Increased proton leak and SOD2 expression in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1832, Issue 10, 2013, Pages 1624-1633

  Aguer, Céline ^a   Pasqua, Melissa ^a   Thrush, A Brianne ^a   Moffat, Cynthia ^a   McBurney, Michael ^b   Jardine, Karen ^b   Zhang, Rui ^a   Beauchamp, Brittany ^a   Dent, Robert ^c   McPherson, Ruth ^d   Harper, Mary Ellen ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

Mitochondrial proton leak; Muscle; Oxidative phosphorylation; Oxidative stress

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; PROTON; TRIACYLGLYCEROL;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; HUMAN; INSULIN RESISTANCE; MITOCHONDRIAL MEMBRANE POTENTIAL; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REST;

2′,7′-DICHLORFLUORESCEIN-DIACETATE; ADENINE NUCLEOTIDE TRANSLOCASE; ANT; C-JUN N-TERMINAL KINASE; CARBONYL CYANIDE 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CITRATE SYNTHASE; COX; CS; CYTOCHROME C OXIDASE; DCFH-DA; FAMILY HISTORY; FCCP; FH; GSH; GSSG; HGI; HIGH GLUCOSE, HIGH INSULIN DIFFERENTIATION MEDIUM; IΚKΒ; INHIBITOR OF NF-ΚB KINASE; INTERNATIONAL PHYSICAL ACTIVITY QUESTIONNAIRE; IPAQ; JNK; LGI; LOW GLUCOSE, LOW INSULIN DIFFERENTIATION MEDIUM; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PROTON LEAK; MUSCLE; OCR; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXIDIZED GLUTATHIONE; OXYGEN CONSUMPTION RATES; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR Γ; PPARΓ; REACTIVE OXYGEN SPECIES; REDUCED GLUTATHIONE; RESPIRATORY QUOTIENT; RESTING METABOLIC RATE; RMR; ROS; RQ; SOD2; T2DM; TETRAMETHYLRHODAMINE ETHYL ESTER; TMRE; TYPE 2 DIABETES MELLITUS; UCP3; UNCOUPLING PROTEIN 3;

CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DNA, MITOCHONDRIAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN RESISTANCE; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIDDLE AGED; MUSCLE FIBERS, SKELETAL; OBESITY; PROTONS; SUPEROXIDE DISMUTASE;

EID: 84879573670     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2013.05.008     Document Type: Article

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