) Am. J. Physiol. , vol.266
    • Himms-Hagen, J.1    Cui, J.2    Danforth Jr., E.3    Taatjes, D.J.4    Lang, S.S.5    Waters, B.L.6    Claus, T.H.7
  • 132
    • 0028237901 scopus 로고
    • 3- adrenoceptor agonist, in mice with monosodium-L-glutamate-induced obesity
    • Yoshida, T., Sakane, N., Wakabayashi, Y., Umekawa, T. and Kondo, M. (1994) Anti-obesity effect of CL 316,243, a highly specific β3-adrenoceptor agonist, in mice with monosodium-L-glutamate-induced obesity. Eur. J. Endocrinol. 131, 97-102 (Pubitemid 24230559)
    • (1994) European Journal of Endocrinology , vol.131 , Issue.1 , pp. 97-102
    • Yoshida, T.1    Sakane, N.2    Wakabayashi, Y.3    Umekawa, T.4    Kondo, M.5
  • 133
    • 47149118684 scopus 로고    scopus 로고
    • The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: Perspectives from β3-adrenoceptor agonists
    • Arch, J. R. (2008) The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from β3-adrenoceptor agonists. Naunyn Schmiedebergs Arch. Pharmacol. 378, 225-240
    • (2008) Naunyn Schmiedebergs Arch. Pharmacol. , vol.378 , pp. 225-240
    • Arch, J.R.1
  • 134
    • 33947678206 scopus 로고    scopus 로고
    • Thermogenic and metabolic antiobesity drugs: Rationale and opportunities
    • DOI 10.1111/j.1463-1326.2006.00608.x
    • Clapham, J. C. and Arch, J. R. (2007) Thermogenic and metabolic antiobesity drugs: rationale and opportunities. Diabetes Obes. Metab. 9, 259-275 (Pubitemid 46502043)
    • (2007) Diabetes, Obesity and Metabolism , vol.9 , Issue.3 , pp. 259-275
    • Clapham, J.C.1    Arch, J.R.S.2
  • 135
    • 1842409029 scopus 로고    scopus 로고
    • Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
    • Enerback, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M. E. and Kozak, L. P. (1997) Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90-94 (Pubitemid 27202655)
    • (1997) Nature , vol.387 , Issue.6628 , pp. 90-94
    • Enerback, S.1    Jacobsson, A.2    Simpson, E.M.3    Guerra, C.4    Yamashita, H.5    Harper, M.-E.6    Kozak, L.P.7
  • 137
    • 0037314231 scopus 로고    scopus 로고
    • Paradoxical resistance to diet-induced obesity in UCP1-deficient mice
    • DOI 10.1172/JCI200315737
    • Liu, X., Rossmeisl, M., McClaine, J., Riachi, M., Harper, M. E. and Kozak, L. P. (2003) Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J. Clin. Invest. 111, 399-407 (Pubitemid 36182217)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.3 , pp. 399-407
    • Liu, X.1    Rossmeisl, M.2    McClaine, J.3    Kozak, L.P.4
  • 139
    • 33845977987 scopus 로고    scopus 로고
    • Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat
    • DOI 10.1194/jlr.M600287-JLR200
    • Xue, B., Rim, J. S., Hogan, J. C., Coulter, A. A., Koza, R. A. and Kozak, L. P. (2007) Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat. J. Lipid Res. 48, 41-51 (Pubitemid 46052896)
    • (2007) Journal of Lipid Research , vol.48 , Issue.1 , pp. 41-51
    • Xue, B.1    Rim, J.-S.2    Hogan, J.C.3    Coulter, A.A.4    Koza, R.A.5    Kozak, L.P.6
  • 142
    • 0037315245 scopus 로고    scopus 로고
    • Uptake in supraclavicular area fat ("USA-Fat"): Description on 18F-FDG PET/CT
    • Cohade, C., Osman, M., Pannu, H. K. and Wahl, R. L. (2003) Uptake in supraclavicular area fat ("USA-Fat"): description on 18F-FDG PET/CT. J. Nucl. Med. 44, 170-176
    • (2003) J. Nucl. Med. , vol.44 , pp. 170-176
    • Cohade, C.1    Osman, M.2    Pannu, H.K.3    Wahl, R.L.4
  • 143
    • 70349334680 scopus 로고    scopus 로고
    • The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    • Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J. and Cinti, S. (2009) The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J. 23, 3113-3120
    • (2009) FASEB J. , vol.23 , pp. 3113-3120
    • Zingaretti, M.C.1    Crosta, F.2    Vitali, A.3    Guerrieri, M.4    Frontini, A.5    Cannon, B.6    Nedergaard, J.7    Cinti, S.8
  • 146
    • 84864087999 scopus 로고    scopus 로고
    • Assessment of oxidative metabolism in brown fat using PET imaging
    • Muzik, O., Mangner, T. J. and Granneman, J. G. (2012) Assessment of oxidative metabolism in brown fat using PET imaging. Front. Endocrin. 3, 15
    • (2012) Front. Endocrin. , vol.3 , pp. 15
    • Muzik, O.1    Mangner, T.J.2    Granneman, J.G.3
  • 148
    • 84871898177 scopus 로고    scopus 로고
    • Characterization of human brown adipose tissue by chemical-shift water-fat MRI
    • Hu, H. H., Perkins, T. G., Chia, J. M. and Gilsanz, V. (2013) Characterization of human brown adipose tissue by chemical-shift water-fat MRI. Am. J. Roentgenol. 200, 177-183
    • (2013) Am. J. Roentgenol. , vol.200 , pp. 177-183
    • Hu, H.H.1    Perkins, T.G.2    Chia, J.M.3    Gilsanz, V.4
  • 150
    • 0013873889 scopus 로고
    • Brown adipose tissue and heat production in the newborn infant
    • Aherne, W. and Hull, D. (1966) Brown adipose tissue and heat production in the newborn infant. J. Pathol. Bacteriol. 91, 223-234
    • (1966) J. Pathol. Bacteriol. , vol.91 , pp. 223-234
    • Aherne, W.1    Hull, D.2


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